Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Wound Infection | D014946 | 12 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Macz-Pop GA et al. | New flavanol-anthocyanin condensed pigments and anthocyanin composition in guatemalan beans (Phaseolus spp.). | 2006 | J. Agric. Food Chem. | pmid:16417317 |
| Cooke D et al. | Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels. | 2006 | Int. J. Cancer | pmid:16823841 |
| Ding M et al. | Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. | 2006 | J. Biol. Chem. | pmid:16618699 |
| Hecht SS et al. | Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. | 2006 | Carcinogenesis | pmid:16522666 |
| Reynertson KA et al. | Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). | 2006 | J. Nat. Prod. | pmid:16933884 |
| Oliveira J et al. | Color properties of four cyanidin-pyruvic acid adducts. | 2006 | J. Agric. Food Chem. | pmid:16939355 |
| Ashton OB et al. | Pigments in avocado tissue and oil. | 2006 | J. Agric. Food Chem. | pmid:17177553 |
| Tsuda T et al. | Microarray profiling of gene expression in human adipocytes in response to anthocyanins. | 2006 | Biochem. Pharmacol. | pmid:16483547 |
| Schauss AG et al. | Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae mart. (acai). | 2006 | J. Agric. Food Chem. | pmid:17061839 |
| Muñoz-Espada AC and Watkins BA | Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells. | 2006 | J. Nutr. Biochem. | pmid:16443360 |
| Wellmann F et al. | Anthocyanidin synthase from Gerbera hybrida catalyzes the conversion of (+)-catechin to cyanidin and a novel procyanidin. | 2006 | FEBS Lett. | pmid:16494872 |
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| Netzel M et al. | Sources of antioxidant activity in Australian native fruits. Identification and quantification of anthocyanins. | 2006 | J. Agric. Food Chem. | pmid:17177507 |
| Kim AJ and Park S | Mulberry extract supplements ameliorate the inflammation-related hematological parameters in carrageenan-induced arthritic rats. | 2006 | J Med Food | pmid:17004912 |
| Solomon A et al. | Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L.). | 2006 | J. Agric. Food Chem. | pmid:17002444 |
| Walton MC et al. | The flavonol quercetin-3-glucoside inhibits cyanidin-3-glucoside absorption in vitro. | 2006 | J. Agric. Food Chem. | pmid:16787048 |
| Fang Z et al. | Chemical composition of clarified bayberry (Myrica rubra Sieb. et Zucc.) juice sediment. | 2006 | J. Agric. Food Chem. | pmid:17002443 |
| Chen PN et al. | Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. | 2006 | Chem. Biol. Interact. | pmid:16970933 |
| Kondo T et al. | Novel and efficient synthesis of cyanidin 3-O-beta-D-glucoside from (+)-catechin via a flav-3-en-3-ol as a key intermediate. | 2006 | Org. Lett. | pmid:16869672 |
| Iwai K et al. | Alpha-glucosidase inhibitory and antihyperglycemic effects of polyphenols in the fruit of Viburnum dilatatum Thunb. | 2006 | J. Agric. Food Chem. | pmid:16787002 |
| Castellarin SD et al. | Colour variation in red grapevines (Vitis vinifera L.): genomic organisation, expression of flavonoid 3'-hydroxylase, flavonoid 3',5'-hydroxylase genes and related metabolite profiling of red cyanidin-/blue delphinidin-based anthocyanins in berry skin. | 2006 | BMC Genomics | pmid:16433923 |
| Tatsuzawa F et al. | Acylated cyanidin 3-sambubioside-5-glucosides in three garden plants of the Cruciferae. | 2006 | Phytochemistry | pmid:16777160 |
| Meng L et al. | Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis. | 2006 | J. Agric. Food Chem. | pmid:16756359 |
| Yoshida K et al. | Ferric ions involved in the flower color development of the Himalayan blue poppy, Meconopsis grandis. | 2006 | Phytochemistry | pmid:16678868 |
| Felgines C et al. | Absorption and metabolism of red orange juice anthocyanins in rats. | 2006 | Br. J. Nutr. | pmid:16611379 |
| Pergola C et al. | Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. | 2006 | Nitric Oxide | pmid:16517190 |
| Tian Q et al. | Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. | 2006 | J. Agric. Food Chem. | pmid:16478275 |
| Wu X et al. | Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption. | 2006 | J. Agric. Food Chem. | pmid:16417325 |
| Pawlowska AM et al. | Phenolics of Arbutus unedo L. (Ericaceae) fruits: identification of anthocyanins and gallic acid derivatives. | 2006 | J. Agric. Food Chem. | pmid:17177565 |
| Harnly JM et al. | Flavonoid content of U.S. fruits, vegetables, and nuts. | 2006 | J. Agric. Food Chem. | pmid:17177529 |
| Cortell JM and Kennedy JA | Effect of shading on accumulation of flavonoid compounds in (Vitis vinifera L.) pinot noir fruit and extraction in a model system. | 2006 | J. Agric. Food Chem. | pmid:17061828 |
| Rahman MM et al. | Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. | 2006 | Free Radic. Res. | pmid:17015281 |
