Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang XW et al. | A new sensor for ammonia based on cyanidin-sensitized titanium dioxide film operating at room temperature. | 2013 | Anal. Chim. Acta | pmid:23830444 |
| Bushakra JM et al. | QTL involved in the modification of cyanidin compounds in black and red raspberry fruit. | 2013 | Theor. Appl. Genet. | pmid:23224381 |
| Gharib A et al. | In vitro and in vivo antibacterial activities of cyanidinum chloride-loaded liposomes against a resistant strain of Pseudomonas aeruginosa. | 2013 | Planta Med. | pmid:23203413 |
| Esselen M et al. | Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats. | 2013 | Carcinogenesis | pmid:23275152 |
| Jia Y et al. | Cyanidin is an agonistic ligand for peroxisome proliferator-activated receptor-alpha reducing hepatic lipid. | 2013 | Biochim. Biophys. Acta | pmid:23228689 |
| Xiao J et al. | A review on structure-activity relationship of dietary polyphenols inhibiting α-amylase. | 2013 | Crit Rev Food Sci Nutr | pmid:23391016 |
| Gao S et al. | Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways. | 2013 | Cancer Lett. | pmid:23360684 |
| Tanaka J et al. | Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo. | 2013 | Life Sci. | pmid:23123597 |
| Chu H et al. | Expression of the sweetpotato R2R3-type IbMYB1a gene induces anthocyanin accumulation in Arabidopsis. | 2013 | Physiol Plant | pmid:23039825 |
| Harb J et al. | Correlation between changes in polyphenol composition of peels and incidence of COâ‚‚ skin burning of 'Cameo' apples as influenced by controlled atmosphere storage. | 2013 | J. Agric. Food Chem. | pmid:23517081 |
| Vodopivec BM et al. | Differences in the structure of anthocyanins from the two amphibious plants, Lobelia cardinalis and Nesaea crassicaulis. | 2013 | Nat. Prod. Res. | pmid:22694738 |
| Elisabetta B et al. | Nutritional profile and productivity of bilberry (Vaccinium myrtillus L.) in different habitats of a protected area of the eastern Italian Alps. | 2013 | J. Food Sci. | pmid:23573813 |
| Brugliera F et al. | Violet/blue chrysanthemums--metabolic engineering of the anthocyanin biosynthetic pathway results in novel petal colors. | 2013 | Plant Cell Physiol. | pmid:23926066 |
| Gharib A et al. | Treatment of diabetes in the mouse model by delphinidin and cyanidin hydrochloride in free and liposomal forms. | 2013 | Planta Med. | pmid:24108435 |
| Pompei A et al. | Cyanidin reduces preadipocyte differentiation and relative ChREBP expression. | 2012 Apr-Jun | J. Biol. Regul. Homeost. Agents | pmid:22824753 |
| Wang Y et al. | Antioxidant activities and major anthocyanins of Myrobalan plum (Prunus cerasifera Ehrh.). | 2012 | J. Food Sci. | pmid:22432436 |
| Arya A et al. | Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. | 2012 | Evid Based Complement Alternat Med | pmid:22474512 |
| Tanaka J et al. | Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. | 2012 | Phytother Res | pmid:21633982 |
| Arapitsas P et al. | A metabolomic approach to the study of wine micro-oxygenation. | 2012 | PLoS ONE | pmid:22662221 |
| Bonarska-Kujawa D et al. | Interaction of selected anthocyanins with erythrocytes and liposome membranes. | 2012 | Cell. Mol. Biol. Lett. | pmid:22396139 |
| Ieri F et al. | Simultaneous determination of anthocyanins, coumarins and phenolic acids in fruits, kernels and liqueur of Prunus mahaleb L. | 2012 | Food Chem | pmid:22980784 |
| Mulabagal V et al. | Quantitative analysis of anthocyanins in Euterpe oleracea (açaÃ) dietary supplement raw materials and capsules by Q-TOF liquid chromatography/mass spectrometry. | 2012 | Pharm Biol | pmid:22900515 |
| Oliveira Lde S et al. | Antioxidant metabolism during fruit development of different acerola (Malpighia emarginata D.C) clones. | 2012 | J. Agric. Food Chem. | pmid:22834960 |
| Kim SM et al. | Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids. | 2012 | Life Sci. | pmid:22575822 |
| Park WT et al. | Metabolic profiling of glucosinolates, anthocyanins, carotenoids, and other secondary metabolites in kohlrabi (Brassica oleracea var. gongylodes). | 2012 | J. Agric. Food Chem. | pmid:22742768 |
