| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Adrenal Gland Neoplasms | D000310 | 6 associated lipids |
| Pheochromocytoma | D010673 | 4 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
Epothilone B
Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone B?
Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone B
PubChem Associated disorders and diseases
What pathways are associated with Epothilone B
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone B?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Epothilone B?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Epothilone B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Epothilone B?
Xenograft Model
Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).
Mouse Model
Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Epothilone B
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Bollag DM et al. | Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. | 1995 | Cancer Res. | pmid:7757983 |
| Gerth K et al. | Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties. | 1996 | J. Antibiot. | pmid:8698639 |
| Cowden CJ and Paterson I | Synthetic chemistry. Cancer drugs better than taxol? | 1997 | Nature | pmid:9153384 |
| Nicolaou KC et al. | Synthesis of epothilones A and B in solid and solution phase. | 1997 | Nature | pmid:9153390 |
| Kowalski RJ et al. | Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). | 1997 | J. Biol. Chem. | pmid:8999970 |
| Giannakakou P et al. | Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization. | 1997 | J. Biol. Chem. | pmid:9202030 |
| Muhlradt PF and Sasse F | Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity. | 1997 | Cancer Res. | pmid:9269992 |
| Sefkow M et al. | Derivatization of the C12-C13 functional groups of epothilones A, B and C. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873670 |
| Yang CP et al. | Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. | 1998 | FEBS Lett. | pmid:9845355 |