Chaetoglobosins

Chaetoglobosins is a lipid of Polyketides (PK) class. The involved functions are known as Drug Interactions, cell motility, Polymerization, Cell Cycle Arrest and Cytokinesis. Chaetoglobosins often locates in host, nucleocapsid location, Microfilaments and Skeletal system. The associated genes with Chaetoglobosins are TP53 gene.

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Introduction

To understand associated biological information of Chaetoglobosins, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Chaetoglobosins?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Chaetoglobosins

MeSH term MeSH ID Detail
Leukemia, Lymphocytic, Chronic, B-Cell D015451 25 associated lipids
Cholangiocarcinoma D018281 7 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Chaetoglobosins

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Chaetoglobosins?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Chaetoglobosins?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Chaetoglobosins?

There are no associated biomedical information in the current reference collection.

What genes are associated with Chaetoglobosins?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Chaetoglobosins?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Chaetoglobosins

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Authors Title Published Journal PubMed Link
Walsh JP et al. Diagnostic fragmentation filtering for the discovery of new chaetoglobosins and cytochalasins. 2019 Rapid Commun. Mass Spectrom. pmid:30325552
Yang MH et al. Aureochaeglobosins A-C, Three [4 + 2] Adducts of Chaetoglobosin and Aureonitol Derivatives from Chaetomium globosum. 2018 Org. Lett. pmid:29771535
Hu Y et al. Gα-cAMP/PKA pathway positively regulates pigmentation, chaetoglobosin A biosynthesis and sexual development in Chaetomium globosum. 2018 PLoS ONE pmid:29652900
Jiang C et al. Identification and characterization of the major antifungal substance against Fusarium Sporotrichioides from Chaetomium globosum. 2017 World J. Microbiol. Biotechnol. pmid:28466302
Zhao SS et al. Chaetomium globosum CDW7, a potential biological control strain and its antifungal metabolites. 2017 FEMS Microbiol. Lett. pmid:28011695
Ashrafi S et al. Ijuhya vitellina sp. nov., a novel source for chaetoglobosin A, is a destructive parasite of the cereal cyst nematode Heterodera filipjevi. 2017 PLoS ONE pmid:28700638
Zhu X et al. Penochalasin K, a new unusual chaetoglobosin from the mangrove endophytic fungus Penicillium chrysogenum V11 and its effective semi-synthesis. 2017 Fitoterapia pmid:28958956
Jiang T et al. Overexpression of the Global Regulator LaeA in Chaetomium globosum Leads to the Biosynthesis of Chaetoglobosin Z. 2016 J. Nat. Prod. pmid:27759375
Chen C et al. Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare. 2015 J. Nat. Prod. pmid:26068802
Dhillon B et al. Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen. 2015 Proc. Natl. Acad. Sci. U.S.A. pmid:25733908
Li B et al. Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent pathway in cisplatin-resistant ovarian cancer cells. 2015 Cancer Lett. pmid:25304379
Rogers KD et al. Diplodiatoxin, chaetoglobosins, and diplonine associated with a field outbreak of Stenocarpella ear rot in Illinois. 2014 Mycotoxin Res pmid:24504633
Zheng QC et al. Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum. 2014 Fitoterapia pmid:24418656
Trendowski M Exploiting the cytoskeletal filaments of neoplastic cells to potentiate a novel therapeutic approach. 2014 Biochim. Biophys. Acta pmid:25286320
Li H et al. Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities. 2014 J. Agric. Food Chem. pmid:24708412
Knudsen PB et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. 2014 Leukemia pmid:24280868
Hua C et al. Chaetoglobosin F, a small molecule compound, possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR9 signaling pathway. 2013 Immunobiology pmid:22739238
Kawahara T et al. New chaetoglobosin derivatives, MBJ-0038, MBJ-0039 and MBJ-0040, isolated from the fungus Chaetomium sp. f24230. 2013 J. Antibiot. pmid:23881215
Ishiuchi K et al. Combinatorial generation of complexity by redox enzymes in the chaetoglobosin A biosynthesis. 2013 J. Am. Chem. Soc. pmid:23611317