| Schrader C et al. | Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. | 2012 | J. Cell. Mol. Med. | pmid:22304296 |
| Li X et al. | Accumulation of phenylpropanoids and correlated gene expression during the development of tartary buckwheat sprouts. | 2012 | J. Agric. Food Chem. | pmid:22587625 |
| Aguayo-Rojas J et al. | Phytochemicals and antioxidant capacity of tortillas obtained after lime-cooking extrusion process of whole pigmented mexican maize. | 2012 | Plant Foods Hum Nutr | pmid:22562094 |
| Wang D et al. | Cyanidin-3-O-β-glucoside upregulates hepatic cholesterol 7α-hydroxylase expression and reduces hypercholesterolemia in mice. | 2012 | Mol Nutr Food Res | pmid:22495986 |
| Saito N et al. | Covalent anthocyanin-flavonol complexes from the violet-blue flowers of Allium 'Blue Perfume'. | 2012 | Phytochemistry | pmid:22704652 |
| Yuan L et al. | Molecular cloning and characterization of PtrLAR3, a gene encoding leucoanthocyanidin reductase from Populus trichocarpa, and its constitutive expression enhances fungal resistance in transgenic plants. | 2012 | J. Exp. Bot. | pmid:22268151 |
| Fernandes I et al. | A new approach on the gastric absorption of anthocyanins. | 2012 | Food Funct | pmid:22391951 |
| Ziberna L et al. | Transport and bioactivity of cyanidin 3-glucoside into the vascular endothelium. | 2012 | Free Radic. Biol. Med. | pmid:22387282 |
| Zou T et al. | Optimization of microwave-assisted extraction of anthocyanins from mulberry and identification of anthocyanins in extract using HPLC-ESI-MS. | 2012 | J. Food Sci. | pmid:22260102 |
| Zilić S et al. | Phenolic compounds, carotenoids, anthocyanins, and antioxidant capacity of colored maize (Zea mays L.) kernels. | 2012 | J. Agric. Food Chem. | pmid:22248075 |
| Abe LT et al. | Potential dietary sources of ellagic acid and other antioxidants among fruits consumed in Brazil: jabuticaba (Myrciaria jaboticaba (Vell.) Berg). | 2012 | J. Sci. Food Agric. | pmid:22173652 |
| Luo X et al. | Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling. | 2012 | Mol. Cell. Biochem. | pmid:22120492 |
| Kovinich N et al. | Identification of two anthocyanidin reductase genes and three red-brown soybean accessions with reduced anthocyanidin reductase 1 mRNA, activity, and seed coat proanthocyanidin amounts. | 2012 | J. Agric. Food Chem. | pmid:22107112 |
| Zhu W et al. | The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP-PKA-dependent signaling pathway. | 2012 | Free Radic. Biol. Med. | pmid:22085656 |
| Hall D et al. | Molecular cloning and biochemical characterization of the UDP-glucose: flavonoid 3-O-glucosyltransferase from Concord grape (Vitis labrusca). | 2012 | Phytochemistry | pmid:22098678 |
| Yang Y et al. | SNARE-wedging polyphenols as small molecular botox. | 2012 | Planta Med. | pmid:22109835 |
| Ernst IM et al. | Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes. | 2012 | Br. J. Nutr. | pmid:21745425 |
| Guo H et al. | Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. | 2012 | J. Nutr. Biochem. | pmid:21543211 |
| Li J et al. | Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy. | 2012 | J. Nutr. Biochem. | pmid:21543205 |
| Akhlaghi M and Bandy B | Preconditioning and acute effects of flavonoids in protecting cardiomyocytes from oxidative cell death. | 2012 | Oxid Med Cell Longev | pmid:22829963 |
| Tatsuzawa F et al. | Triacylated peonidin 3-sophoroside-5-glucosides from the purple flowers of Moricandia ramburii Webb. | 2012 | Phytochemistry | pmid:22264647 |
| Brown PN et al. | Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis. | 2012 | Planta Med. | pmid:22337317 |
| Sun Y et al. | Arabidopsis TT19 functions as a carrier to transport anthocyanin from the cytosol to tonoplasts. | 2012 | Mol Plant | pmid:22201047 |
| Su M et al. | Physical changes and physiological characteristics of red and green peel during nectarine (cv. Hu018) maturation. | 2012 | J. Sci. Food Agric. | pmid:22144032 |
| Asada T and Tamura H | Isolation of bilberry anthocyanidin 3-glycosides bearing ortho-dihydroxyl groups on the B ring by forming an aluminum complex and their antioxidant activity. | 2012 | J. Agric. Food Chem. | pmid:23025407 |
