Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Gargouri M et al. | Structure and epimerase activity of anthocyanidin reductase from Vitis vinifera. | 2009 | Acta Crystallogr. D Biol. Crystallogr. | pmid:19690377 |
| Delazar A et al. | Isolation and free-radical-scavenging properties of cyanidin 3-O-glycosides from the fruits of Ribes biebersteinii Berl. | 2010 | Acta Pharm | pmid:20228037 |
| Burdulis D et al. | Comparative study of anthocyanin composition, antimicrobial and antioxidant activity in bilberry (Vaccinium myrtillus L.) and blueberry (Vaccinium corymbosum L.) fruits. | 2009 Jul-Aug | Acta Pol Pharm | pmid:19702172 |
| Horbowicz M et al. | Effects of methyl jasmonate on accumulation of flavonoids in seedlings of common buckwheat (Fagopyrum esculentum Moench). | 2011 | Acta. Biol. Hung. | pmid:21840829 |
| Li CY et al. | Gastroprotective effect of cyanidin 3-glucoside on ethanol-induced gastric lesions in rats. | 2008 | Alcohol | pmid:19038699 |
| McCarthy EW et al. | Related allopolyploids display distinct floral pigment profiles and transgressive pigments. | 2017 | Am. J. Bot. | pmid:28057690 |
| Abdel-Moemin AR | Switching to black rice diets modulates low-density lipoprotein oxidation and lipid measurements in rabbits. | 2011 | Am. J. Med. Sci. | pmid:21289511 |
| Yoshimura Y et al. | Visualization of anthocyanin species in rabbiteye blueberry Vaccinium ashei by matrix-assisted laser desorption/ionization imaging mass spectrometry. | 2012 | Anal Bioanal Chem | pmid:22399120 |
| Schütz K et al. | Characterization and quantification of anthocyanins in selected artichoke (Cynara scolymus L.) cultivars by HPLC-DAD-ESI-MSn. | 2006 | Anal Bioanal Chem | pmid:16534575 |
| Shrestha B et al. | In situ cell-by-cell imaging and analysis of small cell populations by mass spectrometry. | 2011 | Anal. Chem. | pmid:21388149 |
| De Rosso M et al. | Study of anthocyanic profiles of twenty-one hybrid grape varieties by liquid chromatography and precursor-ion mass spectrometry. | 2012 | Anal. Chim. Acta | pmid:22688043 |
| Huang XW et al. | A new sensor for ammonia based on cyanidin-sensitized titanium dioxide film operating at room temperature. | 2013 | Anal. Chim. Acta | pmid:23830444 |
| Esparza I et al. | Complexing capacity profiles of naturally occurring ligands in Tempranillo wines for Cu and Zn: an electroanalytical approach for cupric casse. | 2007 | Anal. Chim. Acta | pmid:17765065 |
| Boehm MMA et al. | Dissecting the 'bacon and eggs' phenotype: transcriptomics of post-anthesis colour change in Lotus. | 2017 | Ann. Bot. | pmid:28981620 |
| Sugita O et al. | A new method of measuring the antioxidant activity of polyphenols using cumene hydroperoxide. | 2004 | Ann. Clin. Biochem. | pmid:14713390 |
| Ben Mansour H et al. | Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyllum. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21880140 |
| Galvano F et al. | Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. | 2007 | Ann. Ist. Super. Sanita | pmid:18209272 |
| Shin DY et al. | Induction of apoptosis and inhibition of invasion in human hepatoma cells by anthocyanins from meoru. | 2009 | Ann. N. Y. Acad. Sci. | pmid:19723048 |
| Li Volti G et al. | Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide? | 2008 | Ann. Surg. | pmid:18362637 |
| Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
| Scheit K and Bauer G | Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis. | 2014 | Anticancer Res. | pmid:25275027 |
| Fimognari C et al. | In vitro anticancer activity of cyanidin-3-O-beta-glucopyranoside: effects on transformed and non-transformed T lymphocytes. | 2005 Jul-Aug | Anticancer Res. | pmid:16080535 |
| Lea MA et al. | Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds. | 2008 Jul-Aug | Anticancer Res. | pmid:18751377 |
| Paixão J et al. | Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. | 2011 | Apoptosis | pmid:21785847 |
| Mewis I et al. | Specific poly-phenolic compounds in cell culture of Vitis vinifera L. cv. Gamay Fréaux. | 2011 | Appl. Biochem. Biotechnol. | pmid:21061087 |
| Gargouri M et al. | Binding-equilibrium and kinetic studies of anthocyanidin reductase from Vitis vinifera. | 2009 | Arch. Biochem. Biophys. | pmid:19772852 |
| Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
| Cvorovic J et al. | Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells. | 2010 | Arch. Biochem. Biophys. | pmid:20494645 |
| Xie DY et al. | Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. | 2004 | Arch. Biochem. Biophys. | pmid:14725861 |
| Yao JW et al. | Affinity interactions between natural pigments and human whole saliva. | 2011 | Arch. Oral Biol. | pmid:21112045 |
| Cristoni A et al. | Effect of a natural flavonoid on gastric mucosal barrier. | 1989 | Arzneimittelforschung | pmid:2757676 |
| Xu JW et al. | Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells. | 2007 | Atherosclerosis | pmid:17045269 |
| Tsuda T et al. | Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15003523 |
| Hattori M et al. | Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18619417 |
| Austin HR et al. | Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24393842 |
| Kamsteeg J et al. | Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica). | 1978 | Biochem. Genet. | pmid:751640 |
| Kim JE et al. | Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1. | 2010 | Biochem. Pharmacol. | pmid:20096264 |
| Wang D et al. | Cyanidin-3-O-β-glucoside with the aid of its metabolite protocatechuic acid, reduces monocyte infiltration in apolipoprotein E-deficient mice. | 2011 | Biochem. Pharmacol. | pmid:21569764 |
| Lim TG et al. | Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity. | 2011 | Biochem. Pharmacol. | pmid:21501596 |
| Tsuda T et al. | Microarray profiling of gene expression in human adipocytes in response to anthocyanins. | 2006 | Biochem. Pharmacol. | pmid:16483547 |
| Guo H et al. | Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation. | 2008 | Biochem. Pharmacol. | pmid:18179781 |
| Sasaki R et al. | Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. | 2007 | Biochem. Pharmacol. | pmid:17869225 |
| Hou DX et al. | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. | 2005 | Biochem. Pharmacol. | pmid:15963474 |
| Gryglewski RJ et al. | On the mechanism of antithrombotic action of flavonoids. | 1987 | Biochem. Pharmacol. | pmid:3101704 |
| Virmaux N et al. | Modulation of rod cyclic GMP-phosphodiesterase activity by anthocyanidin derivatives. | 1990 | Biochem. Soc. Trans. | pmid:2177424 |
| Jia Y et al. | Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid. | 2013 | Biochim. Biophys. Acta | pmid:23228689 |
| Kuhn I et al. | Schistosoma mansoni NAD(+) catabolizing enzyme: identification of key residues in catalysis. | 2013 | Biochim. Biophys. Acta | pmid:24035885 |
| Tsuda T et al. | Gene expression profile of isolated rat adipocytes treated with anthocyanins. | 2005 | Biochim. Biophys. Acta | pmid:15863361 |
| Natarajan T et al. | Idaein chloride induced p53 dependent apoptosis in cervical cancer cells through inhibition of viral oncoproteins. | 2016 | Biochimie | pmid:26586108 |