Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tooth Discoloration | D014075 | 7 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu J et al. | Bog bilberry (Vaccinium uliginosum L.) extract reduces cultured Hep-G2, Caco-2, and 3T3-L1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability. | 2010 | J. Food Sci. | pmid:20492295 |
| Liu Y et al. | Comparative study of phenolic compounds and antioxidant activity in different species of cherries. | 2011 | J. Food Sci. | pmid:22417346 |
| Andrade JM et al. | Phenolic composition in different genotypes of Guabiju fruits (Myrcianthes pungens) and their potential as antioxidant and antichemotactic agents. | 2011 | J. Food Sci. | pmid:22417582 |
| Walton MC et al. | Viscous food matrix influences absorption and excretion but not metabolism of blackcurrant anthocyanins in rats. | J. Food Sci. | pmid:19200098 | |
| Oh YS et al. | Characterization and quantification of anthocyanins in grape juices obtained from the grapes cultivated in Korea by HPLC/DAD, HPLC/MS, and HPLC/MS/MS. | 2008 | J. Food Sci. | pmid:18576983 |
| Wu TY et al. | Effect of antioxidant activity and functional properties of Chingshey purple sweet potato fermented milk by Lactobacillus acidophilus, L. delbrueckii subsp. lactis, and L. gasseri strains. | 2012 | J. Food Sci. | pmid:22182227 |
| Modolo LV et al. | Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids. | 2009 | J. Mol. Biol. | pmid:19683002 |
| Maldonado-Rojas W and Olivero-Verbel J | Potential interaction of natural dietary bioactive compounds with COX-2. | 2011 | J. Mol. Graph. Model. | pmid:21803623 |
| Grajeda-Iglesias C et al. | Isolation and Characterization of Anthocyanins from Hibiscus sabdariffa Flowers. | 2016 | J. Nat. Prod. | pmid:27312226 |
| Larsson J et al. | Expanding the ChemGPS chemical space with natural products. | 2005 | J. Nat. Prod. | pmid:16038536 |
| Reynertson KA et al. | Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). | 2006 | J. Nat. Prod. | pmid:16933884 |
| Vanzo A et al. | Exceptionally fast uptake and metabolism of cyanidin 3-glucoside by rat kidneys and liver. | 2011 | J. Nat. Prod. | pmid:21510696 |
| Wang H et al. | Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. | 1999 | J. Nat. Prod. | pmid:10075763 |
| Youdim KA et al. | Interaction between flavonoids and the blood-brain barrier: in vitro studies. | 2003 | J. Neurochem. | pmid:12641740 |
| Kadigamuwa CC et al. | 2, 2'- and 4, 4'-Cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPPâº. | 2015 | J. Neurochem. | pmid:26094622 |
| Ke Z et al. | Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain. | 2011 | J. Neurosci. Res. | pmid:21671257 |
| Vitaglione P et al. | Protocatechuic acid is the major human metabolite of cyanidin-glucosides. | 2007 | J. Nutr. | pmid:17709440 |
| Wu X et al. | Pelargonidin is absorbed and metabolized differently than cyanidin after marionberry consumption in pigs. | 2004 | J. Nutr. | pmid:15465754 |
| Galvano F et al. | Cyanidins: metabolism and biological properties. | 2004 | J. Nutr. Biochem. | pmid:14711454 |
| Guo H et al. | Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. | 2012 | J. Nutr. Biochem. | pmid:21543211 |
| Li J et al. | Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy. | 2012 | J. Nutr. Biochem. | pmid:21543205 |
| Muñoz-Espada AC and Watkins BA | Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells. | 2006 | J. Nutr. Biochem. | pmid:16443360 |
| Garcia-Alonso M et al. | Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma. | 2009 | J. Nutr. Biochem. | pmid:18789665 |
| Russo A et al. | Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-beta-d-glucoside. | 2005 | J. Nutr. Biochem. | pmid:15629238 |
| Kamiyama M et al. | Inhibition of low-density lipoprotein oxidation by Nagano purple grape (Vitis viniferaxVitis labrusca). | 2009 | J. Nutr. Sci. Vitaminol. | pmid:20086316 |
