Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tooth Discoloration | D014075 | 7 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Matsui T et al. | alpha-Glucosidase inhibitory action of natural acylated anthocyanins. 2. alpha-Glucosidase inhibition by isolated acylated anthocyanins. | 2001 | J. Agric. Food Chem. | pmid:11308352 |
| Oliveira Lde S et al. | Antioxidant metabolism during fruit development of different acerola (Malpighia emarginata D.C) clones. | 2012 | J. Agric. Food Chem. | pmid:22834960 |
| Park WT et al. | Metabolic profiling of glucosinolates, anthocyanins, carotenoids, and other secondary metabolites in kohlrabi (Brassica oleracea var. gongylodes). | 2012 | J. Agric. Food Chem. | pmid:22742768 |
| Li X et al. | Accumulation of phenylpropanoids and correlated gene expression during the development of tartary buckwheat sprouts. | 2012 | J. Agric. Food Chem. | pmid:22587625 |
| Li CY et al. | Corn husk as a potential source of anthocyanins. | 2008 | J. Agric. Food Chem. | pmid:19007127 |
| Iliopoulou I et al. | Analysis of the Thermal Degradation of the Individual Anthocyanin Compounds of Black Carrot (Daucus carota L.): A New Approach Using High-Resolution Proton Nuclear Magnetic Resonance Spectroscopy. | 2015 | J. Agric. Food Chem. | pmid:26160425 |
| Tsao R et al. | Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). | 2003 | J. Agric. Food Chem. | pmid:14518966 |
| Jo YH et al. | Metabolomic Analysis Reveals Cyanidins in Black Raspberry as Candidates for Suppression of Lipopolysaccharide-Induced Inflammation in Murine Macrophages. | 2015 | J. Agric. Food Chem. | pmid:26023864 |
| Kanamoto Y et al. | A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. | 2011 | J. Agric. Food Chem. | pmid:21751816 |
| Cuevas Montilla E et al. | Soluble and bound phenolic compounds in different Bolivian purple corn ( Zea mays L.) cultivars. | 2011 | J. Agric. Food Chem. | pmid:21639140 |
| Jordheim M et al. | Identification of cyanidin 3-O-β-(6″-(3-hydroxy-3-methylglutaroyl)glucoside) and other anthocyanins from wild and cultivated blackberries. | 2011 | J. Agric. Food Chem. | pmid:21635009 |
| Esselen M et al. | Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase I and II poisons in colon carcinoma cells. | 2011 | J. Agric. Food Chem. | pmid:21599019 |
| Macz-Pop GA et al. | New flavanol-anthocyanin condensed pigments and anthocyanin composition in guatemalan beans (Phaseolus spp.). | 2006 | J. Agric. Food Chem. | pmid:16417317 |
| Wiczkowski W et al. | Bioavailability of cyanidin glycosides from natural chokeberry (Aronia melanocarpa) juice with dietary-relevant dose of anthocyanins in humans. | 2010 | J. Agric. Food Chem. | pmid:21067240 |
| Tanaka J et al. | Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo. | 2011 | J. Agric. Food Chem. | pmid:21175193 |
| Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
| Josuttis M et al. | Solar UVB response of bioactives in strawberry (Fragaria × ananassa Duch. L.): a comparison of protected and open-field cultivation. | 2010 | J. Agric. Food Chem. | pmid:21086998 |
| Speciale A et al. | Cyanidin-3-O-glucoside protection against TNF-α-induced endothelial dysfunction: involvement of nuclear factor-κB signaling. | 2010 | J. Agric. Food Chem. | pmid:20958056 |
| Sentandreu E et al. | LC-DAD-ESI/MS(n) determination of direct condensation flavanol-anthocyanin adducts in pressure extracted pomegranate (Punica granatum L.) juice. | 2010 | J. Agric. Food Chem. | pmid:20839870 |
| Oliveira J et al. | Color properties of four cyanidin-pyruvic acid adducts. | 2006 | J. Agric. Food Chem. | pmid:16939355 |
| Ashton OB et al. | Pigments in avocado tissue and oil. | 2006 | J. Agric. Food Chem. | pmid:17177553 |
| Zhang Y et al. | Spectral alteration and degradation of cyanidin-3-glucoside exposed to pulsed electric field. | 2010 | J. Agric. Food Chem. | pmid:20163112 |
| Johnson ET et al. | Constitutive expression of the maize genes B1 and C1 in transgenic Hi II maize results in differential tissue pigmentation and generates resistance to Helicoverpa zea. | 2010 | J. Agric. Food Chem. | pmid:20108901 |
