Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bashandy H and Teeri TH | Genetically engineered orange petunias on the market. | 2017 | Planta | pmid:28647812 |
| Shi MZ and Xie DY | Features of anthocyanin biosynthesis in pap1-D and wild-type Arabidopsis thaliana plants grown in different light intensity and culture media conditions. | 2010 | Planta | pmid:20309578 |
| Ben-Simhon Z et al. | A pomegranate (Punica granatum L.) WD40-repeat gene is a functional homologue of Arabidopsis TTG1 and is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development. | 2011 | Planta | pmid:21643990 |
| Yuan Y et al. | Transcriptional regulation of anthocyanin biosynthesis in red cabbage. | 2009 | Planta | pmid:19756724 |
| Peng QZ et al. | An integrated approach to demonstrating the ANR pathway of proanthocyanidin biosynthesis in plants. | 2012 | Planta | pmid:22678031 |
| Zhou LL et al. | Development of tobacco callus cultures over expressing Arabidopsis PAP1/MYB75 transcription factor and characterization of anthocyanin biosynthesis. | 2008 | Planta | pmid:18766373 |
| Ikegami A et al. | Molecular identification of 1-Cys peroxiredoxin and anthocyanidin/flavonol 3-O-galactosyltransferase from proanthocyanidin-rich young fruits of persimmon (Diospyros kaki Thunb.). | 2009 | Planta | pmid:19641937 |
| Rose A et al. | Purification and characterization of glycosyltransferases involved in anthocyanin biosynthesis in cell-suspension cultures of Daucus carota L. | 1996 | Planta | pmid:8717136 |
| Page JE and Towers GH | Anthocyanins protect light-sensitive thiarubrine phototoxins. | 2002 | Planta | pmid:12111231 |
| Vogt T | Substrate specificity and sequence analysis define a polyphyletic origin of betanidin 5- and 6-O-glucosyltransferase from Dorotheanthus bellidiformis. | 2002 | Planta | pmid:11855654 |
| Khandelwal N and Abraham SK | Protective effects of common anthocyanidins against genotoxic damage induced by chemotherapeutic drugs in mice. | 2014 | Planta Med. | pmid:25184891 |
| Yang Y et al. | SNARE-wedging polyphenols as small molecular botox. | 2012 | Planta Med. | pmid:22109835 |
| Brown PN et al. | Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis. | 2012 | Planta Med. | pmid:22337317 |
| Gharib A et al. | In vitro and in vivo antibacterial activities of cyanidinum chloride-loaded liposomes against a resistant strain of Pseudomonas aeruginosa. | 2013 | Planta Med. | pmid:23203413 |
| Gharib A et al. | Treatment of diabetes in the mouse model by delphinidin and cyanidin hydrochloride in free and liposomal forms. | 2013 | Planta Med. | pmid:24108435 |
| Arapitsas P et al. | A metabolomic approach to the study of wine micro-oxygenation. | 2012 | PLoS ONE | pmid:22662221 |
| Ahn JH et al. | De Novo Transcriptome Analysis to Identify Anthocyanin Biosynthesis Genes Responsible for Tissue-Specific Pigmentation in Zoysiagrass (Zoysia japonica Steud.). | 2015 | PLoS ONE | pmid:25905914 |
| Miosic S et al. | Dihydroflavonol 4-reductase genes encode enzymes with contrasting substrate specificity and show divergent gene expression profiles in Fragaria species. | 2014 | PLoS ONE | pmid:25393679 |
| Cheng DM et al. | Development and phytochemical characterization of high polyphenol red lettuce with anti-diabetic properties. | 2014 | PLoS ONE | pmid:24637790 |
| Zhu M et al. | Relationship between the composition of flavonoids and flower colors variation in tropical water lily (Nymphaea) cultivars. | 2012 | PLoS ONE | pmid:22485167 |
| Fujimura Y et al. | Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars. | 2011 | PLoS ONE | pmid:21853132 |
| Shimazaki M et al. | Pink-colored grape berry is the result of short insertion in intron of color regulatory gene. | 2011 | PLoS ONE | pmid:21695059 |
| Poobathy R et al. | Autofluorescence study and selected cyanidin quantification in the Jewel orchids Anoectochilus sp. and Ludisia discolor. | 2018 | PLoS ONE | pmid:29649288 |
| Kumar S et al. | Genomic selection for fruit quality traits in apple (Malus×domestica Borkh.). | 2012 | PLoS ONE | pmid:22574211 |
