CYTOCHALASIN B

CYTOCHALASIN B is a lipid of Polyketides (PK) class. Cytochalasin b is associated with abnormalities such as Renal tubular disorder and Chagas Disease. The involved functions are known as Membrane Protein Traffic, inhibitors, Metabolic Inhibition, Biochemical Pathway and Increased Sensitivy. Cytochalasin b often locates in Cytoplasmic matrix, Plasma membrane, Microtubules, Extracellular and Protoplasm. The associated genes with CYTOCHALASIN B are SLC2A2 gene, PFDN5 gene, SLC2A1 gene, OMG gene and SPEN gene. The related lipids are Steroids, Lipopolysaccharides and Liposomes. The related experimental models are Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of CYTOCHALASIN B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with CYTOCHALASIN B?

CYTOCHALASIN B is suspected in Renal tubular disorder, Chagas Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with CYTOCHALASIN B

MeSH term MeSH ID Detail
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Systemic Inflammatory Response Syndrome D018746 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Glucose Intolerance D018149 13 associated lipids
CREST Syndrome D017675 2 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Lymphoma, T-Cell D016399 11 associated lipids
Lymphoma, B-Cell D016393 24 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Wounds and Injuries D014947 20 associated lipids
Wiskott-Aldrich Syndrome D014923 3 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Uremia D014511 33 associated lipids
Tuberculosis D014376 20 associated lipids
Trisomy D014314 6 associated lipids
Tongue Neoplasms D014062 15 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Starvation D013217 47 associated lipids
Pituitary Neoplasms D010911 4 associated lipids
Pharyngeal Neoplasms D010610 4 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Neutropenia D009503 15 associated lipids
Melanoma D008545 69 associated lipids
Medulloblastoma D008527 22 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Lymphoproliferative Disorders D008232 7 associated lipids
Lymphoma D008223 18 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukemia D007938 74 associated lipids
Kidney Diseases D007674 29 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
Insulinoma D007340 28 associated lipids
Insulin Resistance D007333 99 associated lipids
Inflammation D007249 119 associated lipids
Infectious Mononucleosis D007244 5 associated lipids
Hypoglycemia D007003 13 associated lipids
Hypertension D006973 115 associated lipids
Hyperinsulinism D006946 27 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Granulomatous Disease, Chronic D006105 4 associated lipids
Glioma D005910 112 associated lipids
Galactosemias D005693 5 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Factor XII Deficiency D005175 2 associated lipids
Eye Diseases D005128 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Erythroblastosis, Fetal D004899 2 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Chondrosarcoma D002813 9 associated lipids
Chancroid D002602 4 associated lipids
Cell Transformation, Viral D002472 26 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Burkitt Lymphoma D002051 15 associated lipids
Body Weight D001835 333 associated lipids
Birth Weight D001724 23 associated lipids
Ataxia Telangiectasia D001260 6 associated lipids
Asthma D001249 52 associated lipids
Arteriosclerosis D001161 86 associated lipids
Anemia D000740 21 associated lipids
Alzheimer Disease D000544 76 associated lipids
Adenocarcinoma D000230 166 associated lipids
Congenital Abnormalities D000013 11 associated lipids
Per page 10 20 50 100 | Total 79

PubChem Associated disorders and diseases

What pathways are associated with CYTOCHALASIN B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with CYTOCHALASIN B?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with CYTOCHALASIN B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with CYTOCHALASIN B?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with CYTOCHALASIN B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with CYTOCHALASIN B?

Xenograft Model

Xenograft Model are used in the study 'Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol.' (Pérez A et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with CYTOCHALASIN B

