Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tooth Discoloration | D014075 | 7 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim JM et al. | Effects of black soybean [Glycine max (L.) Merr.] seed coats and its anthocyanidins on colonic inflammation and cell proliferation in vitro and in vivo. | 2008 | J. Agric. Food Chem. | pmid:18710248 |
| Li CY et al. | Corn husk as a potential source of anthocyanins. | 2008 | J. Agric. Food Chem. | pmid:19007127 |
| Mertens-Talcott SU et al. | Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. | 2008 | J. Agric. Food Chem. | pmid:18693743 |
| Zhang G et al. | Structure-dependent photodegradation of carotenoids accelerated by dimethyl tetrasulfide under UVA irradiation. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18685214 |
| Steigerwalt RD et al. | Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. | 2008 | Mol. Vis. | pmid:18618008 |
| Fukamachi K et al. | Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat. | 2008 | Cancer Sci. | pmid:18616524 |
| Dancs G et al. | The effects of enhanced methionine synthesis on amino acid and anthocyanin content of potato tubers. | 2008 | BMC Plant Biol. | pmid:18549488 |
| Lillo C et al. | Nutrient depletion as a key factor for manipulating gene expression and product formation in different branches of the flavonoid pathway. | 2008 | Plant Cell Environ. | pmid:18031469 |
| Galvano F et al. | Protocatechuic acid: the missing human cyanidins' metabolite. | 2008 | Mol Nutr Food Res | pmid:18320575 |
| Kim MK et al. | Identification and quantification of anthocyanin pigments in colored rice. | 2008 | Nutr Res Pract | pmid:20126365 |
| Hassimotto NM et al. | Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. | 2008 | Nutr Res | pmid:19083408 |
| Hassimotto NM et al. | Antioxidant status in humans after consumption of blackberry (Rubus fruticosus L.) juices with and without defatted milk. | 2008 | J. Agric. Food Chem. | pmid:19053224 |
| Li CY et al. | Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats. | 2008 | Alcohol | pmid:19038699 |
| De Rosso VV et al. | Singlet oxygen quenching by anthocyanin's flavylium cations. | 2008 | Free Radic. Res. | pmid:18985487 |
| Tarozzi A et al. | Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity. | 2008 | Neuroreport | pmid:18797302 |
| Lin LZ and Harnly JM | Phenolic compounds and chromatographic profiles of pear skins (Pyrus spp.). | 2008 | J. Agric. Food Chem. | pmid:18778075 |
| Zhou LL et al. | Development of tobacco callus cultures over expressing Arabidopsis PAP1/MYB75 transcription factor and characterization of anthocyanin biosynthesis. | 2008 | Planta | pmid:18766373 |
| Jensen GS et al. | In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. | 2008 | J. Agric. Food Chem. | pmid:18717569 |
| Comandini P et al. | CZE separation of strawberry anthocyanins with acidic buffer and comparison with HPLC. | 2008 | J Sep Sci | pmid:18704996 |
| Pawlowska AM et al. | Quali-quantitative analyses of Flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits. | 2008 | J. Agric. Food Chem. | pmid:18412362 |
| Sakaguchi Y et al. | Major anthocyanins from purple asparagus (Asparagus officinalis). | 2008 | Phytochemistry | pmid:18406435 |
| Li Volti G et al. | Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide? | 2008 | Ann. Surg. | pmid:18362637 |
| Tulio AZ et al. | Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry. | 2008 | J. Agric. Food Chem. | pmid:18290621 |
| Guo H et al. | Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation. | 2008 | Biochem. Pharmacol. | pmid:18179781 |
| Scalzo J et al. | The anthocyanin composition of different Vaccinium, Ribes and Rubus genotypes. | 2008 | Biofactors | pmid:19706968 |
