Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jang HH et al. | In vitro and in vivo hypoglycemic effects of cyanidin 3-caffeoyl-p-hydroxybenzoylsophoroside-5-glucoside, an anthocyanin isolated from purple-fleshed sweet potato. | 2019 | Food Chem | pmid:30309599 |
| Gras CC et al. | Effect of chlorogenic acid on spectral properties and stability of acylated and non-acylated cyanidin-3-O-glycosides. | 2018 | Food Chem | pmid:28946365 |
| Cheng J et al. | Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways. | 2018 | J. Cell. Physiol. | pmid:28771720 |
| Cao Z et al. | Cyanidin suppresses autophagic activity regulating chondrocyte hypertrophic differentiation. | 2018 | J. Cell. Physiol. | pmid:28722162 |
| Daveri E et al. | Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. | 2018 | Redox Biol | pmid:29890336 |
| Zykin PA et al. | Anthocyanin Composition and Content in Rye Plants with Different Grain Color. | 2018 | Molecules | pmid:29671758 |
| González-Barrio R et al. | Chemical composition of the edible flowers, pansy (Viola wittrockiana) and snapdragon (Antirrhinum majus) as new sources of bioactive compounds. | 2018 | Food Chem | pmid:29478556 |
| Henarejos-Escudero P et al. | Digestive glands extraction and precise pigment analysis support the exclusion of the carnivorous plant Dionaea muscipula Ellis from the Caryophyllales order. | 2018 | Plant Sci. | pmid:30080622 |
| Chen J et al. | Cyanidin Protects SH-SY5Y Human Neuroblastoma Cells from 1-Methyl-4-Phenylpyridinium-Induced Neurotoxicity. | 2018 | Pharmacology | pmid:29982258 |
| Cásedas G et al. | Regulation of redox status in neuronal SH-SY5Y cells by blueberry (Vaccinium myrtillus L.) juice, cranberry (Vaccinium macrocarpon A.) juice and cyanidin. | 2018 | Food Chem. Toxicol. | pmid:29860017 |
| Li F et al. | Cyanidin ameliorates endotoxin-induced myocardial toxicity by modulating inflammation and oxidative stress through mitochondria and other factors. | 2018 | Food Chem. Toxicol. | pmid:29803697 |
| Liu X et al. | Cyanidin Curtails Renal Cell Carcinoma Tumorigenesis. | 2018 | Cell. Physiol. Biochem. | pmid:29742507 |
| Farr JE et al. | Influence of cyanidin glycosylation patterns on carboxypyranoanthocyanin formation. | 2018 | Food Chem | pmid:29680053 |
| Feng K et al. | Isolation, purification, and characterization of AgUCGalT1, a galactosyltransferase involved in anthocyanin galactosylation in purple celery (Apium graveolens L.). | 2018 | Planta | pmid:29520459 |
| Poobathy R et al. | Autofluorescence study and selected cyanidin quantification in the Jewel orchids Anoectochilus sp. and Ludisia discolor. | 2018 | PLoS ONE | pmid:29649288 |
| Du H et al. | Characterisation of flower colouration in 30 Rhododendron species via anthocyanin and flavonol identification and quantitative traits. | 2018 | Plant Biol (Stuttg) | pmid:29054107 |
| Cyboran-Mikołajczyk S et al. | The Impact of O-Glycosylation on Cyanidin Interaction with POPC Membranes: Structure-Activity Relationship. | 2018 | Molecules | pmid:30366469 |
| Aybastıer Ö et al. | Investigation of antioxidant ability of grape seeds extract to prevent oxidatively induced DNA damage by gas chromatography-tandem mass spectrometry. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29223045 |
| Yari A and Rashnoo S | Optimization of a new method for extraction of cyanidin chloride and pelargonidin chloride anthocyanins with magnetic solid phase extraction and determination in fruit samples by HPLC with central composite design. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28987497 |
| Boehm MMA et al. | Dissecting the 'bacon and eggs' phenotype: transcriptomics of post-anthesis colour change in Lotus. | 2017 | Ann. Bot. | pmid:28981620 |
| Bashandy H and Teeri TH | Genetically engineered orange petunias on the market. | 2017 | Planta | pmid:28647812 |
| Petruk G et al. | Malvidin and cyanidin derivatives from açai fruit (Euterpe oleracea Mart.) counteract UV-A-induced oxidative stress in immortalized fibroblasts. | 2017 | J. Photochem. Photobiol. B, Biol. | pmid:28527426 |
| Sgherri C et al. | Elevated CO and salinity are responsible for phenolics-enrichment in two differently pigmented lettuces. | 2017 | Plant Physiol. Biochem. | pmid:28411511 |
