Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dancs G et al. | The effects of enhanced methionine synthesis on amino acid and anthocyanin content of potato tubers. | 2008 | BMC Plant Biol. | pmid:18549488 |
| Irani NG and Grotewold E | Light-induced morphological alteration in anthocyanin-accumulating vacuoles of maize cells. | 2005 | BMC Plant Biol. | pmid:15907203 |
| Payyavula RS et al. | Differential effects of environment on potato phenylpropanoid and carotenoid expression. | 2012 | BMC Plant Biol. | pmid:22429339 |
| Gillman JD et al. | Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in brown hilum and brown seed coats. | 2011 | BMC Plant Biol. | pmid:22070454 |
| Fortes AM et al. | Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. | 2011 | BMC Plant Biol. | pmid:22047180 |
| Ernst IM et al. | Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes. | 2012 | Br. J. Nutr. | pmid:21745425 |
| Felgines C et al. | Radiolabelled cyanidin 3-O-glucoside is poorly absorbed in the mouse. | 2010 | Br. J. Nutr. | pmid:20187984 |
| Renis M et al. | Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. | 2008 | Br. J. Nutr. | pmid:18053307 |
| Di Giacomo C et al. | Protective effect of cyanidin 3-O-beta-D-glucoside on ochratoxin A-mediated damage in the rat. | 2007 | Br. J. Nutr. | pmid:17562227 |
| Felgines C et al. | Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. | 2007 | Br. J. Nutr. | pmid:17559698 |
| Felgines C et al. | Absorption and metabolism of red orange juice anthocyanins in rats. | 2006 | Br. J. Nutr. | pmid:16611379 |
| Kay CD et al. | Anthocyanin metabolites in human urine and serum. | 2004 | Br. J. Nutr. | pmid:15228048 |
| Oak MH et al. | Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. | 2006 | Br. J. Pharmacol. | pmid:16921400 |
| Bakowska-Barczak AM et al. | Survey of bioactive components in Western Canadian berries. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066116 |
| Frank T et al. | Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774848 |
| Marczylo TH et al. | Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice. | 2009 | Cancer Chemother. Pharmacol. | pmid:19363608 |
| Thomasset S et al. | Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? | 2009 | Cancer Chemother. Pharmacol. | pmid:19294386 |
| Kang SY et al. | Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. | 2003 | Cancer Lett. | pmid:12706854 |
| Gao S et al. | Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways. | 2013 | Cancer Lett. | pmid:23360684 |
| Chen PN et al. | Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. | 2006 | Cancer Lett. | pmid:15975709 |
| Mallery SR et al. | Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins. | 2011 | Cancer Prev Res (Phila) | pmid:21558412 |
| Fukamachi K et al. | Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat. | 2008 | Cancer Sci. | pmid:18616524 |
| Scheit K and Bauer G | Direct and indirect inactivation of tumor cell protective catalase by salicylic acid and anthocyanidins reactivates intercellular ROS signaling and allows for synergistic effects. | 2015 | Carcinogenesis | pmid:25653236 |
| Hecht SS et al. | Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. | 2006 | Carcinogenesis | pmid:16522666 |
| Esselen M et al. | Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats. | 2013 | Carcinogenesis | pmid:23275152 |
| Lazzè MC et al. | Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. | 2004 | Carcinogenesis | pmid:15016660 |
| Chao PY et al. | Inhibitive effect of purple sweet potato leaf extract and its components on cell adhesion and inflammatory response in human aortic endothelial cells. | 2013 Mar-Apr | Cell Adh Migr | pmid:23466865 |