Download all related citations
Per page 10 20 50 100 | Total 4982
Authors Title Published Journal PubMed Link
Andreassen PR et al. Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state. 1996 Mutat. Res. pmid:9015137
Zijno A et al. Analysis of chromosome segregation by means of fluorescence in situ hybridization: application to cytokinesis-blocked human lymphocytes. 1996 Mutat. Res. pmid:9015140
Kirkland D Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): summary of results in the collaborative trial. 2010 Mutat. Res. pmid:20149894
Kirkland D Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): introduction to the collaborative trial. 2010 Mutat. Res. pmid:20176128
Ramalho A et al. Use of the frequencies of micronuclei as quantitative indicators of X-ray-induced chromosomal aberrations in human peripheral blood lymphocytes: comparison of two methods. 1988 Mar-Apr Mutat. Res. pmid:3357490
Kormos C and Köteles GJ Micronuclei in X-irradiated human lymphocytes. 1988 Mutat. Res. pmid:3362162
Prosser JS et al. Radiation induction of micronuclei in human lymphocytes. 1988 Mutat. Res. pmid:3362163
Johnston PJ et al. Induction and distribution of damage in CHO-K1 and the X-ray-sensitive hamster cell line xrs5, measured by the cytochalasin-B-cytokinesis block micronucleus assay. 1997 Mutat. Res. pmid:9372843
Krishna G et al. Use of the cytokinesis-block method for the analysis of micronuclei in V79 Chinese hamster lung cells: results with mitomycin C and cyclophosphamide. 1989 Mutat. Res. pmid:2492079
Nito S et al. Spontaneous expulsion of micronuclei by enucleation in the micronucleus assay. 1988 Mar-Apr Mutat. Res. pmid:3128735
Antoccia A et al. Cytokinesis-block micronucleus assay with kinetochore detection in colchicine-treated human fibroblasts. 1993 Mutat. Res. pmid:7683388
Miller B et al. Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft für Umwelt-Mutations-forschung. 1998 Mutat. Res. pmid:9587425
Gutiérrez-Enríquez S and Hall J Use of the cytokinesis-block micronucleus assay to measure radiation-induced chromosome damage in lymphoblastoid cell lines. 2003 Mutat. Res. pmid:12547278
Curren RD et al. Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm). 2006 Mutat. Res. pmid:16781186
Wakata A et al. SFTG international collaborative study on in vitro micronucleus test IV. Using CHL cells. 2006 Mutat. Res. pmid:16782396
Lorge E et al. SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study. 2006 Mutat. Res. pmid:16815079
Migliore L et al. Induction of binucleation in human lymphocytes by 14 synthetic isoindolone derivatives related to cytochalasins. 1994 Mutat. Res. pmid:7519314
Fenech M Commentary on the SFTG international collaborative study on the in vitro micronucleus test: to Cyt-B or not to Cyt-B? 2006 Mutat. Res. pmid:16720100
Murray D et al. Effect of thiols on micronucleus frequency in gamma-irradiated mammalian cells. 1991 Mutat. Res. pmid:2002801
Phelps JB et al. A protocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity. 2002 Mutat. Res. pmid:12438008
al-Sabti K Micronuclei induced by selenium, mercury, methylmercury and their mixtures in binucleated blocked fish erythrocyte cells. 1994 Mutat. Res. pmid:7506383
Matsuoka A et al. The 2-phenylbenzotriazole-type water pollutant PBTA-2 has cytochalasin B-mimetic activity. 2000 Mutat. Res. pmid:10648903
Nefic H and Handzic I The effect of age, sex, and lifestyle factors on micronucleus frequency in peripheral blood lymphocytes of the Bosnian population. 2013 Mutat. Res. pmid:23499242
Terzoudi GI et al. Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26520389
Hatzi VI et al. Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26520375
Whitwell J et al. Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26232254
Matsushima T et al. Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). 1999 Mutagenesis pmid:10567032
Fenech M et al. Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. 1999 Mutagenesis pmid:10567036
Snyder RD and Diehl MS The bleomycin amplification assay in V79 cells predicts frameshift mutagenicity of intercalative agents. 2000 Mutagenesis pmid:10792011
Tomanin R et al. Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis block method. 1991 Mutagenesis pmid:2056912
Norppa H et al. Detection of whole chromosomes in micronuclei of cytokinesis-blocked human lymphocytes by antikinetochore staining and in situ hybridization. 1993 Mutagenesis pmid:8133781
Slavotinek A et al. A comparison of micronucleus frequency and radiation survival in lymphoblastoid cell lines. 1993 Mutagenesis pmid:8133787
Wojda A et al. Effects of age and gender on micronucleus and chromosome nondisjunction frequencies in centenarians and younger subjects. 2007 Mutagenesis pmid:17284771
Schultz N and Onfelt A Video time-lapse study of mitosis in binucleate V79 cells: chromosome segregation and cleavage. 1994 Mutagenesis pmid:8201944
Crott J and Fenech M Preliminary study of the genotoxic potential of homocysteine in human lymphocytes in vitro. 2001 Mutagenesis pmid:11320146
Tsai MH et al. Dynamics of changes in micronucleus frequencies in subjects post cessation of chronic low-dose radiation exposure. 2001 Mutagenesis pmid:11320151
de Stoppelaar JM et al. In vivo cytokinesis blocked micronucleus assay with carbendazim in rat fibroblasts and comparison with in vitro assays. 2000 Mutagenesis pmid:10719042
Castelain P et al. Automated detection of cytochalasin-B blocked binucleated lymphocytes for scoring micronuclei. 1993 Mutagenesis pmid:7690875
Varga D et al. An automated scoring procedure for the micronucleus test by image analysis. 2004 Mutagenesis pmid:15388812
Burgaz S et al. Micronucleus frequencies in lymphocytes and buccal epithelial cells from patients having head and neck cancer and their first-degree relatives. 2011 Mutagenesis pmid:21248276
Kirsch-Volders M et al. Mitotic non-disjunction as a mechanism for in vitro aneuploidy induction by X-rays in primary human cells. 1996 Mutagenesis pmid:8671754
Zijno A et al. Simultaneous detection of X-chromosome loss and non-disjunction in cytokinesis-blocked human lymphocytes by in situ hybridization with a centromeric DNA probe; implications for the human lymphocyte in vitro micronucleus assay using cytochalasin B. 1994 Mutagenesis pmid:7934962
Nesslany F and Marzin D A micromethod for the in vitro micronucleus assay. 1999 Mutagenesis pmid:10390508
Guccini S et al. Effects of spindle poisons in peripheral human lymphocytes by the in vitro cytokinesis-block micronucleus assay. 2012 Mutagenesis pmid:22952150
Touil N et al. Analysis of chromosome loss and chromosome segregation in cytokinesis-blocked human lymphocytes: non-disjunction is the prevalent mistake in chromosome segregation produced by low dose exposure to ionizing radiation. 2000 Mutagenesis pmid:10640524
Oliveira NG et al. Assessment of the adaptive response induced by quercetin using the MNCB peripheral blood human lymphocytes assay. 2000 Mutagenesis pmid:10640534
Heddle JA et al. Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells. 1990 Mutagenesis pmid:2188072
Littlefield LG et al. Comparisons of dose-response parameters for radiation-induced acentric fragments and micronuclei observed in cytokinesis-arrested lymphocytes. 1989 Mutagenesis pmid:2674605
Minissi S et al. Direct and indirect non-disjunction in the origin of trisomy in cultured human lymphocytes. 1999 Mutagenesis pmid:10567030
Cimini D et al. Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells. 1999 Mutagenesis pmid:10567031