MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Neoplasms | D009369 | 13 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Epothilone A
MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Neoplasms | D009369 | 13 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tang L et al. | Cloning and heterologous expression of the epothilone gene cluster. | 2000 | Science | pmid:10649995 |
Santi DV et al. | An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. | 2000 | Gene | pmid:10773448 |
Martello LA et al. | Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. | 2000 | Clin. Cancer Res. | pmid:10815923 |
Hamel E et al. | The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. | 1999 | Biochemistry | pmid:10220336 |
Taraschi TF et al. | Plasmodium falciparum: characterization of organelle migration during merozoite morphogenesis in asexual malaria infections. | 1998 | Exp. Parasitol. | pmid:9562421 |
Sefkow M et al. | Oxidative and reductive transformations of epothilone A. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873669 |
Sefkow M et al. | Derivatization of the C12-C13 functional groups of epothilones A, B and C. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873670 |
Bornscheuer UT et al. | Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones. | 1998 | Biotechnol. Bioeng. | pmid:10099292 |
Sinha SC et al. | The antibody catalysis route to the total synthesis of epothilones. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9843936 |
Finney NS | Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. | 1998 | Chem. Biol. | pmid:9571210 |
Cowden CJ and Paterson I | Synthetic chemistry. Cancer drugs better than taxol? | 1997 | Nature | pmid:9153384 |
Nicolaou KC et al. | Synthesis of epothilones A and B in solid and solution phase. | 1997 | Nature | pmid:9153390 |
Kowalski RJ et al. | Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). | 1997 | J. Biol. Chem. | pmid:8999970 |
Mann J | Myxobacterial bounty. | 1997 | Nature | pmid:8990108 |
Gerth K et al. | Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. | 1996 | J. Antibiot. | pmid:8698639 |
Service RF | Tumor-killer made; how does it work? | 1996 | Science | pmid:8984658 |
Bollag DM et al. | Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. | 1995 | Cancer Res. | pmid:7757983 |
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