Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Saito N et al. | The blue anthocyanin pigments from the blue flowers of Heliophila coronopifolia L. (Brassicaceae). | 2011 | Phytochemistry | pmid:21903230 |
| Tatsuzawa F et al. | Acylated cyanidin 3-sambubioside-5-glucosides in three garden plants of the Cruciferae. | 2006 | Phytochemistry | pmid:16777160 |
| Seeram NP et al. | Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. | 2001 | Phytomedicine | pmid:11695879 |
| Tanaka J et al. | Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. | 2012 | Phytother Res | pmid:21633982 |
| Matsunaga N et al. | Inhibitory actions of bilberry anthocyanidins on angiogenesis. | 2010 | Phytother Res | pmid:19496063 |
| Du H et al. | Characterisation of flower colouration in 30 Rhododendron species via anthocyanin and flavonol identification and quantitative traits. | 2018 | Plant Biol (Stuttg) | pmid:29054107 |
| Mutwil M et al. | PlaNet: combined sequence and expression comparisons across plant networks derived from seven species. | 2011 | Plant Cell | pmid:21441431 |
| Rubin G et al. | Members of the LBD family of transcription factors repress anthocyanin synthesis and affect additional nitrogen responses in Arabidopsis. | 2009 | Plant Cell | pmid:19933203 |
| Zhao J and Dixon RA | MATE transporters facilitate vacuolar uptake of epicatechin 3'-O-glucoside for proanthocyanidin biosynthesis in Medicago truncatula and Arabidopsis. | 2009 | Plant Cell | pmid:19684242 |
| Marinova K et al. | The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat. | 2007 | Plant Cell | pmid:17601828 |
| Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
| Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
| Ono E et al. | Functional differentiation of the glycosyltransferases that contribute to the chemical diversity of bioactive flavonol glycosides in grapevines (Vitis vinifera). | 2010 | Plant Cell | pmid:20693356 |
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| Lee SG et al. | Contribution of Anthocyanin Composition to Total Antioxidant Capacity of Berries. | 2015 | Plant Foods Hum Nutr | pmid:26515081 |
| Aguayo-Rojas J et al. | Phytochemicals and antioxidant capacity of tortillas obtained after lime-cooking extrusion process of whole pigmented mexican maize. | 2012 | Plant Foods Hum Nutr | pmid:22562094 |
| Faramarzi S et al. | Red-fleshed Apples: Old Autochthonous Fruits as a Novel Source of Anthocyanin Antioxidants. | 2015 | Plant Foods Hum Nutr | pmid:26134879 |
| Savikin K et al. | Phenolic content and radical scavenging capacity of berries and related jams from certificated area in Serbia. | 2009 | Plant Foods Hum Nutr | pmid:19468835 |
| Montefiori M et al. | Identification and characterisation of F3GT1 and F3GGT1, two glycosyltransferases responsible for anthocyanin biosynthesis in red-fleshed kiwifruit (Actinidia chinensis). | 2011 | Plant J. | pmid:21175894 |
| Peel GJ et al. | The LAP1 MYB transcription factor orchestrates anthocyanidin biosynthesis and glycosylation in Medicago. | 2009 | Plant J. | pmid:19368693 |
| Espley RV et al. | Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10. | 2007 | Plant J. | pmid:17181777 |
| Shimada S et al. | Anthocyanidin synthase in non-anthocyanin-producing Caryophyllales species. | 2005 | Plant J. | pmid:16359388 |
| Morita Y et al. | Japanese morning glory dusky mutants displaying reddish-brown or purplish-gray flowers are deficient in a novel glycosylation enzyme for anthocyanin biosynthesis, UDP-glucose:anthocyanidin 3-O-glucoside-2''-O-glucosyltransferase, due to 4-bp insertions in the gene. | 2005 | Plant J. | pmid:15842621 |
| Tohge T et al. | Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. | 2005 | Plant J. | pmid:15807784 |
| Aharoni A et al. | The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco. | 2001 | Plant J. | pmid:11722774 |
