Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Larsson J et al. | Expanding the ChemGPS chemical space with natural products. | 2005 | J. Nat. Prod. | pmid:16038536 |
| Al-Farsi M et al. | Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman. | 2005 | J. Agric. Food Chem. | pmid:16159191 |
| Ichiyanagi T et al. | Extended glucuronidation is another major path of cyanidin 3-O-beta-D-glucopyranoside metabolism in rats. | 2005 | J. Agric. Food Chem. | pmid:16131148 |
| Habermeyer M et al. | Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity. | 2005 | Chem. Res. Toxicol. | pmid:16167831 |
| Russo A et al. | Ochratoxin A-induced DNA damage in human fibroblast: protective effect of cyanidin 3-O-beta-d-glucoside. | 2005 | J. Nutr. Biochem. | pmid:15629238 |
| Fedenko VS et al. | [Complexation of cyanidin with cadmium ions in solution]. | 2005 Jan-Feb | Ukr Biokhim Zh (1999) | pmid:16335277 |
| Fimognari C et al. | In vitro anticancer activity of cyanidin-3-O-beta-glucopyranoside: effects on transformed and non-transformed T lymphocytes. | 2005 Jul-Aug | Anticancer Res. | pmid:16080535 |
| Jang YP et al. | Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. | 2005 May-Jun | Photochem. Photobiol. | pmid:15745429 |
| Macz-Pop GA et al. | New flavanol-anthocyanin condensed pigments and anthocyanin composition in guatemalan beans (Phaseolus spp.). | 2006 | J. Agric. Food Chem. | pmid:16417317 |
| Cooke D et al. | Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels. | 2006 | Int. J. Cancer | pmid:16823841 |
| Ding M et al. | Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. | 2006 | J. Biol. Chem. | pmid:16618699 |
| Hecht SS et al. | Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. | 2006 | Carcinogenesis | pmid:16522666 |
| Reynertson KA et al. | Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). | 2006 | J. Nat. Prod. | pmid:16933884 |
| Oliveira J et al. | Color properties of four cyanidin-pyruvic acid adducts. | 2006 | J. Agric. Food Chem. | pmid:16939355 |
| Ashton OB et al. | Pigments in avocado tissue and oil. | 2006 | J. Agric. Food Chem. | pmid:17177553 |
| Tsuda T et al. | Microarray profiling of gene expression in human adipocytes in response to anthocyanins. | 2006 | Biochem. Pharmacol. | pmid:16483547 |
| Schauss AG et al. | Phytochemical and nutrient composition of the freeze-dried amazonian palm berry, Euterpe oleraceae mart. (acai). | 2006 | J. Agric. Food Chem. | pmid:17061839 |
| Muñoz-Espada AC and Watkins BA | Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells. | 2006 | J. Nutr. Biochem. | pmid:16443360 |
| Wellmann F et al. | Anthocyanidin synthase from Gerbera hybrida catalyzes the conversion of (+)-catechin to cyanidin and a novel procyanidin. | 2006 | FEBS Lett. | pmid:16494872 |
| Pawlak K et al. | Blue natural organic dyestuffs--from textile dyeing to mural painting. Separation and characterization of coloring matters present in elderberry, logwood and indigo. | 2006 | J Mass Spectrom | pmid:16575781 |
| Netzel M et al. | Sources of antioxidant activity in Australian native fruits. Identification and quantification of anthocyanins. | 2006 | J. Agric. Food Chem. | pmid:17177507 |
| Kim AJ and Park S | Mulberry extract supplements ameliorate the inflammation-related hematological parameters in carrageenan-induced arthritic rats. | 2006 | J Med Food | pmid:17004912 |
| Solomon A et al. | Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L.). | 2006 | J. Agric. Food Chem. | pmid:17002444 |
| Walton MC et al. | The flavonol quercetin-3-glucoside inhibits cyanidin-3-glucoside absorption in vitro. | 2006 | J. Agric. Food Chem. | pmid:16787048 |
