Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tooth Discoloration | D014075 | 7 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Cvorovic J et al. | Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells. | 2010 | Arch. Biochem. Biophys. | pmid:20494645 |
| Cuevas-RodrÃguez EO et al. | Characterization of anthocyanins and proanthocyanidins in wild and domesticated Mexican blackberries (Rubus spp.). | 2010 | J. Agric. Food Chem. | pmid:20507066 |
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| Kovinich N et al. | Functional characterization of a UDP-glucose:flavonoid 3-O-glucosyltransferase from the seed coat of black soybean (Glycine max (L.) Merr.). | 2010 | Phytochemistry | pmid:20621794 |
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| Montilla EC et al. | Preparative isolation of anthocyanins from Japanese purple sweet potato (Ipomoea batatas L.) varieties by high-speed countercurrent chromatography. | 2010 | J. Agric. Food Chem. | pmid:20731350 |
| Gutha LR et al. | Modulation of flavonoid biosynthetic pathway genes and anthocyanins due to virus infection in grapevine (Vitis vinifera L.) leaves. | 2010 | BMC Plant Biol. | pmid:20731850 |
| Bedon F et al. | Subgroup 4 R2R3-MYBs in conifer trees: gene family expansion and contribution to the isoprenoid- and flavonoid-oriented responses. | 2010 | J. Exp. Bot. | pmid:20732878 |
| Salvatierra A et al. | Comparison of transcriptional profiles of flavonoid genes and anthocyanin contents during fruit development of two botanical forms of Fragaria chiloensis ssp. chiloensis. | 2010 | Phytochemistry | pmid:20800857 |
| Takasawa R et al. | Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. | 2010 | Bioorg. Med. Chem. | pmid:20801663 |
| Gill CI et al. | Profiling of phenols in human fecal water after raspberry supplementation. | 2010 | J. Agric. Food Chem. | pmid:20809621 |
| Sentandreu E et al. | LC-DAD-ESI/MS(n) determination of direct condensation flavanol-anthocyanin adducts in pressure extracted pomegranate (Punica granatum L.) juice. | 2010 | J. Agric. Food Chem. | pmid:20839870 |
| Agati G et al. | The biosynthesis of flavonoids is enhanced similarly by UV radiation and root zone salinity in L. vulgare leaves. | 2011 | J. Plant Physiol. | pmid:20850892 |
| Chiu LW et al. | The purple cauliflower arises from activation of a MYB transcription factor. | 2010 | Plant Physiol. | pmid:20855520 |
| Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
| Ozgen M et al. | Total phenolic, anthocyanin contents and antioxidant capacity of selected elderberry (Sambucus canadensis L.) accessions. | 2010 | Pharmacogn Mag | pmid:20931079 |
| Falginella L et al. | Expansion and subfunctionalisation of flavonoid 3',5'-hydroxylases in the grapevine lineage. | 2010 | BMC Genomics | pmid:20939908 |
| Kuhn I et al. | Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme. | 2010 | Bioorg. Med. Chem. | pmid:20951593 |
| Khandelwal VK et al. | Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts. | 2011 | Evid Based Complement Alternat Med | pmid:20953394 |
| Akkarachiyasit S et al. | Inhibitory activities of cyanidin and its glycosides and synergistic effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase. | 2010 | Int J Mol Sci | pmid:20957102 |
| Speciale A et al. | Cyanidin-3-O-glucoside protection against TNF-α-induced endothelial dysfunction: involvement of nuclear factor-κB signaling. | 2010 | J. Agric. Food Chem. | pmid:20958056 |
| Xu M et al. | Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2. | 2010 | Mol. Cancer | pmid:21034468 |
| Zu XY et al. | Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells. | 2010 | Chin. Med. J. | pmid:21034658 |
| Mewis I et al. | Specific poly-phenolic compounds in cell culture of Vitis vinifera L. cv. Gamay Fréaux. | 2011 | Appl. Biochem. Biotechnol. | pmid:21061087 |
| Wiczkowski W et al. | Bioavailability of cyanidin glycosides from natural chokeberry (Aronia melanocarpa) juice with dietary-relevant dose of anthocyanins in humans. | 2010 | J. Agric. Food Chem. | pmid:21067240 |
| Josuttis M et al. | Solar UVB response of bioactives in strawberry (Fragaria × ananassa Duch. L.): a comparison of protected and open-field cultivation. | 2010 | J. Agric. Food Chem. | pmid:21086998 |
| Okazaki Y et al. | A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats. | 2010 | J Clin Biochem Nutr | pmid:21103028 |