| Yi L et al. | Differential suppression of intracellular reactive oxygen species-mediated signaling pathway in vascular endothelial cells by several subclasses of flavonoids. | 2012 | Biochimie | pmid:22683914 |
| Ojwang LO et al. | Ultra performance liquid chromatography-tandem quadrupole mass spectrometry profiling of anthocyanins and flavonols in cowpea (Vigna unguiculata) of varying genotypes. | 2012 | J. Agric. Food Chem. | pmid:22429113 |
| Peng QZ et al. | An integrated approach to demonstrating the ANR pathway of proanthocyanidin biosynthesis in plants. | 2012 | Planta | pmid:22678031 |
| Yoshimura Y et al. | Visualization of anthocyanin species in rabbiteye blueberry Vaccinium ashei by matrix-assisted laser desorption/ionization imaging mass spectrometry. | 2012 | Anal Bioanal Chem | pmid:22399120 |
| De Rosso M et al. | Study of anthocyanic profiles of twenty-one hybrid grape varieties by liquid chromatography and precursor-ion mass spectrometry. | 2012 | Anal. Chim. Acta | pmid:22688043 |
| Romera-Fernández M et al. | Feasibility study of FT-MIR spectroscopy and PLS-R for the fast determination of anthocyanins in wine. | 2012 | Talanta | pmid:22265503 |
| Shih PH et al. | Synergistic effect of cyanidin and PPAR agonist against nonalcoholic steatohepatitis-mediated oxidative stress-induced cytotoxicity through MAPK and Nrf2 transduction pathways. | 2012 | J. Agric. Food Chem. | pmid:22364184 |
| Ishiguro K et al. | Functional analysis of Antirrhinum kelloggii flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase genes; critical role in flower color and evolution in the genus Antirrhinum. | 2012 | J. Plant Res. | pmid:21959781 |
| Kamonpatana K et al. | Susceptibility of anthocyanins to ex vivo degradation in human saliva. | 2012 | Food Chem | pmid:22868153 |
| Treutter D et al. | Diversity of phenolic profiles in the fruit skin of Prunus domestica plums and related species. | 2012 | J. Agric. Food Chem. | pmid:23140499 |
| Zhu L et al. | Phenolic contents and compositions in skins of red wine grape cultivars among various genetic backgrounds and originations. | 2012 | Int J Mol Sci | pmid:22489164 |
| de Jesus NZ et al. | Tannins, peptic ulcers and related mechanisms. | 2012 | Int J Mol Sci | pmid:22489149 |
| Zhu M et al. | Relationship between the composition of flavonoids and flower colors variation in tropical water lily (Nymphaea) cultivars. | 2012 | PLoS ONE | pmid:22485167 |
| Jang HH et al. | Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation. | 2012 | Nutr Metab (Lond) | pmid:22458550 |
| Payyavula RS et al. | Differential effects of environment on potato phenylpropanoid and carotenoid expression. | 2012 | BMC Plant Biol. | pmid:22429339 |
| Aqil F et al. | Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). | 2012 | Nutr Cancer | pmid:22420901 |
| Devi PS et al. | DNA Damage Protecting Activity and Free Radical Scavenging Activity of Anthocyanins from Red Sorghum (Sorghum bicolor) Bran. | 2012 | Biotechnol Res Int | pmid:22400119 |
| Oloyede FM et al. | Effect of NPK fertilizer on chemical composition of pumpkin (Cucurbita pepo Linn.) seeds. | 2012 | ScientificWorldJournal | pmid:22629204 |
| Poulose SM et al. | Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells. | 2012 | J. Agric. Food Chem. | pmid:22224493 |
| Ghanbari R et al. | Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review. | 2012 | Int J Mol Sci | pmid:22489153 |
| Guo H et al. | Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells. | 2012 | Lipids Health Dis | pmid:22243683 |
| Di Giacomo C et al. | Effect of Treatment with Cyanidin-3-O-β-D-Glucoside on Rat Ischemic/Reperfusion Brain Damage. | 2012 | Evid Based Complement Alternat Med | pmid:23008739 |
| Zhang X et al. | Characterisation of anthocyanidin reductase from Shuchazao green tea. | 2012 | J. Sci. Food Agric. | pmid:22173936 |
| Sorrenti V et al. | Dimethylarginine dimethylaminohydrolase/nitric oxide synthase pathway in liver and kidney: protective effect of cyanidin 3-O-β-D-glucoside on ochratoxin-A toxicity. | 2012 | Toxins (Basel) | pmid:22778905 |