| Yonekura-Sakakibara K et al. | Two glycosyltransferases involved in anthocyanin modification delineated by transcriptome independent component analysis in Arabidopsis thaliana. | 2012 | Plant J. | pmid:21899608 |
| Behnke K et al. | RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism under high temperature and high light intensities: a transcriptomic and metabolomic analysis. | 2010 | Plant Mol. Biol. | pmid:20526857 |
| Jaakola L et al. | A SQUAMOSA MADS box gene involved in the regulation of anthocyanin accumulation in bilberry fruits. | 2010 | Plant Physiol. | pmid:20566708 |
| Hugueney P et al. | A novel cation-dependent O-methyltransferase involved in anthocyanin methylation in grapevine. | 2009 | Plant Physiol. | pmid:19525322 |
| Han Y et al. | Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress. | 2010 | Plant Physiol. | pmid:20357139 |
| Gomez C et al. | Grapevine MATE-type proteins act as vacuolar H+-dependent acylated anthocyanin transporters. | 2009 | Plant Physiol. | pmid:19297587 |
| Osmani SA et al. | Catalytic key amino acids and UDP-sugar donor specificity of a plant glucuronosyltransferase, UGT94B1: molecular modeling substantiated by site-specific mutagenesis and biochemical analyses. | 2008 | Plant Physiol. | pmid:18829982 |
| Pang Y et al. | Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula. | 2007 | Plant Physiol. | pmid:17885080 |
| Suzuki H et al. | cDNA cloning, heterologous expressions, and functional characterization of malonyl-coenzyme a:anthocyanidin 3-o-glucoside-6"-o-malonyltransferase from dahlia flowers. | 2002 | Plant Physiol. | pmid:12481098 |
| Chiu LW et al. | The purple cauliflower arises from activation of a MYB transcription factor. | 2010 | Plant Physiol. | pmid:20855520 |
| Lo SC and Nicholson RL | Reduction of light-induced anthocyanin accumulation in inoculated sorghum mesocotyls. Implications for a compensatory role in the defense response. | 1998 | Plant Physiol. | pmid:9501130 |
| Sgherri C et al. | Elevated CO and salinity are responsible for phenolics-enrichment in two differently pigmented lettuces. | 2017 | Plant Physiol. Biochem. | pmid:28411511 |
| An CH et al. | Heterologous expression of IbMYB1a by different promoters exhibits different patterns of anthocyanin accumulation in tobacco. | 2015 | Plant Physiol. Biochem. | pmid:25681576 |
| Simões C et al. | Anthocyanin production in callus cultures of Cleome rosea: modulation by culture conditions and characterization of pigments by means of HPLC-DAD/ESIMS. | 2009 | Plant Physiol. Biochem. | pmid:19589687 |
| Toffali K et al. | Carrot-specific features of the phenylpropanoid pathway identified by feeding cultured cells with defined intermediates. | 2013 | Plant Sci. | pmid:23759106 |
| Henarejos-Escudero P et al. | Digestive glands extraction and precise pigment analysis support the exclusion of the carnivorous plant Dionaea muscipula Ellis from the Caryophyllales order. | 2018 | Plant Sci. | pmid:30080622 |
| Shi MZ and Xie DY | Features of anthocyanin biosynthesis in pap1-D and wild-type Arabidopsis thaliana plants grown in different light intensity and culture media conditions. | 2010 | Planta | pmid:20309578 |
| Ikegami A et al. | Molecular identification of 1-Cys peroxiredoxin and anthocyanidin/flavonol 3-O-galactosyltransferase from proanthocyanidin-rich young fruits of persimmon (Diospyros kaki Thunb.). | 2009 | Planta | pmid:19641937 |
| Rose A et al. | Purification and characterization of glycosyltransferases involved in anthocyanin biosynthesis in cell-suspension cultures of Daucus carota L. | 1996 | Planta | pmid:8717136 |
| Vogt T | Substrate specificity and sequence analysis define a polyphyletic origin of betanidin 5- and 6-O-glucosyltransferase from Dorotheanthus bellidiformis. | 2002 | Planta | pmid:11855654 |