| Sharif T et al. | Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells. | 2012 | PLoS ONE | pmid:22412883 |
| Yoshimura Y et al. | Different localization patterns of anthocyanin species in the pericarp of black rice revealed by imaging mass spectrometry. | 2012 | PLoS ONE | pmid:22363605 |
| Alvarez-Suarez JM et al. | Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. | 2011 | PLoS ONE | pmid:22016781 |
| He Q et al. | Natural variation in petal color in Lycoris longituba revealed by anthocyanin components. | 2011 | PLoS ONE | pmid:21829604 |
| Wei YZ et al. | Differential expression of anthocyanin biosynthetic genes in relation to anthocyanin accumulation in the pericarp of Litchi chinensis Sonn. | 2011 | PLoS ONE | pmid:21559331 |
| Feng Y et al. | A three-component gene expression system and its application for inducible flavonoid overproduction in transgenic Arabidopsis thaliana. | 2011 | PLoS ONE | pmid:21408135 |
| Yang Y et al. | Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21135223 |
| Daveri E et al. | Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. | 2018 | Redox Biol | pmid:29890336 |
| Qaâdan F et al. | Polyphenols from Ginkgo biloba. | 2010 Oct-Dec | Sci Pharm | pmid:21179324 |
| Liu C et al. | The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo. | 2017 | Sci Signal | pmid:28223414 |
| JOSLYN MA and GOLDSTEIN JL | CONVERSION OF LEUCOANTHOCYANINS INTO THE CORRESPONDING ANTHOCYANIDINS. | 1964 | Science | pmid:14090143 |
| Oloyede FM et al. | Effect of NPK fertilizer on chemical composition of pumpkin (Cucurbita pepo Linn.) seeds. | 2012 | ScientificWorldJournal | pmid:22629204 |
| Taha RM and Wafa SN | Plant regeneration and cellular behaviour studies in Celosia cristata grown in vivo and in vitro. | 2012 | ScientificWorldJournal | pmid:22593677 |
| Agostini F et al. | Supercritical extraction from vinification residues: fatty acids, α-tocopherol, and phenolic compounds in the oil seeds from different varieties of grape. | 2012 | ScientificWorldJournal | pmid:22593706 |
| Wolniak M and Wawer I | (13)C CPMAS NMR and DFT calculations of anthocyanidins. | Solid State Nucl Magn Reson | pmid:18657953 | |
| Lim A et al. | Potential natural sensitizers extracted from the skin of Canarium odontophyllum fruits for dye-sensitized solar cells. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25541396 |
| Khaodee W et al. | Effectively simultaneous naked-eye detection of Cu(II), Pb(II), Al(III) and Fe(III) using cyanidin extracted from red cabbage as chelating agent. | 2014 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:24594882 |
| Dimitrić Marković JM et al. | Electronic and infrared vibrational analysis of cyanidin-quercetin copigment complex. | 2005 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:16257774 |
| Romera-Fernández M et al. | Feasibility study of FT-MIR spectroscopy and PLS-R for the fast determination of anthocyanins in wine. | 2012 | Talanta | pmid:22265503 |
| Bushakra JM et al. | QTL involved in the modification of cyanidin compounds in black and red raspberry fruit. | 2013 | Theor. Appl. Genet. | pmid:23224381 |
| Zhang Y et al. | The potato R locus codes for dihydroflavonol 4-reductase. | 2009 | Theor. Appl. Genet. | pmid:19588118 |
| Nakajima T et al. | Insertion and excision of a transposable element governs the red floral phenotype in commercial petunias. | 2005 | Theor. Appl. Genet. | pmid:15731929 |
| Glei M et al. | Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. | 2003 Oct-Dec | Toxicol In Vitro | pmid:14599469 |
| Jing Yu V et al. | Identification of components of grape powder with anti-apoptotic effects. | 2011 | Toxicol Ind Health | pmid:20699283 |
| Fusi E et al. | Alpha-tocopherol counteracts the cytotoxicity induced by ochratoxin a in primary porcine fibroblasts. | 2010 | Toxins (Basel) | pmid:22069637 |
| Sorrenti V et al. | Dimethylarginine dimethylaminohydrolase/nitric oxide synthase pathway in liver and kidney: protective effect of cyanidin 3-O-β-D-glucoside on ochratoxin-A toxicity. | 2012 | Toxins (Basel) | pmid:22778905 |