Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Wound Infection | D014946 | 12 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guo H et al. | Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells. | 2012 | Lipids Health Dis | pmid:22243683 |
| Milbury PE et al. | Bioavailablility of elderberry anthocyanins. | 2002 | Mech. Ageing Dev. | pmid:12044949 |
| Bijak M et al. | Thrombin inhibitory activity of some polyphenolic compounds. | 2014 | Med Chem Res | pmid:24610996 |
| Hirai S et al. | Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. | 2010 | Mediators Inflamm. | pmid:20508825 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Burdulis D et al. | Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits. | 2007 | Medicina (Kaunas) | pmid:18182842 |
| Burdulis D et al. | [Analysis of anthocyanin content in bilberry (Vaccinium myrtillus L.) fruit crude drugs by high-performance liquid chromatography method]. | 2007 | Medicina (Kaunas) | pmid:17768372 |
| Woodward GM et al. | Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation. | 2011 | Mol Nutr Food Res | pmid:21370450 |
| Marques C et al. | Pharmacokinetics of blackberry anthocyanins consumed with or without ethanol: A randomized and crossover trial. | 2016 | Mol Nutr Food Res | pmid:27306520 |
| Singh CK et al. | Combination chemoprevention with grape antioxidants. | 2016 | Mol Nutr Food Res | pmid:26829056 |
| Wang D et al. | Cyanidin-3-O-β-glucoside upregulates hepatic cholesterol 7α-hydroxylase expression and reduces hypercholesterolemia in mice. | 2012 | Mol Nutr Food Res | pmid:22495986 |
| Kay CD et al. | The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products. | 2009 | Mol Nutr Food Res | pmid:19415657 |
| Galvano F et al. | Protocatechuic acid: the missing human cyanidins' metabolite. | 2008 | Mol Nutr Food Res | pmid:18320575 |
| Garcia-Alonso M et al. | Electron spin resonance spectroscopy studies on the free radical scavenging activity of wine anthocyanins and pyranoanthocyanins. | 2005 | Mol Nutr Food Res | pmid:16254886 |
| Felgines C et al. | Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet. | 2009 | Mol Nutr Food Res | pmid:19653220 |
| Kassim A et al. | Environmental and seasonal influences on red raspberry anthocyanin antioxidant contents and identification of quantitative traits loci (QTL). | 2009 | Mol Nutr Food Res | pmid:19156716 |
| Felgines C et al. | Influence of glucose on cyanidin 3-glucoside absorption in rats. | 2008 | Mol Nutr Food Res | pmid:18646002 |
| Hollands W et al. | Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit. | 2008 | Mol Nutr Food Res | pmid:18645999 |
| Matsunaga N et al. | Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. | 2009 | Mol Nutr Food Res | pmid:19415665 |
| Knaup B et al. | Anthocyanins as lipoxygenase inhibitors. | 2009 | Mol Nutr Food Res | pmid:19072887 |
| Stewart D et al. | Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. | 2007 | Mol Nutr Food Res | pmid:17492796 |
| Kern M et al. | Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. | 2007 | Mol Nutr Food Res | pmid:17729219 |
| Batista ÂG et al. | Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. | 2017 | Mol Nutr Food Res | pmid:28544198 |
| Jakobs S et al. | Natural flavonoids are potent inhibitors of glycogen phosphorylase. | 2006 | Mol Nutr Food Res | pmid:16317787 |
| Lazzè MC et al. | Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. | 2006 | Mol Nutr Food Res | pmid:16288501 |
| Marko D et al. | The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. | 2004 | Mol Nutr Food Res | pmid:15497183 |
| Sorrenti V et al. | Heme oxygenase induction by cyanidin-3-O-beta-glucoside in cultured human endothelial cells. | 2007 | Mol Nutr Food Res | pmid:17440991 |
| Del Bo' C et al. | Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. | 2016 | Mol Nutr Food Res | pmid:27324255 |
| Pourcel L et al. | The formation of Anthocyanic Vacuolar Inclusions in Arabidopsis thaliana and implications for the sequestration of anthocyanin pigments. | 2010 | Mol Plant | pmid:20085894 |
| Morant M et al. | Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2. | 2010 | Mol Plant | pmid:20008451 |
| Sun Y et al. | Arabidopsis TT19 functions as a carrier to transport anthocyanin from the cytosol to tonoplasts. | 2012 | Mol Plant | pmid:22201047 |
| Xu M et al. | Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2. | 2010 | Mol. Cancer | pmid:21034468 |
| Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
| Luo X et al. | Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling. | 2012 | Mol. Cell. Biochem. | pmid:22120492 |
| Xu F et al. | Molecular cloning and function analysis of an anthocyanidin synthase gene from Ginkgo biloba, and its expression in abiotic stress responses. | 2008 | Mol. Cells | pmid:18779661 |
| Nishizaki Y et al. | Structure of the acyl-glucose-dependent anthocyanin 5-O-glucosyltransferase gene in carnations and its disruption by transposable elements in some varieties. | 2011 | Mol. Genet. Genomics | pmid:22048706 |
| Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
| Nakatsuka T et al. | Two different transposable elements inserted in flavonoid 3',5'-hydroxylase gene contribute to pink flower coloration in Gentiana scabra. | 2006 | Mol. Genet. Genomics | pmid:16362368 |
| Steigerwalt RD et al. | Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. | 2008 | Mol. Vis. | pmid:18618008 |
| Chen R et al. | Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:24623967 |
| Meng L et al. | Antioxidant activities of polyphenols extracted from Perilla frutescens varieties. | 2008 | Molecules | pmid:19127243 |
| Han FL et al. | Principal component regression analysis of the relation between CIELAB color and monomeric anthocyanins in young Cabernet Sauvignon wines. | 2008 | Molecules | pmid:19015625 |
| Sun LL et al. | Composition and antioxidant activity of the anthocyanins of the fruit of Berberis heteropoda Schrenk. | 2014 | Molecules | pmid:25415473 |
| Xia N et al. | Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. | 2014 | Molecules | pmid:24662080 |
| Zykin PA et al. | Anthocyanin Composition and Content in Rye Plants with Different Grain Color. | 2018 | Molecules | pmid:29671758 |
| Lopes-Lutz D et al. | Characterization and quantification of polyphenols in Amazon grape (Pourouma cecropiifolia Martius). | 2010 | Molecules | pmid:21116224 |
| Cyboran-Mikołajczyk S et al. | The Impact of O-Glycosylation on Cyanidin Interaction with POPC Membranes: Structure-Activity Relationship. | 2018 | Molecules | pmid:30366469 |
| Akkarachiyasit S et al. | In vitro inhibitory effects of cyandin-3-rutinoside on pancreatic α-amylase and its combined effect with acarbose. | 2011 | Molecules | pmid:21368719 |
| Lazzé MC et al. | Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. | 2003 | Mutat. Res. | pmid:12547288 |
| Cambie RC and Ferguson LR | Potential functional foods in the traditional Maori diet. | Mutat. Res. | pmid:12628508 |