| Hemachandran H et al. | Unraveling the inhibition mechanism of cyanidin-3-sophoroside on polyphenol oxidase and its effect on enzymatic browning of apples. | 2017 | Food Chem | pmid:28274409 |
| Fedenko VS et al. | UV-vis spectroscopy and colorimetric models for detecting anthocyanin-metal complexes in plants: An overview of in vitro and in vivo techniques. | 2017 | J. Plant Physiol. | pmid:28242414 |
| Liu C et al. | The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo. | 2017 | Sci Signal | pmid:28223414 |
| McCarthy EW et al. | Related allopolyploids display distinct floral pigment profiles and transgressive pigments. | 2017 | Am. J. Bot. | pmid:28057690 |
| Sigurdson GT et al. | Spectral and colorimetric characteristics of metal chelates of acylated cyanidin derivatives. | 2017 | Food Chem | pmid:27979063 |
| Kimura Y et al. | Synthesis of 8-Aryl-O-methylcyanidins and Their Usage for Dye-Sensitized Solar Cell Devices. | 2017 | Int J Mol Sci | pmid:28212330 |
| Raj P et al. | Effects of cyanidin 3-0-glucoside on cardiac structure and function in an animal model of myocardial infarction. | 2017 | Food Funct | pmid:28990610 |
| Suantawee T et al. | Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca Channels. | 2017 | Nutrients | pmid:28788070 |
| Xu Z et al. | ROS Induces Anthocyanin Production Via Late Biosynthetic Genes and Anthocyanin Deficiency Confers the Hypersensitivity to ROS-Generating Stresses in Arabidopsis. | 2017 | Plant Cell Physiol. | pmid:28586465 |
| Batista ÂG et al. | Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. | 2017 | Mol Nutr Food Res | pmid:28544198 |
| Lagoa R et al. | Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity. | 2017 | Biofactors | pmid:28317253 |
| Liu YY et al. | [Establishment of myocardial targeted nanoparticles and preliminary evaluation of its effects on prevention and treatment of myocardial injury]. | 2017 | Zhonghua Shao Shang Za Zhi | pmid:29166707 |
| Carvalho MJ et al. | Nutritional and Phytochemical Composition of Vaccinium padifolium Sm Wild Berries and Radical Scavenging Activity. | 2017 | J. Food Sci. | pmid:28960302 |
| Suantawee T et al. | Protective effect of cyanidin against glucose- and methylglyoxal-induced protein glycation and oxidative DNA damage. | 2016 | Int. J. Biol. Macromol. | pmid:27645922 |
| Strugała P et al. | Interaction between Mimic Lipid Membranes and Acylated and Nonacylated Cyanidin and Its Bioactivity. | 2016 | J. Agric. Food Chem. | pmid:27624410 |
| Grajeda-Iglesias C et al. | Isolation and Characterization of Anthocyanins from Hibiscus sabdariffa Flowers. | 2016 | J. Nat. Prod. | pmid:27312226 |
| Marques C et al. | Pharmacokinetics of blackberry anthocyanins consumed with or without ethanol: A randomized and crossover trial. | 2016 | Mol Nutr Food Res | pmid:27306520 |
| Camelo-Méndez GA et al. | Effect on in vitro starch digestibility of Mexican blue maize anthocyanins. | 2016 | Food Chem | pmid:27283633 |
| Santos FT et al. | Comparison of five agro-industrial waste-based composts as growing media for lettuce: Effect on yield, phenolic compounds and vitamin C. | 2016 | Food Chem | pmid:27173566 |
| Sigurdson GT et al. | Evaluating the role of metal ions in the bathochromic and hyperchromic responses of cyanidin derivatives in acidic and alkaline pH. | 2016 | Food Chem | pmid:27132820 |
| Feng C et al. | Antioxidant capacities and anthocyanin characteristics of the black-red wild berries obtained in Northeast China. | 2016 | Food Chem | pmid:26988488 |
| Nankar AN et al. | Quantitative and qualitative evaluation of kernel anthocyanins from southwestern United States blue corn. | 2016 | J. Sci. Food Agric. | pmid:26879128 |
| Singh CK et al. | Combination chemoprevention with grape antioxidants. | 2016 | Mol Nutr Food Res | pmid:26829056 |
| Ahmadiani N et al. | Molar absorptivity (ε) and spectral characteristics of cyanidin-based anthocyanins from red cabbage. | 2016 | Food Chem | pmid:26617032 |
| Natarajan T et al. | Idaein chloride induced p53 dependent apoptosis in cervical cancer cells through inhibition of viral oncoproteins. | 2016 | Biochimie | pmid:26586108 |
| Liao J et al. | Identification and analysis of anthocyanin components in fruit color variation in Schisandra chinensis. | 2016 | J. Sci. Food Agric. | pmid:26493497 |
| Dou C et al. | Dual Effect of Cyanidin on RANKL-Induced Differentiation and Fusion of Osteoclasts. | 2016 | J. Cell. Physiol. | pmid:25545964 |
