Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee J et al. | Natural products and body weight control. | 2011 | N Am J Med Sci | pmid:22540057 |
| Meng S et al. | Natural dyes adsorbed on TiO2 nanowire for photovoltaic applications: enhanced light absorption and ultrafast electron injection. | 2008 | Nano Lett. | pmid:18788788 |
| Sparzak B et al. | HPLC analysis of polyphenols in the fruits of Rubus idaeus L. (Rosaceae). | 2010 | Nat. Prod. Res. | pmid:21104526 |
| Qin C et al. | Separation and elucidation of anthocyanins in the fruit of mockstrawberry (Duchesnea indica Focke). | 2009 | Nat. Prod. Res. | pmid:19851924 |
| Vodopivec BM et al. | Differences in the structure of anthocyanins from the two amphibious plants, Lobelia cardinalis and Nesaea crassicaulis. | 2013 | Nat. Prod. Res. | pmid:22694738 |
| Thummayot S et al. | Neuroprotective effects of cyanidin against Aβ-induced oxidative and ER stress in SK-N-SH cells. | 2016 | Neurochem. Int. | pmid:27697517 |
| Tarozzi A et al. | Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity. | 2008 | Neuroreport | pmid:18797302 |
| Min J et al. | Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. | 2011 | Neurosci. Lett. | pmid:21651957 |
| Tarozzi A et al. | Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells. | 2007 | Neurosci. Lett. | pmid:17709193 |
| Tarozzi A et al. | Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity. | 2010 | Neurosci. Lett. | pmid:20152881 |
| Chen G et al. | Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta. | 2009 | Neurotox Res | pmid:19384566 |
| Thummayot S et al. | Neuroprotective effect of purple rice extract and its constituent against amyloid beta-induced neuronal cell death in SK-N-SH cells. | 2014 | Neurotoxicology | pmid:25451968 |
| Yao Y and Vieira A | Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. | 2007 | Neurotoxicology | pmid:16956663 |
| Vignolini S et al. | The mirror crack'd: both pigment and structure contribute to the glossy blue appearance of the mirror orchid, Ophrys speculum. | 2012 | New Phytol. | pmid:23043621 |
| Wallerath T et al. | A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. | 2005 | Nitric Oxide | pmid:15740983 |
| Pergola C et al. | Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. | 2006 | Nitric Oxide | pmid:16517190 |
| Briviba K et al. | Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. | 2001 | Nutr Cancer | pmid:12094622 |
| Zikri NN et al. | Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. | 2009 | Nutr Cancer | pmid:20155622 |
| Aqil F et al. | Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). | 2012 | Nutr Cancer | pmid:22420901 |
| Chen PN et al. | Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. | 2005 | Nutr Cancer | pmid:16573384 |
| Seeram NP et al. | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. | 2003 | Nutr Cancer | pmid:12925310 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Udani JK et al. | Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. | 2011 | Nutr J | pmid:21569436 |
| Deguchi Y and Miyazaki K | Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract. | 2010 | Nutr Metab (Lond) | pmid:20181067 |
| Nunn AV et al. | Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? | 2009 | Nutr Metab (Lond) | pmid:19371409 |
| Jang HH et al. | Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation. | 2012 | Nutr Metab (Lond) | pmid:22458550 |
| Suzuki R et al. | Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. | 2011 | Nutr Metab (Lond) | pmid:21385419 |
| Sarr M et al. | In vitro vasorelaxation mechanisms of bioactive compounds extracted from Hibiscus sabdariffa on rat thoracic aorta. | 2009 | Nutr Metab (Lond) | pmid:19883513 |
| Hassimotto NM et al. | Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. | 2008 | Nutr Res | pmid:19083408 |
| Lee SJ et al. | Grape skin improves antioxidant capacity in rats fed a high fat diet. | 2009 | Nutr Res Pract | pmid:20098580 |
| Kim MK et al. | Identification and quantification of anthocyanin pigments in colored rice. | 2008 | Nutr Res Pract | pmid:20126365 |
| Park MY et al. | Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin. | 2008 | Nutr Res Pract | pmid:20126360 |
| Bae JY et al. | Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts. | 2007 | Nutr Res Pract | pmid:20368951 |
| Tsao R | Chemistry and biochemistry of dietary polyphenols. | 2010 | Nutrients | pmid:22254006 |
| Suantawee T et al. | Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca Channels. | 2017 | Nutrients | pmid:28788070 |
| Fortalezas S et al. | Antioxidant properties and neuroprotective capacity of strawberry tree fruit (Arbutus unedo). | 2010 | Nutrients | pmid:22254017 |
| Fang J | Classification of fruits based on anthocyanin types and relevance to their health effects. | Nutrition | pmid:26250485 | |
| Hoorens B et al. | Neighbour identity hardly affects litter-mixture effects on decomposition rates of New Zealand forest species. | 2010 | Oecologia | pmid:19756760 |
| Katsuzaki H et al. | Cyanidin 3-O-beta-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells. | Oncol. Rep. | pmid:12579261 | |
| Kondo T et al. | Novel and efficient synthesis of cyanidin 3-O-beta-D-glucoside from (+)-catechin via a flav-3-en-3-ol as a key intermediate. | 2006 | Org. Lett. | pmid:16869672 |
| Pandey KB and Rizvi SI | Plant polyphenols as dietary antioxidants in human health and disease. | 2009 Nov-Dec | Oxid Med Cell Longev | pmid:20716914 |
| Akhlaghi M and Bandy B | Preconditioning and acute effects of flavonoids in protecting cardiomyocytes from oxidative cell death. | 2012 | Oxid Med Cell Longev | pmid:22829963 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Mulabagal V et al. | Quantitative analysis of anthocyanins in Euterpe oleracea (açaÃ) dietary supplement raw materials and capsules by Q-TOF liquid chromatography/mass spectrometry. | 2012 | Pharm Biol | pmid:22900515 |
| Ugalde CM et al. | Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers. | 2009 | Pharm. Res. | pmid:19137418 |
| Ozgen M et al. | Total phenolic, anthocyanin contents and antioxidant capacity of selected elderberry (Sambucus canadensis L.) accessions. | 2010 | Pharmacogn Mag | pmid:20931079 |
| Ozen T and Türkekul I | Antioxidant activities of Sarcodon imbricatum wildly grown in the Black Sea Region of Turkey. | 2010 | Pharmacogn Mag | pmid:20668572 |
| Kumar D et al. | A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae). | 2011 | Pharmacogn Rev | pmid:22279376 |
| Mohanty S and Cock IE | The chemotherapeutic potential of Terminalia ferdinandiana: Phytochemistry and bioactivity. | 2012 | Pharmacogn Rev | pmid:22654402 |
| Korać RR and Khambholja KM | Potential of herbs in skin protection from ultraviolet radiation. | 2011 | Pharmacogn Rev | pmid:22279374 |