| Schippers PG and Prop FJ | Delphinidin- and cyanidin-chlorides, promotors of cell aggregation in vitro. | 1978 | Cell Biol. Int. Rep. | pmid:667963 |
| Acquaviva R et al. | Cyanidin and cyanidin 3-O-beta-D -glucoside as DNA cleavage protectors and antioxidants. | 2003 | Cell Biol. Toxicol. | pmid:14686616 |
| Bonarska-Kujawa D et al. | Interaction of selected anthocyanins with erythrocytes and liposome membranes. | 2012 | Cell. Mol. Biol. Lett. | pmid:22396139 |
| Li DW et al. | Attenuation of Cisplatin-Induced Neurotoxicity by Cyanidin, a Natural Inhibitor of ROS-Mediated Apoptosis in PC12 Cells. | 2015 | Cell. Mol. Neurobiol. | pmid:25895624 |
| Liu X et al. | Cyanidin Curtails Renal Cell Carcinoma Tumorigenesis. | 2018 | Cell. Physiol. Biochem. | pmid:29742507 |
| Chen PN et al. | Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. | 2006 | Chem. Biol. Interact. | pmid:16970933 |
| Zhang Q et al. | A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3',5'-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans. | 2011 | Chem. Commun. (Camb.) | pmid:21892498 |
| Tatsuzawa F et al. | Diacylated 8-C-glucosylcyanidin 3-glucoside from the flowers of Tricyrtis formosana. | 2004 | Chem. Pharm. Bull. | pmid:15133223 |
| Habermeyer M et al. | Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity. | 2005 | Chem. Res. Toxicol. | pmid:16167831 |
| Zu XY et al. | Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells. | 2010 | Chin. Med. J. | pmid:21034658 |
| Xiao J et al. | A review on structure-activity relationship of dietary polyphenols inhibiting α-amylase. | 2013 | Crit Rev Food Sci Nutr | pmid:23391016 |
| Xiao J et al. | Advance in dietary polyphenols as α-glucosidases inhibitors: a review on structure-activity relationship aspect. | 2013 | Crit Rev Food Sci Nutr | pmid:23768145 |
| Massaad CA | Neuronal and vascular oxidative stress in Alzheimer's disease. | 2011 | Curr Neuropharmacol | pmid:22654724 |
| Scazzocchio B et al. | Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes. | 2011 | Diabetes | pmid:21788573 |
| Bendia E et al. | Effect of cyanidin 3-O-beta-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress. | 2005 | Dig Liver Dis | pmid:15843084 |
| Du C et al. | Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells. | 2015 | Drug Des Devel Ther | pmid:26379423 |
| Fimognari C et al. | Effect of cyanidin 3-O-beta-glucopyranoside on micronucleus induction in cultured human lymphocytes by four different mutagens. | 2004 | Environ. Mol. Mutagen. | pmid:14743345 |
| Khandelwal N and Abraham SK | Intake of anthocyanidins pelargonidin and cyanidin reduces genotoxic stress in mice induced by diepoxybutane, urethane and endogenous nitrosation. | 2014 | Environ. Toxicol. Pharmacol. | pmid:24642102 |
| Jin Y et al. | A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects. | 2011 | Eur J Clin Nutr | pmid:21540876 |
| Duthie SJ et al. | DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro--modulation by the dietary anthocyanin, cyanidin-3-glycoside. | 2005 | Eur J Nutr | pmid:15309415 |
| Duthie SJ et al. | The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. | 2006 | Eur J Nutr | pmid:16032375 |
| Aura AM et al. | In vitro metabolism of anthocyanins by human gut microflora. | 2005 | Eur J Nutr | pmid:15309431 |
| Andlauer W et al. | Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol. | 2003 | Eur J Nutr | pmid:12923653 |
| Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
| Khandelwal VK et al. | Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts. | 2011 | Evid Based Complement Alternat Med | pmid:20953394 |
| Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
| Rawat S et al. | Assessment of Antioxidant Properties in Fruits of Myrica esculenta: A Popular Wild Edible Species in Indian Himalayan Region. | 2011 | Evid Based Complement Alternat Med | pmid:21785629 |
