Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fang J | Classification of fruits based on anthocyanin types and relevance to their health effects. | Nutrition | pmid:26250485 | |
| Gargouri M et al. | The epimerase activity of anthocyanidin reductase from Vitis vinifera and its regiospecific hydride transfers. | Biol. Chem. | pmid:20030585 | |
| Owens DK and McIntosh CA | Identification, recombinant expression, and biochemical characterization of a flavonol 3-O-glucosyltransferase clone from Citrus paradisi. | Phytochemistry | pmid:19733370 | |
| Hanlon PR and Barnes DM | Phytochemical composition and biological activity of 8 varieties of radish (Raphanus sativus L.) sprouts and mature taproots. | J. Food Sci. | pmid:21535648 | |
| Tirupula KC et al. | pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 2. Functional aspects. | Photochem. Photobiol. | pmid:19267871 | |
| Yanamala N et al. | pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 1. Structural aspects. | Photochem. Photobiol. | pmid:19192199 | |
| Walton MC et al. | Viscous food matrix influences absorption and excretion but not metabolism of blackcurrant anthocyanins in rats. | J. Food Sci. | pmid:19200098 | |
| Wolniak M and Wawer I | (13)C CPMAS NMR and DFT calculations of anthocyanidins. | Solid State Nucl Magn Reson | pmid:18657953 | |
| pmid: | ||||
| Afaq F et al. | Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. | Photochem. Photobiol. | pmid:15493960 | |
| Asenstorfer RE et al. | Purification of anthocyanins from species of Banksia and Acacia using high-voltage paper electrophoresis. | Phytochem Anal | pmid:12793461 | |
| Romani A et al. | Identification and quantification of galloyl derivatives, flavonoid glycosides and anthocyanins in leaves of Pistacia lentiscus L. | Phytochem Anal | pmid:12018027 | |
| Cambie RC and Ferguson LR | Potential functional foods in the traditional Maori diet. | Mutat. Res. | pmid:12628508 | |
| Katsuzaki H et al. | Cyanidin 3-O-beta-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells. | Oncol. Rep. | pmid:12579261 | |
| JOSLYN MA and GOLDSTEIN JL | CONVERSION OF LEUCOANTHOCYANINS INTO THE CORRESPONDING ANTHOCYANIDINS. | 1964 | Science | pmid:14090143 |
| Schippers PG and Prop FJ | Delphinidin- and cyanidin-chlorides, promotors of cell aggregation in vitro. | 1978 | Cell Biol. Int. Rep. | pmid:667963 |
| Kamsteeg J et al. | Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica). | 1978 | Biochem. Genet. | pmid:751640 |
| Gryglewski RJ et al. | On the mechanism of antithrombotic action of flavonoids. | 1987 | Biochem. Pharmacol. | pmid:3101704 |
| Cristoni A et al. | Effect of a natural flavonoid on gastric mucosal barrier. | 1989 | Arzneimittelforschung | pmid:2757676 |
| Virmaux N et al. | Modulation of rod cyclic GMP-phosphodiesterase activity by anthocyanidin derivatives. | 1990 | Biochem. Soc. Trans. | pmid:2177424 |
| Barzaghi N et al. | Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects. | 1991 | Ital J Gastroenterol | pmid:1742514 |
| Rose A et al. | Purification and characterization of glycosyltransferases involved in anthocyanin biosynthesis in cell-suspension cultures of Daucus carota L. | 1996 | Planta | pmid:8717136 |
| Tsuda T et al. | Oxidation products of cyanidin 3-O-beta-D-glucoside with a free radical initiator. | 1996 | Lipids | pmid:8972458 |
| Goda Y et al. | Two acylated anthocyanins from purple sweet potato. | 1997 | Phytochemistry | pmid:8983218 |
| Lo SC and Nicholson RL | Reduction of light-induced anthocyanin accumulation in inoculated sorghum mesocotyls. Implications for a compensatory role in the defense response. | 1998 | Plant Physiol. | pmid:9501130 |
