Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watanabe M | An anthocyanin compound in buckwheat sprouts and its contribution to antioxidant capacity. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284830 |
| Espley RV et al. | Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10. | 2007 | Plant J. | pmid:17181777 |
| Xu JW et al. | Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells. | 2007 | Atherosclerosis | pmid:17045269 |
| Nicoué EE et al. | Anthocyanins in wild blueberries of Quebec: extraction and identification. | 2007 | J. Agric. Food Chem. | pmid:17579428 |
| Di Giacomo C et al. | Protective effect of cyanidin 3-O-beta-D-glucoside on ochratoxin A-mediated damage in the rat. | 2007 | Br. J. Nutr. | pmid:17562227 |
| Felgines C et al. | Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. | 2007 | Br. J. Nutr. | pmid:17559698 |
| Stewart D et al. | Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. | 2007 | Mol Nutr Food Res | pmid:17492796 |
| Aaby K et al. | Characterization of phenolic compounds in strawberry (Fragaria x ananassa) fruits by different HPLC detectors and contribution of individual compounds to total antioxidant capacity. | 2007 | J. Agric. Food Chem. | pmid:17472391 |
| Milbury PE et al. | Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460300 |
| Liu YC et al. | Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. | 2007 | Life Sci. | pmid:17320913 |
| Hamauzu Y et al. | Reddish coloration of Chinese quince (Pseudocydonia sinensis) procyanidins during heat treatment and effect on antioxidant and antiinfluenza viral activities. | 2007 | J. Agric. Food Chem. | pmid:17300149 |
| Jordheim M et al. | Anthocyanins in berries of ribes including gooseberry cultivars with a high content of acylated pigments. | 2007 | J. Agric. Food Chem. | pmid:17579440 |
| Choi EH et al. | Cytoprotective effect of anthocyanins against doxorubicin-induced toxicity in H9c2 cardiomyocytes in relation to their antioxidant activities. | 2007 | Food Chem. Toxicol. | pmid:17524543 |
| Kim MJ et al. | Relationship between phenolic compounds, anthocyanins content and antioxidant activity in colored barley germplasm. | 2007 | J. Agric. Food Chem. | pmid:17516656 |
| Srivastava A et al. | Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. | 2007 | J. Agric. Food Chem. | pmid:17381106 |
| Lamy S et al. | Anthocyanidins inhibit migration of glioblastoma cells: structure-activity relationship and involvement of the plasminolytic system. | 2007 | J. Cell. Biochem. | pmid:16823770 |
| Bae JY et al. | Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts. | 2007 | Nutr Res Pract | pmid:20368951 |
| Terasawa N et al. | Identification and some properties of anthocyanin isolated from Zuiki, stalk of Colocasia esculenta. | 2007 | J. Agric. Food Chem. | pmid:17447784 |
| Bononi M and Tateo F | Stabilization of cranberry anthocyanins in nutraceutical capsules. | 2007 | Int J Food Sci Nutr | pmid:17469769 |
| Sorrenti V et al. | Heme oxygenase induction by cyanidin-3-O-beta-glucoside in cultured human endothelial cells. | 2007 | Mol Nutr Food Res | pmid:17440991 |
| Alcalde-Eon C et al. | Identification of dimeric anthocyanins and new oligomeric pigments in red wine by means of HPLC-DAD-ESI/MSn. | 2007 | J Mass Spectrom | pmid:17511019 |
| Cassinese C et al. | New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations. | 2007 Jul-Aug | J AOAC Int | pmid:17760327 |
| Fedenko VS | [Dose effect of cyanidin interaction with lead ions in roots of maize seedlings]. | 2007 Mar-Apr | Ukr Biokhim Zh (1999) | pmid:18030746 |
| Kim JM et al. | Effects of black soybean [Glycine max (L.) Merr.] seed coats and its anthocyanidins on colonic inflammation and cell proliferation in vitro and in vivo. | 2008 | J. Agric. Food Chem. | pmid:18710248 |
| Li CY et al. | Corn husk as a potential source of anthocyanins. | 2008 | J. Agric. Food Chem. | pmid:19007127 |
