Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Wound Infection | D014946 | 12 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang Z et al. | Comparison of HPLC methods for determination of anthocyanins and anthocyanidins in bilberry extracts. | 2004 | J. Agric. Food Chem. | pmid:14969517 |
| Chaovanalikit A et al. | Characterization and quantification of anthocyanins and polyphenolics in bluehHoneysuckle (Lonicera caerulea L.). | 2004 | J. Agric. Food Chem. | pmid:14969540 |
| Herath HM et al. | Inhibitory effect of some flavonoids on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated mouse macrophage cell line J774.1. | 2003 | J Med Food | pmid:14977446 |
| Yousef GG et al. | Biosynthesis and characterization of 14C-enriched flavonoid fractions from plant cell suspension cultures. | 2004 | J. Agric. Food Chem. | pmid:14995111 |
| Tsuda T et al. | Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15003523 |
| Lazzè MC et al. | Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. | 2004 | Carcinogenesis | pmid:15016660 |
| Del Pozo-Insfran D et al. | Phytochemical composition and pigment stability of Açai (Euterpe oleracea Mart.). | 2004 | J. Agric. Food Chem. | pmid:15030208 |
| Scordino M et al. | Adsorption of flavonoids on resins: cyanidin 3-glucoside. | 2004 | J. Agric. Food Chem. | pmid:15053537 |
| Romero C et al. | Polyphenol changes during fermentation of naturally black olives. | 2004 | J. Agric. Food Chem. | pmid:15053538 |
| Aumont V et al. | Production of highly 13C-labeled polyphenols in Vitis vinifera cell bioreactor cultures. | 2004 | J. Biotechnol. | pmid:15066766 |
| Hyun JW and Chung HS | Cyanidin and Malvidin from Oryza sativa cv. Heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G(2)/M phase and induction of apoptosis. | 2004 | J. Agric. Food Chem. | pmid:15080622 |
| Matsumoto M et al. | Gastroprotective effect of red pigments in black chokeberry fruit (Aronia melanocarpa Elliot) on acute gastric hemorrhagic lesions in rats. | 2004 | J. Agric. Food Chem. | pmid:15080625 |
| Tatsuzawa F et al. | Diacylated 8-C-glucosylcyanidin 3-glucoside from the flowers of Tricyrtis formosana. | 2004 | Chem. Pharm. Bull. | pmid:15133223 |
| Turker N et al. | Effect of storage temperature on the stability of anthocyanins of a fermented black carrot (Daucus carota var. L.) beverage: shalgam. | 2004 | J. Agric. Food Chem. | pmid:15186101 |
| Chun OK et al. | Antioxidant properties of raw and processed cabbages. | 2004 | Int J Food Sci Nutr | pmid:15223595 |
| Xu JW et al. | Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. | 2004 | Hypertension | pmid:15226277 |
| Kay CD et al. | Anthocyanin metabolites in human urine and serum. | 2004 | Br. J. Nutr. | pmid:15228048 |
| Harada K et al. | Absorption of acylated anthocyanins in rats and humans after ingesting an extract of Ipomoea batatas purple sweet potato tuber. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15277754 |
| Schwarz M et al. | Isolation and identification of novel pyranoanthocyanins from black carrot (Daucus carota L.) juice. | 2004 | J. Agric. Food Chem. | pmid:15291481 |
| Duthie SJ et al. | DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro--modulation by the dietary anthocyanin, cyanidin-3-glycoside. | 2005 | Eur J Nutr | pmid:15309415 |
| Aura AM et al. | In vitro metabolism of anthocyanins by human gut microflora. | 2005 | Eur J Nutr | pmid:15309431 |
| Zhang J et al. | The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. | 2004 | Free Radic. Biol. Med. | pmid:15336320 |
| Xu JW et al. | Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. | 2004 | FEBS Lett. | pmid:15358561 |
| Matsufuji H and Shibamoto T | Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. | 2004 | J. Agric. Food Chem. | pmid:15373421 |
| Zhao C et al. | Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. | 2004 | J. Agric. Food Chem. | pmid:15453676 |