| Sparzak B et al. | HPLC analysis of polyphenols in the fruits of Rubus idaeus L. (Rosaceae). | 2010 | Nat. Prod. Res. | pmid:21104526 |
| Yao JW et al. | Affinity interactions between natural pigments and human whole saliva. | 2011 | Arch. Oral Biol. | pmid:21112045 |
| Lopes-Lutz D et al. | Characterization and quantification of polyphenols in Amazon grape (Pourouma cecropiifolia Martius). | 2010 | Molecules | pmid:21116224 |
| Yang Y et al. | Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21135223 |
| Pinho C et al. | Optimization of conditions for anthocyanin hydrolysis from red wine using response surface methodology (RSM). | 2011 | J. Agric. Food Chem. | pmid:21158431 |
| Tanaka J et al. | Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo. | 2011 | J. Agric. Food Chem. | pmid:21175193 |
| Montefiori M et al. | Identification and characterisation of F3GT1 and F3GGT1, two glycosyltransferases responsible for anthocyanin biosynthesis in red-fleshed kiwifruit (Actinidia chinensis). | 2011 | Plant J. | pmid:21175894 |
| Qaâdan F et al. | Polyphenols from Ginkgo biloba. | 2010 Oct-Dec | Sci Pharm | pmid:21179324 |
| Ali MB et al. | Berry skin development in Norton grape: distinct patterns of transcriptional regulation and flavonoid biosynthesis. | 2011 | BMC Plant Biol. | pmid:21219654 |
| Venkatesha SH et al. | Immunomodulation of Autoimmune Arthritis by Herbal CAM. | 2011 | Evid Based Complement Alternat Med | pmid:21234398 |
| Liu X et al. | Preparative separation and enrichment of syringopicroside from Folium syringae leaves with macroporous resins. | 2010 | J. Biomed. Biotechnol. | pmid:21234415 |
| Xu C et al. | Influence of growing season on phenolic compounds and antioxidant properties of grape berries from vines grown in subtropical climate. | 2011 | J. Agric. Food Chem. | pmid:21235208 |
| Rababah TM et al. | Effect of jam processing and storage on total phenolics, antioxidant activity, and anthocyanins of different fruits. | 2011 | J. Sci. Food Agric. | pmid:21254073 |
| Jakesevic M et al. | Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion. | 2011 | BMC Complement Altern Med | pmid:21272305 |
| Kim CK et al. | Identification and characterization of seed-specific transcription factors regulating anthocyanin biosynthesis in black rice. | 2011 | J. Appl. Genet. | pmid:21286901 |
| Abdel-Moemin AR | Switching to black rice diets modulates low-density lipoprotein oxidation and lipid measurements in rabbits. | 2011 | Am. J. Med. Sci. | pmid:21289511 |
| Yang H et al. | Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice. | 2011 | J. Agric. Food Chem. | pmid:21302942 |
| Kayodé AP et al. | Uncommonly high levels of 3-deoxyanthocyanidins and antioxidant capacity in the leaf sheaths of dye sorghum. | 2011 | J. Agric. Food Chem. | pmid:21322653 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Kortstee AJ et al. | Anthocyanin production as a potential visual selection marker during plant transformation. | 2011 | Transgenic Res. | pmid:21340526 |
| Wei X et al. | Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity. | 2011 | J. Sci. Food Agric. | pmid:21360538 |
| Sahay A and Shakya M | Structure prediction of dihydroflavonol 4- reductase and anthocyanidin synthase from spinach. | 2010 | Bioinformation | pmid:21364828 |
| Akkarachiyasit S et al. | In vitro inhibitory effects of cyandin-3-rutinoside on pancreatic α-amylase and its combined effect with acarbose. | 2011 | Molecules | pmid:21368719 |
| Woodward GM et al. | Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation. | 2011 | Mol Nutr Food Res | pmid:21370450 |
| Montilla EC et al. | Anthocyanin composition of black carrot (Daucus carota ssp. sativus var. atrorubens Alef.) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze. | 2011 | J. Agric. Food Chem. | pmid:21381748 |
| Lätti AK et al. | Phenolic compounds in berries and flowers of a natural hybrid between bilberry and lingonberry (Vaccinium × intermedium Ruthe). | 2011 | Phytochemistry | pmid:21382629 |
| Reber JD et al. | Antioxidant capacity interactions and a chemical/structural model of phenolic compounds found in strawberries. | 2011 | Int J Food Sci Nutr | pmid:21385007 |
| Suzuki R et al. | Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. | 2011 | Nutr Metab (Lond) | pmid:21385419 |
