| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Adrenal Gland Neoplasms | D000310 | 6 associated lipids |
| Pheochromocytoma | D010673 | 4 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
Epothilone B
Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone B?
Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone B
PubChem Associated disorders and diseases
What pathways are associated with Epothilone B
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone B?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Epothilone B?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Epothilone B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Epothilone B?
Xenograft Model
Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).
Mouse Model
Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Epothilone B
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cheng H et al. | Synthesis and antitumor activity of epothilone B. | 2018 | Eur J Med Chem | pmid:30149324 |
| Rogalska A and Marczak A | Therapeutic potential of patupilone in epithelial ovarian cancer and future directions. | 2018 | Life Sci. | pmid:29727613 |
| Hsu CY et al. | Stabilization of microtubules restores barrier function after cytokine-induced defects in reconstructed human epidermis. | 2018 | J. Dermatol. Sci. | pmid:29691121 |
| Zhu W et al. | Enhanced anti-proliferative efficacy of epothilone B loaded with Escherichia coli Nissle 1917 bacterial ghosts on the HeLa cells by mitochondrial pathway of apoptosis. | 2018 | Drug Dev Ind Pharm | pmid:29521115 |
| Mao L et al. | Epothilone B impairs functional recovery after spinal cord injury by increasing secretion of macrophage colony-stimulating factor. | 2017 | Cell Death Dis | pmid:29095439 |
| Shin DH and Kwon GS | Pre-clinical evaluation of a themosensitive gel containing epothilone B and mTOR/Hsp90 targeted agents in an ovarian tumor model. | 2017 | J Control Release | pmid:29056443 |
| Park MN et al. | Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. | 2017 | Biomed Res Int | pmid:29181405 |
| Lee JH et al. | The Application of REDOR NMR to Understand the Conformation of Epothilone B. | 2017 | Int J Mol Sci | pmid:28698492 |
| Nicolaou KC et al. | 12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents. | 2017 | J. Am. Chem. Soc. | pmid:28513142 |
| Shin DH and Kwon GS | Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy. | 2017 | Int J Pharm | pmid:28062368 |
| Yan J et al. | Patupilone-loaded poly(L-glutamic acid)-graft-methoxy-poly(ethylene glycol) micelle for oncotherapy. | 2017 | J Biomater Sci Polym Ed | pmid:28027693 |
| Gornstein EL and Schwarz TL | Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects. | 2017 | Exp. Neurol. | pmid:27894788 |
| Jang EH et al. | Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons. | 2016 | Neural Plast. | pmid:27872763 |
| Bukowska B et al. | Why a Combination of WP 631 and Epo B is an Improvement on the Drugs Singly - Involvement in the Cell Cycle and Mitotic Slippage. | 2016 | Asian Pac. J. Cancer Prev. | pmid:27039763 |
| Pittman SK et al. | Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons. | 2016 | Exp. Neurol. | pmid:26883566 |
| Deng Y et al. | Improved i.p. drug delivery with bioadhesive nanoparticles. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27663731 |
| Ye W et al. | A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26803504 |
| Li YL et al. | Epothilone B induces apoptosis and enhances apoptotic effects of ABT-737 on human cancer cells via PI3K/AKT/mTOR pathway. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27591861 |
| Bukowska B et al. | New potential chemotherapy for ovarian cancer - Combined therapy with WP 631 and epothilone B. | 2016 | Life Sci. | pmid:26944437 |
| Rogalska A and Marczak A | Nuclear DNA Damage and Repair in Normal Ovarian Cells Caused by Epothilone B. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26434870 |
