Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Castellarin SD et al. | Colour variation in red grapevines (Vitis vinifera L.): genomic organisation, expression of flavonoid 3'-hydroxylase, flavonoid 3',5'-hydroxylase genes and related metabolite profiling of red cyanidin-/blue delphinidin-based anthocyanins in berry skin. | 2006 | BMC Genomics | pmid:16433923 |
| Muñoz-Espada AC and Watkins BA | Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells. | 2006 | J. Nutr. Biochem. | pmid:16443360 |
| Tian Q et al. | Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. | 2006 | J. Agric. Food Chem. | pmid:16478275 |
| Tsuda T et al. | Microarray profiling of gene expression in human adipocytes in response to anthocyanins. | 2006 | Biochem. Pharmacol. | pmid:16483547 |
| Wellmann F et al. | Anthocyanidin synthase from Gerbera hybrida catalyzes the conversion of (+)-catechin to cyanidin and a novel procyanidin. | 2006 | FEBS Lett. | pmid:16494872 |
| Pergola C et al. | Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. | 2006 | Nitric Oxide | pmid:16517190 |
| Hecht SS et al. | Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. | 2006 | Carcinogenesis | pmid:16522666 |
| Schütz K et al. | Characterization and quantification of anthocyanins in selected artichoke (Cynara scolymus L.) cultivars by HPLC-DAD-ESI-MSn. | 2006 | Anal Bioanal Chem | pmid:16534575 |
| Chen PN et al. | Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. | 2005 | Nutr Cancer | pmid:16573384 |
| Pawlak K et al. | Blue natural organic dyestuffs--from textile dyeing to mural painting. Separation and characterization of coloring matters present in elderberry, logwood and indigo. | 2006 | J Mass Spectrom | pmid:16575781 |
| Felgines C et al. | Absorption and metabolism of red orange juice anthocyanins in rats. | 2006 | Br. J. Nutr. | pmid:16611379 |
| Ding M et al. | Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. | 2006 | J. Biol. Chem. | pmid:16618699 |
| Yoshida K et al. | Ferric ions involved in the flower color development of the Himalayan blue poppy, Meconopsis grandis. | 2006 | Phytochemistry | pmid:16678868 |
| Wu X et al. | Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. | 2006 | J. Agric. Food Chem. | pmid:16719536 |
| Meng L et al. | Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis. | 2006 | J. Agric. Food Chem. | pmid:16756359 |
| Espinosa-Alonso LG et al. | Polyphenols in wild and weedy Mexican common beans (Phaseolus vulgaris L.). | 2006 | J. Agric. Food Chem. | pmid:16756378 |
| Tatsuzawa F et al. | Acylated cyanidin 3-sambubioside-5-glucosides in three garden plants of the Cruciferae. | 2006 | Phytochemistry | pmid:16777160 |
| Iwai K et al. | Alpha-glucosidase inhibitory and antihyperglycemic effects of polyphenols in the fruit of Viburnum dilatatum Thunb. | 2006 | J. Agric. Food Chem. | pmid:16787002 |
| Abdel-Aal el-SM et al. | Anthocyanin composition in black, blue, pink, purple, and red cereal grains. | 2006 | J. Agric. Food Chem. | pmid:16787017 |
| Walton MC et al. | The flavonol quercetin-3-glucoside inhibits cyanidin-3-glucoside absorption in vitro. | 2006 | J. Agric. Food Chem. | pmid:16787048 |
| Lamy S et al. | Anthocyanidins inhibit migration of glioblastoma cells: structure-activity relationship and involvement of the plasminolytic system. | 2007 | J. Cell. Biochem. | pmid:16823770 |
| Cooke D et al. | Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels. | 2006 | Int. J. Cancer | pmid:16823841 |
| Ichiyanagi T et al. | Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. | 2006 | J. Agric. Food Chem. | pmid:16848510 |
| Kondo T et al. | Novel and efficient synthesis of cyanidin 3-O-beta-D-glucoside from (+)-catechin via a flav-3-en-3-ol as a key intermediate. | 2006 | Org. Lett. | pmid:16869672 |
| Oak MH et al. | Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. | 2006 | Br. J. Pharmacol. | pmid:16921400 |