| Chirinos R et al. | High-performance liquid chromatography with photodiode array detection (HPLC-DAD)/HPLC-mass spectrometry (MS) profiling of anthocyanins from Andean Mashua Tubers (Tropaeolum tuberosum RuÃz and Pavón) and their contribution to the overall antioxidant activity. | 2006 | J. Agric. Food Chem. | pmid:16968067 |
| Ichiyanagi T et al. | Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats. | 2006 | J. Agric. Food Chem. | pmid:16939312 |
| Pinelo M et al. | Effect of clarification techniques and rat intestinal extract incubation on phenolic composition and antioxidant activity of black currant juice. | 2006 | J. Agric. Food Chem. | pmid:16939310 |
| Hieber AD et al. | Color genes in the orchid Oncidium Gower Ramsey: identification, expression, and potential genetic instability in an interspecific cross. | 2006 | Planta | pmid:16151849 |
| Ichiyanagi T et al. | Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. | 2006 | J. Agric. Food Chem. | pmid:16848510 |
| Vareed SK et al. | Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida fruits with health benefits. | 2006 | Life Sci. | pmid:16139847 |
| Jakobs S et al. | Natural flavonoids are potent inhibitors of glycogen phosphorylase. | 2006 | Mol Nutr Food Res | pmid:16317787 |
| Matsufuji H et al. | Formation and inhibition of genotoxic malonaldehyde from DNA oxidation controlled with EDTA. | 2006 | Food Chem. Toxicol. | pmid:16122862 |
| Lazzè MC et al. | Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. | 2006 | Mol Nutr Food Res | pmid:16288501 |
| Abdel-Aal el-SM et al. | Anthocyanin composition in black, blue, pink, purple, and red cereal grains. | 2006 | J. Agric. Food Chem. | pmid:16787017 |
| Espinosa-Alonso LG et al. | Polyphenols in wild and weedy Mexican common beans (Phaseolus vulgaris L.). | 2006 | J. Agric. Food Chem. | pmid:16756378 |
| Duthie SJ et al. | The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. | 2006 | Eur J Nutr | pmid:16032375 |
| Schütz K et al. | Characterization and quantification of anthocyanins in selected artichoke (Cynara scolymus L.) cultivars by HPLC-DAD-ESI-MSn. | 2006 | Anal Bioanal Chem | pmid:16534575 |
| Nakatsuka T et al. | Two different transposable elements inserted in flavonoid 3',5'-hydroxylase gene contribute to pink flower coloration in Gentiana scabra. | 2006 | Mol. Genet. Genomics | pmid:16362368 |
| Chen PN et al. | Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. | 2006 | Cancer Lett. | pmid:15975709 |
| Oak MH et al. | Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. | 2006 | Br. J. Pharmacol. | pmid:16921400 |
| Jordheim M et al. | Characterization of hemiacetal forms of anthocyanidin 3-O-beta-glycopyranosides. | 2006 | J. Agric. Food Chem. | pmid:17147416 |
| Wu X et al. | Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. | 2006 | J. Agric. Food Chem. | pmid:16719536 |
| Jin XH et al. | Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo. | 2006 | Exp. Eye Res. | pmid:16309673 |
| Jang YP et al. | Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. | 2005 May-Jun | Photochem. Photobiol. | pmid:15745429 |
| Fimognari C et al. | In vitro anticancer activity of cyanidin-3-O-beta-glucopyranoside: effects on transformed and non-transformed T lymphocytes. | 2005 Jul-Aug | Anticancer Res. | pmid:16080535 |
| Fedenko VS et al. | [Complexation of cyanidin with cadmium ions in solution]. | 2005 Jan-Feb | Ukr Biokhim Zh (1999) | pmid:16335277 |
| Duthie SJ et al. | DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro--modulation by the dietary anthocyanin, cyanidin-3-glycoside. | 2005 | Eur J Nutr | pmid:15309415 |
| Irani NG and Grotewold E | Light-induced morphological alteration in anthocyanin-accumulating vacuoles of maize cells. | 2005 | BMC Plant Biol. | pmid:15907203 |
| Shimada S et al. | Anthocyanidin synthase in non-anthocyanin-producing Caryophyllales species. | 2005 | Plant J. | pmid:16359388 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Passamonti S et al. | Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase. | 2005 | FEBS J. | pmid:15978035 |
| Kano M et al. | Antioxidative activity of anthocyanins from purple sweet potato, Ipomoera batatas cultivar Ayamurasaki. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15914919 |
| Morita Y et al. | Japanese morning glory dusky mutants displaying reddish-brown or purplish-gray flowers are deficient in a novel glycosylation enzyme for anthocyanin biosynthesis, UDP-glucose:anthocyanidin 3-O-glucoside-2''-O-glucosyltransferase, due to 4-bp insertions in the gene. | 2005 | Plant J. | pmid:15842621 |
| Honda T et al. | Acylated anthocyanins from the violet-blue flowers of Orychophragonus violaceus. | 2005 | Phytochemistry | pmid:16023157 |
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| He YH et al. | [Antioxidant and anti-inflammatory effects of cyanidin from cherries on rat adjuvant-induced arthritis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16422543 |