| Fang Z et al. | Chemical composition of clarified bayberry (Myrica rubra Sieb. et Zucc.) juice sediment. | 2006 | J. Agric. Food Chem. | pmid:17002443 |
| Chen PN et al. | Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. | 2006 | Chem. Biol. Interact. | pmid:16970933 |
| Kondo T et al. | Novel and efficient synthesis of cyanidin 3-O-beta-D-glucoside from (+)-catechin via a flav-3-en-3-ol as a key intermediate. | 2006 | Org. Lett. | pmid:16869672 |
| Iwai K et al. | Alpha-glucosidase inhibitory and antihyperglycemic effects of polyphenols in the fruit of Viburnum dilatatum Thunb. | 2006 | J. Agric. Food Chem. | pmid:16787002 |
| Castellarin SD et al. | Colour variation in red grapevines (Vitis vinifera L.): genomic organisation, expression of flavonoid 3'-hydroxylase, flavonoid 3',5'-hydroxylase genes and related metabolite profiling of red cyanidin-/blue delphinidin-based anthocyanins in berry skin. | 2006 | BMC Genomics | pmid:16433923 |
| Tatsuzawa F et al. | Acylated cyanidin 3-sambubioside-5-glucosides in three garden plants of the Cruciferae. | 2006 | Phytochemistry | pmid:16777160 |
| Meng L et al. | Anthocyanin and flavonoid production from Perilla frutescens: pilot plant scale processing including cross-flow microfiltration and reverse osmosis. | 2006 | J. Agric. Food Chem. | pmid:16756359 |
| Yoshida K et al. | Ferric ions involved in the flower color development of the Himalayan blue poppy, Meconopsis grandis. | 2006 | Phytochemistry | pmid:16678868 |
| Felgines C et al. | Absorption and metabolism of red orange juice anthocyanins in rats. | 2006 | Br. J. Nutr. | pmid:16611379 |
| Pergola C et al. | Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. | 2006 | Nitric Oxide | pmid:16517190 |
| Tian Q et al. | Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. | 2006 | J. Agric. Food Chem. | pmid:16478275 |
| Wu X et al. | Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption. | 2006 | J. Agric. Food Chem. | pmid:16417325 |
| Pawlowska AM et al. | Phenolics of Arbutus unedo L. (Ericaceae) fruits: identification of anthocyanins and gallic acid derivatives. | 2006 | J. Agric. Food Chem. | pmid:17177565 |
| Harnly JM et al. | Flavonoid content of U.S. fruits, vegetables, and nuts. | 2006 | J. Agric. Food Chem. | pmid:17177529 |
| Cortell JM and Kennedy JA | Effect of shading on accumulation of flavonoid compounds in (Vitis vinifera L.) pinot noir fruit and extraction in a model system. | 2006 | J. Agric. Food Chem. | pmid:17061828 |
| Rahman MM et al. | Superoxide radical- and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. | 2006 | Free Radic. Res. | pmid:17015281 |
| Chirinos R et al. | High-performance liquid chromatography with photodiode array detection (HPLC-DAD)/HPLC-mass spectrometry (MS) profiling of anthocyanins from Andean Mashua Tubers (Tropaeolum tuberosum RuÃz and Pavón) and their contribution to the overall antioxidant activity. | 2006 | J. Agric. Food Chem. | pmid:16968067 |
| Ichiyanagi T et al. | Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats. | 2006 | J. Agric. Food Chem. | pmid:16939312 |
| Pinelo M et al. | Effect of clarification techniques and rat intestinal extract incubation on phenolic composition and antioxidant activity of black currant juice. | 2006 | J. Agric. Food Chem. | pmid:16939310 |
| Hieber AD et al. | Color genes in the orchid Oncidium Gower Ramsey: identification, expression, and potential genetic instability in an interspecific cross. | 2006 | Planta | pmid:16151849 |
| Ichiyanagi T et al. | Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. | 2006 | J. Agric. Food Chem. | pmid:16848510 |
| Vareed SK et al. | Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida fruits with health benefits. | 2006 | Life Sci. | pmid:16139847 |
