CYTOCHALASIN B

CYTOCHALASIN B is a lipid of Polyketides (PK) class. Cytochalasin b is associated with abnormalities such as Renal tubular disorder and Chagas Disease. The involved functions are known as Membrane Protein Traffic, inhibitors, Metabolic Inhibition, Biochemical Pathway and Increased Sensitivy. Cytochalasin b often locates in Cytoplasmic matrix, Plasma membrane, Microtubules, Extracellular and Protoplasm. The associated genes with CYTOCHALASIN B are SLC2A2 gene, PFDN5 gene, SLC2A1 gene, OMG gene and SPEN gene. The related lipids are Steroids, Lipopolysaccharides and Liposomes. The related experimental models are Xenograft Model.

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Introduction

To understand associated biological information of CYTOCHALASIN B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with CYTOCHALASIN B?

CYTOCHALASIN B is suspected in Renal tubular disorder, Chagas Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with CYTOCHALASIN B

MeSH term MeSH ID Detail
Granulomatous Disease, Chronic D006105 4 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with CYTOCHALASIN B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with CYTOCHALASIN B?

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What functions are associated with CYTOCHALASIN B?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with CYTOCHALASIN B?

Related references are published most in these journals:

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What genes are associated with CYTOCHALASIN B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with CYTOCHALASIN B?

Xenograft Model

Xenograft Model are used in the study 'Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol.' (Pérez A et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with CYTOCHALASIN B

