Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Redus M et al. | Rate and equilibrium constants for the dehydration and deprotonation reactions of some monoacylated and glycosylated cyanidin derivatives. | 1999 | J. Agric. Food Chem. | pmid:10552670 |
| Terahara N et al. | Anthocyanins from red flower tea (Benibana-cha), Camellia sinensis. | 2001 | Phytochemistry | pmid:11249101 |
| Tanaka M et al. | A malonylated anthocyanin and flavonols in blue Meconopsis flowers. | 2001 | Phytochemistry | pmid:11249104 |
| Meiers S et al. | The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. | 2001 | J. Agric. Food Chem. | pmid:11262056 |
| Matsui T et al. | alpha-Glucosidase inhibitory action of natural acylated anthocyanins. 2. alpha-Glucosidase inhibition by isolated acylated anthocyanins. | 2001 | J. Agric. Food Chem. | pmid:11308352 |
| Matsumoto H et al. | Preparative-scale isolation of four anthocyanin components of black currant (Ribes nigrum L.) fruits. | 2001 | J. Agric. Food Chem. | pmid:11312893 |
| Matsumoto H et al. | Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. | 2001 | J. Agric. Food Chem. | pmid:11312894 |
| Nakajima J et al. | Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis. | 2001 | J. Biol. Chem. | pmid:11316805 |
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| Bloor SJ and Abrahams S | The structure of the major anthocyanin in Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:11830144 |
| Vogt T | Substrate specificity and sequence analysis define a polyphyletic origin of betanidin 5- and 6-O-glucosyltransferase from Dorotheanthus bellidiformis. | 2002 | Planta | pmid:11855654 |
| Gennaro L et al. | Flavonoid and carbohydrate contents in Tropea red onions: effects of homelike peeling and storage. | 2002 | J. Agric. Food Chem. | pmid:11902931 |
| Seeram NP et al. | Characterization, quantification, and bioactivities of anthocyanins in Cornus species. | 2002 | J. Agric. Food Chem. | pmid:11958615 |
| Slimestad R and Solheim H | Anthocyanins from black currants (Ribes nigrum L.). | 2002 | J. Agric. Food Chem. | pmid:12009991 |
| Romani A et al. | Identification and quantification of galloyl derivatives, flavonoid glycosides and anthocyanins in leaves of Pistacia lentiscus L. | Phytochem Anal | pmid:12018027 | |
| Saito N et al. | Acylated anthocyanins from the blue-violet flowers of Anemone coronaria. | 2002 | Phytochemistry | pmid:12031427 |
| Milbury PE et al. | Bioavailablility of elderberry anthocyanins. | 2002 | Mech. Ageing Dev. | pmid:12044949 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
| Briviba K et al. | Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. | 2001 | Nutr Cancer | pmid:12094622 |
| Page JE and Towers GH | Anthocyanins protect light-sensitive thiarubrine phototoxins. | 2002 | Planta | pmid:12111231 |
| Es-Safi NE et al. | Interactions between cyanidin 3-O-glucoside and furfural derivatives and their impact on food color changes. | 2002 | J. Agric. Food Chem. | pmid:12236682 |
| Cantos E et al. | Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. | 2002 | J. Agric. Food Chem. | pmid:12236700 |
| Yan X et al. | Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon). | 2002 | J. Agric. Food Chem. | pmid:12358448 |
| Stintzing FC et al. | Color and antioxidant properties of cyanidin-based anthocyanin pigments. | 2002 | J. Agric. Food Chem. | pmid:12358498 |
| Wang SY et al. | Cultural system affects fruit quality and antioxidant capacity in strawberries. | 2002 | J. Agric. Food Chem. | pmid:12381146 |
| Frank J et al. | Effects of dietary anthocyanins on tocopherols and lipids in rats. | 2002 | J. Agric. Food Chem. | pmid:12452636 |
| Eiro MJ and Heinonen M | Anthocyanin color behavior and stability during storage: effect of intermolecular copigmentation. | 2002 | J. Agric. Food Chem. | pmid:12452676 |
| Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
| Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
| Suzuki H et al. | cDNA cloning, heterologous expressions, and functional characterization of malonyl-coenzyme a:anthocyanidin 3-o-glucoside-6"-o-malonyltransferase from dahlia flowers. | 2002 | Plant Physiol. | pmid:12481098 |