| Matsuura R et al. | Determination of antioxidant activity and characterization of antioxidant phenolics in the plum vinegar extract of cherry blossom (Prunus lannesiana). | 2008 | J. Agric. Food Chem. | pmid:18092753 |
| Yan Y et al. | High-yield anthocyanin biosynthesis in engineered Escherichia coli. | 2008 | Biotechnol. Bioeng. | pmid:18023053 |
| Nicoletti I et al. | Identification and quantification of phenolic compounds in grapes by HPLC-PDA-ESI-MS on a semimicro separation scale. | 2008 | J. Agric. Food Chem. | pmid:18781764 |
| Zhang J et al. | Determination of anthocyanins and exploration of relationship between their composition and petal coloration in crape myrtle (Lagerstroemia hybrid). | 2008 | J Integr Plant Biol | pmid:18713426 |
| Nakatsuka T et al. | Cloning and characterization of the UDP-glucose:anthocyanin 5-O-glucosyltransferase gene from blue-flowered gentian. | 2008 | J. Exp. Bot. | pmid:18375606 |
| Maruyama C et al. | Azuki bean juice lowers serum triglyceride concentrations in healthy young women. | 2008 | J Clin Biochem Nutr | pmid:18648655 |
| Griesser M et al. | Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | 2008 | J. Exp. Bot. | pmid:18487633 |
| Park MY et al. | Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin. | 2008 | Nutr Res Pract | pmid:20126360 |
| Park JS et al. | Arabidopsis R2R3-MYB transcription factor AtMYB60 functions as a transcriptional repressor of anthocyanin biosynthesis in lettuce (Lactuca sativa). | 2008 | Plant Cell Rep. | pmid:18317777 |
| Jugdé H et al. | Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple. | 2008 | FEBS J. | pmid:18573104 |
| Dani C et al. | Protective effects of purple grape juice on carbon tetrachloride-induced oxidative stress in brains of adult Wistar rats. | 2008 | J Med Food | pmid:18361738 |
| Fedenko VS | [Dose effect of cyanidin interaction with lead ions in roots of maize seedlings]. | 2007 Mar-Apr | Ukr Biokhim Zh (1999) | pmid:18030746 |
| Cassinese C et al. | New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations. | 2007 Jul-Aug | J AOAC Int | pmid:17760327 |
| Giordano L et al. | Development and validation of an LC-MS/MS analysis for simultaneous determination of delphinidin-3-glucoside, cyanidin-3-glucoside and cyanidin-3-(6-malonylglucoside) in human plasma and urine after blood orange juice administration. | 2007 | J Sep Sci | pmid:18027360 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Suzuki T et al. | Structural identification of anthocyanins and analysis of concentrations during growth and flowering in buckwheat (Fagopyrum esculentum Moench) petals. | 2007 | J. Agric. Food Chem. | pmid:17941697 |
| Li JB et al. | Anthocyanins from red flowers of Camellia reticulata LINDL. | 2007 | Biosci. Biotechnol. Biochem. | pmid:18037731 |
| Ozga JA et al. | Characterization of cyanidin- and quercetin-derived flavonoids and other phenolics in mature saskatoon fruits (Amelanchier alnifolia Nutt.). | 2007 | J. Agric. Food Chem. | pmid:17994693 |
| Pang Y et al. | Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula. | 2007 | Plant Physiol. | pmid:17885080 |
| Marinova K et al. | The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat. | 2007 | Plant Cell | pmid:17601828 |
| Ayaz E and Alpsoy HC | [Garlic (Allium sativum) and traditional medicine]. | 2007 | Turkiye Parazitol Derg | pmid:17594659 |
| Galvano F et al. | Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. | 2007 | Ann. Ist. Super. Sanita | pmid:18209272 |
| Coates EM et al. | Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. | 2007 | J Carcinog | pmid:17442116 |
| Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
| Feng R et al. | Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. | 2007 | J. Biol. Chem. | pmid:17360708 |
| Tarozzi A et al. | Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells. | 2007 | Neurosci. Lett. | pmid:17709193 |