| Li S and Yao J | [Adsorption dynamics study on interactions of pigments and human whole saliva]. | 2012 | Hua Xi Kou Qiang Yi Xue Za Zhi | pmid:22768757 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Rozza AL et al. | Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. | 2012 | Evid Based Complement Alternat Med | pmid:22666296 |
| Mohanty S and Cock IE | The chemotherapeutic potential of Terminalia ferdinandiana: Phytochemistry and bioactivity. | 2012 | Pharmacogn Rev | pmid:22654402 |
| Taha RM and Wafa SN | Plant regeneration and cellular behaviour studies in Celosia cristata grown in vivo and in vitro. | 2012 | ScientificWorldJournal | pmid:22593677 |
| Kumar S et al. | Genomic selection for fruit quality traits in apple (Malus×domestica Borkh.). | 2012 | PLoS ONE | pmid:22574211 |
| Ganugapati J et al. | Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus. | 2012 | Bioinformation | pmid:22493522 |
| Roslan ND et al. | Flavonoid biosynthesis genes putatively identified in the aromatic plant Polygonum minus via Expressed Sequences Tag (EST) analysis. | 2012 | Int J Mol Sci | pmid:22489118 |
| Sharif T et al. | Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells. | 2012 | PLoS ONE | pmid:22412883 |
| Arfan M et al. | Antioxidant activity of mulberry fruit extracts. | 2012 | Int J Mol Sci | pmid:22408465 |
| Kanwal S et al. | Docking of human rhodopsin mutant (Gly90→Asp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness. | 2012 | Bioinformation | pmid:22368384 |
| Yoshimura Y et al. | Different localization patterns of anthocyanin species in the pericarp of black rice revealed by imaging mass spectrometry. | 2012 | PLoS ONE | pmid:22363605 |
| Vignolini S et al. | The mirror crack'd: both pigment and structure contribute to the glossy blue appearance of the mirror orchid, Ophrys speculum. | 2012 | New Phytol. | pmid:23043621 |
| Bak MJ et al. | Procyanidins from wild grape (Vitis amurensis) seeds regulate ARE-mediated enzyme expression via Nrf2 coupled with p38 and PI3K/Akt pathway in HepG2 cells. | 2012 | Int J Mol Sci | pmid:22312287 |
| Ibrahim MH et al. | Involvement of nitrogen on flavonoids, glutathione, anthocyanin, ascorbic acid and antioxidant activities of Malaysian medicinal plant Labisia pumila Blume (Kacip Fatimah). | 2012 | Int J Mol Sci | pmid:22312260 |
| Huang WY et al. | Survey of antioxidant capacity and phenolic composition of blueberry, blackberry, and strawberry in Nanjing. | 2012 | J Zhejiang Univ Sci B | pmid:22302422 |
| Chagné D et al. | QTL and candidate gene mapping for polyphenolic composition in apple fruit. | 2012 | BMC Plant Biol. | pmid:22269060 |
| Han Y et al. | Introduction of apple ANR genes into tobacco inhibits expression of both CHI and DFR genes in flowers, leading to loss of anthocyanin. | 2012 | J. Exp. Bot. | pmid:22238451 |
| Sun CD et al. | Cyanidin-3-glucoside-rich extract from Chinese bayberry fruit protects pancreatic β cells and ameliorates hyperglycemia in streptozotocin-induced diabetic mice. | 2012 | J Med Food | pmid:22181073 |
| Khater F et al. | Identification and functional characterization of cDNAs coding for hydroxybenzoate/hydroxycinnamate glucosyltransferases co-expressed with genes related to proanthocyanidin biosynthesis. | 2012 | J. Exp. Bot. | pmid:22090445 |
| Wu TY et al. | Effect of antioxidant activity and functional properties of Chingshey purple sweet potato fermented milk by Lactobacillus acidophilus, L. delbrueckii subsp. lactis, and L. gasseri strains. | 2012 | J. Food Sci. | pmid:22182227 |
| Yonekura-Sakakibara K et al. | Two glycosyltransferases involved in anthocyanin modification delineated by transcriptome independent component analysis in Arabidopsis thaliana. | 2012 | Plant J. | pmid:21899608 |
| Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
| Crupi P et al. | HPLC-DAD-ESI-MS analysis of flavonoid compounds in 5 seedless table grapes grown in Apulian Region. | 2012 | J. Food Sci. | pmid:22309436 |
| Agostini F et al. | Supercritical extraction from vinification residues: fatty acids, α-tocopherol, and phenolic compounds in the oil seeds from different varieties of grape. | 2012 | ScientificWorldJournal | pmid:22593706 |
| Stalmach A et al. | Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. | 2011 | J. Agric. Food Chem. | pmid:21812481 |