| Kim RJ et al. | Antioxidant's cytoprotective effects on rotator cuff tenofibroblasts exposed to aminoamide local anesthetics. | 2015 | J. Orthop. Res. | pmid:25639557 |
| Kim RJ et al. | Do antioxidants inhibit oxidative-stress-induced autophagy of tenofibroblasts? | 2014 | J. Orthop. Res. | pmid:24644146 |
| Santos J et al. | Inhibition of host- and bacteria-derived proteinases by natural anthocyanins. | 2011 | J. Periodont. Res. | pmid:21517858 |
| Petruk G et al. | Malvidin and cyanidin derivatives from açai fruit (Euterpe oleracea Mart.) counteract UV-A-induced oxidative stress in immortalized fibroblasts. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28527426 |
| Fedenko VS et al. | UV-vis spectroscopy and colorimetric models for detecting anthocyanin-metal complexes in plants: An overview of in vitro and in vivo techniques. | 2017 | J. Plant Physiol. | pmid:28242414 |
| Agati G et al. | The biosynthesis of flavonoids is enhanced similarly by UV radiation and root zone salinity in L. vulgare leaves. | 2011 | J. Plant Physiol. | pmid:20850892 |
| Ishiguro K et al. | Functional analysis of Antirrhinum kelloggii flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase genes; critical role in flower color and evolution in the genus Antirrhinum. | 2012 | J. Plant Res. | pmid:21959781 |
| Wang LS et al. | Chemical taxonomy of the Xibei tree peony from China by floral pigmentation. | 2004 | J. Plant Res. | pmid:14685820 |
| Nankar AN et al. | Quantitative and qualitative evaluation of kernel anthocyanins from southwestern United States blue corn. | 2016 | J. Sci. Food Agric. | pmid:26879128 |
| Liao J et al. | Identification and analysis of anthocyanin components in fruit color variation in Schisandra chinensis. | 2016 | J. Sci. Food Agric. | pmid:26493497 |
| Abe LT et al. | Potential dietary sources of ellagic acid and other antioxidants among fruits consumed in Brazil: jabuticaba (Myrciaria jaboticaba (Vell.) Berg). | 2012 | J. Sci. Food Agric. | pmid:22173652 |
| Wei X et al. | Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity. | 2011 | J. Sci. Food Agric. | pmid:21360538 |
| Rababah TM et al. | Effect of jam processing and storage on total phenolics, antioxidant activity, and anthocyanins of different fruits. | 2011 | J. Sci. Food Agric. | pmid:21254073 |
| Su M et al. | Physical changes and physiological characteristics of red and green peel during nectarine (cv. Hu018) maturation. | 2012 | J. Sci. Food Agric. | pmid:22144032 |
| Zhang X et al. | Characterisation of anthocyanidin reductase from Shuchazao green tea. | 2012 | J. Sci. Food Agric. | pmid:22173936 |
| Bhuiyan MI et al. | The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation. | 2011 | Korean J. Physiol. Pharmacol. | pmid:22359473 |
| Kwon SC and Kim YB | Antioxidative and aldose reductase-inhibitory effects of a fermentation filtrate of Rubus coreanus. | 2011 | Lab Anim Res | pmid:22232649 |
| Kim SM et al. | Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids. | 2012 | Life Sci. | pmid:22575822 |
| Wang Q et al. | Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages. | 2008 | Life Sci. | pmid:18619979 |
| Tanaka J et al. | Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo. | 2013 | Life Sci. | pmid:23123597 |
| Liu YC et al. | Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. | 2007 | Life Sci. | pmid:17320913 |
| Vareed SK et al. | Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida fruits with health benefits. | 2006 | Life Sci. | pmid:16139847 |
| Zhang Y et al. | Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. | 2005 | Life Sci. | pmid:15680311 |
| Serraino I et al. | Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. | 2003 | Life Sci. | pmid:12818719 |
| Tsuda T et al. | Oxidation products of cyanidin 3-O-beta-D-glucoside with a free radical initiator. | 1996 | Lipids | pmid:8972458 |