Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kang SY et al. | Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. | 2003 | Cancer Lett. | pmid:12706854 |
| Kaneko T et al. | Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843669 |
| Tsao R et al. | Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). | 2003 | J. Agric. Food Chem. | pmid:14518966 |
| Curtin C et al. | Manipulating anthocyanin composition in Vitis vinifera suspension cultures by elicitation with jasmonic acid and light irradiation. | 2003 | Biotechnol. Lett. | pmid:12966999 |
| Nielsen IL et al. | Quantification of anthocyanins in commercial black currant juices by simple high-performance liquid chromatography. Investigation of their pH stability and antioxidative potency. | 2003 | J. Agric. Food Chem. | pmid:13129285 |
| Marles MA et al. | New perspectives on proanthocyanidin biochemistry and molecular regulation. | 2003 | Phytochemistry | pmid:12943753 |
| Kuskoski EM et al. | Characterization of anthocyanins from the fruits of baguaçu (Eugenia umbelliflora Berg). | 2003 | J. Agric. Food Chem. | pmid:12926896 |
| Seeram NP et al. | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. | 2003 | Nutr Cancer | pmid:12925310 |
| Kim MY et al. | Identification and antiradical properties of anthocyanins in fruits of Viburnum dilatatum thunb. | 2003 | J. Agric. Food Chem. | pmid:14518940 |
| Hu C et al. | Black rice (Oryza sativa L. indica) pigmented fraction suppresses both reactive oxygen species and nitric oxide in chemical and biological model systems. | 2003 | J. Agric. Food Chem. | pmid:12926869 |
| Glei M et al. | Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. | 2003 Oct-Dec | Toxicol In Vitro | pmid:14599469 |
| Galvano F et al. | Cyanidins: metabolism and biological properties. | 2004 | J. Nutr. Biochem. | pmid:14711454 |
| Zhang J et al. | The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus. | 2004 | Free Radic. Biol. Med. | pmid:15336320 |
| Hyun JW and Chung HS | Cyanidin and Malvidin from Oryza sativa cv. Heugjinjubyeo mediate cytotoxicity against human monocytic leukemia cells by arrest of G(2)/M phase and induction of apoptosis. | 2004 | J. Agric. Food Chem. | pmid:15080622 |
| Ueda H et al. | A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production. | 2004 | Biosci. Biotechnol. Biochem. | pmid:14745173 |
| Tsuda T et al. | Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15003523 |
| Wu X et al. | Pelargonidin is absorbed and metabolized differently than cyanidin after marionberry consumption in pigs. | 2004 | J. Nutr. | pmid:15465754 |
| Xu JW et al. | Cyanidin-3-glucoside regulates phosphorylation of endothelial nitric oxide synthase. | 2004 | FEBS Lett. | pmid:15358561 |
| Harada K et al. | Absorption of acylated anthocyanins in rats and humans after ingesting an extract of Ipomoea batatas purple sweet potato tuber. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15277754 |
| Xu JW et al. | Upregulation of endothelial nitric oxide synthase by cyanidin-3-glucoside, a typical anthocyanin pigment. | 2004 | Hypertension | pmid:15226277 |
| Tatsuzawa F et al. | Diacylated 8-C-glucosylcyanidin 3-glucoside from the flowers of Tricyrtis formosana. | 2004 | Chem. Pharm. Bull. | pmid:15133223 |
| Matsumoto M et al. | Gastroprotective effect of red pigments in black chokeberry fruit (Aronia melanocarpa Elliot) on acute gastric hemorrhagic lesions in rats. | 2004 | J. Agric. Food Chem. | pmid:15080625 |
| Scordino M et al. | Adsorption of flavonoids on resins: cyanidin 3-glucoside. | 2004 | J. Agric. Food Chem. | pmid:15053537 |
| Ando T et al. | Delphinidin accumulation is associated with abnormal flower development in petunias. | 2004 | Phytochemistry | pmid:15587706 |
| Hillebrand S et al. | Characterization of anthocyanins and pyranoanthocyanins from blood orange [Citrus sinensis (L.) Osbeck] juice. | 2004 | J. Agric. Food Chem. | pmid:15563216 |