| Jakobs S et al. | Natural flavonoids are potent inhibitors of glycogen phosphorylase. | 2006 | Mol Nutr Food Res | pmid:16317787 |
| Matsufuji H et al. | Formation and inhibition of genotoxic malonaldehyde from DNA oxidation controlled with EDTA. | 2006 | Food Chem. Toxicol. | pmid:16122862 |
| Lazzè MC et al. | Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. | 2006 | Mol Nutr Food Res | pmid:16288501 |
| Abdel-Aal el-SM et al. | Anthocyanin composition in black, blue, pink, purple, and red cereal grains. | 2006 | J. Agric. Food Chem. | pmid:16787017 |
| Espinosa-Alonso LG et al. | Polyphenols in wild and weedy Mexican common beans (Phaseolus vulgaris L.). | 2006 | J. Agric. Food Chem. | pmid:16756378 |
| Duthie SJ et al. | The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. | 2006 | Eur J Nutr | pmid:16032375 |
| Schütz K et al. | Characterization and quantification of anthocyanins in selected artichoke (Cynara scolymus L.) cultivars by HPLC-DAD-ESI-MSn. | 2006 | Anal Bioanal Chem | pmid:16534575 |
| Nakatsuka T et al. | Two different transposable elements inserted in flavonoid 3',5'-hydroxylase gene contribute to pink flower coloration in Gentiana scabra. | 2006 | Mol. Genet. Genomics | pmid:16362368 |
| Chen PN et al. | Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. | 2006 | Cancer Lett. | pmid:15975709 |
| Oak MH et al. | Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK. | 2006 | Br. J. Pharmacol. | pmid:16921400 |
| Jordheim M et al. | Characterization of hemiacetal forms of anthocyanidin 3-O-beta-glycopyranosides. | 2006 | J. Agric. Food Chem. | pmid:17147416 |
| Wu X et al. | Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. | 2006 | J. Agric. Food Chem. | pmid:16719536 |
| Jin XH et al. | Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo. | 2006 | Exp. Eye Res. | pmid:16309673 |
| Bononi M et al. | 'Cyanidin volumetric index' and 'chromaticity coordinates ratio' to characterize red raspberry (Rubus idaeus). | 2006 Aug-Sep | Int J Food Sci Nutr | pmid:17135027 |
| Fedenko VS | [Cyanidin complexation with metal ions]. | 2006 Mar-Apr | Ukr Biokhim Zh (1999) | pmid:17100297 |
| Giordano L et al. | Development and validation of an LC-MS/MS analysis for simultaneous determination of delphinidin-3-glucoside, cyanidin-3-glucoside and cyanidin-3-(6-malonylglucoside) in human plasma and urine after blood orange juice administration. | 2007 | J Sep Sci | pmid:18027360 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Suzuki T et al. | Structural identification of anthocyanins and analysis of concentrations during growth and flowering in buckwheat (Fagopyrum esculentum Moench) petals. | 2007 | J. Agric. Food Chem. | pmid:17941697 |
| Li JB et al. | Anthocyanins from red flowers of Camellia reticulata LINDL. | 2007 | Biosci. Biotechnol. Biochem. | pmid:18037731 |
| Ozga JA et al. | Characterization of cyanidin- and quercetin-derived flavonoids and other phenolics in mature saskatoon fruits (Amelanchier alnifolia Nutt.). | 2007 | J. Agric. Food Chem. | pmid:17994693 |
| Pang Y et al. | Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula. | 2007 | Plant Physiol. | pmid:17885080 |
| Marinova K et al. | The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat. | 2007 | Plant Cell | pmid:17601828 |
| Ayaz E and Alpsoy HC | [Garlic (Allium sativum) and traditional medicine]. | 2007 | Turkiye Parazitol Derg | pmid:17594659 |
| Galvano F et al. | Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. | 2007 | Ann. Ist. Super. Sanita | pmid:18209272 |
| Coates EM et al. | Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. | 2007 | J Carcinog | pmid:17442116 |
