Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Wound Infection | D014946 | 12 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stoner GD et al. | Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. | 2005 | J Clin Pharmacol | pmid:16172180 |
| Frank T et al. | Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. | 2005 | J Clin Pharmacol | pmid:15647413 |
| Adisakwattana S et al. | Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase. | 2011 | J Clin Biochem Nutr | pmid:21765605 |
| Okazaki Y et al. | A beverage containing fermented black soybean ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats. | 2010 | J Clin Biochem Nutr | pmid:21103028 |
| Noda Y et al. | Inhibitory effect of fermented papaya preparation on hydroxyl radical generation from methylguanidine. | 2008 | J Clin Biochem Nutr | pmid:19015753 |
| Maruyama C et al. | Azuki bean juice lowers serum triglyceride concentrations in healthy young women. | 2008 | J Clin Biochem Nutr | pmid:18648655 |
| Füzfai Z and Molnár-Perl I | Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits. | 2007 | J Chromatogr A | pmid:17289064 |
| Di Paola-Naranjo RD et al. | Liquid chromatographic-mass spectrometric analysis of anthocyanin composition of dark blue bee pollen from Echium plantagineum. | 2004 | J Chromatogr A | pmid:15553145 |
| Coates EM et al. | Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. | 2007 | J Carcinog | pmid:17442116 |
| Cassinese C et al. | New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations. | 2007 Jul-Aug | J AOAC Int | pmid:17760327 |
| Barzaghi N et al. | Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects. | 1991 | Ital J Gastroenterol | pmid:1742514 |
| Milbury PE et al. | Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460300 |
| Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
| Lacombe A et al. | Antimicrobial action of the American cranberry constituents; phenolics, anthocyanins, and organic acids, against Escherichia coli O157:H7. | 2010 | Int. J. Food Microbiol. | pmid:20153540 |
| Cooke D et al. | Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels. | 2006 | Int. J. Cancer | pmid:16823841 |
| Suantawee T et al. | Protective effect of cyanidin against glucose- and methylglyoxal-induced protein glycation and oxidative DNA damage. | 2016 | Int. J. Biol. Macromol. | pmid:27645922 |
| Min SW et al. | Anti-inflammatory effects of black rice, cyanidin-3-O-beta-D-glycoside, and its metabolites, cyanidin and protocatechuic acid. | 2010 | Int. Immunopharmacol. | pmid:20669401 |
| Titta L et al. | Blood orange juice inhibits fat accumulation in mice. | 2010 | Int J Obes (Lond) | pmid:20029381 |
| D'Archivio M et al. | Bioavailability of the polyphenols: status and controversies. | 2010 | Int J Mol Sci | pmid:20480022 |
| Wei S et al. | Concentration of rutin model solutions from their mixtures with glucose using ultrafiltration. | 2010 | Int J Mol Sci | pmid:20386660 |
| Tanaka T et al. | Chemistry of secondary polyphenols produced during processing of tea and selected foods. | 2009 | Int J Mol Sci | pmid:20161999 |
| Halbwirth H | The creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway. | 2010 | Int J Mol Sci | pmid:20386656 |
| Philpott M et al. | Dietary protection against free radicals: a case for multiple testing to establish structure-activity relationships for antioxidant potential of anthocyanic plant species. | 2009 | Int J Mol Sci | pmid:19399239 |
| Kimura Y et al. | Synthesis of 8-Aryl-O-methylcyanidins and Their Usage for Dye-Sensitized Solar Cell Devices. | 2017 | Int J Mol Sci | pmid:28212330 |
| Zhu L et al. | Phenolic contents and compositions in skins of red wine grape cultivars among various genetic backgrounds and originations. | 2012 | Int J Mol Sci | pmid:22489164 |
