| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Adrenal Gland Neoplasms | D000310 | 6 associated lipids |
| Pheochromocytoma | D010673 | 4 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
Epothilone B
Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Epothilone B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Epothilone B?
Epothilone B is suspected in Peripheral Neuropathy, Myelosuppression, Neuropathy, Morphologically altered structure, Measurable Disease, Neutropenia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Epothilone B
PubChem Associated disorders and diseases
What pathways are associated with Epothilone B
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Epothilone B?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Epothilone B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Epothilone B?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Epothilone B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Epothilone B?
Xenograft Model
Xenograft Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005), Xenograft Model are used in the study 'Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.' (Hofstetter B et al., 2005) and Xenograft Model are used in the study 'In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.' (Peterson JK et al., 2005).
Mouse Model
Mouse Model are used in the study 'Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.' (Lin B et al., 2005).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Epothilone B
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cheng H et al. | Synthesis and antitumor activity of epothilone B. | 2018 | Eur J Med Chem | pmid:30149324 |
| Rogalska A and Marczak A | Therapeutic potential of patupilone in epithelial ovarian cancer and future directions. | 2018 | Life Sci. | pmid:29727613 |
| Hsu CY et al. | Stabilization of microtubules restores barrier function after cytokine-induced defects in reconstructed human epidermis. | 2018 | J. Dermatol. Sci. | pmid:29691121 |
| Zhu W et al. | Enhanced anti-proliferative efficacy of epothilone B loaded with Escherichia coli Nissle 1917 bacterial ghosts on the HeLa cells by mitochondrial pathway of apoptosis. | 2018 | Drug Dev Ind Pharm | pmid:29521115 |
| Mao L et al. | Epothilone B impairs functional recovery after spinal cord injury by increasing secretion of macrophage colony-stimulating factor. | 2017 | Cell Death Dis | pmid:29095439 |
| Shin DH and Kwon GS | Pre-clinical evaluation of a themosensitive gel containing epothilone B and mTOR/Hsp90 targeted agents in an ovarian tumor model. | 2017 | J Control Release | pmid:29056443 |
| Park MN et al. | Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs. | 2017 | Biomed Res Int | pmid:29181405 |
| Lee JH et al. | The Application of REDOR NMR to Understand the Conformation of Epothilone B. | 2017 | Int J Mol Sci | pmid:28698492 |
| Nicolaou KC et al. | 12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents. | 2017 | J. Am. Chem. Soc. | pmid:28513142 |
| Shin DH and Kwon GS | Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy. | 2017 | Int J Pharm | pmid:28062368 |
| Yan J et al. | Patupilone-loaded poly(L-glutamic acid)-graft-methoxy-poly(ethylene glycol) micelle for oncotherapy. | 2017 | J Biomater Sci Polym Ed | pmid:28027693 |
| Gornstein EL and Schwarz TL | Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects. | 2017 | Exp. Neurol. | pmid:27894788 |
| Jang EH et al. | Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons. | 2016 | Neural Plast. | pmid:27872763 |
| Bukowska B et al. | Why a Combination of WP 631 and Epo B is an Improvement on the Drugs Singly - Involvement in the Cell Cycle and Mitotic Slippage. | 2016 | Asian Pac. J. Cancer Prev. | pmid:27039763 |
| Pittman SK et al. | Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons. | 2016 | Exp. Neurol. | pmid:26883566 |
| Deng Y et al. | Improved i.p. drug delivery with bioadhesive nanoparticles. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27663731 |
| Ye W et al. | A new approach for improving epothilone B yield in Sorangium cellulosum by the introduction of vgb epoF genes. | 2016 | J. Ind. Microbiol. Biotechnol. | pmid:26803504 |
| Li YL et al. | Epothilone B induces apoptosis and enhances apoptotic effects of ABT-737 on human cancer cells via PI3K/AKT/mTOR pathway. | 2016 | J. Cancer Res. Clin. Oncol. | pmid:27591861 |
| Bukowska B et al. | New potential chemotherapy for ovarian cancer - Combined therapy with WP 631 and epothilone B. | 2016 | Life Sci. | pmid:26944437 |
| Rogalska A and Marczak A | Nuclear DNA Damage and Repair in Normal Ovarian Cells Caused by Epothilone B. | 2015 | Asian Pac. J. Cancer Prev. | pmid:26434870 |
