Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone A?

Related references are published most in these journals:

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What functions are associated with Epothilone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
Kowalski RJ et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). 1997 J. Biol. Chem. pmid:8999970
Cowden CJ and Paterson I Synthetic chemistry. Cancer drugs better than taxol? 1997 Nature pmid:9153384
Nicolaou KC et al. Synthesis of epothilones A and B in solid and solution phase. 1997 Nature pmid:9153390
Taraschi TF et al. Plasmodium falciparum: characterization of organelle migration during merozoite morphogenesis in asexual malaria infections. 1998 Exp. Parasitol. pmid:9562421
Finney NS Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. 1998 Chem. Biol. pmid:9571210
Sinha SC et al. The antibody catalysis route to the total synthesis of epothilones. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9843936
Sefkow M et al. Oxidative and reductive transformations of epothilone A. 1998 Bioorg. Med. Chem. Lett. pmid:9873669
Sefkow M et al. Derivatization of the C12-C13 functional groups of epothilones A, B and C. 1998 Bioorg. Med. Chem. Lett. pmid:9873670