| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Neoplasms | D009369 | 13 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Total
3
Epothilone A
Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.
Cross Reference
Introduction
To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone A?
Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone A
PubChem Associated disorders and diseases
What pathways are associated with Epothilone A
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone A?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone A?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
What genes are associated with Epothilone A?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone A?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Epothilone A
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Carlomagno T et al. | Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: a C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin. | 2003 | Angew. Chem. Int. Ed. Engl. | pmid:12800174 |
| Walsh CT et al. | Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits. | 2003 | J. Ind. Microbiol. Biotechnol. | pmid:12707798 |
| Wittmann S et al. | Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis. | 2003 | Cancer Res. | pmid:12517783 |
| Altmann KH et al. | 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. | 2004 | Prog Med Chem | pmid:15003721 |
| Hu W et al. | A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro. | 2004 | Acta Pharmacol. Sin. | pmid:15169631 |
| Nettles JH et al. | The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. | 2004 | Science | pmid:15297674 |
| Kingston DG | What makes epothilones stick? | 2004 | Chem. Biol. | pmid:15123274 |
| Ogura H et al. | EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. | 2004 | Biochemistry | pmid:15544342 |
| Ramachandran PV et al. | Studies towards the synthesis of epothilone A via organoboranes. | 2005 | Org. Biomol. Chem. | pmid:16211118 |
| Heinz DW et al. | Much anticipated--the bioactive conformation of epothilone and its binding to tubulin. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:15714588 |