| Thummayot S et al. | Neuroprotective effects of cyanidin against Aβ-induced oxidative and ER stress in SK-N-SH cells. | 2016 | Neurochem. Int. | pmid:27697517 |
| Del Bo' C et al. | Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. | 2016 | Mol Nutr Food Res | pmid:27324255 |
| Pantelić MM et al. | Identification and quantification of phenolic compounds in berry skin, pulp, and seeds in 13 grapevine varieties grown in Serbia. | 2016 | Food Chem | pmid:27283628 |
| Lai YS et al. | The Dark-Purple Tea Cultivar 'Ziyan' Accumulates a Large Amount of Delphinidin-Related Anthocyanins. | 2016 | J. Agric. Food Chem. | pmid:26996195 |
| Lee SG et al. | Contribution of Anthocyanin Composition to Total Antioxidant Capacity of Berries. | 2015 | Plant Foods Hum Nutr | pmid:26515081 |
| Riha J et al. | Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes. | 2015 | Food Funct | pmid:25578040 |
| Iliopoulou I et al. | Analysis of the Thermal Degradation of the Individual Anthocyanin Compounds of Black Carrot (Daucus carota L.): A New Approach Using High-Resolution Proton Nuclear Magnetic Resonance Spectroscopy. | 2015 | J. Agric. Food Chem. | pmid:26160425 |
| Faramarzi S et al. | Red-fleshed Apples: Old Autochthonous Fruits as a Novel Source of Anthocyanin Antioxidants. | 2015 | Plant Foods Hum Nutr | pmid:26134879 |
| Lima Mdos S et al. | Phenolic compounds, organic acids and antioxidant activity of grape juices produced in industrial scale by different processes of maceration. | 2015 | Food Chem | pmid:26041208 |
| Antolak H et al. | Adhesion of Asaia bogorensis to Glass and Polystyrene in the Presence of Cranberry Juice. | 2015 | J. Food Prot. | pmid:26038911 |
| Jo YH et al. | Metabolomic Analysis Reveals Cyanidins in Black Raspberry as Candidates for Suppression of Lipopolysaccharide-Induced Inflammation in Murine Macrophages. | 2015 | J. Agric. Food Chem. | pmid:26023864 |
| Li DW et al. | Attenuation of Cisplatin-Induced Neurotoxicity by Cyanidin, a Natural Inhibitor of ROS-Mediated Apoptosis in PC12 Cells. | 2015 | Cell. Mol. Neurobiol. | pmid:25895624 |
| Moriya C et al. | New acylated anthocyanins from purple yam and their antioxidant activity. | 2015 | Biosci. Biotechnol. Biochem. | pmid:25848974 |
| Zhang C et al. | Binding characteristics and protective capacity of cyanidin-3-glucoside and its aglycon to calf thymus DNA. | 2015 | J. Food Sci. | pmid:25810071 |
| Li SY et al. | Association between modification of phenolic profiling and development of wine color during alcohol fermentation. | 2015 | J. Food Sci. | pmid:25807971 |
| An CH et al. | Heterologous expression of IbMYB1a by different promoters exhibits different patterns of anthocyanin accumulation in tobacco. | 2015 | Plant Physiol. Biochem. | pmid:25681576 |
| Scheit K and Bauer G | Direct and indirect inactivation of tumor cell protective catalase by salicylic acid and anthocyanidins reactivates intercellular ROS signaling and allows for synergistic effects. | 2015 | Carcinogenesis | pmid:25653236 |
| Lim A et al. | Potential natural sensitizers extracted from the skin of Canarium odontophyllum fruits for dye-sensitized solar cells. | 2015 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:25541396 |
| Zhang H et al. | Phenolic compounds and antioxidant properties of breeding lines between the white and black rice. | 2015 | Food Chem | pmid:25442600 |
| Du C et al. | Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells. | 2015 | Drug Des Devel Ther | pmid:26379423 |
| Kadigamuwa CC et al. | 2, 2'- and 4, 4'-Cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPPâº. | 2015 | J. Neurochem. | pmid:26094622 |
| Ahn JH et al. | De Novo Transcriptome Analysis to Identify Anthocyanin Biosynthesis Genes Responsible for Tissue-Specific Pigmentation in Zoysiagrass (Zoysia japonica Steud.). | 2015 | PLoS ONE | pmid:25905914 |
| Kim RJ et al. | Antioxidant's cytoprotective effects on rotator cuff tenofibroblasts exposed to aminoamide local anesthetics. | 2015 | J. Orthop. Res. | pmid:25639557 |
| Khandelwal N and Abraham SK | Protective effects of common anthocyanidins against genotoxic damage induced by chemotherapeutic drugs in mice. | 2014 | Planta Med. | pmid:25184891 |