| Li X et al. | Purple canola: Arabidopsis PAP1 increases antioxidants and phenolics in Brassica napus leaves. | 2010 | J. Agric. Food Chem. | pmid:20073469 |
| White BL et al. | Proximate and polyphenolic characterization of cranberry pomace. | 2010 | J. Agric. Food Chem. | pmid:20020689 |
| Truong VD et al. | Characterization of anthocyanins and anthocyanidins in purple-fleshed sweetpotatoes by HPLC-DAD/ESI-MS/MS. | 2010 | J. Agric. Food Chem. | pmid:20017481 |
| Chakraborty M et al. | Effect of the novel radiant zone drying method on anthocyanins and phenolics of three blueberry liquids. | 2010 | J. Agric. Food Chem. | pmid:19954224 |
| Slavin M et al. | Antioxidant properties, phytochemical composition, and antiproliferative activity of Maryland-grown soybeans with colored seed coats. | 2009 | J. Agric. Food Chem. | pmid:19950996 |
| Ojwang LO et al. | Ultra performance liquid chromatography-tandem quadrupole mass spectrometry profiling of anthocyanins and flavonols in cowpea (Vigna unguiculata) of varying genotypes. | 2012 | J. Agric. Food Chem. | pmid:22429113 |
| Shih PH et al. | Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 transduction pathways. | 2012 | J. Agric. Food Chem. | pmid:22364184 |
| Stalmach A et al. | Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. | 2011 | J. Agric. Food Chem. | pmid:21812481 |
| Jin J et al. | Analysis of phytochemical composition and chemoprotective capacity of rocket (Eruca sativa and Diplotaxis tenuifolia) leafy salad following cultivation in different environments. | 2009 | J. Agric. Food Chem. | pmid:19489541 |
| Moze S et al. | Phenolics in Slovenian bilberries ( Vaccinium myrtillus L.) and blueberries ( Vaccinium corymbosum L.). | 2011 | J. Agric. Food Chem. | pmid:21574578 |
| Treutter D et al. | Diversity of phenolic profiles in the fruit skin of Prunus domestica plums and related species. | 2012 | J. Agric. Food Chem. | pmid:23140499 |
| Xu C et al. | Influence of growing season on phenolic compounds and antioxidant properties of grape berries from vines grown in subtropical climate. | 2011 | J. Agric. Food Chem. | pmid:21235208 |
| Pinho C et al. | Optimization of conditions for anthocyanin hydrolysis from red wine using response surface methodology (RSM). | 2011 | J. Agric. Food Chem. | pmid:21158431 |
| Meiers S et al. | The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. | 2001 | J. Agric. Food Chem. | pmid:11262056 |
| Vasco C et al. | Phenolic compounds in Rosaceae fruits from Ecuador. | 2009 | J. Agric. Food Chem. | pmid:19143537 |
| You Q et al. | Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities. | 2011 | J. Agric. Food Chem. | pmid:21797278 |
| Cao S et al. | A comparison of two determination methods for studying degradation kinetics of the major anthocyanins from blood orange. | 2009 | J. Agric. Food Chem. | pmid:19099393 |
| Kähkönen MP and Heinonen M | Antioxidant activity of anthocyanins and their aglycons. | 2003 | J. Agric. Food Chem. | pmid:12537433 |
| Hassimotto NM et al. | Antioxidant status in humans after consumption of blackberry (Rubus fruticosus L.) juices with and without defatted milk. | 2008 | J. Agric. Food Chem. | pmid:19053224 |
| Lätti AK et al. | Anthocyanin and flavonol variation in bog bilberries (Vaccinium uliginosum L.) in Finland. | 2010 | J. Agric. Food Chem. | pmid:20000402 |
| Lin LZ and Harnly JM | Phenolic compounds and chromatographic profiles of pear skins (Pyrus spp.). | 2008 | J. Agric. Food Chem. | pmid:18778075 |
| Jensen GS et al. | In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. | 2008 | J. Agric. Food Chem. | pmid:18717569 |
| Lätti AK et al. | Characterization of anthocyanins in caucasian blueberries (Vaccinium arctostaphylos L.) native to Turkey. | 2009 | J. Agric. Food Chem. | pmid:19480388 |
| Persson IA et al. | Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells. | 2009 | J. Agric. Food Chem. | pmid:19441816 |
| Tulio AZ et al. | Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry. | 2008 | J. Agric. Food Chem. | pmid:18290621 |
| Fernandes I et al. | Enzymatic hemisynthesis of metabolites and conjugates of anthocyanins. | 2009 | J. Agric. Food Chem. | pmid:19113877 |