| Chen PN et al. | Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. | 2005 | Nutr Cancer | pmid:16573384 |
| Kim DO et al. | Sweet and sour cherry phenolics and their protective effects on neuronal cells. | 2005 | J. Agric. Food Chem. | pmid:16366675 |
| Longo L and Vasapollo G | Anthocyanins from bay (Laurus nobilis L.) berries. | 2005 | J. Agric. Food Chem. | pmid:16190671 |
| Mylnikov SV et al. | Rubus fruit juices affect lipid peroxidation in a Drosophila melanogaster model in vivo. | 2005 | J. Agric. Food Chem. | pmid:16190624 |
| Felgines C et al. | Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans. | 2005 | J. Agric. Food Chem. | pmid:16190623 |
| Longo L et al. | Identification of anthocyanins in Rhamnus alaternus L. berries. | 2005 | J. Agric. Food Chem. | pmid:15740065 |
| Stoner GD et al. | Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. | 2005 | J Clin Pharmacol | pmid:16172180 |
| Al-Farsi M et al. | Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. | 2005 | J. Agric. Food Chem. | pmid:16159191 |
| Ichiyanagi T et al. | Extended glucuronidation is another major path of cyanidin 3-O-beta-D-glucopyranoside metabolism in rats. | 2005 | J. Agric. Food Chem. | pmid:16131148 |
| Tian Q et al. | Probing anthocyanin profiles in purple sweet potato cell line (Ipomoea batatas L. Cv. Ayamurasaki) by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2005 | J. Agric. Food Chem. | pmid:16076141 |
| Punyasiri PA et al. | Preformed and induced chemical resistance of tea leaf against Exobasidium vexans infection. | 2005 | J. Chem. Ecol. | pmid:16222773 |
| Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
| Hou DX et al. | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. | 2005 | Biochem. Pharmacol. | pmid:15963474 |
| McDougall GJ et al. | Anthocyanins from red wine--their stability under simulated gastrointestinal digestion. | 2005 | Phytochemistry | pmid:16242736 |
| Talavéra S et al. | Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain. | 2005 | J. Agric. Food Chem. | pmid:15884815 |
| McDougall GJ et al. | Anthocyanin-flavanol condensation products from black currant (Ribes nigrum L.). | 2005 | J. Agric. Food Chem. | pmid:16190645 |
| Tsuda T et al. | Gene expression profile of isolated rat adipocytes treated with anthocyanins. | 2005 | Biochim. Biophys. Acta | pmid:15863361 |
| Habermeyer M et al. | Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity. | 2005 | Chem. Res. Toxicol. | pmid:16167831 |
| Bendia E et al. | Effect of cyanidin 3-O-beta-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress. | 2005 | Dig Liver Dis | pmid:15843084 |
| Innocenti M et al. | Evaluation of the phenolic content in the aerial parts of different varieties of Cichorium intybus L. | 2005 | J. Agric. Food Chem. | pmid:16076140 |
| Wu X and Prior RL | Identification and characterization of anthocyanins by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry in common foods in the United States: vegetables, nuts, and grains. | 2005 | J. Agric. Food Chem. | pmid:15826066 |
| Flamini R | Some advances in the knowledge of grape, wine and distillates chemistry as achieved by mass spectrometry. | 2005 | J Mass Spectrom | pmid:15954164 |
| Berardini N et al. | Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. | 2005 | J. Agric. Food Chem. | pmid:15740041 |
| Nakajima T et al. | Insertion and excision of a transposable element governs the red floral phenotype in commercial petunias. | 2005 | Theor. Appl. Genet. | pmid:15731929 |
| Wu X and Prior RL | Systematic identification and characterization of anthocyanins by HPLC-ESI-MS/MS in common foods in the United States: fruits and berries. | 2005 | J. Agric. Food Chem. | pmid:15796599 |
| Riso P et al. | Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. | 2005 | J. Agric. Food Chem. | pmid:15713002 |
| Zhang Y et al. | Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. | 2005 | Life Sci. | pmid:15680311 |
| Frank T et al. | Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. | 2005 | J Clin Pharmacol | pmid:15647413 |
| Jayaprakasam B et al. | Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. | 2005 | J. Agric. Food Chem. | pmid:15631504 |
| Ichiyanagi T et al. | Metabolic pathway of cyanidin 3-O-beta-D-glucopyranoside in rats. | 2005 | J. Agric. Food Chem. | pmid:15631521 |
| Russo A et al. | Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-beta-d-glucoside. | 2005 | J. Nutr. Biochem. | pmid:15629238 |
| Aura AM et al. | In vitro metabolism of anthocyanins by human gut microflora. | 2005 | Eur J Nutr | pmid:15309431 |
| Shih PH et al. | Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. | 2005 | Food Chem. Toxicol. | pmid:15964118 |
| Nielsen AH et al. | Flavonoids in flowers of 16 Kalanchoë blossfeldiana varieties. | 2005 | Phytochemistry | pmid:16297414 |