| Escribano-Bailón MT et al. | Anthocyanin composition of the fruit of Coriaria myrtifolia L. | 2002 Nov-Dec | Phytochem Anal | pmid:12494755 |
| Islam MS et al. | Anthocyanin compositions in sweetpotato (Ipomoea batatas L.) leaves. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12506993 |
| Zheng W and Wang SY | Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. | 2003 | J. Agric. Food Chem. | pmid:12517117 |
| Wolfe K et al. | Antioxidant activity of apple peels. | 2003 | J. Agric. Food Chem. | pmid:12537430 |
| Kähkönen MP and Heinonen M | Antioxidant activity of anthocyanins and their aglycons. | 2003 | J. Agric. Food Chem. | pmid:12537433 |
| Lazzé MC et al. | Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. | 2003 | Mutat. Res. | pmid:12547288 |
| Katsuzaki H et al. | Cyanidin 3-O-beta-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells. | Oncol. Rep. | pmid:12579261 | |
| Wolfe KL and Liu RH | Apple peels as a value-added food ingredient. | 2003 | J. Agric. Food Chem. | pmid:12617604 |
| Cambie RC and Ferguson LR | Potential functional foods in the traditional Maori diet. | Mutat. Res. | pmid:12628508 | |
| Youdim KA et al. | Interaction between flavonoids and the blood-brain barrier: in vitro studies. | 2003 | J. Neurochem. | pmid:12641740 |
| Wang H et al. | Characterization of anthocyanins in grape juices by ion trap liquid chromatography-mass spectrometry. | 2003 | J. Agric. Food Chem. | pmid:12643639 |
| Tatsuzawa F et al. | 6-Hydroxypelargonidin glycosides in the orange-red flowers of Alstroemeria. | 2003 | Phytochemistry | pmid:12648544 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Abdel-Aal el-SM and Hucl P | Composition and stability of anthocyanins in blue-grained wheat. | 2003 | J. Agric. Food Chem. | pmid:12670152 |
| Kang SY et al. | Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. | 2003 | Cancer Lett. | pmid:12706854 |
| Matsumoto H et al. | Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. | 2003 | J. Agric. Food Chem. | pmid:12769524 |
| Frank T et al. | Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774848 |
| Asenstorfer RE et al. | Purification of anthocyanins from species of Banksia and Acacia using high-voltage paper electrophoresis. | Phytochem Anal | pmid:12793461 | |
| Serraino I et al. | Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. | 2003 | Life Sci. | pmid:12818719 |
| Kaneko T et al. | Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843669 |
| Wang SY et al. | Elevated carbon dioxide increases contents of antioxidant compounds in field-grown strawberries. | 2003 | J. Agric. Food Chem. | pmid:12848504 |
| Fossen T and Øvstedal DO | Anthocyanins from flowers of the orchids Dracula chimaera and D. cordobae. | 2003 | Phytochemistry | pmid:12877919 |
| Conn S et al. | Anthocyanic vacuolar inclusions (AVIs) selectively bind acylated anthocyanins in Vitis vinifera L. (grapevine) suspension culture. | 2003 | Biotechnol. Lett. | pmid:12889790 |
| Gonnet JF | Origin of the color of Cv. rhapsody in blue rose and some other so-called "blue" roses. | 2003 | J. Agric. Food Chem. | pmid:12903958 |
| Andlauer W et al. | Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol. | 2003 | Eur J Nutr | pmid:12923653 |
| Seeram NP et al. | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. | 2003 | Nutr Cancer | pmid:12925310 |
| Hu C et al. | Black rice (Oryza sativa L. indica) pigmented fraction suppresses both reactive oxygen species and nitric oxide in chemical and biological model systems. | 2003 | J. Agric. Food Chem. | pmid:12926869 |
| Kuskoski EM et al. | Characterization of anthocyanins from the fruits of baguaçu (Eugenia umbelliflora Berg). | 2003 | J. Agric. Food Chem. | pmid:12926896 |
| Marles MA et al. | New perspectives on proanthocyanidin biochemistry and molecular regulation. | 2003 | Phytochemistry | pmid:12943753 |
| Curtin C et al. | Manipulating anthocyanin composition in Vitis vinifera suspension cultures by elicitation with jasmonic acid and light irradiation. | 2003 | Biotechnol. Lett. | pmid:12966999 |
