Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Xie DY et al. | Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. | 2004 | Arch. Biochem. Biophys. | pmid:14725861 |
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| Austin HR et al. | Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24393842 |
| Kamsteeg J et al. | Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica). | 1978 | Biochem. Genet. | pmid:751640 |
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| Guo H et al. | Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation. | 2008 | Biochem. Pharmacol. | pmid:18179781 |
| Sasaki R et al. | Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. | 2007 | Biochem. Pharmacol. | pmid:17869225 |
| Hou DX et al. | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. | 2005 | Biochem. Pharmacol. | pmid:15963474 |
| Gryglewski RJ et al. | On the mechanism of antithrombotic action of flavonoids. | 1987 | Biochem. Pharmacol. | pmid:3101704 |
| Virmaux N et al. | Modulation of rod cyclic GMP-phosphodiesterase activity by anthocyanidin derivatives. | 1990 | Biochem. Soc. Trans. | pmid:2177424 |
| Jia Y et al. | Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid. | 2013 | Biochim. Biophys. Acta | pmid:23228689 |
| Kuhn I et al. | Schistosoma mansoni NAD(+) catabolizing enzyme: identification of key residues in catalysis. | 2013 | Biochim. Biophys. Acta | pmid:24035885 |
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| Yi L et al. | Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids. | 2012 | Biochimie | pmid:22683914 |
| Scalzo J et al. | The anthocyanin composition of different Vaccinium, Ribes and Rubus genotypes. | 2008 | Biofactors | pmid:19706968 |
| Iwai K et al. | Physiological effects and active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress. | 2004 | Biofactors | pmid:15630210 |
| Lagoa R et al. | Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity. | 2017 | Biofactors | pmid:28317253 |
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| Kanwal S et al. | Docking of human rhodopsin mutant (Gly90→Asp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness. | 2012 | Bioinformation | pmid:22368384 |
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| Choi MJ et al. | Anti-aging effects of cyanidin under a stress-induced premature senescence cellular system. | 2010 | Biol. Pharm. Bull. | pmid:20190403 |
| Takasawa R et al. | Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. | 2010 | Bioorg. Med. Chem. | pmid:20801663 |
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| Turnbull JJ et al. | The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14552794 |
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