MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
Cholangiocarcinoma | D018281 | 7 associated lipids |
Chaetoglobosins is a lipid of Polyketides (PK) class. The involved functions are known as Drug Interactions, cell motility, Polymerization, Cell Cycle Arrest and Cytokinesis. Chaetoglobosins often locates in host, nucleocapsid location, Microfilaments and Skeletal system. The associated genes with Chaetoglobosins are TP53 gene.
To understand associated biological information of Chaetoglobosins, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Chaetoglobosins
MeSH term | MeSH ID | Detail |
---|---|---|
Leukemia, Lymphocytic, Chronic, B-Cell | D015451 | 25 associated lipids |
Cholangiocarcinoma | D018281 | 7 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
pmid:10209577 | ||||
Tikoo A et al. | Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. | 1999 Sep-Oct | Cancer J Sci Am | pmid:10526670 |
Maruta H et al. | Cytoskeletal tumor suppressors that block oncogenic RAS signaling. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10667202 |
Shinohara C et al. | Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B. | 2000 | J. Antibiot. | pmid:10819297 |
Matesic DF et al. | Prevention of organochlorine-induced inhibition of gap junctional communication by chaetoglobosin K in astrocytes. | 2001 | Cell Biol. Toxicol. | pmid:11787861 |
Fog Nielsen K | Mycotoxin production by indoor molds. | 2003 | Fungal Genet. Biol. | pmid:12781669 |
Andersen B et al. | Penicillium expansum: consistent production of patulin, chaetoglobosins, and other secondary metabolites in culture and their natural occurrence in fruit products. | 2004 | J. Agric. Food Chem. | pmid:15080656 |
Jiao W et al. | Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum. | 2004 | J. Nat. Prod. | pmid:15497948 |
Matesic DF et al. | Inhibition of cytokinesis and akt phosphorylation by chaetoglobosin K in ras-transformed epithelial cells. | 2006 | Cancer Chemother. Pharmacol. | pmid:16254733 |
Christian OE et al. | Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi. | 2005 | J. Nat. Prod. | pmid:16309305 |
Ding G et al. | Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. | 2006 | J. Nat. Prod. | pmid:16499339 |
Fogle MR et al. | Growth and mycotoxin production by Chaetomium globosum. | 2007 | Mycopathologia | pmid:17551849 |
Sidorova TS and Matesic DF | Protective effect of the natural product, chaetoglobosin K, on lindane- and dieldrin-induced changes in astroglia: identification of activated signaling pathways. | 2008 | Pharm. Res. | pmid:18040759 |
Fogle MR et al. | Heat stability of chaetoglobosins A and C. | 2008 | Can. J. Microbiol. | pmid:18449228 |
Qin JC et al. | Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19246197 |
Cui CM et al. | Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. | 2010 | J. Nat. Prod. | pmid:20225834 |
Zhang J et al. | Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. | 2010 | Planta Med. | pmid:20486076 |
Thohinung S et al. | Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01. | 2010 | Arch. Pharm. Res. | pmid:20803114 |
Ge HM et al. | Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. | 2011 | Chem. Commun. (Camb.) | pmid:21152613 |
Straus DC | The possible role of fungal contamination in sick building syndrome. | 2011 | Front Biosci (Elite Ed) | pmid:21196335 |
Wang Y et al. | Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. | 2012 | Phytomedicine | pmid:22112725 |
Dou H et al. | Chaetoglobosin Fex from the marine-derived endophytic fungus inhibits induction of inflammatory mediators via Toll-like receptor 4 signaling in macrophages. | 2011 | Biol. Pharm. Bull. | pmid:22130243 |
Xue M et al. | Chaetoglobosin Vb from endophytic Chaetomium globosum: absolute configuration of chaetoglobosins. | 2012 | Chirality | pmid:22593034 |
