Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lätti AK et al. | Anthocyanin and flavonol variation in bog bilberries (Vaccinium uliginosum L.) in Finland. | 2010 | J. Agric. Food Chem. | pmid:20000402 |
| Kim CK et al. | Identification and characterization of seed-specific transcription factors regulating anthocyanin biosynthesis in black rice. | 2011 | J. Appl. Genet. | pmid:21286901 |
| Feng R et al. | Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. | 2007 | J. Biol. Chem. | pmid:17360708 |
| Ding M et al. | Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. | 2006 | J. Biol. Chem. | pmid:16618699 |
| Sawada S et al. | UDP-glucuronic acid:anthocyanin glucuronosyltransferase from red daisy (Bellis perennis) flowers. Enzymology and phylogenetics of a novel glucuronosyltransferase involved in flower pigment biosynthesis. | 2005 | J. Biol. Chem. | pmid:15509561 |
| Nakajima J et al. | Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis. | 2001 | J. Biol. Chem. | pmid:11316805 |
| Pompei A et al. | Cyanidin reduces preadipocyte differentiation and relative ChREBP expression. | 2012 Apr-Jun | J. Biol. Regul. Homeost. Agents | pmid:22824753 |
| Liu X et al. | Preparative separation and enrichment of syringopicroside from Folium syringae leaves with macroporous resins. | 2010 | J. Biomed. Biotechnol. | pmid:21234415 |
| Shan Q et al. | Purple sweet potato color ameliorates cognition deficits and attenuates oxidative damage and inflammation in aging mouse brain induced by d-galactose. | 2009 | J. Biomed. Biotechnol. | pmid:19865488 |
| Aumont V et al. | Production of highly 13C-labeled polyphenols in Vitis vinifera cell bioreactor cultures. | 2004 | J. Biotechnol. | pmid:15066766 |
| Lamy S et al. | Anthocyanidins inhibit migration of glioblastoma cells: structure-activity relationship and involvement of the plasminolytic system. | 2007 | J. Cell. Biochem. | pmid:16823770 |
| Schrader C et al. | Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. | 2012 | J. Cell. Mol. Med. | pmid:22304296 |
| Cheng J et al. | Cyanidin Chloride inhibits ovariectomy-induced osteoporosis by suppressing RANKL-mediated osteoclastogenesis and associated signaling pathways. | 2018 | J. Cell. Physiol. | pmid:28771720 |
| Cao Z et al. | Cyanidin suppresses autophagic activity regulating chondrocyte hypertrophic differentiation. | 2018 | J. Cell. Physiol. | pmid:28722162 |
| Dou C et al. | Dual Effect of Cyanidin on RANKL-Induced Differentiation and Fusion of Osteoclasts. | 2016 | J. Cell. Physiol. | pmid:25545964 |
| Punyasiri PA et al. | Preformed and induced chemical resistance of tea leaf against Exobasidium vexans infection. | 2005 | J. Chem. Ecol. | pmid:16222773 |
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| Ling Y et al. | A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19896910 |
| Aybastıer Ö et al. | Investigation of antioxidant ability of grape seeds extract to prevent oxidatively induced DNA damage by gas chromatography-tandem mass spectrometry. | 2018 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29223045 |
| Laitinen RA et al. | Identification of target genes for a MYB-type anthocyanin regulator in Gerbera hybrida. | 2008 | J. Exp. Bot. | pmid:18725377 |
| Yuan L et al. | Molecular cloning and characterization of PtrLAR3, a gene encoding leucoanthocyanidin reductase from Populus trichocarpa, and its constitutive expression enhances fungal resistance in transgenic plants. | 2012 | J. Exp. Bot. | pmid:22268151 |
| Harding SA et al. | A comparative analysis of phenylpropanoid metabolism, N utilization, and carbon partitioning in fast- and slow-growing Populus hybrid clones. | 2009 | J. Exp. Bot. | pmid:19516073 |
| Conn S et al. | Purification, molecular cloning, and characterization of glutathione S-transferases (GSTs) from pigmented Vitis vinifera L. cell suspension cultures as putative anthocyanin transport proteins. | 2008 | J. Exp. Bot. | pmid:18836188 |
| Merzlyak MN et al. | Light absorption by anthocyanins in juvenile, stressed, and senescing leaves. | 2008 | J. Exp. Bot. | pmid:18796701 |
| Nakatsuka T et al. | Cloning and characterization of the UDP-glucose:anthocyanin 5-O-glucosyltransferase gene from blue-flowered gentian. | 2008 | J. Exp. Bot. | pmid:18375606 |