| Harb J et al. | Changes in polyphenols and expression levels of related genes in 'Duke' blueberries stored under high CO2 levels. | 2014 | J. Agric. Food Chem. | pmid:24999801 |
| Miladinović B et al. | Chemical profile and antioxidative and antimicrobial activity of juices and extracts of 4 black currants varieties (Ribes nigrum L.). | 2014 | J. Food Sci. | pmid:24506271 |
| Thummayot S et al. | Neuroprotective effect of purple rice extract and its constituent against amyloid beta-induced neuronal cell death in SK-N-SH cells. | 2014 | Neurotoxicology | pmid:25451968 |
| Scheit K and Bauer G | Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis. | 2014 | Anticancer Res. | pmid:25275027 |
| Xie Q et al. | Accumulation and molecular regulation of anthocyanin in purple tumorous stem mustard (Brassica juncea var. tumida Tsen et Lee). | 2014 | J. Agric. Food Chem. | pmid:25055052 |
| Khandelwal N and Abraham SK | Intake of anthocyanidins pelargonidin and cyanidin reduces genotoxic stress in mice induced by diepoxybutane, urethane and endogenous nitrosation. | 2014 | Environ. Toxicol. Pharmacol. | pmid:24642102 |
| Khaodee W et al. | Effectively simultaneous naked-eye detection of Cu(II), Pb(II), Al(III) and Fe(III) using cyanidin extracted from red cabbage as chelating agent. | 2014 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:24594882 |
| Park S et al. | Quantification of glucosinolates, anthocyanins, free amino acids, and vitamin C in inbred lines of cabbage (Brassica oleracea L.). | 2014 | Food Chem | pmid:24128451 |
| Sun LL et al. | Composition and antioxidant activity of the anthocyanins of the fruit of Berberis heteropoda Schrenk. | 2014 | Molecules | pmid:25415473 |
| Miosic S et al. | Dihydroflavonol 4-reductase genes encode enzymes with contrasting substrate specificity and show divergent gene expression profiles in Fragaria species. | 2014 | PLoS ONE | pmid:25393679 |
| Xu ZS et al. | Transcript profiling of structural genes involved in cyanidin-based anthocyanin biosynthesis between purple and non-purple carrot (Daucus carota L.) cultivars reveals distinct patterns. | 2014 | BMC Plant Biol. | pmid:25269413 |
| Cheng DM et al. | Development and phytochemical characterization of high polyphenol red lettuce with anti-diabetic properties. | 2014 | PLoS ONE | pmid:24637790 |
| Sui X and Zhou W | Monte Carlo modelling of non-isothermal degradation of two cyanidin-based anthocyanins in aqueous system at high temperatures and its impact on antioxidant capacities. | 2014 | Food Chem | pmid:24262567 |
| Austin HR et al. | Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24393842 |
| Chen R et al. | Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:24623967 |
| Bijak M et al. | Thrombin inhibitory activity of some polyphenolic compounds. | 2014 | Med Chem Res | pmid:24610996 |
| Kim RJ et al. | Do antioxidants inhibit oxidative-stress-induced autophagy of tenofibroblasts? | 2014 | J. Orthop. Res. | pmid:24644146 |
| Xia N et al. | Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. | 2014 | Molecules | pmid:24662080 |
| Ogawa K et al. | Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro. | 2014 | BMC Complement Altern Med | pmid:24690313 |
| Chao PY et al. | Inhibitive effect of purple sweet potato leaf extract and its components on cell adhesion and inflammatory response in human aortic endothelial cells. | 2013 Mar-Apr | Cell Adh Migr | pmid:23466865 |
| Huang XW et al. | A new sensor for ammonia based on cyanidin-sensitized titanium dioxide film operating at room temperature. | 2013 | Anal. Chim. Acta | pmid:23830444 |
| Bushakra JM et al. | QTL involved in the modification of cyanidin compounds in black and red raspberry fruit. | 2013 | Theor. Appl. Genet. | pmid:23224381 |
| Gharib A et al. | In vitro and in vivo antibacterial activities of cyanidinum chloride-loaded liposomes against a resistant strain of Pseudomonas aeruginosa. | 2013 | Planta Med. | pmid:23203413 |
| Esselen M et al. | Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats. | 2013 | Carcinogenesis | pmid:23275152 |
| Jia Y et al. | Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid. | 2013 | Biochim. Biophys. Acta | pmid:23228689 |
| Xiao J et al. | A review on structure-activity relationship of dietary polyphenols inhibiting α-amylase. | 2013 | Crit Rev Food Sci Nutr | pmid:23391016 |