| Iwai K et al. | Physiological effects and active ingredients of Viburnum dilatatum Thunb fruits on oxidative stress. | 2004 | Biofactors | pmid:15630210 |
| Lee J et al. | Comparison of anthocyanin pigment and other phenolic compounds of Vaccinium membranaceum and Vaccinium ovatum native to the Pacific Northwest of North America. | 2004 | J. Agric. Food Chem. | pmid:15537315 |
| Chang Q and Wong YS | Identification of flavonoids in Hakmeitau beans (Vigna sinensis) by high-performance liquid chromatography-electrospray mass spectrometry (LC-ESI/MS). | 2004 | J. Agric. Food Chem. | pmid:15506802 |
| Muñoz-Espada AC et al. | Anthocyanin quantification and radical scavenging capacity of Concord, Norton, and Marechal Foch grapes and wines. | 2004 | J. Agric. Food Chem. | pmid:15506816 |
| Nimal Punyasiri PA et al. | Exobasidium vexans infection of Camellia sinensis increased 2,3-cis isomerisation and gallate esterification of proanthocyanidins. | 2004 | Phytochemistry | pmid:15504433 |
| Määttä-Riihinen KR et al. | Identification and quantification of phenolic compounds in berries of Fragaria and Rubus species (family Rosaceae). | 2004 | J. Agric. Food Chem. | pmid:15453684 |
| Aumont V et al. | Production of highly 13C-labeled polyphenols in Vitis vinifera cell bioreactor cultures. | 2004 | J. Biotechnol. | pmid:15066766 |
| Zhao C et al. | Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. | 2004 | J. Agric. Food Chem. | pmid:15453676 |
| Zhang Z et al. | Comparison of HPLC methods for determination of anthocyanins and anthocyanidins in bilberry extracts. | 2004 | J. Agric. Food Chem. | pmid:14969517 |
| Matsufuji H and Shibamoto T | Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants. | 2004 | J. Agric. Food Chem. | pmid:15373421 |
| Lee JH and Talcott ST | Fruit maturity and juice extraction influences ellagic acid derivatives and other antioxidant polyphenolics in muscadine grapes. | 2004 | J. Agric. Food Chem. | pmid:14733522 |
| Marko D et al. | The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. | 2004 | Mol Nutr Food Res | pmid:15497183 |
| Schwarz M et al. | Isolation and identification of novel pyranoanthocyanins from black carrot (Daucus carota L.) juice. | 2004 | J. Agric. Food Chem. | pmid:15291481 |
| Kay CD et al. | Anthocyanin metabolites in human urine and serum. | 2004 | Br. J. Nutr. | pmid:15228048 |
| Chun OK et al. | Antioxidant properties of raw and processed cabbages. | 2004 | Int J Food Sci Nutr | pmid:15223595 |
| Turker N et al. | Effect of storage temperature on the stability of anthocyanins of a fermented black carrot (Daucus carota var. L.) beverage: shalgam. | 2004 | J. Agric. Food Chem. | pmid:15186101 |
| Romero C et al. | Polyphenol changes during fermentation of naturally black olives. | 2004 | J. Agric. Food Chem. | pmid:15053538 |
| Del Pozo-Insfran D et al. | Phytochemical composition and pigment stability of Açai (Euterpe oleracea Mart.). | 2004 | J. Agric. Food Chem. | pmid:15030208 |
| Lazzè MC et al. | Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. | 2004 | Carcinogenesis | pmid:15016660 |
| Sugita O et al. | A new method of measuring the antioxidant activity of polyphenols using cumene hydroperoxide. | 2004 | Ann. Clin. Biochem. | pmid:14713390 |
| Yousef GG et al. | Biosynthesis and characterization of 14C-enriched flavonoid fractions from plant cell suspension cultures. | 2004 | J. Agric. Food Chem. | pmid:14995111 |
| Chaovanalikit A et al. | Characterization and quantification of anthocyanins and polyphenolics in bluehHoneysuckle (Lonicera caerulea L.). | 2004 | J. Agric. Food Chem. | pmid:14969540 |
| Gonçalves B et al. | Effect of ripeness and postharvest storage on the phenolic profiles of Cherries (Prunus avium L.). | 2004 | J. Agric. Food Chem. | pmid:14759143 |
