Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone A?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Epothilone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
Altmann KH et al. 4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies. 2004 Prog Med Chem pmid:15003721
Service RF Tumor-killer made; how does it work? 1996 Science pmid:8984658
Tang L et al. Cloning and heterologous expression of the epothilone gene cluster. 2000 Science pmid:10649995
Nettles JH et al. The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography. 2004 Science pmid:15297674
Prota AE et al. Molecular mechanism of action of microtubule-stabilizing anticancer agents. 2013 Science pmid:23287720
Rogalska A et al. Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells. 2018 Toxicol In Vitro pmid:29117515
Rogalska A et al. Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. 2013 Toxicol In Vitro pmid:22995584
Li Y et al. [Diversity of metabolites and their bio-activities in myxobacterium Sorangium cellulosum]. 2001 Wei Sheng Wu Xue Bao pmid:12552829