| Venkatesha SH et al. | Immunomodulation of Autoimmune Arthritis by Herbal CAM. | 2011 | Evid Based Complement Alternat Med | pmid:21234398 |
| Wang SC et al. | Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model. | 2011 | Evid Based Complement Alternat Med | pmid:19965962 |
| Choi JG et al. | In Vitro and In Vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract against Salmonella. | 2011 | Evid Based Complement Alternat Med | pmid:19687188 |
| Matsunaga N et al. | Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo. | 2010 | Evid Based Complement Alternat Med | pmid:18955266 |
| Di Giacomo C et al. | Effect of Treatment with Cyanidin-3-O-β-D-Glucoside on Rat Ischemic/Reperfusion Brain Damage. | 2012 | Evid Based Complement Alternat Med | pmid:23008739 |
| Rozza AL et al. | Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. | 2012 | Evid Based Complement Alternat Med | pmid:22666296 |
| Huang SS et al. | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. | 2011 | Evid Based Complement Alternat Med | pmid:21584194 |
| Jin XH et al. | Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo. | 2006 | Exp. Eye Res. | pmid:16309673 |
| Passamonti S et al. | Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase. | 2005 | FEBS J. | pmid:15978035 |
| Jugdé H et al. | Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple. | 2008 | FEBS J. | pmid:18573104 |
| D'Auria JC et al. | Identification and characterization of the BAHD acyltransferase malonyl CoA: anthocyanidin 5-O-glucoside-6''-O-malonyltransferase (At5MAT) in Arabidopsis thaliana. | 2007 | FEBS Lett. | pmid:17292360 |
| Xu JW et al. | Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. | 2004 | FEBS Lett. | pmid:15358561 |
| Wellmann F et al. | Anthocyanidin synthase from Gerbera hybrida catalyzes the conversion of (+)-catechin to cyanidin and a novel procyanidin. | 2006 | FEBS Lett. | pmid:16494872 |
| Song J et al. | Determination of cyanidin-3-glucoside (red kernel food colour) in beverages by high performance liquid chromatography and a study of its degradation by quadruple time-of-flight mass spectrometry. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:22014114 |
| Gras CC et al. | Effect of chlorogenic acid on spectral properties and stability of acylated and non-acylated cyanidin-3-O-glycosides. | 2018 | Food Chem | pmid:28946365 |
| Hemachandran H et al. | Unraveling the inhibition mechanism of cyanidin-3-sophoroside on polyphenol oxidase and its effect on enzymatic browning of apples. | 2017 | Food Chem | pmid:28274409 |
| Sigurdson GT et al. | Spectral and colorimetric characteristics of metal chelates of acylated cyanidin derivatives. | 2017 | Food Chem | pmid:27979063 |
| Camelo-Méndez GA et al. | Effect on in vitro starch digestibility of Mexican blue maize anthocyanins. | 2016 | Food Chem | pmid:27283633 |
| Ieri F et al. | Simultaneous determination of anthocyanins, coumarins and phenolic acids in fruits, kernels and liqueur of Prunus mahaleb L. | 2012 | Food Chem | pmid:22980784 |
| Santos FT et al. | Comparison of five agro-industrial waste-based composts as growing media for lettuce: Effect on yield, phenolic compounds and vitamin C. | 2016 | Food Chem | pmid:27173566 |
| Sigurdson GT et al. | Evaluating the role of metal ions in the bathochromic and hyperchromic responses of cyanidin derivatives in acidic and alkaline pH. | 2016 | Food Chem | pmid:27132820 |
| Feng C et al. | Antioxidant capacities and anthocyanin characteristics of the black-red wild berries obtained in Northeast China. | 2016 | Food Chem | pmid:26988488 |
| Ahmadiani N et al. | Molar absorptivity (ε) and spectral characteristics of cyanidin-based anthocyanins from red cabbage. | 2016 | Food Chem | pmid:26617032 |