| Nielsen IL et al. | Quantification of anthocyanins in commercial black currant juices by simple high-performance liquid chromatography. Investigation of their pH stability and antioxidative potency. | 2003 | J. Agric. Food Chem. | pmid:13129285 |
| JOSLYN MA and GOLDSTEIN JL | CONVERSION OF LEUCOANTHOCYANINS INTO THE CORRESPONDING ANTHOCYANIDINS. | 1964 | Science | pmid:14090143 |
| Kim MY et al. | Identification and antiradical properties of anthocyanins in fruits of Viburnum dilatatum thunb. | 2003 | J. Agric. Food Chem. | pmid:14518940 |
| Tsao R et al. | Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). | 2003 | J. Agric. Food Chem. | pmid:14518966 |
| Turnbull JJ et al. | The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14552794 |
| Yoshimura Y et al. | Evaluation of the NO scavenging activity of procyanidin in grape seed by use of the TMA-PTIO/NOC 7 ESR system. | 2003 | J. Agric. Food Chem. | pmid:14558755 |
| Kim DO et al. | Quantification of polyphenolics and their antioxidant capacity in fresh plums. | 2003 | J. Agric. Food Chem. | pmid:14558771 |
| Reiersen B et al. | Anthocyanins acylated with gallic acid from chenille plant, Acalypha hispida. | 2003 | Phytochemistry | pmid:14559283 |
| Määttä KR et al. | High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: ribes species. | 2003 | J. Agric. Food Chem. | pmid:14582969 |
| Glei M et al. | Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. | 2003 Oct-Dec | Toxicol In Vitro | pmid:14599469 |
| Choung MG et al. | Anthocyanin profile of Korean cultivated kidney bean (Phaseolus vulgaris L.). | 2003 | J. Agric. Food Chem. | pmid:14611168 |
| Fossen T et al. | Anthocyanins with 4'-glucosidation from red onion, Allium cepa. | 2003 | Phytochemistry | pmid:14630001 |
| Pale E et al. | Two triacylated and tetraglucosylated anthocyanins from Ipomoea asarifolia flowers. | 2003 | Phytochemistry | pmid:14630005 |
| Ella Missang C et al. | Flavonols and anthocyanins of bush butter, Dacryodes edulis (G. Don) H.J. Lam, fruit. changes in their composition during ripening. | 2003 | J. Agric. Food Chem. | pmid:14640602 |
| Wang LS et al. | Chemical taxonomy of the Xibei tree peony from China by floral pigmentation. | 2004 | J. Plant Res. | pmid:14685820 |
| Acquaviva R et al. | Cyanidin and cyanidin 3-O-beta-D -glucoside as DNA cleavage protectors and antioxidants. | 2003 | Cell Biol. Toxicol. | pmid:14686616 |
| Chun OK et al. | Superoxide radical scavenging activity of the major polyphenols in fresh plums. | 2003 | J. Agric. Food Chem. | pmid:14690398 |
| Caldwell CR | Alkylperoxyl radical scavenging activity of red leaf lettuce (Lactuca sativa L.) phenolics. | 2003 | J. Agric. Food Chem. | pmid:14705882 |
| Galvano F et al. | Cyanidins: metabolism and biological properties. | 2004 | J. Nutr. Biochem. | pmid:14711454 |
| Sugita O et al. | A new method of measuring the antioxidant activity of polyphenols using cumene hydroperoxide. | 2004 | Ann. Clin. Biochem. | pmid:14713390 |
| Su V and Hsu BD | Cloning and expression of a putative cytochrome P450 gene that influences the colour of Phalaenopsis flowers. | 2003 | Biotechnol. Lett. | pmid:14719829 |
| Xie DY et al. | Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. | 2004 | Arch. Biochem. Biophys. | pmid:14725861 |
| Lee JH and Talcott ST | Fruit maturity and juice extraction influences ellagic acid derivatives and other antioxidant polyphenolics in muscadine grapes. | 2004 | J. Agric. Food Chem. | pmid:14733522 |
| Fimognari C et al. | Effect of cyanidin 3-O-beta-glucopyranoside on micronucleus induction in cultured human lymphocytes by four different mutagens. | 2004 | Environ. Mol. Mutagen. | pmid:14743345 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
| Beckwith AG et al. | Relationship of light quantity and anthocyanin production in Pennisetum setaceum Cvs. rubrum and red riding hood. | 2004 | J. Agric. Food Chem. | pmid:14759132 |
| Gonçalves B et al. | Effect of ripeness and postharvest storage on the phenolic profiles of Cherries (Prunus avium L.). | 2004 | J. Agric. Food Chem. | pmid:14759143 |