| Matsuura R et al. | Determination of antioxidant activity and characterization of antioxidant phenolics in the plum vinegar extract of cherry blossom (Prunus lannesiana). | 2008 | J. Agric. Food Chem. | pmid:18092753 |
| GarcÃa-MacÃas P et al. | Changes in the flavonoid and phenolic acid contents and antioxidant activity of red leaf lettuce (Lollo Rosso) due to cultivation under plastic films varying in ultraviolet transparency. | 2007 | J. Agric. Food Chem. | pmid:18001028 |
| Matsumoto M et al. | Gastroprotective effect of red pigments in black chokeberry fruit (Aronia melanocarpa Elliot) on acute gastric hemorrhagic lesions in rats. | 2004 | J. Agric. Food Chem. | pmid:15080625 |
| Nicoletti I et al. | Identification and quantification of phenolic compounds in grapes by HPLC-PDA-ESI-MS on a semimicro separation scale. | 2008 | J. Agric. Food Chem. | pmid:18781764 |
| Hamauzu Y et al. | Reddish coloration of Chinese quince (Pseudocydonia sinensis) procyanidins during heat treatment and effect on antioxidant and antiinfluenza viral activities. | 2007 | J. Agric. Food Chem. | pmid:17300149 |
| Netzel M et al. | Sources of antioxidant activity in Australian native fruits. Identification and quantification of anthocyanins. | 2006 | J. Agric. Food Chem. | pmid:17177507 |
| Hosseinian FS and Beta T | Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries. | 2007 | J. Agric. Food Chem. | pmid:18052240 |
| Frank J et al. | Effects of dietary anthocyanins on tocopherols and lipids in rats. | 2002 | J. Agric. Food Chem. | pmid:12452636 |
| Jordheim M et al. | Molar absorptivities and reducing capacity of pyranoanthocyanins and other anthocyanins. | 2007 | J. Agric. Food Chem. | pmid:18047275 |
| de Brito ES et al. | Anthocyanins present in selected tropical fruits: acerola, jambolão, jussara, and guajiru. | 2007 | J. Agric. Food Chem. | pmid:17929888 |
| Meng L et al. | Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis. | 2006 | J. Agric. Food Chem. | pmid:16756359 |
| Tian Q et al. | Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. | 2006 | J. Agric. Food Chem. | pmid:16478275 |
| Srivastava A et al. | Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. | 2007 | J. Agric. Food Chem. | pmid:17381106 |
| Wu X et al. | Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption. | 2006 | J. Agric. Food Chem. | pmid:16417325 |
| Yoshimura Y et al. | Evaluation of the NO scavenging activity of procyanidin in grape seed by use of the TMA-PTIO/NOC 7 ESR system. | 2003 | J. Agric. Food Chem. | pmid:14558755 |
| Kim DO et al. | Sweet and sour cherry phenolics and their protective effects on neuronal cells. | 2005 | J. Agric. Food Chem. | pmid:16366675 |
| Pawlowska AM et al. | Phenolics of Arbutus unedo L. (Ericaceae) fruits: identification of anthocyanins and gallic acid derivatives. | 2006 | J. Agric. Food Chem. | pmid:17177565 |
| Li L et al. | Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. | 2009 | J. Agric. Food Chem. | pmid:19166352 |
| Harnly JM et al. | Flavonoid content of U.S. fruits, vegetables, and nuts. | 2006 | J. Agric. Food Chem. | pmid:17177529 |
| Tian Q et al. | Probing anthocyanin profiles in purple sweet potato cell line (Ipomoea batatas L. Cv. Ayamurasaki) by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2005 | J. Agric. Food Chem. | pmid:16076141 |
| Espinosa-Alonso LG et al. | Polyphenols in wild and weedy Mexican common beans (Phaseolus vulgaris L.). | 2006 | J. Agric. Food Chem. | pmid:16756378 |
| Talavéra S et al. | Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain. | 2005 | J. Agric. Food Chem. | pmid:15884815 |
| Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
| Innocenti M et al. | Evaluation of the phenolic content in the aerial parts of different varieties of Cichorium intybus L. | 2005 | J. Agric. Food Chem. | pmid:16076140 |
| Wu X and Prior RL | Identification and characterization of anthocyanins by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in common foods in the United States: vegetables, nuts, and grains. | 2005 | J. Agric. Food Chem. | pmid:15826066 |