Hua C et al. | Chaetoglobosin F, a small molecule compound, possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR9 signaling pathway. | 2013 | Immunobiology | pmid:22739238 |
Xu GB et al. | Electrospray ionization tandem mass spectrometry of chaetoglobosins. | 2012 | Rapid Commun. Mass Spectrom. | pmid:22886807 |
Boettger D et al. | Evolutionary imprint of catalytic domains in fungal PKS-NRPS hybrids. | 2012 | Chembiochem | pmid:23023987 |
Ali A et al. | Dual modulation of JNK and Akt signaling pathways by chaetoglobosin K in human lung carcinoma and ras-transformed epithelial cells. | 2013 | Invest New Drugs | pmid:23054210 |
Hu Y et al. | Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. | 2013 | J. Agric. Food Chem. | pmid:23214998 |
Hu Y et al. | A PKS gene, pks-1, is involved in chaetoglobosin biosynthesis, pigmentation and sporulation in Chaetomium globosum. | 2012 | Sci China Life Sci | pmid:23233225 |
McMullin DR et al. | Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment. | 2013 | Mycotoxin Res | pmid:23334724 |
Ishiuchi K et al. | Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis. | 2013 | J. Am. Chem. Soc. | pmid:23611317 |
Luo H et al. | Chaetoglobosin K inhibits tumor angiogenesis through downregulation of vascular epithelial growth factor-binding hypoxia-inducible factor 1α. | 2013 | Anticancer Drugs | pmid:23695013 |
Kawahara T et al. | New chaetoglobosin derivatives, MBJ-0038, MBJ-0039 and MBJ-0040, isolated from the fungus Chaetomium sp. f24230. | 2013 | J. Antibiot. | pmid:23881215 |
Knudsen PB et al. | Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. | 2014 | Leukemia | pmid:24280868 |
Zheng QC et al. | Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum. | 2014 | Fitoterapia | pmid:24418656 |
Rogers KD et al. | Diplodiatoxin, chaetoglobosins, and diplonine associated with a field outbreak of Stenocarpella ear rot in Illinois. | 2014 | Mycotoxin Res | pmid:24504633 |
Li H et al. | Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities. | 2014 | J. Agric. Food Chem. | pmid:24708412 |
Trendowski M | Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach. | 2014 | Biochim. Biophys. Acta | pmid:25286320 |
Li B et al. | Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent pathway in cisplatin-resistant ovarian cancer cells. | 2015 | Cancer Lett. | pmid:25304379 |
Dhillon B et al. | Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25733908 |
Chen C et al. | Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare. | 2015 | J. Nat. Prod. | pmid:26068802 |
Jiang T et al. | Overexpression of the Global Regulator LaeA in Chaetomium globosum Leads to the Biosynthesis of Chaetoglobosin Z. | 2016 | J. Nat. Prod. | pmid:27759375 |
Zhao SS et al. | Chaetomium globosum CDW7, a potential biological control strain and its antifungal metabolites. | 2017 | FEMS Microbiol. Lett. | pmid:28011695 |
Jiang C et al. | New production process of the antifungal chaetoglobosin A using cornstalks. | Braz. J. Microbiol. | pmid:28223029 | |
van Haelst C and Rothstein TL | Cytochalasin stimulates phosphoinositide metabolism in murine B lymphocytes. | 1988 | J. Immunol. | pmid:2830337 |
Jiang C et al. | Identification and characterization of the major antifungal substance against Fusarium Sporotrichioides from Chaetomium globosum. | 2017 | World J. Microbiol. Biotechnol. | pmid:28466302 |
Ashrafi S et al. | Ijuhya vitellina sp. nov., a novel source for chaetoglobosin A, is a destructive parasite of the cereal cyst nematode Heterodera filipjevi. | 2017 | PLoS ONE | pmid:28700638 |
Zhu X et al. | Penochalasin K, a new unusual chaetoglobosin from the mangrove endophytic fungus Penicillium chrysogenum V11 and its effective semi-synthesis. | 2017 | Fitoterapia | pmid:28958956 |
Hu Y et al. | Gα-cAMP/PKA pathway positively regulates pigmentation, chaetoglobosin A biosynthesis and sexual development in Chaetomium globosum. | 2018 | PLoS ONE | pmid:29652900 |