CYTOCHALASIN B

CYTOCHALASIN B is a lipid of Polyketides (PK) class. Cytochalasin b is associated with abnormalities such as Renal tubular disorder and Chagas Disease. The involved functions are known as Membrane Protein Traffic, inhibitors, Metabolic Inhibition, Biochemical Pathway and Increased Sensitivy. Cytochalasin b often locates in Cytoplasmic matrix, Plasma membrane, Microtubules, Extracellular and Protoplasm. The associated genes with CYTOCHALASIN B are SLC2A2 gene, PFDN5 gene, SLC2A1 gene, OMG gene and SPEN gene. The related lipids are Steroids, Lipopolysaccharides and Liposomes. The related experimental models are Xenograft Model.

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Introduction

To understand associated biological information of CYTOCHALASIN B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with CYTOCHALASIN B?

CYTOCHALASIN B is suspected in Renal tubular disorder, Chagas Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with CYTOCHALASIN B

MeSH term MeSH ID Detail
Cell Transformation, Viral D002472 26 associated lipids
Infectious Mononucleosis D007244 5 associated lipids
Ataxia Telangiectasia D001260 6 associated lipids
Pharyngeal Neoplasms D010610 4 associated lipids
Coronavirus Infections D018352 4 associated lipids
Chancroid D002602 4 associated lipids
Trisomy D014314 6 associated lipids
CREST Syndrome D017675 2 associated lipids
Factor XII Deficiency D005175 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with CYTOCHALASIN B

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with CYTOCHALASIN B?

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What functions are associated with CYTOCHALASIN B?


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What lipids are associated with CYTOCHALASIN B?

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What genes are associated with CYTOCHALASIN B?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with CYTOCHALASIN B?

Xenograft Model

Xenograft Model are used in the study 'Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol.' (Pérez A et al., 2009).

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Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with CYTOCHALASIN B