| Reynertson KA et al. | Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). | 2006 | J. Nat. Prod. | pmid:16933884 |
| Pinelo M et al. | Effect of clarification techniques and rat intestinal extract incubation on phenolic composition and antioxidant activity of black currant juice. | 2006 | J. Agric. Food Chem. | pmid:16939310 |
| Ichiyanagi T et al. | Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats. | 2006 | J. Agric. Food Chem. | pmid:16939312 |
| Oliveira J et al. | Color properties of four cyanidin-pyruvic acid adducts. | 2006 | J. Agric. Food Chem. | pmid:16939355 |
| Yao Y and Vieira A | Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. | 2007 | Neurotoxicology | pmid:16956663 |
| Chirinos R et al. | High-performance liquid chromatography with photodiode array detection (HPLC-DAD)/HPLC-mass spectrometry (MS) profiling of anthocyanins from Andean Mashua Tubers (Tropaeolum tuberosum RuÃz and Pavón) and their contribution to the overall antioxidant activity. | 2006 | J. Agric. Food Chem. | pmid:16968067 |
| Chen PN et al. | Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. | 2006 | Chem. Biol. Interact. | pmid:16970933 |
| Fang Z et al. | Chemical composition of clarified bayberry (Myrica rubra Sieb. et Zucc.) juice sediment. | 2006 | J. Agric. Food Chem. | pmid:17002443 |
| Solomon A et al. | Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L.). | 2006 | J. Agric. Food Chem. | pmid:17002444 |
| Kim AJ and Park S | Mulberry extract supplements ameliorate the inflammation-related hematological parameters in carrageenan-induced arthritic rats. | 2006 | J Med Food | pmid:17004912 |
| Rahman MM et al. | Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. | 2006 | Free Radic. Res. | pmid:17015281 |
| Xu JW et al. | Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells. | 2007 | Atherosclerosis | pmid:17045269 |
| Cortell JM and Kennedy JA | Effect of shading on accumulation of flavonoid compounds in (Vitis vinifera L.) pinot noir fruit and extraction in a model system. | 2006 | J. Agric. Food Chem. | pmid:17061828 |
| Schauss AG et al. | Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae mart. (acai). | 2006 | J. Agric. Food Chem. | pmid:17061839 |
| Fedenko VS | [Cyanidin complexation with metal ions]. | 2006 Mar-Apr | Ukr Biokhim Zh (1999) | pmid:17100297 |
| Bononi M et al. | 'Cyanidin volumetric index' and 'chromaticity coordinates ratio' to characterize red raspberry (Rubus idaeus). | 2006 Aug-Sep | Int J Food Sci Nutr | pmid:17135027 |
| Jordheim M et al. | Characterization of hemiacetal forms of anthocyanidin 3-O-beta-glycopyranosides. | 2006 | J. Agric. Food Chem. | pmid:17147416 |
| Netzel M et al. | Sources of antioxidant activity in Australian native fruits. Identification and quantification of anthocyanins. | 2006 | J. Agric. Food Chem. | pmid:17177507 |
| Harnly JM et al. | Flavonoid content of U.S. fruits, vegetables, and nuts. | 2006 | J. Agric. Food Chem. | pmid:17177529 |
| Ashton OB et al. | Pigments in avocado tissue and oil. | 2006 | J. Agric. Food Chem. | pmid:17177553 |
| Pawlowska AM et al. | Phenolics of Arbutus unedo L. (Ericaceae) fruits: identification of anthocyanins and gallic acid derivatives. | 2006 | J. Agric. Food Chem. | pmid:17177565 |
| Espley RV et al. | Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10. | 2007 | Plant J. | pmid:17181777 |
| Bjorøy O et al. | Anthocyanin 3-galactosides from Cornus alba 'Sibirica' with glucosidation of the B-ring. | 2007 | Phytochemistry | pmid:17207823 |
| Watanabe M | An anthocyanin compound in buckwheat sprouts and its contribution to antioxidant capacity. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17284830 |
| Seitz C et al. | Redirection of anthocyanin synthesis in Osteospermum hybrida by a two-enzyme manipulation strategy. | 2007 | Phytochemistry | pmid:17286993 |
| Füzfai Z and Molnár-Perl I | Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits. | 2007 | J Chromatogr A | pmid:17289064 |