| Wang H et al. | Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. | 1999 | J. Nat. Prod. | pmid:10075763 |
| Redus M et al. | Rate and equilibrium constants for the dehydration and deprotonation reactions of some monoacylated and glycosylated cyanidin derivatives. | 1999 | J. Agric. Food Chem. | pmid:10552670 |
| Briviba K et al. | Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. | 2001 | Nutr Cancer | pmid:12094622 |
| Fossen T et al. | Anthocyanins from maize (Zea mays) and reed canarygrass (Phalaris arundinacea). | 2001 | J. Agric. Food Chem. | pmid:11368596 |
| Matsui T et al. | alpha-Glucosidase inhibitory action of natural acylated anthocyanins. 2. alpha-Glucosidase inhibition by isolated acylated anthocyanins. | 2001 | J. Agric. Food Chem. | pmid:11308352 |
| Aharoni A et al. | The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco. | 2001 | Plant J. | pmid:11722774 |
| Nakajima J et al. | Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis. | 2001 | J. Biol. Chem. | pmid:11316805 |
| Meiers S et al. | The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. | 2001 | J. Agric. Food Chem. | pmid:11262056 |
| Tanaka M et al. | A malonylated anthocyanin and flavonols in blue Meconopsis flowers. | 2001 | Phytochemistry | pmid:11249104 |
| Ramirez-Tortosa C et al. | Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats. | 2001 | Free Radic. Biol. Med. | pmid:11677035 |
| Nyman NA and Kumpulainen JT | Determination of anthocyanidins in berries and red wine by high-performance liquid chromatography. | 2001 | J. Agric. Food Chem. | pmid:11559107 |
| Terahara N et al. | Acylated anthocyanidin 3-sophoroside-5-glucosides from Ajuga reptans flowers and the corresponding cell cultures. | 2001 | Phytochemistry | pmid:11557083 |
| Matsumoto H et al. | Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. | 2001 | J. Agric. Food Chem. | pmid:11312894 |
| Matsumoto H et al. | Preparative-scale isolation of four anthocyanin components of black currant (Ribes nigrum L.) fruits. | 2001 | J. Agric. Food Chem. | pmid:11312893 |
| Terahara N et al. | Anthocyanins from red flower tea (Benibana-cha), Camellia sinensis. | 2001 | Phytochemistry | pmid:11249101 |
| Seeram NP et al. | Degradation products of cyanidin glycosides from tart cherries and their bioactivities. | 2001 | J. Agric. Food Chem. | pmid:11600045 |
| Wang SY and Zheng W | Effect of plant growth temperature on antioxidant capacity in strawberry. | 2001 | J. Agric. Food Chem. | pmid:11600054 |
| Seeram NP et al. | Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. | 2001 | Phytomedicine | pmid:11695879 |
| Chandra A et al. | Separation, identification, quantification, and method validation of anthocyanins in botanical supplement raw materials by HPLC and HPLC-MS. | 2001 | J. Agric. Food Chem. | pmid:11513621 |
| Stintzing FC et al. | Color and antioxidant properties of cyanidin-based anthocyanin pigments. | 2002 | J. Agric. Food Chem. | pmid:12358498 |
| Islam MS et al. | Anthocyanin compositions in sweetpotato (Ipomoea batatas L.) leaves. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12506993 |
| Suzuki H et al. | cDNA cloning, heterologous expressions, and functional characterization of malonyl-coenzyme a:anthocyanidin 3-o-glucoside-6"-o-malonyltransferase from dahlia flowers. | 2002 | Plant Physiol. | pmid:12481098 |
| Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
| Frank J et al. | Effects of dietary anthocyanins on tocopherols and lipids in rats. | 2002 | J. Agric. Food Chem. | pmid:12452636 |