| Määttä-Riihinen KR et al. | Identification and quantification of phenolic compounds in berries of Fragaria and Rubus species (family Rosaceae). | 2004 | J. Agric. Food Chem. | pmid:15453684 |
| Wu X et al. | Pelargonidin is absorbed and metabolized differently than cyanidin after marionberry consumption in pigs. | 2004 | J. Nutr. | pmid:15465754 |
| Afaq F et al. | Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. | Photochem. Photobiol. | pmid:15493960 | |
| Marko D et al. | The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. | 2004 | Mol Nutr Food Res | pmid:15497183 |
| Nimal Punyasiri PA et al. | Exobasidium vexans infection of Camellia sinensis increased 2,3-cis isomerisation and gallate esterification of proanthocyanidins. | 2004 | Phytochemistry | pmid:15504433 |
| Chang Q and Wong YS | Identification of flavonoids in Hakmeitau beans (Vigna sinensis) by high-performance liquid chromatography-electrospray mass spectrometry (LC-ESI/MS). | 2004 | J. Agric. Food Chem. | pmid:15506802 |
| Muñoz-Espada AC et al. | Anthocyanin quantification and radical scavenging capacity of Concord, Norton, and Marechal Foch grapes and wines. | 2004 | J. Agric. Food Chem. | pmid:15506816 |
| Sawada S et al. | UDP-glucuronic acid:anthocyanin glucuronosyltransferase from red daisy (Bellis perennis) flowers. Enzymology and phylogenetics of a novel glucuronosyltransferase involved in flower pigment biosynthesis. | 2005 | J. Biol. Chem. | pmid:15509561 |
| Lee J et al. | Comparison of anthocyanin pigment and other phenolic compounds of Vaccinium membranaceum and Vaccinium ovatum native to the Pacific Northwest of North America. | 2004 | J. Agric. Food Chem. | pmid:15537315 |
| Di Paola-Naranjo RD et al. | Liquid chromatographic-mass spectrometric analysis of anthocyanin composition of dark blue bee pollen from Echium plantagineum. | 2004 | J Chromatogr A | pmid:15553145 |
| Hillebrand S et al. | Characterization of anthocyanins and pyranoanthocyanins from blood orange [Citrus sinensis (L.) Osbeck] juice. | 2004 | J. Agric. Food Chem. | pmid:15563216 |
| Ando T et al. | Delphinidin accumulation is associated with abnormal flower development in petunias. | 2004 | Phytochemistry | pmid:15587706 |
| Russo A et al. | Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-beta-d-glucoside. | 2005 | J. Nutr. Biochem. | pmid:15629238 |
| Iwai K et al. | Physiological effects and active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress. | 2004 | Biofactors | pmid:15630210 |
| Jayaprakasam B et al. | Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. | 2005 | J. Agric. Food Chem. | pmid:15631504 |
| Ichiyanagi T et al. | Metabolic pathway of cyanidin 3-O-beta-D-glucopyranoside in rats. | 2005 | J. Agric. Food Chem. | pmid:15631521 |
| Frank T et al. | Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. | 2005 | J Clin Pharmacol | pmid:15647413 |
| Zhang Y et al. | Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. | 2005 | Life Sci. | pmid:15680311 |
| Riso P et al. | Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. | 2005 | J. Agric. Food Chem. | pmid:15713002 |
| Nakajima T et al. | Insertion and excision of a transposable element governs the red floral phenotype in commercial petunias. | 2005 | Theor. Appl. Genet. | pmid:15731929 |
| Berardini N et al. | Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. | 2005 | J. Agric. Food Chem. | pmid:15740041 |
| Longo L et al. | Identification of anthocyanins in Rhamnus alaternus L. berries. | 2005 | J. Agric. Food Chem. | pmid:15740065 |
| Yeh CT and Yen GC | Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells. | 2005 | J. Agric. Food Chem. | pmid:15740068 |
| Wallerath T et al. | A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. | 2005 | Nitric Oxide | pmid:15740983 |
