Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone A?

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What functions are associated with Epothilone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
Zhan W et al. Design and synthesis of C6-C8 bridged epothilone A. 2008 Org. Lett. pmid:18355076
Erdélyi M et al. Conformational preferences of natural and C3-modified epothilones in aqueous solution. 2008 J. Med. Chem. pmid:18271516
Reese M et al. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. 2007 Angew. Chem. Int. Ed. Engl. pmid:17274084
Buey RM et al. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. 2007 Nat. Chem. Biol. pmid:17206139
Cachoux F et al. Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition. 2006 Chembiochem pmid:16345113
Han C et al. Prostaglandins from a zoanthid: paclitaxel-like neurite-degenerating and microtubule-stabilizating activities. 2006 Biosci. Biotechnol. Biochem. pmid:16556989
Seyb KI et al. beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton. 2006 J. Mol. Neurosci. pmid:16679552
Ramachandran PV et al. Studies towards the synthesis of epothilone A via organoboranes. 2005 Org. Biomol. Chem. pmid:16211118
Heinz DW et al. Much anticipated--the bioactive conformation of epothilone and its binding to tubulin. 2005 Angew. Chem. Int. Ed. Engl. pmid:15714588
Sánchez-Pedregal VM et al. The INPHARMA method: protein-mediated interligand NOEs for pharmacophore mapping. 2005 Angew. Chem. Int. Ed. Engl. pmid:15929149
Altmann KH et al. 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. 2004 Prog Med Chem pmid:15003721
Hu W et al. A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro. 2004 Acta Pharmacol. Sin. pmid:15169631
Nettles JH et al. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. 2004 Science pmid:15297674
Kingston DG What makes epothilones stick? 2004 Chem. Biol. pmid:15123274
Ogura H et al. EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. 2004 Biochemistry pmid:15544342
Carlomagno T et al. The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800173
Carlomagno T et al. Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: a C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800174
Walsh CT et al. Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. 2003 J. Ind. Microbiol. Biotechnol. pmid:12707798
Wittmann S et al. Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. 2003 Cancer Res. pmid:12517783
Gerth K et al. Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F. 2002 J. Antibiot. pmid:11918064