Epothilone B

Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Epothilone B?

Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Epothilone B

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Adrenal Gland Neoplasms D000310 6 associated lipids
Pheochromocytoma D010673 4 associated lipids
Glioma D005910 112 associated lipids
Uterine Neoplasms D014594 18 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Epothilone B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Epothilone B?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Epothilone B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Epothilone B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Epothilone B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Epothilone B?

Xenograft Model

Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).

Mouse Model

Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Epothilone B

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Per page 10 20 50 100 | Total 253
Authors Title Published Journal PubMed Link
pmid:
Harichand-Herdt S and O'regan RM Identifying subsets of metastatic breast cancer patients likely to benefit from treatment with the epothilone B analog ixabepilone. 2010 Am. J. Clin. Oncol. pmid:20051810
Kratzer E et al. Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization. 2012 Am. J. Respir. Cell Mol. Biol. pmid:22842495
Wang C et al. Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. 2013 Angew. Chem. Int. Ed. Engl. pmid:23307513
Heinz DW et al. Much anticipated--the bioactive conformation of epothilone and its binding to tubulin. 2005 Angew. Chem. Int. Ed. Engl. pmid:15714588
Yoshimura F et al. Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones. 2003 Angew. Chem. Int. Ed. Engl. pmid:12800175
Nicolaou KC et al. Design, synthesis, and biological properties of highly potent epothilone B analogues. 2003 Angew. Chem. Int. Ed. Engl. pmid:12900969
Kumar A et al. Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy. 2010 Angew. Chem. Int. Ed. Engl. pmid:20809556
Larkin JM and Kaye SB Potential clinical applications of epothilones: a review of phase II studies. 2007 Ann. Oncol. pmid:17656559
Chi KN et al. A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a. 2012 Ann. Oncol. pmid:21765178