| Mertens-Talcott SU et al. | Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers. | 2008 | J. Agric. Food Chem. | pmid:18693743 |
| Laitinen RA et al. | Identification of target genes for a MYB-type anthocyanin regulator in Gerbera hybrida. | 2008 | J. Exp. Bot. | pmid:18725377 |
| Meng L et al. | Antioxidant activities of polyphenols extracted from Perilla frutescens varieties. | 2008 | Molecules | pmid:19127243 |
| Han FL et al. | Principal component regression analysis of the relation between CIELAB color and monomeric anthocyanins in young Cabernet Sauvignon wines. | 2008 | Molecules | pmid:19015625 |
| Conn S et al. | Purification, molecular cloning, and characterization of glutathione S-transferases (GSTs) from pigmented Vitis vinifera L. cell suspension cultures as putative anthocyanin transport proteins. | 2008 | J. Exp. Bot. | pmid:18836188 |
| Osmani SA et al. | Catalytic key amino acids and UDP-sugar donor specificity of a plant glucuronosyltransferase, UGT94B1: molecular modeling substantiated by site-specific mutagenesis and biochemical analyses. | 2008 | Plant Physiol. | pmid:18829982 |
| Gastrointestinal pharmacology. | 2008 | Indian J Pharmacol | pmid:21593966 | |
| Merzlyak MN et al. | Light absorption by anthocyanins in juvenile, stressed, and senescing leaves. | 2008 | J. Exp. Bot. | pmid:18796701 |
| Xu F et al. | Molecular cloning and function analysis of an anthocyanidin synthase gene from Ginkgo biloba, and its expression in abiotic stress responses. | 2008 | Mol. Cells | pmid:18779661 |
| Zhang G et al. | Structure-dependent photodegradation of carotenoids accelerated by dimethyl tetrasulfide under UVA irradiation. | 2008 | Biosci. Biotechnol. Biochem. | pmid:18685214 |
| Steigerwalt RD et al. | Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. | 2008 | Mol. Vis. | pmid:18618008 |
| Fukamachi K et al. | Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat. | 2008 | Cancer Sci. | pmid:18616524 |
| Tatsuzawa F et al. | Triacylated cyanidin 3-(3X-glucosylsambubioside)-5-glucosides from the flowers of Malcolmia maritima. | 2008 | Phytochemistry | pmid:17928016 |
| Dancs G et al. | The effects of enhanced methionine synthesis on amino acid and anthocyanin content of potato tubers. | 2008 | BMC Plant Biol. | pmid:18549488 |
| Lillo C et al. | Nutrient depletion as a key factor for manipulating gene expression and product formation in different branches of the flavonoid pathway. | 2008 | Plant Cell Environ. | pmid:18031469 |
| Galvano F et al. | Protocatechuic acid: the missing human cyanidins' metabolite. | 2008 | Mol Nutr Food Res | pmid:18320575 |
| Saito N et al. | Tetra-acylated cyanidin 3-sophoroside-5-glucosides from the flowers of Iberis umbellata L. (Cruciferae). | 2008 | Phytochemistry | pmid:18514755 |
| Wang Q et al. | Cyanidin-3-O-beta-glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages. | 2008 | Life Sci. | pmid:18619979 |
| Hattori M et al. | Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18619417 |
| Meng S et al. | Natural dyes adsorbed on TiO2 nanowire for photovoltaic applications: enhanced light absorption and ultrafast electron injection. | 2008 | Nano Lett. | pmid:18788788 |
| Renis M et al. | Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. | 2008 | Br. J. Nutr. | pmid:18053307 |
| Kim MK et al. | Identification and quantification of anthocyanin pigments in colored rice. | 2008 | Nutr Res Pract | pmid:20126365 |
| Hassimotto NM et al. | Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. | 2008 | Nutr Res | pmid:19083408 |
| Hassimotto NM et al. | Antioxidant status in humans after consumption of blackberry (Rubus fruticosus L.) juices with and without defatted milk. | 2008 | J. Agric. Food Chem. | pmid:19053224 |
| Li CY et al. | Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats. | 2008 | Alcohol | pmid:19038699 |