| Nayak L et al. | Multicenter phase 2 study of patupilone for recurrent or progressive brain metastases from non-small cell lung cancer. | 2015 | Cancer | pmid:26308485 |
| Morley S et al. | Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. | 2015 | Sci Rep | pmid:26179371 |
| Seagle BL et al. | TP53 hot spot mutations in ovarian cancer: selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas. | 2015 | Gynecol. Oncol. | pmid:25958320 |
| Ruschel J et al. | Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. | 2015 | Science | pmid:25765066 |
| Jiménez VA et al. | Structural insight into epothilones antitumor activity based on the conformational preferences and tubulin binding modes of epothilones A and B obtained from molecular dynamics simulations. | 2015 | J. Biomol. Struct. Dyn. | pmid:24773261 |
| Nicolaou KC et al. | Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues. | 2015 | ChemMedChem | pmid:26447977 |
| Navarrete KR et al. | Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B. | 2015 | J. Biomol. Struct. Dyn. | pmid:26081685 |
| Baumgart T et al. | Investigation of epothilone B-induced cell death mechanisms in human epithelial cancer cells -in consideration of combined treatment with ionizing radiation. | 2015 | Cancer Invest. | pmid:25919223 |
| Tran AP and Silver J | Neuroscience. Systemically treating spinal cord injury. | 2015 | Science | pmid:25883342 |
| Rogalska A and Marczak A | Epothilone B induces human ovarian cancer OV-90 cell apoptosis via external pathway. | 2015 | Environ. Toxicol. Pharmacol. | pmid:25721485 |
| Broggini-Tenzer A et al. | Combined treatment strategies for microtubule stabilizing agent-resistant tumors. | 2015 | J. Natl. Cancer Inst. | pmid:25694444 |
| Shen CJ et al. | Ionizing radiation induces tumor cell lysyl oxidase secretion. | 2014 | BMC Cancer | pmid:25052686 |
| Suraokar MB et al. | Expression profiling stratifies mesothelioma tumors and signifies deregulation of spindle checkpoint pathway and microtubule network with therapeutic implications. | 2014 | Ann. Oncol. | pmid:24669013 |
| Ceresa C et al. | Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B. | 2014 | Anticancer Res. | pmid:24403510 |
| Peereboom DM et al. | Phase II trial of patupilone in patients with brain metastases from breast cancer. | 2014 | Neuro-oncology | pmid:24470546 |
| Marczak A et al. | WP 631 and Epo B synergize in SKOV-3 human ovarian cancer cells. | 2014 | Environ. Toxicol. Pharmacol. | pmid:24374386 |
| Melichar B et al. | Intestinal permeability in patients with metastatic colon cancer treated with patupilone. | 2014 | Clin. Chem. Lab. Med. | pmid:24937505 |
| Rogalska A et al. | Caspases and ROS - dependent mechanism of action mediated by combination of WP 631 and epothilone B. | 2014 | Anticancer Agents Med Chem | pmid:24913659 |
| Rogalska A et al. | Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells. | 2014 | Toxicol In Vitro | pmid:24583341 |
| Meier V et al. | Use of epothilone B (patupilone) in refractory lymphoma and advanced solid tumors in dogs. | 2013 Jan-Feb | J. Vet. Intern. Med. | pmid:23205945 |
| Kelly KR et al. | Metabolism of patupilone in patients with advanced solid tumor malignancies. | 2013 | Invest New Drugs | pmid:22918719 |
| Rogalska A et al. | Activation of apoptotic pathway in normal, cancer ovarian cells by epothilone B. | 2013 | Environ. Toxicol. Pharmacol. | pmid:23838010 |
| Moorcraft SY et al. | Patupilone in patients with pretreated metastatic/locally recurrent colorectal cancer: results of the Phase II CINATRA trial. | 2013 | Invest New Drugs | pmid:23801302 |
| Scherzinger-Laude K et al. | Treatment of neuroblastoma and rhabdomyosarcoma using RGD-modified liposomal formulations of patupilone (EPO906). | 2013 | Int J Nanomedicine | pmid:23818777 |
| Wang C et al. | Molybdenum-based complexes with two aryloxides and a pentafluoroimido ligand: catalysts for efficient Z-selective synthesis of a macrocyclic trisubstituted alkene by ring-closing metathesis. | 2013 | Angew. Chem. Int. Ed. Engl. | pmid:23307513 |
| Furmanova-Hollenstein P et al. | The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion. | 2013 | Radiat Oncol | pmid:23631818 |
| Kaiser S et al. | From bacteria to antineoplastic: epothilones a successful history. | 2013 | Anticancer Agents Med Chem | pmid:23343081 |
| Roque DM et al. | Tubulin-β-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones. | 2013 | Cancer | pmid:23585021 |
| Rogalska A et al. | Analysis of epothilone B-induced cell death in normal ovarian cells. | 2013 | Cell Biol. Int. | pmid:23955989 |
| Yu D et al. | Mechanical and functional properties of epothilone-stabilized microtubules. | 2013 | Cytoskeleton (Hoboken) | pmid:23135951 |