| Nayak L et al. | Multicenter phase 2 study of patupilone for recurrent or progressive brain metastases from non-small cell lung cancer. | 2015 | Cancer | pmid:26308485 |
| Morley S et al. | Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. | 2015 | Sci Rep | pmid:26179371 |
| Seagle BL et al. | TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas. | 2015 | Gynecol. Oncol. | pmid:25958320 |
| Ruschel J et al. | Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. | 2015 | Science | pmid:25765066 |
| Jiménez VA et al. | Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations. | 2015 | J. Biomol. Struct. Dyn. | pmid:24773261 |
| Nicolaou KC et al. | Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues. | 2015 | ChemMedChem | pmid:26447977 |
| Navarrete KR et al. | Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B. | 2015 | J. Biomol. Struct. Dyn. | pmid:26081685 |
| Baumgart T et al. | Investigation of epothilone B-induced cell death mechanisms in human epithelial cancer cells -in consideration of combined treatment with ionizing radiation. | 2015 | Cancer Invest. | pmid:25919223 |
| Tran AP and Silver J | Neuroscience. Systemically treating spinal cord injury. | 2015 | Science | pmid:25883342 |
| Rogalska A and Marczak A | Epothilone B induces human ovarian cancer OV-90 cell apoptosis via external pathway. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25721485 |
| Broggini-Tenzer A et al. | Combined treatment strategies for microtubule stabilizing agent-resistant tumors. | 2015 | J. Natl. Cancer Inst. | pmid:25694444 |
| Shen CJ et al. | Ionizing radiation induces tumor cell lysyl oxidase secretion. | 2014 | BMC Cancer | pmid:25052686 |
| Suraokar MB et al. | Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications. | 2014 | Ann. Oncol. | pmid:24669013 |
| Ceresa C et al. | Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B. | 2014 | Anticancer Res. | pmid:24403510 |
| Peereboom DM et al. | Phase II trial of patupilone in patients with brain metastases from breast cancer. | 2014 | Neuro-oncology | pmid:24470546 |
| Marczak A et al. | WP 631 and Epo B synergize in SKOV-3 human ovarian cancer cells. | 2014 | Environ. Toxicol. Pharmacol. | pmid:24374386 |
| Melichar B et al. | Intestinal permeability in patients with metastatic colon cancer treated with patupilone. | 2014 | Clin. Chem. Lab. Med. | pmid:24937505 |
| Rogalska A et al. | Caspases and ROS - dependent mechanism of action mediated by combination of WP 631 and epothilone B. | 2014 | Anticancer Agents Med Chem | pmid:24913659 |
| Rogalska A et al. | Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells. | 2014 | Toxicol In Vitro | pmid:24583341 |
| Meier V et al. | Use of epothilone B (patupilone) in refractory lymphoma and advanced solid tumors in dogs. | 2013 Jan-Feb | J. Vet. Intern. Med. | pmid:23205945 |
| Kelly KR et al. | Metabolism of patupilone in patients with advanced solid tumor malignancies. | 2013 | Invest New Drugs | pmid:22918719 |
| Rogalska A et al. | Activation of apoptotic pathway in normal, cancer ovarian cells by epothilone B. | 2013 | Environ. Toxicol. Pharmacol. | pmid:23838010 |
| Moorcraft SY et al. | Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial. | 2013 | Invest New Drugs | pmid:23801302 |
| Scherzinger-Laude K et al. | Treatment of neuroblastoma and rhabdomyosarcoma using RGD-modified liposomal formulations of patupilone (EPO906). | 2013 | Int J Nanomedicine | pmid:23818777 |
| Wang C et al. | Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23307513 |
| Furmanova-Hollenstein P et al. | The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion. | 2013 | Radiat Oncol | pmid:23631818 |
| Kaiser S et al. | From bacteria to antineoplastic: epothilones a successful history. | 2013 | Anticancer Agents Med Chem | pmid:23343081 |
| Roque DM et al. | Tubulin-β-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones. | 2013 | Cancer | pmid:23585021 |