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Authors Title Published Journal PubMed Link
Whitwell J et al. 2-Aminoanthracene, 5-fluorouracil, colchicine, benzo[a]pyrene, cadmium chloride and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster ovary (CHO) cells at Covance Laboratories, Harrogate UK in support of OECD draft Test Guideline 487. 2010 Mutat. Res. pmid:20478394
Whitwell J et al. 5-Fluorouracil, colchicine, benzo[a]pyrene and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster V79 cells at Covance Laboratories, Harrogate, UK in support of OECD draft Test Guideline 487. 2010 Mutat. Res. pmid:20438860
Fenech M et al. Preliminary studies on scoring micronuclei by computerised image analysis. 1988 Mutat. Res. pmid:3340091
Parry JM and Kirsch-Volders M Special issue on in vitro MN trial. 2010 Mutat. Res. pmid:20654729
Dimitrijević A et al. Micronucleus frequency in women with genital Chlamydia Trachomatis infection before and after therapy. 2006 Mutat. Res. pmid:16777475
Leach NT and Jackson-Cook C The application of spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) technology to determine the chromosomal content(s) of micronuclei. 2001 Mutat. Res. pmid:11448638
Steiblen G et al. Comparison of the relative sensitivity of human lymphocytes and mouse splenocytes to two spindle poisons. 2005 Mutat. Res. pmid:16310403
Kligerman AD et al. Cytogenetic studies of mice exposed to styrene by inhalation. 1992 Mutat. Res. pmid:1377343
Streffer C et al. Micronuclei-biological indicator for retrospective dosimetry after exposure to ionizing radiation. 1998 Mutat. Res. pmid:9729308
Fenech M Important variables that influence base-line micronucleus frequency in cytokinesis-blocked lymphocytes-a biomarker for DNA damage in human populations. 1998 Mutat. Res. pmid:9729354
Santos-Mello R et al. Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years. 2002 Mutat. Res. pmid:11943607
Garriott ML et al. A protocol for the in vitro micronucleus test. I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity. 2002 Mutat. Res. pmid:12034314
Pascoe SA and Stemp G A modified method and staining technique for the in vitro micronucleus test in human lymphocytes using cytochalasin B. 1990 Jun-Aug Mutat. Res. pmid:1694963
Kligerman AD and Erexson GL An evaluation of the feasibility of using cytogenetic damage as a biomarker for alachlor exposure. 1999 Mutat. Res. pmid:10224326
Fucić A et al. X-rays, microwaves and vinyl chloride monomer: their clastogenic and aneugenic activity, using the micronucleus assay on human lymphocytes. 1992 Mutat. Res. pmid:1379689
Whong WZ et al. Use of rat primary lung cells for studying genotoxicity with the sister-chromatid exchange and micronucleus assays. 1990 Mutat. Res. pmid:2333086
Uma Devi P et al. A method to score micronuclei in vivo using cytochalasin B-induced cytokinesis block. 1998 Mutat. Res. pmid:9639669
Mun GC et al. Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay. 2009 Mutat. Res. pmid:19167515
Erexson GL et al. Induction of micronuclei by X-radiation in human, mouse and rat peripheral blood lymphocytes. 1991 Mutat. Res. pmid:1922145
Fellows MD et al. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. II: Practical aspects with toxic agents. 2008 Aug-Sep Mutat. Res. pmid:18602493
Lorge E et al. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects. 2008 Aug-Sep Mutat. Res. pmid:18602494
Poma A et al. Inhibition of L-tyrosine-induced micronuclei production by phenylthiourea in human melanoma cells. 1999 Mutat. Res. pmid:10635335
Santos-Mello R et al. Induction of micronuclei by CsCl in vivo and in vitro. 1999 Mutat. Res. pmid:10635347
Terzoudi GI et al. Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26520389
Hatzi VI et al. Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26520375
Whitwell J et al. Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26232254
Matsushima T et al. Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). 1999 Mutagenesis pmid:10567032
Fenech M et al. Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide. 1999 Mutagenesis pmid:10567036
Tomanin R et al. Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis block method. 1991 Mutagenesis pmid:2056912
Doepker CL et al. Lack of induction of micronuclei in human peripheral blood lymphocytes treated with hydroquinone. 2000 Mutagenesis pmid:11076999
Maffei F et al. Increased cytogenetic damage detected by FISH analysis on micronuclei in peripheral lymphocytes from alcoholics. 2000 Mutagenesis pmid:11077004
Falck GC et al. Nature of anaphase laggards and micronuclei in female cytokinesis-blocked lymphocytes. 2002 Mutagenesis pmid:11880539
Schultz N and Onfelt A Video time-lapse study of mitosis in binucleate V79 cells: chromosome segregation and cleavage. 1994 Mutagenesis pmid:8201944
Leopardi P et al. Influence of donor age on vinblastine-induced chromosome malsegregation in cultured peripheral lymphocytes. 2002 Mutagenesis pmid:11752239
Champion AR et al. The micronucleus assay: an evaluation of its use in determining radiosensitivity in vitro. 1995 Mutagenesis pmid:7666771
Ellard S and Parry EM A modified protocol for the cytochalasin B in vitro micronucleus assay using whole human blood or separated lymphocyte cultures. 1993 Mutagenesis pmid:8377650
Crofton-Sleigh C et al. Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase. 1993 Mutagenesis pmid:8377657
Balajee AS et al. Multicolour FISH analysis of ionising radiation induced micronucleus formation in human lymphocytes. 2014 Mutagenesis pmid:25217771
Castelain P et al. Automated detection of cytochalasin-B blocked binucleated lymphocytes for scoring micronuclei. 1993 Mutagenesis pmid:7690875
Surrallés J et al. A collaborative study on the improvement of the micronucleus test in cultured human lymphocytes. 1992 Mutagenesis pmid:1474915
Van Hummelen P and Kirsch-Volders M Analysis of eight known or suspected aneugens by the in vitro human lymphocyte micronucleus test. 1992 Mutagenesis pmid:1474920
Cakmak Demircigil G et al. Micronucleus frequencies in peripheral blood lymphocytes of children with chronic kidney disease. 2011 Mutagenesis pmid:21669938
Lee TK et al. Assessment of two protocols for the human lymphocyte cytokinesis-blocked micronucleus assay. 1995 Mutagenesis pmid:7476276
Burgaz S et al. Micronucleus frequencies in lymphocytes and buccal epithelial cells from patients having head and neck cancer and their first-degree relatives. 2011 Mutagenesis pmid:21248276
Minissi S et al. Effect of cytochalasin B on the induction of chromosome missegregation by colchicine at low concentrations in human lymphocytes. 1999 Mutagenesis pmid:10474820
Guccini S et al. Effects of spindle poisons in peripheral human lymphocytes by the in vitro cytokinesis-block micronucleus assay. 2012 Mutagenesis pmid:22952150
Arsoy NS et al. Micronuclei in peripheral blood from patients after cytostatic therapy mainly arise ex vivo from persistent damage. 2009 Mutagenesis pmid:19423564
Surrallés J et al. The effect of cytochalasin-B concentration on the frequency of micronuclei induced by four standard mutagens. Results from two laboratories. 1994 Mutagenesis pmid:7968577
Minissi S et al. Direct and indirect non-disjunction in the origin of trisomy in cultured human lymphocytes. 1999 Mutagenesis pmid:10567030
Cimini D et al. Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells. 1999 Mutagenesis pmid:10567031