| Noda Y et al. | Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. | 2002 | J. Agric. Food Chem. | pmid:11754562 |
| Saito N et al. | Acylated anthocyanins from the blue-violet flowers of Anemone coronaria. | 2002 | Phytochemistry | pmid:12031427 |
| Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
| Slimestad R and Solheim H | Anthocyanins from black currants (Ribes nigrum L.). | 2002 | J. Agric. Food Chem. | pmid:12009991 |
| Seeram NP et al. | Characterization, quantification, and bioactivities of anthocyanins in Cornus species. | 2002 | J. Agric. Food Chem. | pmid:11958615 |
| Gennaro L et al. | Flavonoid and carbohydrate contents in Tropea red onions: effects of homelike peeling and storage. | 2002 | J. Agric. Food Chem. | pmid:11902931 |
| Cantos E et al. | Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. | 2002 | J. Agric. Food Chem. | pmid:12236700 |
| Wang J and Mazza G | Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. | 2002 | J. Agric. Food Chem. | pmid:11829656 |
| Eiro MJ and Heinonen M | Anthocyanin color behavior and stability during storage: effect of intermolecular copigmentation. | 2002 | J. Agric. Food Chem. | pmid:12452676 |
| Wang SY et al. | Cultural system affects fruit quality and antioxidant capacity in strawberries. | 2002 | J. Agric. Food Chem. | pmid:12381146 |
| Yan X et al. | Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon). | 2002 | J. Agric. Food Chem. | pmid:12358448 |
| Es-Safi NE et al. | Interactions between cyanidin 3-O-glucoside and furfural derivatives and their impact on food color changes. | 2002 | J. Agric. Food Chem. | pmid:12236682 |
| Page JE and Towers GH | Anthocyanins protect light-sensitive thiarubrine phototoxins. | 2002 | Planta | pmid:12111231 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
| Milbury PE et al. | Bioavailablility of elderberry anthocyanins. | 2002 | Mech. Ageing Dev. | pmid:12044949 |
| Bloor SJ and Abrahams S | The structure of the major anthocyanin in Arabidopsis thaliana. | 2002 | Phytochemistry | pmid:11830144 |
| Stintzing FC et al. | A novel zwitterionic anthocyanin from evergreen blackberry (Rubus laciniatus Willd.). | 2002 | J. Agric. Food Chem. | pmid:11782214 |
| Vogt T | Substrate specificity and sequence analysis define a polyphyletic origin of betanidin 5- and 6-O-glucosyltransferase from Dorotheanthus bellidiformis. | 2002 | Planta | pmid:11855654 |
| Escribano-Bailón MT et al. | Anthocyanin composition of the fruit of Coriaria myrtifolia L. | 2002 Nov-Dec | Phytochem Anal | pmid:12494755 |
| Kang SY et al. | Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. | 2003 | Cancer Lett. | pmid:12706854 |
| Kaneko T et al. | Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843669 |
| Acquaviva R et al. | Cyanidin and cyanidin 3-O-beta-D -glucoside as DNA cleavage protectors and antioxidants. | 2003 | Cell Biol. Toxicol. | pmid:14686616 |
| Tsao R et al. | Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). | 2003 | J. Agric. Food Chem. | pmid:14518966 |
| Curtin C et al. | Manipulating anthocyanin composition in Vitis vinifera suspension cultures by elicitation with jasmonic acid and light irradiation. | 2003 | Biotechnol. Lett. | pmid:12966999 |
| Pale E et al. | Two triacylated and tetraglucosylated anthocyanins from Ipomoea asarifolia flowers. | 2003 | Phytochemistry | pmid:14630005 |
| Kähkönen MP and Heinonen M | Antioxidant activity of anthocyanins and their aglycons. | 2003 | J. Agric. Food Chem. | pmid:12537433 |
| Tatsuzawa F et al. | 6-Hydroxypelargonidin glycosides in the orange-red flowers of Alstroemeria. | 2003 | Phytochemistry | pmid:12648544 |