| D'Auria JC et al. | Identification and characterization of the BAHD acyltransferase malonyl CoA: anthocyanidin 5-O-glucoside-6''-O-malonyltransferase (At5MAT) in Arabidopsis thaliana. | 2007 | FEBS Lett. | pmid:17292360 |
| Vitaglione P et al. | Protocatechuic acid is the major human metabolite of cyanidin-glucosides. | 2007 | J. Nutr. | pmid:17709440 |
| Watanabe M | An anthocyanin compound in buckwheat sprouts and its contribution to antioxidant capacity. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284830 |
| Espley RV et al. | Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10. | 2007 | Plant J. | pmid:17181777 |
| Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
| Xu JW et al. | Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells. | 2007 | Atherosclerosis | pmid:17045269 |
| GarcÃa-MacÃas P et al. | Changes in the flavonoid and phenolic acid contents and antioxidant activity of red leaf lettuce (Lollo Rosso) due to cultivation under plastic films varying in ultraviolet transparency. | 2007 | J. Agric. Food Chem. | pmid:18001028 |
| Liu L et al. | Degradation of cyanidin 3-rutinoside in the presence of (-)-epicatechin and litchi pericarp polyphenol oxidase. | 2007 | J. Agric. Food Chem. | pmid:17914871 |
| Sasaki R et al. | Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. | 2007 | Biochem. Pharmacol. | pmid:17869225 |
| Mulabagal V et al. | Cultivars of apple fruits that are not marketed with potential for anthocyanin production. | 2007 | J. Agric. Food Chem. | pmid:17822290 |
| Esparza I et al. | Complexing capacity profiles of naturally occurring ligands in Tempranillo wines for Cu and Zn: an electroanalytical approach for cupric casse. | 2007 | Anal. Chim. Acta | pmid:17765065 |
| Kim SJ et al. | Identification of anthocyanins in the sprouts of buckwheat. | 2007 | J. Agric. Food Chem. | pmid:17580874 |
| Nicoué EE et al. | Anthocyanins in wild blueberries of Quebec: extraction and identification. | 2007 | J. Agric. Food Chem. | pmid:17579428 |
| Di Giacomo C et al. | Protective effect of cyanidin 3-O-beta-D-glucoside on ochratoxin A-mediated damage in the rat. | 2007 | Br. J. Nutr. | pmid:17562227 |
| Felgines C et al. | Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. | 2007 | Br. J. Nutr. | pmid:17559698 |
| Stewart D et al. | Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. | 2007 | Mol Nutr Food Res | pmid:17492796 |
| Aaby K et al. | Characterization of phenolic compounds in strawberry (Fragaria x ananassa) fruits by different HPLC detectors and contribution of individual compounds to total antioxidant capacity. | 2007 | J. Agric. Food Chem. | pmid:17472391 |
| Milbury PE et al. | Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460300 |
| Liu YC et al. | Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. | 2007 | Life Sci. | pmid:17320913 |
| Hamauzu Y et al. | Reddish coloration of Chinese quince (Pseudocydonia sinensis) procyanidins during heat treatment and effect on antioxidant and antiinfluenza viral activities. | 2007 | J. Agric. Food Chem. | pmid:17300149 |
| Füzfai Z and Molnár-Perl I | Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits. | 2007 | J Chromatogr A | pmid:17289064 |
| Bakowska-Barczak AM et al. | Survey of bioactive components in Western Canadian berries. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066116 |
| Hosseinian FS and Beta T | Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries. | 2007 | J. Agric. Food Chem. | pmid:18052240 |
| Jordheim M et al. | Molar absorptivities and reducing capacity of pyranoanthocyanins and other anthocyanins. | 2007 | J. Agric. Food Chem. | pmid:18047275 |
| de Brito ES et al. | Anthocyanins present in selected tropical fruits: acerola, jambolão, jussara, and guajiru. | 2007 | J. Agric. Food Chem. | pmid:17929888 |
| Yao Y and Vieira A | Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. | 2007 | Neurotoxicology | pmid:16956663 |