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Authors Title Published Journal PubMed Link
Champion AR et al. The micronucleus assay: an evaluation of its use in determining radiosensitivity in vitro. 1995 Mutagenesis pmid:7666771
Ellard S and Parry EM A modified protocol for the cytochalasin B in vitro micronucleus assay using whole human blood or separated lymphocyte cultures. 1993 Mutagenesis pmid:8377650
Crofton-Sleigh C et al. Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase. 1993 Mutagenesis pmid:8377657
Varga D et al. An automated scoring procedure for the micronucleus test by image analysis. 2004 Mutagenesis pmid:15388812
Surrallés J et al. A collaborative study on the improvement of the micronucleus test in cultured human lymphocytes. 1992 Mutagenesis pmid:1474915
Van Hummelen P and Kirsch-Volders M Analysis of eight known or suspected aneugens by the in vitro human lymphocyte micronucleus test. 1992 Mutagenesis pmid:1474920
Terzoudi GI et al. Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26520389
Hatzi VI et al. Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26520375
Whitwell J et al. Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays. 2015 Mutat Res Genet Toxicol Environ Mutagen pmid:26232254
Whitwell J et al. 2-Aminoanthracene, 5-fluorouracil, colchicine, benzo[a]pyrene, cadmium chloride and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster ovary (CHO) cells at Covance Laboratories, Harrogate UK in support of OECD draft Test Guideline 487. 2010 Mutat. Res. pmid:20478394
Whitwell J et al. 5-Fluorouracil, colchicine, benzo[a]pyrene and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster V79 cells at Covance Laboratories, Harrogate, UK in support of OECD draft Test Guideline 487. 2010 Mutat. Res. pmid:20438860
Parry JM and Kirsch-Volders M Special issue on in vitro MN trial. 2010 Mutat. Res. pmid:20654729
Andreassen PR et al. Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state. 1996 Mutat. Res. pmid:9015137
Zijno A et al. Analysis of chromosome segregation by means of fluorescence in situ hybridization: application to cytokinesis-blocked human lymphocytes. 1996 Mutat. Res. pmid:9015140
Kirkland D Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): summary of results in the collaborative trial. 2010 Mutat. Res. pmid:20149894
Marshall RR et al. Fluorescence in situ hybridisation with chromosome-specific centromeric probes: a sensitive method to detect aneuploidy. 1996 Mutat. Res. pmid:9015142
Johnston PJ et al. Induction and distribution of damage in CHO-K1 and the X-ray-sensitive hamster cell line xrs5, measured by the cytochalasin-B-cytokinesis block micronucleus assay. 1997 Mutat. Res. pmid:9372843
Fenech M The advantages and disadvantages of the cytokinesis-block micronucleus method. 1997 Mutat. Res. pmid:9269327
Falck G et al. Influence of culture time on the frequency and contents of human lymphocyte micronuclei with and without cytochalasin B. 1997 Mutat. Res. pmid:9269332
Sgura A et al. Micronuclei, centromere-positive micronuclei and chromosome nondisjunction in cytokinesis blocked human lymphocytes following mitomycin C or vincristine treatment. 1997 Mutat. Res. pmid:9269334
Surrallés J and Natarajan AT Human lymphocytes micronucleus assay in Europe. An international survey. 1997 Mutat. Res. pmid:9269340
Krishna G et al. Use of the cytokinesis-block method for the analysis of micronuclei in V79 Chinese hamster lung cells: results with mitomycin C and cyclophosphamide. 1989 Mutat. Res. pmid:2492079
Dimitrijević A et al. Micronucleus frequency in women with genital Chlamydia Trachomatis infection before and after therapy. 2006 Mutat. Res. pmid:16777475
Erexson GL et al. Diaziquone-induced micronuclei in cytochalasin B-blocked mouse peripheral blood lymphocytes. 1987 Mutat. Res. pmid:3574322
Leach NT and Jackson-Cook C The application of spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) technology to determine the chromosomal content(s) of micronuclei. 2001 Mutat. Res. pmid:11448638
Steiblen G et al. Comparison of the relative sensitivity of human lymphocytes and mouse splenocytes to two spindle poisons. 2005 Mutat. Res. pmid:16310403
Nito S et al. Spontaneous expulsion of micronuclei by enucleation in the micronucleus assay. 1988 Mar-Apr Mutat. Res. pmid:3128735
Domínguez I et al. Adaptive response to radiation damage in human lymphocytes conditioned with hydrogen peroxide as measured by the cytokinesis-block micronucleus technique. 1993 Mutat. Res. pmid:7678171
Scarfì MR et al. Measurement of micronuclei by cytokinesis-block method in bovine lymphocytes. 1993 Mutat. Res. pmid:7690898
Wakata A and Sasaki MS Measurement of micronuclei by cytokinesis-block method in cultured Chinese hamster cells: comparison with types and rates of chromosome aberrations. 1987 Mutat. Res. pmid:3099194
Santos-Mello R et al. Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years. 2002 Mutat. Res. pmid:11943607
Pascoe SA and Stemp G A modified method and staining technique for the in vitro micronucleus test in human lymphocytes using cytochalasin B. 1990 Jun-Aug Mutat. Res. pmid:1694963
Miller B et al. Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft für Umwelt-Mutations-forschung. 1998 Mutat. Res. pmid:9587425
Aardema MJ et al. SFTG international collaborative study on in vitro micronucleus test III. Using CHO cells. 2006 Mutat. Res. pmid:16797224
Fucić A et al. X-rays, microwaves and vinyl chloride monomer: their clastogenic and aneugenic activity, using the micronucleus assay on human lymphocytes. 1992 Mutat. Res. pmid:1379689
Gutiérrez-Enríquez S and Hall J Use of the cytokinesis-block micronucleus assay to measure radiation-induced chromosome damage in lymphoblastoid cell lines. 2003 Mutat. Res. pmid:12547278
Curren RD et al. Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm). 2006 Mutat. Res. pmid:16781186
Wakata A et al. SFTG international collaborative study on in vitro micronucleus test IV. Using CHL cells. 2006 Mutat. Res. pmid:16782396
Fenech M and Morley AA Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. 1986 Mutat. Res. pmid:3724773
Migliore L et al. Induction of binucleation in human lymphocytes by 14 synthetic isoindolone derivatives related to cytochalasins. 1994 Mutat. Res. pmid:7519314
Murray D et al. Effect of thiols on micronucleus frequency in gamma-irradiated mammalian cells. 1991 Mutat. Res. pmid:2002801
Mun GC et al. Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay. 2009 Mutat. Res. pmid:19167515
Fellows MD et al. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. II: Practical aspects with toxic agents. 2008 Aug-Sep Mutat. Res. pmid:18602493
Lorge E et al. Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects. 2008 Aug-Sep Mutat. Res. pmid:18602494
al-Sabti K Micronuclei induced by selenium, mercury, methylmercury and their mixtures in binucleated blocked fish erythrocyte cells. 1994 Mutat. Res. pmid:7506383
Mudry MD et al. Mutagenic bioassay of certain pharmacological drugs: III. Metronidazole (MTZ). 1994 Mutat. Res. pmid:7510021
Fenech M and Morley AA Measurement of micronuclei in lymphocytes. 1985 Feb-Apr Mutat. Res. pmid:3974610
Matsuoka A et al. The 2-phenylbenzotriazole-type water pollutant PBTA-2 has cytochalasin B-mimetic activity. 2000 Mutat. Res. pmid:10648903
Elhajouji A Mitomycin C, 5-fluoruracil, colchicine and etoposide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Novartis in support of OECD draft Test Guideline 487. 2010 Mutat. Res. pmid:20338262
Schuler M et al. Evaluation of phenolphthalein, diazepam and quinacrine dihydrochloride in the in vitro mammalian cell micronucleus test in Chinese hamster ovary (CHO) and TK6 cells. 2010 Mutat. Res. pmid:20399283