| Yoshimura Y et al. | Evaluation of the NO scavenging activity of procyanidin in grape seed by use of the TMA-PTIO/NOC 7 ESR system. | 2003 | J. Agric. Food Chem. | pmid:14558755 |
| Turnbull JJ et al. | The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14552794 |
| Su V and Hsu BD | Cloning and expression of a putative cytochrome P450 gene that influences the colour of Phalaenopsis flowers. | 2003 | Biotechnol. Lett. | pmid:14719829 |
| Choung MG et al. | Anthocyanin profile of Korean cultivated kidney bean (Phaseolus vulgaris L.). | 2003 | J. Agric. Food Chem. | pmid:14611168 |
| Nielsen IL et al. | Quantification of anthocyanins in commercial black currant juices by simple high-performance liquid chromatography. Investigation of their pH stability and antioxidative potency. | 2003 | J. Agric. Food Chem. | pmid:13129285 |
| Frank T et al. | Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice. | 2003 | Can. J. Physiol. Pharmacol. | pmid:12774848 |
| Fukui Y et al. | A rationale for the shift in colour towards blue in transgenic carnation flowers expressing the flavonoid 3',5'-hydroxylase gene. | 2003 | Phytochemistry | pmid:12657292 |
| Wang H et al. | Characterization of anthocyanins in grape juices by ion trap liquid chromatography-mass spectrometry. | 2003 | J. Agric. Food Chem. | pmid:12643639 |
| Lazzé MC et al. | Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. | 2003 | Mutat. Res. | pmid:12547288 |
| Caldwell CR | Alkylperoxyl radical scavenging activity of red leaf lettuce (Lactuca sativa L.) phenolics. | 2003 | J. Agric. Food Chem. | pmid:14705882 |
| Chun OK et al. | Superoxide radical scavenging activity of the major polyphenols in fresh plums. | 2003 | J. Agric. Food Chem. | pmid:14690398 |
| Ella Missang C et al. | Flavonols and anthocyanins of bush butter, Dacryodes edulis (G. Don) H.J. Lam, fruit. changes in their composition during ripening. | 2003 | J. Agric. Food Chem. | pmid:14640602 |
| Fossen T et al. | Anthocyanins with 4'-glucosidation from red onion, Allium cepa. | 2003 | Phytochemistry | pmid:14630001 |
| Määttä KR et al. | High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: ribes species. | 2003 | J. Agric. Food Chem. | pmid:14582969 |
| Reiersen B et al. | Anthocyanins acylated with gallic acid from chenille plant, Acalypha hispida. | 2003 | Phytochemistry | pmid:14559283 |
| Kim DO et al. | Quantification of polyphenolics and their antioxidant capacity in fresh plums. | 2003 | J. Agric. Food Chem. | pmid:14558771 |
| Kim MY et al. | Identification and antiradical properties of anthocyanins in fruits of Viburnum dilatatum thunb. | 2003 | J. Agric. Food Chem. | pmid:14518940 |
| Wang SY et al. | Elevated carbon dioxide increases contents of antioxidant compounds in field-grown strawberries. | 2003 | J. Agric. Food Chem. | pmid:12848504 |
| Serraino I et al. | Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. | 2003 | Life Sci. | pmid:12818719 |
| Matsumoto H et al. | Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. | 2003 | J. Agric. Food Chem. | pmid:12769524 |
| Abdel-Aal el-SM and Hucl P | Composition and stability of anthocyanins in blue-grained wheat. | 2003 | J. Agric. Food Chem. | pmid:12670152 |
| Wolfe KL and Liu RH | Apple peels as a value-added food ingredient. | 2003 | J. Agric. Food Chem. | pmid:12617604 |
| Wolfe K et al. | Antioxidant activity of apple peels. | 2003 | J. Agric. Food Chem. | pmid:12537430 |
| Zheng W and Wang SY | Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. | 2003 | J. Agric. Food Chem. | pmid:12517117 |