| Beckwith AG et al. | Relationship of light quantity and anthocyanin production in Pennisetum setaceum Cvs. rubrum and red riding hood. | 2004 | J. Agric. Food Chem. | pmid:14759132 |
| Fimognari C et al. | Effect of cyanidin 3-O-beta-glucopyranoside on micronucleus induction in cultured human lymphocytes by four different mutagens. | 2004 | Environ. Mol. Mutagen. | pmid:14743345 |
| Xie DY et al. | Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. | 2004 | Arch. Biochem. Biophys. | pmid:14725861 |
| Wang LS et al. | Chemical taxonomy of the Xibei tree peony from China by floral pigmentation. | 2004 | J. Plant Res. | pmid:14685820 |
| Di Paola-Naranjo RD et al. | Liquid chromatographic-mass spectrometric analysis of anthocyanin composition of dark blue bee pollen from Echium plantagineum. | 2004 | J Chromatogr A | pmid:15553145 |
| Duthie SJ et al. | DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro--modulation by the dietary anthocyanin, cyanidin-3-glycoside. | 2005 | Eur J Nutr | pmid:15309415 |
| Irani NG and Grotewold E | Light-induced morphological alteration in anthocyanin-accumulating vacuoles of maize cells. | 2005 | BMC Plant Biol. | pmid:15907203 |
| Shimada S et al. | Anthocyanidin synthase in non-anthocyanin-producing Caryophyllales species. | 2005 | Plant J. | pmid:16359388 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Garcia-Alonso M et al. | Electron spin resonance spectroscopy studies on the free radical scavenging activity of wine anthocyanins and pyranoanthocyanins. | 2005 | Mol Nutr Food Res | pmid:16254886 |
| Passamonti S et al. | Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase. | 2005 | FEBS J. | pmid:15978035 |
| Dimitrić Marković JM et al. | Electronic and infrared vibrational analysis of cyanidin-quercetin copigment complex. | 2005 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:16257774 |
| Kano M et al. | Antioxidative activity of anthocyanins from purple sweet potato, Ipomoera batatas cultivar Ayamurasaki. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15914919 |
| Morita Y et al. | Japanese morning glory dusky mutants displaying reddish-brown or purplish-gray flowers are deficient in a novel glycosylation enzyme for anthocyanin biosynthesis, UDP-glucose:anthocyanidin 3-O-glucoside-2''-O-glucosyltransferase, due to 4-bp insertions in the gene. | 2005 | Plant J. | pmid:15842621 |
| Honda T et al. | Acylated anthocyanins from the violet-blue flowers of Orychophragonus violaceus. | 2005 | Phytochemistry | pmid:16023157 |
| Tohge T et al. | Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. | 2005 | Plant J. | pmid:15807784 |
| Larsson J et al. | Expanding the ChemGPS chemical space with natural products. | 2005 | J. Nat. Prod. | pmid:16038536 |
| Sawada S et al. | UDP-glucuronic acid:anthocyanin glucuronosyltransferase from red daisy (Bellis perennis) flowers. Enzymology and phylogenetics of a novel glucuronosyltransferase involved in flower pigment biosynthesis. | 2005 | J. Biol. Chem. | pmid:15509561 |
| He YH et al. | [Antioxidant and anti-inflammatory effects of cyanidin from cherries on rat adjuvant-induced arthritis]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16422543 |
| Chen PN et al. | Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. | 2005 | Nutr Cancer | pmid:16573384 |
| Ruiz D et al. | Characterization and quantitation of phenolic compounds in new apricot (Prunus armeniaca L.) varieties. | 2005 | J. Agric. Food Chem. | pmid:16302775 |
| Montefiori M et al. | Pigments in the fruit of red-fleshed kiwifruit (Actinidia chinensis and Actinidia deliciosa). | 2005 | J. Agric. Food Chem. | pmid:16302772 |
| Longo L and Vasapollo G | Anthocyanins from bay (Laurus nobilis L.) berries. | 2005 | J. Agric. Food Chem. | pmid:16190671 |
| Mylnikov SV et al. | Rubus fruit juices affect lipid peroxidation in a Drosophila melanogaster model in vivo. | 2005 | J. Agric. Food Chem. | pmid:16190624 |