| D'Auria JC et al. | Identification and characterization of the BAHD acyltransferase malonyl CoA: anthocyanidin 5-O-glucoside-6''-O-malonyltransferase (At5MAT) in Arabidopsis thaliana. | 2007 | FEBS Lett. | pmid:17292360 |
| Hamauzu Y et al. | Reddish coloration of Chinese quince (Pseudocydonia sinensis) procyanidins during heat treatment and effect on antioxidant and antiinfluenza viral activities. | 2007 | J. Agric. Food Chem. | pmid:17300149 |
| Liu YC et al. | Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. | 2007 | Life Sci. | pmid:17320913 |
| Lans C et al. | Ethnoveterinary medicines used for ruminants in British Columbia, Canada. | 2007 | J Ethnobiol Ethnomed | pmid:17324258 |
| Fujihara T et al. | High-molecular-weight polyphenols from oolong tea and black tea: purification, some properties, and role in increasing mitochondrial membrane potential. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17341825 |
| Feng R et al. | Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. | 2007 | J. Biol. Chem. | pmid:17360708 |
| Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
| Srivastava A et al. | Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. | 2007 | J. Agric. Food Chem. | pmid:17381106 |
| Barzaghi N et al. | Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects. | 1991 | Ital J Gastroenterol | pmid:1742514 |
| Sorrenti V et al. | Heme oxygenase induction by cyanidin-3-O-beta-glucoside in cultured human endothelial cells. | 2007 | Mol Nutr Food Res | pmid:17440991 |
| Coates EM et al. | Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. | 2007 | J Carcinog | pmid:17442116 |
| Terasawa N et al. | Identification and some properties of anthocyanin isolated from Zuiki, stalk of Colocasia esculenta. | 2007 | J. Agric. Food Chem. | pmid:17447784 |
| Milbury PE et al. | Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460300 |
| Bononi M and Tateo F | Stabilization of cranberry anthocyanins in nutraceutical capsules. | 2007 | Int J Food Sci Nutr | pmid:17469769 |
| Aaby K et al. | Characterization of phenolic compounds in strawberry (Fragaria x ananassa) fruits by different HPLC detectors and contribution of individual compounds to total antioxidant capacity. | 2007 | J. Agric. Food Chem. | pmid:17472391 |
| Stewart D et al. | Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. | 2007 | Mol Nutr Food Res | pmid:17492796 |
| Alcalde-Eon C et al. | Identification of dimeric anthocyanins and new oligomeric pigments in red wine by means of HPLC-DAD-ESI/MSn. | 2007 | J Mass Spectrom | pmid:17511019 |
| Kim MJ et al. | Relationship between phenolic compounds, anthocyanins content and antioxidant activity in colored barley germplasm. | 2007 | J. Agric. Food Chem. | pmid:17516656 |
| Choi EH et al. | Cytoprotective effect of anthocyanins against doxorubicin-induced toxicity in H9c2 cardiomyocytes in relation to their antioxidant activities. | 2007 | Food Chem. Toxicol. | pmid:17524543 |
| Felgines C et al. | Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. | 2007 | Br. J. Nutr. | pmid:17559698 |
| Di Giacomo C et al. | Protective effect of cyanidin 3-O-beta-D-glucoside on ochratoxin A-mediated damage in the rat. | 2007 | Br. J. Nutr. | pmid:17562227 |
| Nicoué EE et al. | Anthocyanins in wild blueberries of Quebec: extraction and identification. | 2007 | J. Agric. Food Chem. | pmid:17579428 |
| Jordheim M et al. | Anthocyanins in berries of ribes including gooseberry cultivars with a high content of acylated pigments. | 2007 | J. Agric. Food Chem. | pmid:17579440 |
| Kim SJ et al. | Identification of anthocyanins in the sprouts of buckwheat. | 2007 | J. Agric. Food Chem. | pmid:17580874 |
| Grimplet J et al. | Tissue-specific mRNA expression profiling in grape berry tissues. | 2007 | BMC Genomics | pmid:17584945 |