| Sharma M et al. | Identification of the pr1 gene product completes the anthocyanin biosynthesis pathway of maize. | 2011 | Genetics | pmid:21385724 |
| Shrestha B et al. | In situ cell-by-cell imaging and analysis of small cell populations by mass spectrometry. | 2011 | Anal. Chem. | pmid:21388149 |
| Feng Y et al. | A three-component gene expression system and its application for inducible flavonoid overproduction in transgenic Arabidopsis thaliana. | 2011 | PLoS ONE | pmid:21408135 |
| Reichel M et al. | Changes in flavonoids and nonphenolic pigments during on-tree maturation and postharvest pericarp browning of litchi (Litchi chinensis Sonn.) as shown by HPLC-MSn. | 2011 | J. Agric. Food Chem. | pmid:21413696 |
| Mutwil M et al. | PlaNet: combined sequence and expression comparisons across plant networks derived from seven species. | 2011 | Plant Cell | pmid:21441431 |
| Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
| Gou JY et al. | Negative regulation of anthocyanin biosynthesis in Arabidopsis by a miR156-targeted SPL transcription factor. | 2011 | Plant Cell | pmid:21487097 |
| Lim TG et al. | Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity. | 2011 | Biochem. Pharmacol. | pmid:21501596 |
| Vanzo A et al. | Exceptionally fast uptake and metabolism of cyanidin 3-glucoside by rat kidneys and liver. | 2011 | J. Nat. Prod. | pmid:21510696 |
| Lin LZ et al. | LC-PDA-ESI/MS(n) identification of new anthocyanins in purple Bordeaux radish ( Raphanus sativus L. variety). | 2011 | J. Agric. Food Chem. | pmid:21513350 |
| Santos J et al. | Inhibition of host- and bacteria-derived proteinases by natural anthocyanins. | 2011 | J. Periodont. Res. | pmid:21517858 |
| Hanlon PR and Barnes DM | Phytochemical composition and biological activity of 8 varieties of radish (Raphanus sativus L.) sprouts and mature taproots. | J. Food Sci. | pmid:21535648 | |
| Liang Z et al. | CIELAB coordinates in response to berry skin anthocyanins and their composition in Vitis. | 2011 | J. Food Sci. | pmid:21535819 |
| El Babili F et al. | Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. | 2011 | J. Food Sci. | pmid:21535822 |
| Jin Y et al. | A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects. | 2011 | Eur J Clin Nutr | pmid:21540876 |
| Wei SD et al. | Antioxidant activities of fractions of polymeric procyanidins from stem bark of Acacia confusa. | 2011 | Int J Mol Sci | pmid:21541049 |
| Li J et al. | Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy. | 2012 | J. Nutr. Biochem. | pmid:21543205 |
| Guo H et al. | Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. | 2012 | J. Nutr. Biochem. | pmid:21543211 |
| Mallery SR et al. | Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins. | 2011 | Cancer Prev Res (Phila) | pmid:21558412 |
| Wei YZ et al. | Differential expression of anthocyanin biosynthetic genes in relation to anthocyanin accumulation in the pericarp of Litchi chinensis Sonn. | 2011 | PLoS ONE | pmid:21559331 |
| Xue YL et al. | Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki. | 2011 | J. Agric. Food Chem. | pmid:21568325 |
| Udani JK et al. | Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. | 2011 | Nutr J | pmid:21569436 |
| Wang D et al. | Cyanidin-3-O-β-glucoside with the aid of its metabolite protocatechuic acid, reduces monocyte infiltration in apolipoprotein E-deficient mice. | 2011 | Biochem. Pharmacol. | pmid:21569764 |
| Moze S et al. | Phenolics in Slovenian bilberries ( Vaccinium myrtillus L.) and blueberries ( Vaccinium corymbosum L.). | 2011 | J. Agric. Food Chem. | pmid:21574578 |
| Huang SS et al. | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. | 2011 | Evid Based Complement Alternat Med | pmid:21584194 |
| Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
| Gastrointestinal pharmacology. | 2008 | Indian J Pharmacol | pmid:21593966 | |
| Esselen M et al. | Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase I and II poisons in colon carcinoma cells. | 2011 | J. Agric. Food Chem. | pmid:21599019 |
| Telias A et al. | Apple skin patterning is associated with differential expression of MYB10. | 2011 | BMC Plant Biol. | pmid:21599973 |
| Kim KT et al. | Neuroprotective effect of anthocyanin on experimental traumatic spinal cord injury. | 2011 | J Korean Neurosurg Soc | pmid:21607177 |
| Tanaka J et al. | Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. | 2012 | Phytother Res | pmid:21633982 |