| Jang YP et al. | Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. | 2005 May-Jun | Photochem. Photobiol. | pmid:15745429 |
| Wu X and Prior RL | Systematic identification and characterization of anthocyanins by HPLC-ESI-MS/MS in common foods in the United States: fruits and berries. | 2005 | J. Agric. Food Chem. | pmid:15796599 |
| Tohge T et al. | Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. | 2005 | Plant J. | pmid:15807784 |
| Wu X and Prior RL | Identification and characterization of anthocyanins by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in common foods in the United States: vegetables, nuts, and grains. | 2005 | J. Agric. Food Chem. | pmid:15826066 |
| Morita Y et al. | Japanese morning glory dusky mutants displaying reddish-brown or purplish-gray flowers are deficient in a novel glycosylation enzyme for anthocyanin biosynthesis, UDP-glucose:anthocyanidin 3-O-glucoside-2''-O-glucosyltransferase, due to 4-bp insertions in the gene. | 2005 | Plant J. | pmid:15842621 |
| Bendia E et al. | Effect of cyanidin 3-O-beta-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress. | 2005 | Dig Liver Dis | pmid:15843084 |
| Tsuda T et al. | Gene expression profile of isolated rat adipocytes treated with anthocyanins. | 2005 | Biochim. Biophys. Acta | pmid:15863361 |
| Talavéra S et al. | Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain. | 2005 | J. Agric. Food Chem. | pmid:15884815 |
| Irani NG and Grotewold E | Light-induced morphological alteration in anthocyanin-accumulating vacuoles of maize cells. | 2005 | BMC Plant Biol. | pmid:15907203 |
| Kano M et al. | Antioxidative activity of anthocyanins from purple sweet potato, Ipomoera batatas cultivar Ayamurasaki. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15914919 |
| Flamini R | Some advances in the knowledge of grape, wine and distillates chemistry as achieved by mass spectrometry. | 2005 | J Mass Spectrom | pmid:15954164 |
| Hou DX et al. | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. | 2005 | Biochem. Pharmacol. | pmid:15963474 |
| Shih PH et al. | Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. | 2005 | Food Chem. Toxicol. | pmid:15964118 |
| Chen PN et al. | Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. | 2006 | Cancer Lett. | pmid:15975709 |
| Passamonti S et al. | Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase. | 2005 | FEBS J. | pmid:15978035 |
| Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
| Honda T et al. | Acylated anthocyanins from the violet-blue flowers of Orychophragonus violaceus. | 2005 | Phytochemistry | pmid:16023157 |
| Duthie SJ et al. | The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. | 2006 | Eur J Nutr | pmid:16032375 |
| Larsson J et al. | Expanding the ChemGPS chemical space with natural products. | 2005 | J. Nat. Prod. | pmid:16038536 |
| Innocenti M et al. | Evaluation of the phenolic content in the aerial parts of different varieties of Cichorium intybus L. | 2005 | J. Agric. Food Chem. | pmid:16076140 |
| Tian Q et al. | Probing anthocyanin profiles in purple sweet potato cell line (Ipomoea batatas L. Cv. Ayamurasaki) by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2005 | J. Agric. Food Chem. | pmid:16076141 |
| Fimognari C et al. | In vitro anticancer activity of cyanidin-3-O-beta-glucopyranoside: effects on transformed and non-transformed T lymphocytes. | 2005 Jul-Aug | Anticancer Res. | pmid:16080535 |
| Matsufuji H et al. | Formation and inhibition of genotoxic malonaldehyde from DNA oxidation controlled with EDTA. | 2006 | Food Chem. Toxicol. | pmid:16122862 |
| Ichiyanagi T et al. | Extended glucuronidation is another major path of cyanidin 3-O-beta-D-glucopyranoside metabolism in rats. | 2005 | J. Agric. Food Chem. | pmid:16131148 |
| Vareed SK et al. | Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida fruits with health benefits. | 2006 | Life Sci. | pmid:16139847 |
