Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

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Introduction

To understand associated biological information of Epothilone A, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone A?

Epothilone A is suspected in and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone A

PubChem Associated disorders and diseases

What pathways are associated with Epothilone A

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone A?

Related references are published most in these journals:

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What functions are associated with Epothilone A?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

What genes are associated with Epothilone A?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone A?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Epothilone A

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Authors Title Published Journal PubMed Link
pmid:
Kamel K and Kolinski A Computational study of binding of epothilone A to β-tubulin. 2011 Acta Biochim. Pol. pmid:21633729
Hu W et al. A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro. 2004 Acta Pharmacol. Sin. pmid:15169631
Carlomagno T et al. The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800173
Carlomagno T et al. Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: a C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800174
Reese M et al. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. 2007 Angew. Chem. Int. Ed. Engl. pmid:17274084
Heinz DW et al. Much anticipated--the bioactive conformation of epothilone and its binding to tubulin. 2005 Angew. Chem. Int. Ed. Engl. pmid:15714588
Sánchez-Pedregal VM et al. The INPHARMA method: protein-mediated interligand NOEs for pharmacophore mapping. 2005 Angew. Chem. Int. Ed. Engl. pmid:15929149
Rogalska A et al. Effects of Epothilone A in Combination with the Antidiabetic Drugs Metformin and Sitagliptin in HepG2 Human Hepatocellular Cancer Cells: Role of Transcriptional Factors NF-κB and p53. 2016 Asian Pac. J. Cancer Prev. pmid:27039825
Hamel E et al. The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. 1999 Biochemistry pmid:10220336