| De Rosso VV et al. | Singlet oxygen quenching by anthocyanin's flavylium cations. | 2008 | Free Radic. Res. | pmid:18985487 |
| Tarozzi A et al. | Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity. | 2008 | Neuroreport | pmid:18797302 |
| Lin LZ and Harnly JM | Phenolic compounds and chromatographic profiles of pear skins (Pyrus spp.). | 2008 | J. Agric. Food Chem. | pmid:18778075 |
| Zhou LL et al. | Development of tobacco callus cultures over expressing Arabidopsis PAP1/MYB75 transcription factor and characterization of anthocyanin biosynthesis. | 2008 | Planta | pmid:18766373 |
| Jensen GS et al. | In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study. | 2008 | J. Agric. Food Chem. | pmid:18717569 |
| Comandini P et al. | CZE separation of strawberry anthocyanins with acidic buffer and comparison with HPLC. | 2008 | J Sep Sci | pmid:18704996 |
| Felgines C et al. | Influence of glucose on cyanidin 3-glucoside absorption in rats. | 2008 | Mol Nutr Food Res | pmid:18646002 |
| Hollands W et al. | Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit. | 2008 | Mol Nutr Food Res | pmid:18645999 |
| Lavelli V et al. | Optimization of color and antioxidant activity of peach and nectarine puree: scale-up study from pilot to industrial plant. | 2008 | J. Agric. Food Chem. | pmid:18620412 |
| Kohyama N et al. | Changes in anthocyanins in the grains of purple waxy hull-less barley during seed maturation and after harvest. | 2008 | J. Agric. Food Chem. | pmid:18558760 |
| Li JB et al. | Anthocyanins from red flowers of Camellia cultivar 'Dalicha'. | 2008 | Phytochemistry | pmid:18466934 |
| Pawlowska AM et al. | Quali-quantitative analyses of Flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits. | 2008 | J. Agric. Food Chem. | pmid:18412362 |
| Sakaguchi Y et al. | Major anthocyanins from purple asparagus (Asparagus officinalis). | 2008 | Phytochemistry | pmid:18406435 |
| Li Volti G et al. | Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide? | 2008 | Ann. Surg. | pmid:18362637 |
| Tulio AZ et al. | Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry. | 2008 | J. Agric. Food Chem. | pmid:18290621 |
| Guo H et al. | Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation. | 2008 | Biochem. Pharmacol. | pmid:18179781 |
| Scalzo J et al. | The anthocyanin composition of different Vaccinium, Ribes and Rubus genotypes. | 2008 | Biofactors | pmid:19706968 |
| Matsuura R et al. | Determination of antioxidant activity and characterization of antioxidant phenolics in the plum vinegar extract of cherry blossom (Prunus lannesiana). | 2008 | J. Agric. Food Chem. | pmid:18092753 |
| Yan Y et al. | High-yield anthocyanin biosynthesis in engineered Escherichia coli. | 2008 | Biotechnol. Bioeng. | pmid:18023053 |
| Nicoletti I et al. | Identification and quantification of phenolic compounds in grapes by HPLC-PDA-ESI-MS on a semimicro separation scale. | 2008 | J. Agric. Food Chem. | pmid:18781764 |
| Zhang J et al. | Determination of anthocyanins and exploration of relationship between their composition and petal coloration in crape myrtle (Lagerstroemia hybrid). | 2008 | J Integr Plant Biol | pmid:18713426 |
| Min K and Ebeler SE | Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels. | 2008 | Food Chem. Toxicol. | pmid:17707569 |
| Bordonaba JG and Terry LA | Biochemical profiling and chemometric analysis of seventeen UK-grown black currant cultivars. | 2008 | J. Agric. Food Chem. | pmid:18642846 |
| Oh YS et al. | Characterization and quantification of anthocyanins in grape juices obtained from the grapes cultivated in Korea by HPLC/DAD, HPLC/MS, and HPLC/MS/MS. | 2008 | J. Food Sci. | pmid:18576983 |
| Ku CS and Mun SP | Optimization of the extraction of anthocyanin from Bokbunja (Rubus coreanus Miq.) marc produced during traditional wine processing and characterization of the extracts. | 2008 | Bioresour. Technol. | pmid:18456493 |