| de Jesus NZ et al. | Tannins, peptic ulcers and related mechanisms. | 2012 | Int J Mol Sci | pmid:22489149 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Akkarachiyasit S et al. | Inhibitory activities of cyanidin and its glycosides and synergistic effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase. | 2010 | Int J Mol Sci | pmid:20957102 |
| Zhao Q et al. | Anthocyanins profile of grape berries of Vitis amurensis, its hybrids and their wines. | 2010 | Int J Mol Sci | pmid:20559511 |
| de Pascual-Teresa S et al. | Flavanols and anthocyanins in cardiovascular health: a review of current evidence. | 2010 | Int J Mol Sci | pmid:20480037 |
| Treutter D | Managing phenol contents in crop plants by phytochemical farming and breeding-visions and constraints. | 2010 | Int J Mol Sci | pmid:20479987 |
| Tanaka Y et al. | Recent progress of flower colour modification by biotechnology. | 2009 | Int J Mol Sci | pmid:20054474 |
| Ghanbari R et al. | Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review. | 2012 | Int J Mol Sci | pmid:22489153 |
| Roslan ND et al. | Flavonoid biosynthesis genes putatively identified in the aromatic plant Polygonum minus via Expressed Sequences Tag (EST) analysis. | 2012 | Int J Mol Sci | pmid:22489118 |
| Arfan M et al. | Antioxidant activity of mulberry fruit extracts. | 2012 | Int J Mol Sci | pmid:22408465 |
| Bak MJ et al. | Procyanidins from wild grape (Vitis amurensis) seeds regulate ARE-mediated enzyme expression via Nrf2 coupled with p38 and PI3K/Akt pathway in HepG2 cells. | 2012 | Int J Mol Sci | pmid:22312287 |
| Ibrahim MH et al. | Involvement of nitrogen on flavonoids, glutathione, anthocyanin, ascorbic acid and antioxidant activities of Malaysian medicinal plant Labisia pumila Blume (Kacip Fatimah). | 2012 | Int J Mol Sci | pmid:22312260 |
| Panickar KS and Anderson RA | Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia. | 2011 | Int J Mol Sci | pmid:22174658 |
| Abidi W et al. | Evaluation of antioxidant compounds and total sugar content in a nectarine [Prunus persica (L.) Batsch] progeny. | 2011 | Int J Mol Sci | pmid:22072927 |
| Wu X et al. | Optimization of phenolic antioxidant extraction from Wuweizi (Schisandra chinensis) pulp using random-centroid optimazation methodology. | 2011 | Int J Mol Sci | pmid:22016656 |
| Zou TB et al. | Optimization of ultrasound-assisted extraction of anthocyanins from mulberry, using response surface methodology. | 2011 | Int J Mol Sci | pmid:21686165 |
| Wei SD et al. | Antioxidant activities of fractions of polymeric procyanidins from stem bark of Acacia confusa. | 2011 | Int J Mol Sci | pmid:21541049 |
| Reber JD et al. | Antioxidant capacity interactions and a chemical/structural model of phenolic compounds found in strawberries. | 2011 | Int J Food Sci Nutr | pmid:21385007 |
| Bononi M et al. | 'Cyanidin volumetric index' and 'chromaticity coordinates ratio' to characterize red raspberry (Rubus idaeus). | 2006 Aug-Sep | Int J Food Sci Nutr | pmid:17135027 |
| Butryee C et al. | Effect of processing on the flavonoid content and antioxidant capacity of Citrus hystrix leaf. | 2009 | Int J Food Sci Nutr | pmid:19572229 |
| Chun OK et al. | Antioxidant properties of raw and processed cabbages. | 2004 | Int J Food Sci Nutr | pmid:15223595 |
| Bononi M and Tateo F | Stabilization of cranberry anthocyanins in nutraceutical capsules. | 2007 | Int J Food Sci Nutr | pmid:17469769 |
| Devi PS et al. | Evaluation of antiproliferative activity of red sorghum bran anthocyanin on a human breast cancer cell line (mcf-7). | 2011 | Int J Breast Cancer | pmid:22312562 |
| Zhang Y et al. | Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkappaBalpha phosphorylation in THP-1 cells. | 2010 | Inflamm. Res. | pmid:20309718 |
| Gastrointestinal pharmacology. | 2008 | Indian J Pharmacol | pmid:21593966 |