RIFAMYCIN B

RIFAMYCIN B is a lipid of Polyketides (PK) class. Rifamycin b is associated with abnormalities such as Tuberculosis, Leprosy and Mycobacterium Infections. The involved functions are known as Anabolism, Stereochemistry, Obstruction and Mutation. Rifamycin b often locates in Chromosomes. The associated genes with RIFAMYCIN B are RNF34 gene and Gene Clusters.

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Introduction

To understand associated biological information of RIFAMYCIN B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with RIFAMYCIN B?

RIFAMYCIN B is suspected in Tuberculosis, Leprosy, Mycobacterium Infections and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with RIFAMYCIN B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with RIFAMYCIN B?

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What functions are associated with RIFAMYCIN B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with RIFAMYCIN B?

There are no associated biomedical information in the current reference collection.

What genes are associated with RIFAMYCIN B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with RIFAMYCIN B?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with RIFAMYCIN B

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Authors Title Published Journal PubMed Link
pmid:
Courtois A et al. Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells. 1999 Life Sci. pmid:10075109
Courtois A et al. Inhibition of multidrug resistance-associated protein (MRP) activity by rifampicin in human multidrug-resistant lung tumor cells. 1999 Cancer Lett. pmid:10408915
Stratmann A et al. Intermediates of rifamycin polyketide synthase produced by an Amycolatopsis mediterranei mutant with inactivated rifF gene. 1999 Microbiology (Reading, Engl.) pmid:10627035
Doi-Katayama Y et al. Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699. 2000 J. Antibiot. pmid:10908112
Floss HG Antibiotic biosynthesis: from natural to unnatural compounds. 2001 J. Ind. Microbiol. Biotechnol. pmid:11780790
Stratmann A et al. New insights into rifamycin B biosynthesis: isolation of proansamycin B and 34a-deoxy-rifamycin W as early macrocyclic intermediates indicating two separated biosynthetic pathways. 2002 J. Antibiot. pmid:12061548
Rasalkar AA et al. Solid state cultivation of Curvularia lunata for transformation of rifamycin B to S. 2002 Indian J. Exp. Biol. pmid:12597025
Xu J et al. Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. 2003 Arch. Biochem. Biophys. pmid:12623077
Jin ZH et al. Improvement of industry-applied rifamycin B-producing strain, Amycolatopsis mediterranei, by rational screening. 2002 J. Gen. Appl. Microbiol. pmid:12682871
MARGALITH P and PAGANI H Rifomycin. XIV. Production of rifomycin B. 1961 Appl Microbiol pmid:13766661
GIUNCHI G The rifamycins. 1963 Antibiot Chemother pmid:13948282
KLUEPFEL D et al. METABOLISM OF BARBITAL BY STREPTOMYCES MEDITERRANEI. 1965 Appl Microbiol pmid:14339268
El-Enshasy HA et al. Improvement of rifemycins production by Amycolatopsis mediterranei in batch and fed-batch cultures. 2003 Acta Microbiol. Pol. pmid:14743983
Bapat PM and Wangikar PP Optimization of rifamycin B fermentation in shake flasks via a machine-learning-based approach. 2004 Biotechnol. Bioeng. pmid:15052640
Vohra RM Novel assay for screening rifamycin B-producing mutants. 1992 Appl. Environ. Microbiol. pmid:1539986
Jin ZH et al. Scale-up of rifamycin B fermentation with Amycolatoposis mediterranei. 2004 J. Zhejiang Univ. Sci. pmid:15547969
Meier RM and Tamm C Studies directed towards the biosynthesis of the C7N-unit of rifamycin B: incorporation of [14C(G)]quinic acid and [1,2-13C2]glycerol. 1992 J. Antibiot. pmid:1577667
Xiong Y et al. A homologue of the Mycobacterium tuberculosis PapA5 protein, rif-orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. 2005 Chembiochem pmid:15791687
Hartung IV et al. Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis. 2005 J. Am. Chem. Soc. pmid:16089423