| Wang CY et al. | Increasing antioxidant activity and reducing decay of blueberries by essential oils. | 2008 | J. Agric. Food Chem. | pmid:18442248 |
| Nakatsuka T et al. | Cloning and characterization of the UDP-glucose:anthocyanin 5-O-glucosyltransferase gene from blue-flowered gentian. | 2008 | J. Exp. Bot. | pmid:18375606 |
| Noda Y et al. | Inhibitory effect of fermented papaya preparation on hydroxyl radical generation from methylguanidine. | 2008 | J Clin Biochem Nutr | pmid:19015753 |
| Maruyama C et al. | Azuki bean juice lowers serum triglyceride concentrations in healthy young women. | 2008 | J Clin Biochem Nutr | pmid:18648655 |
| Griesser M et al. | Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | 2008 | J. Exp. Bot. | pmid:18487633 |
| Park MY et al. | Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin. | 2008 | Nutr Res Pract | pmid:20126360 |
| Park JS et al. | Arabidopsis R2R3-MYB transcription factor AtMYB60 functions as a transcriptional repressor of anthocyanin biosynthesis in lettuce (Lactuca sativa). | 2008 | Plant Cell Rep. | pmid:18317777 |
| Jugdé H et al. | Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple. | 2008 | FEBS J. | pmid:18573104 |
| Dani C et al. | Protective effects of purple grape juice on carbon tetrachloride-induced oxidative stress in brains of adult Wistar rats. | 2008 | J Med Food | pmid:18361738 |
| Fedenko VS | [Cyanidin as endogenous chelator of metal ions in maize seedling roots]. | 2008 Jan-Feb | Ukr Biokhim Zh (1999) | pmid:18710034 |
| Lea MA et al. | Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds. | 2008 Jul-Aug | Anticancer Res. | pmid:18751377 |
| Hugueney P et al. | A novel cation-dependent O-methyltransferase involved in anthocyanin methylation in grapevine. | 2009 | Plant Physiol. | pmid:19525322 |
| Chen G et al. | Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta. | 2009 | Neurotox Res | pmid:19384566 |
| Philpott M et al. | Dietary protection against free radicals: a case for multiple testing to establish structure-activity relationships for antioxidant potential of anthocyanic plant species. | 2009 | Int J Mol Sci | pmid:19399239 |
| Harding SA et al. | A comparative analysis of phenylpropanoid metabolism, N utilization, and carbon partitioning in fast- and slow-growing Populus hybrid clones. | 2009 | J. Exp. Bot. | pmid:19516073 |
| Qiu F et al. | Preparative isolation and purification of anthocyanins from purple sweet potato by high-speed counter-current chromatography. | 2009 | J Sep Sci | pmid:19479751 |
| Savikin K et al. | Phenolic content and radical scavenging capacity of berries and related jams from certificated area in Serbia. | 2009 | Plant Foods Hum Nutr | pmid:19468835 |
| Jordheim M et al. | Acylated anthocyanins in inflorescence of spider flower (Cleome hassleriana). | 2009 | Phytochemistry | pmid:19427007 |
| Dreiseitel A et al. | Berry anthocyanins and their aglycons inhibit monoamine oxidases A and B. | 2009 | Pharmacol. Res. | pmid:19416630 |
| Persson IA et al. | Effect of Vaccinium myrtillus and its polyphenols on angiotensin-converting enzyme activity in human endothelial cells. | 2009 | J. Agric. Food Chem. | pmid:19441816 |
| Garcia-Alonso M et al. | Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma. | 2009 | J. Nutr. Biochem. | pmid:18789665 |
| Korte G et al. | An examination of anthocyanins' and anthocyanidins' affinity for cannabinoid receptors. | 2009 | J Med Food | pmid:20041802 |
| Zhang Y et al. | The potato R locus codes for dihydroflavonol 4-reductase. | 2009 | Theor. Appl. Genet. | pmid:19588118 |
| Albert NW et al. | Light-induced vegetative anthocyanin pigmentation in Petunia. | 2009 | J. Exp. Bot. | pmid:19380423 |
| Deluc LG et al. | Water deficit alters differentially metabolic pathways affecting important flavor and quality traits in grape berries of Cabernet Sauvignon and Chardonnay. | 2009 | BMC Genomics | pmid:19426499 |