CYTOCHALASIN B is a lipid of Polyketides (PK) class. Cytochalasin b is associated with abnormalities such as Renal tubular disorder and Chagas Disease. The involved functions are known as Membrane Protein Traffic, inhibitors, Metabolic Inhibition, Biochemical Pathway and Increased Sensitivy. Cytochalasin b often locates in Cytoplasmic matrix, Plasma membrane, Microtubules, Extracellular and Protoplasm. The associated genes with CYTOCHALASIN B are SLC2A2 gene, PFDN5 gene, SLC2A1 gene, OMG gene and SPEN gene. The related lipids are Steroids, Lipopolysaccharides and Liposomes. The related experimental models are Xenograft Model.
To understand associated biological information of CYTOCHALASIN B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
CYTOCHALASIN B is suspected in Renal tubular disorder, Chagas Disease and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with CYTOCHALASIN B
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol.' (Pérez A et al., 2009).
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Authors | Title | Published | Journal | PubMed Link |
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Curren RD et al. | Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm). | 2006 | Mutat. Res. | pmid:16781186 |
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Migliore L et al. | Induction of binucleation in human lymphocytes by 14 synthetic isoindolone derivatives related to cytochalasins. | 1994 | Mutat. Res. | pmid:7519314 |
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Murray D et al. | Effect of thiols on micronucleus frequency in gamma-irradiated mammalian cells. | 1991 | Mutat. Res. | pmid:2002801 |
Phelps JB et al. | A protocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity. | 2002 | Mutat. Res. | pmid:12438008 |
al-Sabti K | Micronuclei induced by selenium, mercury, methylmercury and their mixtures in binucleated blocked fish erythrocyte cells. | 1994 | Mutat. Res. | pmid:7506383 |
Matsuoka A et al. | The 2-phenylbenzotriazole-type water pollutant PBTA-2 has cytochalasin B-mimetic activity. | 2000 | Mutat. Res. | pmid:10648903 |
Nefic H and Handzic I | The effect of age, sex, and lifestyle factors on micronucleus frequency in peripheral blood lymphocytes of the Bosnian population. | 2013 | Mutat. Res. | pmid:23499242 |
Terzoudi GI et al. | Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis. | 2015 | Mutat Res Genet Toxicol Environ Mutagen | pmid:26520389 |
Hatzi VI et al. | Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH. | 2015 | Mutat Res Genet Toxicol Environ Mutagen | pmid:26520375 |
Whitwell J et al. | Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays. | 2015 | Mutat Res Genet Toxicol Environ Mutagen | pmid:26232254 |
Matsushima T et al. | Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). | 1999 | Mutagenesis | pmid:10567032 |
Fenech M et al. | Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. | 1999 | Mutagenesis | pmid:10567036 |
Snyder RD and Diehl MS | The bleomycin amplification assay in V79 cells predicts frameshift mutagenicity of intercalative agents. | 2000 | Mutagenesis | pmid:10792011 |
Tomanin R et al. | Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis block method. | 1991 | Mutagenesis | pmid:2056912 |
Norppa H et al. | Detection of whole chromosomes in micronuclei of cytokinesis-blocked human lymphocytes by antikinetochore staining and in situ hybridization. | 1993 | Mutagenesis | pmid:8133781 |
Slavotinek A et al. | A comparison of micronucleus frequency and radiation survival in lymphoblastoid cell lines. | 1993 | Mutagenesis | pmid:8133787 |
Wojda A et al. | Effects of age and gender on micronucleus and chromosome nondisjunction frequencies in centenarians and younger subjects. | 2007 | Mutagenesis | pmid:17284771 |
Schultz N and Onfelt A | Video time-lapse study of mitosis in binucleate V79 cells: chromosome segregation and cleavage. | 1994 | Mutagenesis | pmid:8201944 |
Crott J and Fenech M | Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro. | 2001 | Mutagenesis | pmid:11320146 |
Tsai MH et al. | Dynamics of changes in micronucleus frequencies in subjects post cessation of chronic low-dose radiation exposure. | 2001 | Mutagenesis | pmid:11320151 |
de Stoppelaar JM et al. | In vivo cytokinesis blocked micronucleus assay with carbendazim in rat fibroblasts and comparison with in vitro assays. | 2000 | Mutagenesis | pmid:10719042 |
Castelain P et al. | Automated detection of cytochalasin-B blocked binucleated lymphocytes for scoring micronuclei. | 1993 | Mutagenesis | pmid:7690875 |
Varga D et al. | An automated scoring procedure for the micronucleus test by image analysis. | 2004 | Mutagenesis | pmid:15388812 |
Burgaz S et al. | Micronucleus frequencies in lymphocytes and buccal epithelial cells from patients having head and neck cancer and their first-degree relatives. | 2011 | Mutagenesis | pmid:21248276 |
Kirsch-Volders M et al. | Mitotic non-disjunction as a mechanism for in vitro aneuploidy induction by X-rays in primary human cells. | 1996 | Mutagenesis | pmid:8671754 |
Zijno A et al. | Simultaneous detection of X-chromosome loss and non-disjunction in cytokinesis-blocked human lymphocytes by in situ hybridization with a centromeric DNA probe; implications for the human lymphocyte in vitro micronucleus assay using cytochalasin B. | 1994 | Mutagenesis | pmid:7934962 |
Nesslany F and Marzin D | A micromethod for the in vitro micronucleus assay. | 1999 | Mutagenesis | pmid:10390508 |
Guccini S et al. | Effects of spindle poisons in peripheral human lymphocytes by the in vitro cytokinesis-block micronucleus assay. | 2012 | Mutagenesis | pmid:22952150 |
Touil N et al. | Analysis of chromosome loss and chromosome segregation in cytokinesis-blocked human lymphocytes: non-disjunction is the prevalent mistake in chromosome segregation produced by low dose exposure to ionizing radiation. | 2000 | Mutagenesis | pmid:10640524 |
Oliveira NG et al. | Assessment of the adaptive response induced by quercetin using the MNCB peripheral blood human lymphocytes assay. | 2000 | Mutagenesis | pmid:10640534 |
Heddle JA et al. | Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells. | 1990 | Mutagenesis | pmid:2188072 |
Littlefield LG et al. | Comparisons of dose-response parameters for radiation-induced acentric fragments and micronuclei observed in cytokinesis-arrested lymphocytes. | 1989 | Mutagenesis | pmid:2674605 |
Minissi S et al. | Direct and indirect non-disjunction in the origin of trisomy in cultured human lymphocytes. | 1999 | Mutagenesis | pmid:10567030 |
Cimini D et al. | Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells. | 1999 | Mutagenesis | pmid:10567031 |