| Rogalska A et al. | Analysis of epothilone B-induced cell death in normal ovarian cells. | 2013 | Cell Biol. Int. | pmid:23955989 |
| Rogalska A et al. | Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B. | 2013 | Toxicol In Vitro | pmid:22995584 |
| Yu D et al. | Mechanical and functional properties of epothilone-stabilized microtubules. | 2013 | Cytoskeleton (Hoboken) | pmid:23135951 |
| Xia B et al. | Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions. | 2012 | Cancer Chemother. Pharmacol. | pmid:22526410 |
| Pagano A et al. | Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. | 2012 | Biochem. Pharmacol. | pmid:22634050 |
| Bennani YL et al. | Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives. | 2012 | J. Med. Chem. | pmid:22320354 |
| Baumgart T et al. | Effect of epothilone B on cell cycle, metabolic activity, and apoptosis induction on human epithelial cancer cells-under special attention of combined treatment with ionizing radiation. | 2012 | Cancer Invest. | pmid:22909073 |
| Mozzetti S et al. | Gli family transcription factors are drivers of patupilone resistance in ovarian cancer. | 2012 | Biochem. Pharmacol. | pmid:22964220 |
| Carrara L et al. | Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. | 2012 | Gynecol. Oncol. | pmid:22209775 |
| Baumgart T et al. | Radiosensitizing effect of epothilone B on human epithelial cancer cells. | 2012 | Strahlenther Onkol | pmid:22234539 |
| Entwistle RA et al. | Differentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modeling. | 2012 | ChemMedChem | pmid:22807375 |
| Oehler C et al. | Patupilone (epothilone B) for recurrent glioblastoma: clinical outcome and translational analysis of a single-institution phase I/II trial. | 2012 | Oncology | pmid:22688083 |
| Lozynski M | Patupilone and ixabepilone: the effect of a point structural change on the exo-endo conformational profile. | 2012 | J Phys Chem B | pmid:22668078 |
| Kratzer E et al. | Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization. | 2012 | Am. J. Respir. Cell Mol. Biol. | pmid:22842495 |
| Orlowski K et al. | Dynamics of tumor hypoxia in response to patupilone and ionizing radiation. | 2012 | PLoS ONE | pmid:23251549 |
| Wang J et al. | An efficient total synthesis of (-)-epothilone B. | 2012 | Org. Lett. | pmid:23214997 |
| Colombo N et al. | Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or -resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer. | 2012 | J. Clin. Oncol. | pmid:22987083 |
| Spriggs DR | Drug development for chronic cancers: time to think differently? | 2012 | J. Clin. Oncol. | pmid:22987092 |
| Lu HM and Ye M | LC-MS/MS method for determination of epothilone B in rat plasma and its application in pharmacokinetic study. | 2012 | Arzneimittelforschung | pmid:23093482 |
| Chi KN et al. | A phase 2 study of patupilone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel: Canadian Urologic Oncology Group study P07a. | 2012 | Ann. Oncol. | pmid:21765178 |
| Kelly WK | Epothilones in prostate cancer. | 2011 Jul-Aug | Urol. Oncol. | pmid:19914096 |
| Stalder MW et al. | Metronomic dosing enhances the anti-angiogenic effect of epothilone B. | 2011 | J. Surg. Res. | pmid:20338584 |
| Chan A et al. | Peloruside A inhibits microtubule dynamics in a breast cancer cell line MCF7. | 2011 | Invest New Drugs | pmid:20169398 |
| Rohrer Bley C et al. | Regulation of VEGF-expression by patupilone and ionizing radiation in lung adenocarcinoma cells. | 2011 | Lung Cancer | pmid:21333376 |
| Meister S et al. | Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. | 2011 | Science | pmid:22096101 |
| Gan PP et al. | Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells. | 2011 | PLoS ONE | pmid:21738778 |
| Oehler C et al. | The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells. | 2011 | Neuro-oncology | pmid:21743064 |
| Melichar B et al. | Clinical activity of patupilone in patients with pretreated advanced/metastatic colon cancer: results of a phase I dose escalation trial. | 2011 | Br. J. Cancer | pmid:22027708 |