| Stushnoff C et al. | Flavonoid profiling and transcriptome analysis reveals new gene-metabolite correlations in tubers of Solanum tuberosum L. | 2010 | J. Exp. Bot. | pmid:20110266 |
| Albert NW et al. | Light-induced vegetative anthocyanin pigmentation in Petunia. | 2009 | J. Exp. Bot. | pmid:19380423 |
| Matus JT et al. | Post-veraison sunlight exposure induces MYB-mediated transcriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera. | 2009 | J. Exp. Bot. | pmid:19129169 |
| Griesser M et al. | Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. | 2008 | J. Exp. Bot. | pmid:18487633 |
| Han Y et al. | Introduction of apple ANR genes into tobacco inhibits expression of both CHI and DFR genes in flowers, leading to loss of anthocyanin. | 2012 | J. Exp. Bot. | pmid:22238451 |
| Khater F et al. | Identification and functional characterization of cDNAs coding for hydroxybenzoate/hydroxycinnamate glucosyltransferases co-expressed with genes related to proanthocyanidin biosynthesis. | 2012 | J. Exp. Bot. | pmid:22090445 |
| Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
| Bedon F et al. | Subgroup 4 R2R3-MYBs in conifer trees: gene family expansion and contribution to the isoprenoid- and flavonoid-oriented responses. | 2010 | J. Exp. Bot. | pmid:20732878 |
| Antolak H et al. | Adhesion of Asaia bogorensis to Glass and Polystyrene in the Presence of Cranberry Juice. | 2015 | J. Food Prot. | pmid:26038911 |
| Biegelmeyer R et al. | Comparative analysis of the chemical composition and antioxidant activity of red (Psidium cattleianum) and yellow (Psidium cattleianum var. lucidum) strawberry guava fruit. | 2011 | J. Food Sci. | pmid:22417549 |
| Zou T et al. | Optimization of microwave-assisted extraction of anthocyanins from mulberry and identification of anthocyanins in extract using HPLC-ESI-MS. | 2012 | J. Food Sci. | pmid:22260102 |
| Han SJ et al. | Metabolism of cyanidin-3-O-beta-D-glucoside isolated from black colored rice and its antiscratching behavioral effect in mice. | 2009 | J. Food Sci. | pmid:19799667 |
| Li SY et al. | Association between modification of phenolic profiling and development of wine color during alcohol fermentation. | 2015 | J. Food Sci. | pmid:25807971 |
| El Babili F et al. | Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. | 2011 | J. Food Sci. | pmid:21535822 |
| Liu J et al. | Bog bilberry (Vaccinium uliginosum L.) extract reduces cultured Hep-G2, Caco-2, and 3T3-L1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability. | 2010 | J. Food Sci. | pmid:20492295 |
| Liu Y et al. | Comparative study of phenolic compounds and antioxidant activity in different species of cherries. | 2011 | J. Food Sci. | pmid:22417346 |
| Andrade JM et al. | Phenolic composition in different genotypes of Guabiju fruits (Myrcianthes pungens) and their potential as antioxidant and antichemotactic agents. | 2011 | J. Food Sci. | pmid:22417582 |
| Hanlon PR and Barnes DM | Phytochemical composition and biological activity of 8 varieties of radish (Raphanus sativus L.) sprouts and mature taproots. | J. Food Sci. | pmid:21535648 | |
| Garzón GA et al. | Determination of anthocyanins, total phenolic content, and antioxidant activity in Andes Berry (Rubus glaucus Benth). | 2009 | J. Food Sci. | pmid:19397707 |
| Kim SH et al. | Structural identification and antioxidant properties of major anthocyanin extracted from Omija (Schizandra chinensis) fruit. | 2009 | J. Food Sci. | pmid:19323727 |
| Walton MC et al. | Viscous food matrix influences absorption and excretion but not metabolism of blackcurrant anthocyanins in rats. | J. Food Sci. | pmid:19200098 | |
| Liang Z et al. | CIELAB coordinates in response to berry skin anthocyanins and their composition in Vitis. | 2011 | J. Food Sci. | pmid:21535819 |
| Oh YS et al. | Characterization and quantification of anthocyanins in grape juices obtained from the grapes cultivated in Korea by HPLC/DAD, HPLC/MS, and HPLC/MS/MS. | 2008 | J. Food Sci. | pmid:18576983 |
| Wu TY et al. | Effect of antioxidant activity and functional properties of Chingshey purple sweet potato fermented milk by Lactobacillus acidophilus, L. delbrueckii subsp. lactis, and L. gasseri strains. | 2012 | J. Food Sci. | pmid:22182227 |
| Crupi P et al. | HPLC-DAD-ESI-MS analysis of flavonoid compounds in 5 seedless table grapes grown in Apulian Region. | 2012 | J. Food Sci. | pmid:22309436 |