| Wu X et al. | Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. | 2006 | J. Agric. Food Chem. | pmid:16719536 |
| Wu X and Prior RL | Systematic identification and characterization of anthocyanins by HPLC-ESI-MS/MS in common foods in the United States: fruits and berries. | 2005 | J. Agric. Food Chem. | pmid:15796599 |
| Chang Q and Wong YS | Identification of flavonoids in Hakmeitau beans (Vigna sinensis) by high-performance liquid chromatography-electrospray mass spectrometry (LC-ESI/MS). | 2004 | J. Agric. Food Chem. | pmid:15506802 |
| Määttä-Riihinen KR et al. | Identification and quantification of phenolic compounds in berries of Fragaria and Rubus species (family Rosaceae). | 2004 | J. Agric. Food Chem. | pmid:15453684 |
| Zhao C et al. | Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. | 2004 | J. Agric. Food Chem. | pmid:15453676 |
| Matsufuji H and Shibamoto T | Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. | 2004 | J. Agric. Food Chem. | pmid:15373421 |
| Schwarz M et al. | Isolation and identification of novel pyranoanthocyanins from black carrot (Daucus carota L.) juice. | 2004 | J. Agric. Food Chem. | pmid:15291481 |
| Choung MG et al. | Anthocyanin profile of Korean cultivated kidney bean (Phaseolus vulgaris L.). | 2003 | J. Agric. Food Chem. | pmid:14611168 |
| Nielsen IL et al. | Quantification of anthocyanins in commercial black currant juices by simple high-performance liquid chromatography. Investigation of their pH stability and antioxidative potency. | 2003 | J. Agric. Food Chem. | pmid:13129285 |
| Turker N et al. | Effect of storage temperature on the stability of anthocyanins of a fermented black carrot (Daucus carota var. L.) beverage: shalgam. | 2004 | J. Agric. Food Chem. | pmid:15186101 |
| Kuskoski EM et al. | Characterization of anthocyanins from the fruits of baguaçu (Eugenia umbelliflora Berg). | 2003 | J. Agric. Food Chem. | pmid:12926896 |
| Ella Missang C et al. | Flavonols and anthocyanins of bush butter, Dacryodes edulis (G. Don) H.J. Lam, fruit. changes in their composition during ripening. | 2003 | J. Agric. Food Chem. | pmid:14640602 |
| Määttä KR et al. | High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: ribes species. | 2003 | J. Agric. Food Chem. | pmid:14582969 |
| Cantos E et al. | Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. | 2002 | J. Agric. Food Chem. | pmid:12236700 |
| Terasawa N et al. | Identification and some properties of anthocyanin isolated from Zuiki, stalk of Colocasia esculenta. | 2007 | J. Agric. Food Chem. | pmid:17447784 |
| Kim DO et al. | Quantification of polyphenolics and their antioxidant capacity in fresh plums. | 2003 | J. Agric. Food Chem. | pmid:14558771 |
| Kim MY et al. | Identification and antiradical properties of anthocyanins in fruits of Viburnum dilatatum thunb. | 2003 | J. Agric. Food Chem. | pmid:14518940 |
| Matsumoto H et al. | Preparative-scale isolation of four anthocyanin components of black currant (Ribes nigrum L.) fruits. | 2001 | J. Agric. Food Chem. | pmid:11312893 |
| Wolfe K et al. | Antioxidant activity of apple peels. | 2003 | J. Agric. Food Chem. | pmid:12537430 |
| Zheng W and Wang SY | Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. | 2003 | J. Agric. Food Chem. | pmid:12517117 |
| Eiro MJ and Heinonen M | Anthocyanin color behavior and stability during storage: effect of intermolecular copigmentation. | 2002 | J. Agric. Food Chem. | pmid:12452676 |
| Wang SY et al. | Cultural system affects fruit quality and antioxidant capacity in strawberries. | 2002 | J. Agric. Food Chem. | pmid:12381146 |
| Rajbhandari R et al. | Determination of cranberry phenolic metabolites in rats by liquid chromatography-tandem mass spectrometry. | 2011 | J. Agric. Food Chem. | pmid:21634376 |
| Yan X et al. | Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon). | 2002 | J. Agric. Food Chem. | pmid:12358448 |
| Es-Safi NE et al. | Interactions between cyanidin 3-O-glucoside and furfural derivatives and their impact on food color changes. | 2002 | J. Agric. Food Chem. | pmid:12236682 |
| Yang H et al. | Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice. | 2011 | J. Agric. Food Chem. | pmid:21302942 |