| Kern M et al. | Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. | 2007 | Mol Nutr Food Res | pmid:17729219 |
| Fujihara T et al. | High-molecular-weight polyphenols from oolong tea and black tea: purification, some properties, and role in increasing mitochondrial membrane potential. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17341825 |
| Cortell JM et al. | Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) anthocyanins. 2. Anthocyanins and pigmented polymers in wine. | 2007 | J. Agric. Food Chem. | pmid:17636934 |
| Cortell JM et al. | Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) anthocyanins. 1. Anthocyanin concentration and composition in fruit. | 2007 | J. Agric. Food Chem. | pmid:17636933 |
| Jordheim M et al. | Anthocyanins in berries of ribes including gooseberry cultivars with a high content of acylated pigments. | 2007 | J. Agric. Food Chem. | pmid:17579440 |
| Choi EH et al. | Cytoprotective effect of anthocyanins against doxorubicin-induced toxicity in H9c2 cardiomyocytes in relation to their antioxidant activities. | 2007 | Food Chem. Toxicol. | pmid:17524543 |
| Kim MJ et al. | Relationship between phenolic compounds, anthocyanins content and antioxidant activity in colored barley germplasm. | 2007 | J. Agric. Food Chem. | pmid:17516656 |
| Seitz C et al. | Redirection of anthocyanin synthesis in Osteospermum hybrida by a two-enzyme manipulation strategy. | 2007 | Phytochemistry | pmid:17286993 |
| Srivastava A et al. | Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. | 2007 | J. Agric. Food Chem. | pmid:17381106 |
| Burdulis D et al. | Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits. | 2007 | Medicina (Kaunas) | pmid:18182842 |
| Burdulis D et al. | [Analysis of anthocyanin content in bilberry (Vaccinium myrtillus L.) fruit crude drugs by high-performance liquid chromatography method]. | 2007 | Medicina (Kaunas) | pmid:17768372 |
| Lans C et al. | Ethnoveterinary medicines used for ruminants in British Columbia, Canada. | 2007 | J Ethnobiol Ethnomed | pmid:17324258 |
| Castellarin SD and Di Gaspero G | Transcriptional control of anthocyanin biosynthetic genes in extreme phenotypes for berry pigmentation of naturally occurring grapevines. | 2007 | BMC Plant Biol. | pmid:17760970 |
| Grimplet J et al. | Tissue-specific mRNA expression profiling in grape berry tissues. | 2007 | BMC Genomics | pmid:17584945 |
| Lamy S et al. | Anthocyanidins inhibit migration of glioblastoma cells: structure-activity relationship and involvement of the plasminolytic system. | 2007 | J. Cell. Biochem. | pmid:16823770 |
| Bae JY et al. | Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts. | 2007 | Nutr Res Pract | pmid:20368951 |
| Bjorøy O et al. | Anthocyanin 3-galactosides from Cornus alba 'Sibirica' with glucosidation of the B-ring. | 2007 | Phytochemistry | pmid:17207823 |
| Terasawa N et al. | Identification and some properties of anthocyanin isolated from Zuiki, stalk of Colocasia esculenta. | 2007 | J. Agric. Food Chem. | pmid:17447784 |
| Bononi M and Tateo F | Stabilization of cranberry anthocyanins in nutraceutical capsules. | 2007 | Int J Food Sci Nutr | pmid:17469769 |
| Sorrenti V et al. | Heme oxygenase induction by cyanidin-3-O-beta-glucoside in cultured human endothelial cells. | 2007 | Mol Nutr Food Res | pmid:17440991 |
| Alcalde-Eon C et al. | Identification of dimeric anthocyanins and new oligomeric pigments in red wine by means of HPLC-DAD-ESI/MSn. | 2007 | J Mass Spectrom | pmid:17511019 |
| Fedenko VS | [Cyanidin complexation with metal ions]. | 2006 Mar-Apr | Ukr Biokhim Zh (1999) | pmid:17100297 |
| Bononi M et al. | 'Cyanidin volumetric index' and 'chromaticity coordinates ratio' to characterize red raspberry (Rubus idaeus). | 2006 Aug-Sep | Int J Food Sci Nutr | pmid:17135027 |