| Lima Mdos S et al. | Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. | 2015 | Food Chem | pmid:26041208 |
| Zhang H et al. | Phenolic compounds and antioxidant properties of breeding lines between the white and black rice. | 2015 | Food Chem | pmid:25442600 |
| Park S et al. | Quantification of glucosinolates, anthocyanins, free amino acids, and vitamin C in inbred lines of cabbage (Brassica oleracea L.). | 2014 | Food Chem | pmid:24128451 |
| Kamonpatana K et al. | Susceptibility of anthocyanins to ex vivo degradation in human saliva. | 2012 | Food Chem | pmid:22868153 |
| Takahama U et al. | Isolation and characterization of a cyanidin-catechin pigment from adzuki bean (Vigna angularis). | 2013 | Food Chem | pmid:23768359 |
| Sui X and Zhou W | Monte Carlo modelling of non-isothermal degradation of two cyanidin-based anthocyanins in aqueous system at high temperatures and its impact on antioxidant capacities. | 2014 | Food Chem | pmid:24262567 |
| Takahama U et al. | Interactions of starch with a cyanidin-catechin pigment (vignacyanidin) isolated from Vigna angularis bean. | 2013 | Food Chem | pmid:23871000 |
| González-Barrio R et al. | Chemical composition of the edible flowers, pansy (Viola wittrockiana) and snapdragon (Antirrhinum majus) as new sources of bioactive compounds. | 2018 | Food Chem | pmid:29478556 |
| Jang HH et al. | In vitro and in vivo hypoglycemic effects of cyanidin 3-caffeoyl-p-hydroxybenzoylsophoroside-5-glucoside, an anthocyanin isolated from purple-fleshed sweet potato. | 2019 | Food Chem | pmid:30309599 |
| Farr JE et al. | Influence of cyanidin glycosylation patterns on carboxypyranoanthocyanin formation. | 2018 | Food Chem | pmid:29680053 |
| Pantelić MM et al. | Identification and quantification of phenolic compounds in berry skin, pulp, and seeds in 13 grapevine varieties grown in Serbia. | 2016 | Food Chem | pmid:27283628 |
| Dai J et al. | A comprehensive study of anthocyanin-containing extracts from selected blackberry cultivars: extraction methods, stability, anticancer properties and mechanisms. | 2009 | Food Chem. Toxicol. | pmid:19271318 |
| Cásedas G et al. | Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vaccinium myrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin. | 2018 | Food Chem. Toxicol. | pmid:29860017 |
| Li F et al. | Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors. | 2018 | Food Chem. Toxicol. | pmid:29803697 |
| Min K and Ebeler SE | Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels. | 2008 | Food Chem. Toxicol. | pmid:17707569 |
| Choi EH et al. | Cytoprotective effect of anthocyanins against doxorubicin-induced toxicity in H9c2 cardiomyocytes in relation to their antioxidant activities. | 2007 | Food Chem. Toxicol. | pmid:17524543 |
| Matsufuji H et al. | Formation and inhibition of genotoxic malonaldehyde from DNA oxidation controlled with EDTA. | 2006 | Food Chem. Toxicol. | pmid:16122862 |
| Shih PH et al. | Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. | 2005 | Food Chem. Toxicol. | pmid:15964118 |
| Riha J et al. | Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes. | 2015 | Food Funct | pmid:25578040 |
| Fernandes I et al. | A new approach on the gastric absorption of anthocyanins. | 2012 | Food Funct | pmid:22391951 |
| Raj P et al. | Effects of cyanidin 3-0-glucoside on cardiac structure and function in an animal model of myocardial infarction. | 2017 | Food Funct | pmid:28990610 |
| Zhang J et al. | The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. | 2004 | Free Radic. Biol. Med. | pmid:15336320 |
| Ziberna L et al. | Transport and bioactivity of cyanidin 3-glucoside into the vascular endothelium. | 2012 | Free Radic. Biol. Med. | pmid:22387282 |