| Ayaz E and Alpsoy HC | [Garlic (Allium sativum) and traditional medicine]. | 2007 | Turkiye Parazitol Derg | pmid:17594659 |
| Marinova K et al. | The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat. | 2007 | Plant Cell | pmid:17601828 |
| Cortell JM et al. | Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) anthocyanins. 1. Anthocyanin concentration and composition in fruit. | 2007 | J. Agric. Food Chem. | pmid:17636933 |
| Cortell JM et al. | Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) anthocyanins. 2. Anthocyanins and pigmented polymers in wine. | 2007 | J. Agric. Food Chem. | pmid:17636934 |
| Min K and Ebeler SE | Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels. | 2008 | Food Chem. Toxicol. | pmid:17707569 |
| Tarozzi A et al. | Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells. | 2007 | Neurosci. Lett. | pmid:17709193 |
| Vitaglione P et al. | Protocatechuic acid is the major human metabolite of cyanidin-glucosides. | 2007 | J. Nutr. | pmid:17709440 |
| Kern M et al. | Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. | 2007 | Mol Nutr Food Res | pmid:17729219 |
| Cassinese C et al. | New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations. | 2007 Jul-Aug | J AOAC Int | pmid:17760327 |
| Castellarin SD and Di Gaspero G | Transcriptional control of anthocyanin biosynthetic genes in extreme phenotypes for berry pigmentation of naturally occurring grapevines. | 2007 | BMC Plant Biol. | pmid:17760970 |
| Esparza I et al. | Complexing capacity profiles of naturally occurring ligands in Tempranillo wines for Cu and Zn: an electroanalytical approach for cupric casse. | 2007 | Anal. Chim. Acta | pmid:17765065 |
| Burdulis D et al. | [Analysis of anthocyanin content in bilberry (Vaccinium myrtillus L.) fruit crude drugs by high-performance liquid chromatography method]. | 2007 | Medicina (Kaunas) | pmid:17768372 |
| Mulabagal V et al. | Cultivars of apple fruits that are not marketed with potential for anthocyanin production. | 2007 | J. Agric. Food Chem. | pmid:17822290 |
| Sasaki R et al. | Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. | 2007 | Biochem. Pharmacol. | pmid:17869225 |
| Pang Y et al. | Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula. | 2007 | Plant Physiol. | pmid:17885080 |
| Liu L et al. | Degradation of cyanidin 3-rutinoside in the presence of (-)-epicatechin and litchi pericarp polyphenol oxidase. | 2007 | J. Agric. Food Chem. | pmid:17914871 |
| Tatsuzawa F et al. | Triacylated cyanidin 3-(3X-glucosylsambubioside)-5-glucosides from the flowers of Malcolmia maritima. | 2008 | Phytochemistry | pmid:17928016 |
| de Brito ES et al. | Anthocyanins present in selected tropical fruits: acerola, jambolão, jussara, and guajiru. | 2007 | J. Agric. Food Chem. | pmid:17929888 |
| Suzuki T et al. | Structural identification of anthocyanins and analysis of concentrations during growth and flowering in buckwheat (Fagopyrum esculentum Moench) petals. | 2007 | J. Agric. Food Chem. | pmid:17941697 |
| Ozga JA et al. | Characterization of cyanidin- and quercetin-derived flavonoids and other phenolics in mature saskatoon fruits (Amelanchier alnifolia Nutt.). | 2007 | J. Agric. Food Chem. | pmid:17994693 |
| Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
| GarcÃa-MacÃas P et al. | Changes in the flavonoid and phenolic acid contents and antioxidant activity of red leaf lettuce (Lollo Rosso) due to cultivation under plastic films varying in ultraviolet transparency. | 2007 | J. Agric. Food Chem. | pmid:18001028 |
| Yan Y et al. | High-yield anthocyanin biosynthesis in engineered Escherichia coli. | 2008 | Biotechnol. Bioeng. | pmid:18023053 |
| Giordano L et al. | Development and validation of an LC-MS/MS analysis for simultaneous determination of delphinidin-3-glucoside, cyanidin-3-glucoside and cyanidin-3-(6-malonylglucoside) in human plasma and urine after blood orange juice administration. | 2007 | J Sep Sci | pmid:18027360 |