| Felgines C et al. | Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans. | 2005 | J. Agric. Food Chem. | pmid:16190623 |
| Longo L et al. | Identification of anthocyanins in Rhamnus alaternus L. berries. | 2005 | J. Agric. Food Chem. | pmid:15740065 |
| Stoner GD et al. | Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. | 2005 | J Clin Pharmacol | pmid:16172180 |
| Al-Farsi M et al. | Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. | 2005 | J. Agric. Food Chem. | pmid:16159191 |
| Ichiyanagi T et al. | Extended glucuronidation is another major path of cyanidin 3-O-beta-D-glucopyranoside metabolism in rats. | 2005 | J. Agric. Food Chem. | pmid:16131148 |
| Tian Q et al. | Probing anthocyanin profiles in purple sweet potato cell line (Ipomoea batatas L. Cv. Ayamurasaki) by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2005 | J. Agric. Food Chem. | pmid:16076141 |
| Punyasiri PA et al. | Preformed and induced chemical resistance of tea leaf against Exobasidium vexans infection. | 2005 | J. Chem. Ecol. | pmid:16222773 |
| Takeda K et al. | Components of protocyanin, a blue pigment from the blue flowers of Centaurea cyanus. | 2005 | Phytochemistry | pmid:16005311 |
| Hou DX et al. | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. | 2005 | Biochem. Pharmacol. | pmid:15963474 |
| McDougall GJ et al. | Anthocyanins from red wine--their stability under simulated gastrointestinal digestion. | 2005 | Phytochemistry | pmid:16242736 |
| Talavéra S et al. | Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain. | 2005 | J. Agric. Food Chem. | pmid:15884815 |
| McDougall GJ et al. | Anthocyanin-flavanol condensation products from black currant (Ribes nigrum L.). | 2005 | J. Agric. Food Chem. | pmid:16190645 |
| Tsuda T et al. | Gene expression profile of isolated rat adipocytes treated with anthocyanins. | 2005 | Biochim. Biophys. Acta | pmid:15863361 |
| Habermeyer M et al. | Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity. | 2005 | Chem. Res. Toxicol. | pmid:16167831 |
| Bendia E et al. | Effect of cyanidin 3-O-beta-glucopyranoside on hepatic stellate cell proliferation and collagen synthesis induced by oxidative stress. | 2005 | Dig Liver Dis | pmid:15843084 |
| Innocenti M et al. | Evaluation of the phenolic content in the aerial parts of different varieties of Cichorium intybus L. | 2005 | J. Agric. Food Chem. | pmid:16076140 |
| Flamini R | Some advances in the knowledge of grape, wine and distillates chemistry as achieved by mass spectrometry. | 2005 | J Mass Spectrom | pmid:15954164 |
| Berardini N et al. | Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. | 2005 | J. Agric. Food Chem. | pmid:15740041 |
| Nakajima T et al. | Insertion and excision of a transposable element governs the red floral phenotype in commercial petunias. | 2005 | Theor. Appl. Genet. | pmid:15731929 |
| Riso P et al. | Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. | 2005 | J. Agric. Food Chem. | pmid:15713002 |
| Zhang Y et al. | Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. | 2005 | Life Sci. | pmid:15680311 |
| Frank T et al. | Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. | 2005 | J Clin Pharmacol | pmid:15647413 |
| Jayaprakasam B et al. | Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. | 2005 | J. Agric. Food Chem. | pmid:15631504 |
| Ichiyanagi T et al. | Metabolic pathway of cyanidin 3-O-beta-D-glucopyranoside in rats. | 2005 | J. Agric. Food Chem. | pmid:15631521 |
| Russo A et al. | Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-beta-d-glucoside. | 2005 | J. Nutr. Biochem. | pmid:15629238 |
| Aura AM et al. | In vitro metabolism of anthocyanins by human gut microflora. | 2005 | Eur J Nutr | pmid:15309431 |
| Shih PH et al. | Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. | 2005 | Food Chem. Toxicol. | pmid:15964118 |
| Nielsen AH et al. | Flavonoids in flowers of 16 Kalanchoë blossfeldiana varieties. | 2005 | Phytochemistry | pmid:16297414 |