| Hieber AD et al. | Color genes in the orchid Oncidium Gower Ramsey: identification, expression, and potential genetic instability in an interspecific cross. | 2006 | Planta | pmid:16151849 |
| Al-Farsi M et al. | Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. | 2005 | J. Agric. Food Chem. | pmid:16159191 |
| Habermeyer M et al. | Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity. | 2005 | Chem. Res. Toxicol. | pmid:16167831 |
| Stoner GD et al. | Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. | 2005 | J Clin Pharmacol | pmid:16172180 |
| Felgines C et al. | Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans. | 2005 | J. Agric. Food Chem. | pmid:16190623 |
| Mylnikov SV et al. | Rubus fruit juices affect lipid peroxidation in a Drosophila melanogaster model in vivo. | 2005 | J. Agric. Food Chem. | pmid:16190624 |
| McDougall GJ et al. | Anthocyanin-flavanol condensation products from black currant (Ribes nigrum L.). | 2005 | J. Agric. Food Chem. | pmid:16190645 |
| Longo L and Vasapollo G | Anthocyanins from bay (Laurus nobilis L.) berries. | 2005 | J. Agric. Food Chem. | pmid:16190671 |
| Punyasiri PA et al. | Preformed and induced chemical resistance of tea leaf against Exobasidium vexans infection. | 2005 | J. Chem. Ecol. | pmid:16222773 |
| McDougall GJ et al. | Anthocyanins from red wine--their stability under simulated gastrointestinal digestion. | 2005 | Phytochemistry | pmid:16242736 |
| Garcia-Alonso M et al. | Electron spin resonance spectroscopy studies on the free radical scavenging activity of wine anthocyanins and pyranoanthocyanins. | 2005 | Mol Nutr Food Res | pmid:16254886 |
| Dimitrić Marković JM et al. | Electronic and infrared vibrational analysis of cyanidin-quercetin copigment complex. | 2005 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:16257774 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Lazzè MC et al. | Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. | 2006 | Mol Nutr Food Res | pmid:16288501 |
| Nielsen AH et al. | Flavonoids in flowers of 16 Kalanchoë blossfeldiana varieties. | 2005 | Phytochemistry | pmid:16297414 |
| Montefiori M et al. | Pigments in the fruit of red-fleshed kiwifruit (Actinidia chinensis and Actinidia deliciosa). | 2005 | J. Agric. Food Chem. | pmid:16302772 |
| Ruiz D et al. | Characterization and quantitation of phenolic compounds in new apricot (Prunus armeniaca L.) varieties. | 2005 | J. Agric. Food Chem. | pmid:16302775 |
| Jin XH et al. | Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo. | 2006 | Exp. Eye Res. | pmid:16309673 |
| Jakobs S et al. | Natural flavonoids are potent inhibitors of glycogen phosphorylase. | 2006 | Mol Nutr Food Res | pmid:16317787 |
| Fedenko VS et al. | [Complexation of cyanidin with cadmium ions in solution]. | 2005 Jan-Feb | Ukr Biokhim Zh (1999) | pmid:16335277 |
| Shimada S et al. | Anthocyanidin synthase in non-anthocyanin-producing Caryophyllales species. | 2005 | Plant J. | pmid:16359388 |
| Nakatsuka T et al. | Two different transposable elements inserted in flavonoid 3',5'-hydroxylase gene contribute to pink flower coloration in Gentiana scabra. | 2006 | Mol. Genet. Genomics | pmid:16362368 |
| Kim DO et al. | Sweet and sour cherry phenolics and their protective effects on neuronal cells. | 2005 | J. Agric. Food Chem. | pmid:16366675 |
| Macz-Pop GA et al. | New flavanol-anthocyanin condensed pigments and anthocyanin composition in guatemalan beans (Phaseolus spp.). | 2006 | J. Agric. Food Chem. | pmid:16417317 |
| Wu X et al. | Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption. | 2006 | J. Agric. Food Chem. | pmid:16417325 |
| He YH et al. | [Antioxidant and anti-inflammatory effects of cyanidin from cherries on rat adjuvant-induced arthritis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16422543 |