| Lin PC et al. | Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction. | 2011 | J. Biol. Chem. | pmid:21953449 |
| Bystricky B and Chau I | Patupilone in cancer treatment. | 2011 | Expert Opin Investig Drugs | pmid:21142807 |
| Pellicciotta I et al. | Epothilone B enhances Class I HLA and HLA-A2 surface molecule expression in ovarian cancer cells. | 2011 | Gynecol. Oncol. | pmid:21621254 |
| Broggini-Tenzer A et al. | Metabolism of tumors under treatment: mapping of metabolites with quantitative bioluminescence. | 2011 | Radiother Oncol | pmid:21665309 |
| Schiess R et al. | Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants. | 2011 | Org. Lett. | pmid:21338105 |
| Tsimberidou AM et al. | Pharmacokinetics and antitumor activity of patupilone combined with midazolam or omeprazole in patients with advanced cancer. | 2011 | Cancer Chemother. Pharmacol. | pmid:21499896 |
| Vollmer LL et al. | A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. | 2011 | Mol. Cancer Ther. | pmid:21490306 |
| Tsimberidou AM et al. | Effects of patupilone on the pharmacokinetics and pharmacodynamics of warfarin in patients with advanced malignancies: a phase I clinical trial. | 2011 | Mol. Cancer Ther. | pmid:21220503 |
| Khrapunovich-Baine M et al. | Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. | 2011 | J. Biol. Chem. | pmid:21245138 |
| Henry WI et al. | The microtubule inhibiting agent epothilone B antagonizes glioma cell motility associated with reorganization of the actin-binding protein α-actinin 4. | 2011 | Oncol. Rep. | pmid:21234524 |
| O'Reilly T et al. | Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic antitumor agents using human tumor models in vitro and in vivo. | 2011 | Anticancer Drugs | pmid:20890178 |
| Nimeiri HS et al. | The epothilone B analogue ixabepilone in patients with advanced hepatobiliary cancers: a trial of the University of Chicago Phase II Consortium. | 2010 | Invest New Drugs | pmid:19669700 |
| Fogh S et al. | Phase I trial using patupilone (epothilone B) and concurrent radiotherapy for central nervous system malignancies. | 2010 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:19879067 |
| Po'uha ST et al. | LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs. | 2010 | Oncogene | pmid:19881550 |
| Forli S et al. | Evaluation of novel epothilone analogues by means of a common pharmacophore and a QSAR pseudoreceptor model for taxanes and epothilones. | 2010 | ChemMedChem | pmid:19904799 |
| Lazo JS et al. | Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20008956 |
| Shen S et al. | Defective autophagy associated with LC3 puncta in epothilone-resistant cancer cells. | 2010 | Cell Cycle | pmid:20023420 |
| Yang CP et al. | The interaction between mitotic checkpoint proteins, CENP-E and BubR1, is diminished in epothilone B-resistant A549 cells. | 2010 | Cell Cycle | pmid:20237434 |
| Harichand-Herdt S and O'regan RM | Identifying subsets of metastatic breast cancer patients likely to benefit from treatment with the epothilone B analog ixabepilone. | 2010 | Am. J. Clin. Oncol. | pmid:20051810 |
| Chanel-Vos C and Giannakakou P | CENP-E checks in microtubule-drug resistance. | 2010 | Cell Cycle | pmid:20421712 |
| Shahabi S et al. | Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. | 2010 | Gynecol. Oncol. | pmid:20674962 |
| Paik D et al. | Higher sensitivity to patupilone versus paclitaxel chemotherapy in primary uterine serous papillary carcinoma cell lines with high versus low HER-2/neu expression in vitro. | 2010 | Gynecol. Oncol. | pmid:20673976 |
| Kong Z et al. | Epothilone B confers radiation dose enhancement in DAB2IP gene knock-down radioresistant prostate cancer cells. | 2010 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:20970033 |
| Egerton N | Optimizing ixabepilone treatment schedules in patients with advanced or metastatic breast cancer. | 2010 | Cancer Chemother. Pharmacol. | pmid:20886213 |