Luo H et al. Chaetoglobosin K inhibits tumor angiogenesis through downregulation of vascular epithelial growth factor-binding hypoxia-inducible factor 1α. 2013 Anticancer Drugs pmid:23695013
Hu Y et al. Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. 2013 J. Agric. Food Chem. pmid:23214998
McMullin DR et al. Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment. 2013 Mycotoxin Res pmid:23334724
Ali A et al. Dual modulation of JNK and Akt signaling pathways by chaetoglobosin K in human lung carcinoma and ras-transformed epithelial cells. 2013 Invest New Drugs pmid:23054210
Wang Y et al. Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. 2012 Phytomedicine pmid:22112725
Xue M et al. Chaetoglobosin Vb from endophytic Chaetomium globosum: absolute configuration of chaetoglobosins. 2012 Chirality pmid:22593034
Xu GB et al. Electrospray ionization tandem mass spectrometry of chaetoglobosins. 2012 Rapid Commun. Mass Spectrom. pmid:22886807
Hu Y et al. A PKS gene, pks-1, is involved in chaetoglobosin biosynthesis, pigmentation and sporulation in Chaetomium globosum. 2012 Sci China Life Sci pmid:23233225
Boettger D et al. Evolutionary imprint of catalytic domains in fungal PKS-NRPS hybrids. 2012 Chembiochem pmid:23023987
Ge HM et al. Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. 2011 Chem. Commun. (Camb.) pmid:21152613
Straus DC The possible role of fungal contamination in sick building syndrome. 2011 Front Biosci (Elite Ed) pmid:21196335
Dou H et al. Chaetoglobosin Fex from the marine-derived endophytic fungus inhibits induction of inflammatory mediators via Toll-like receptor 4 signaling in macrophages. 2011 Biol. Pharm. Bull. pmid:22130243
Thohinung S et al. Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01. 2010 Arch. Pharm. Res. pmid:20803114
Cui CM et al. Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. 2010 J. Nat. Prod. pmid:20225834
Zhang J et al. Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. 2010 Planta Med. pmid:20486076
Qin JC et al. Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. 2009 Bioorg. Med. Chem. Lett. pmid:19246197
Sidorova TS and Matesic DF Protective effect of the natural product, chaetoglobosin K, on lindane- and dieldrin-induced changes in astroglia: identification of activated signaling pathways. 2008 Pharm. Res. pmid:18040759
Fogle MR et al. Heat stability of chaetoglobosins A and C. 2008 Can. J. Microbiol. pmid:18449228
Fogle MR et al. Growth and mycotoxin production by Chaetomium globosum. 2007 Mycopathologia pmid:17551849
Matesic DF et al. Inhibition of cytokinesis and akt phosphorylation by chaetoglobosin K in ras-transformed epithelial cells. 2006 Cancer Chemother. Pharmacol. pmid:16254733
Ding G et al. Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. 2006 J. Nat. Prod. pmid:16499339
Christian OE et al. Using jasplakinolide to turn on pathways that enable the isolation of new chaetoglobosins from Phomospis asparagi. 2005 J. Nat. Prod. pmid:16309305
Andersen B et al. Penicillium expansum: consistent production of patulin, chaetoglobosins, and other secondary metabolites in culture and their natural occurrence in fruit products. 2004 J. Agric. Food Chem. pmid:15080656
Jiao W et al. Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum. 2004 J. Nat. Prod. pmid:15497948
Fog Nielsen K Mycotoxin production by indoor molds. 2003 Fungal Genet. Biol. pmid:12781669
Matesic DF et al. Prevention of organochlorine-induced inhibition of gap junctional communication by chaetoglobosin K in astrocytes. 2001 Cell Biol. Toxicol. pmid:11787861
Shinohara C et al. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B. 2000 J. Antibiot. pmid:10819297
Tikoo A et al. Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445. 1999 Sep-Oct Cancer J Sci Am pmid:10526670
Maruta H et al. Cytoskeletal tumor suppressors that block oncogenic RAS signaling. 1999 Ann. N. Y. Acad. Sci. pmid:10667202
Frisvad JC et al. Penicillium discolor, a new species from cheese, nuts and vegetables. 1997 Antonie Van Leeuwenhoek pmid:9298190
Kobayashi H et al. A screening method for antimitotic and antifungal substances using conidia of Pyricularia oryzae, modification and application to tropical marine fungi. 1996 J. Antibiot. pmid:8931720