| Omoigui S | The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. | 2007 | Immun Ageing | pmid:17374166 |
| Tarozzi A et al. | Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells. | 2007 | Neurosci. Lett. | pmid:17709193 |
| Vitaglione P et al. | Protocatechuic acid is the major human metabolite of cyanidin-glucosides. | 2007 | J. Nutr. | pmid:17709440 |
| Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
| Xu JW et al. | Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells. | 2007 | Atherosclerosis | pmid:17045269 |
| GarcÃa-MacÃas P et al. | Changes in the flavonoid and phenolic acid contents and antioxidant activity of red leaf lettuce (Lollo Rosso) due to cultivation under plastic films varying in ultraviolet transparency. | 2007 | J. Agric. Food Chem. | pmid:18001028 |
| Liu L et al. | Degradation of cyanidin 3-rutinoside in the presence of (-)-epicatechin and litchi pericarp polyphenol oxidase. | 2007 | J. Agric. Food Chem. | pmid:17914871 |
| Sasaki R et al. | Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. | 2007 | Biochem. Pharmacol. | pmid:17869225 |
| Mulabagal V et al. | Cultivars of apple fruits that are not marketed with potential for anthocyanin production. | 2007 | J. Agric. Food Chem. | pmid:17822290 |
| Esparza I et al. | Complexing capacity profiles of naturally occurring ligands in Tempranillo wines for Cu and Zn: an electroanalytical approach for cupric casse. | 2007 | Anal. Chim. Acta | pmid:17765065 |
| Milbury PE et al. | Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460300 |
| Liu YC et al. | Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. | 2007 | Life Sci. | pmid:17320913 |
| Hamauzu Y et al. | Reddish coloration of Chinese quince (Pseudocydonia sinensis) procyanidins during heat treatment and effect on antioxidant and antiinfluenza viral activities. | 2007 | J. Agric. Food Chem. | pmid:17300149 |
| Füzfai Z and Molnár-Perl I | Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits. | 2007 | J Chromatogr A | pmid:17289064 |
| Bakowska-Barczak AM et al. | Survey of bioactive components in Western Canadian berries. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066116 |
| Hosseinian FS and Beta T | Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries. | 2007 | J. Agric. Food Chem. | pmid:18052240 |
| Jordheim M et al. | Molar absorptivities and reducing capacity of pyranoanthocyanins and other anthocyanins. | 2007 | J. Agric. Food Chem. | pmid:18047275 |
| de Brito ES et al. | Anthocyanins present in selected tropical fruits: acerola, jambolão, jussara, and guajiru. | 2007 | J. Agric. Food Chem. | pmid:17929888 |
| Kern M et al. | Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. | 2007 | Mol Nutr Food Res | pmid:17729219 |
| Seitz C et al. | Redirection of anthocyanin synthesis in Osteospermum hybrida by a two-enzyme manipulation strategy. | 2007 | Phytochemistry | pmid:17286993 |
| Srivastava A et al. | Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. | 2007 | J. Agric. Food Chem. | pmid:17381106 |
| Burdulis D et al. | Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits. | 2007 | Medicina (Kaunas) | pmid:18182842 |
| Burdulis D et al. | [Analysis of anthocyanin content in bilberry (Vaccinium myrtillus L.) fruit crude drugs by high-performance liquid chromatography method]. | 2007 | Medicina (Kaunas) | pmid:17768372 |
| Castellarin SD and Di Gaspero G | Transcriptional control of anthocyanin biosynthetic genes in extreme phenotypes for berry pigmentation of naturally occurring grapevines. | 2007 | BMC Plant Biol. | pmid:17760970 |
| Grimplet J et al. | Tissue-specific mRNA expression profiling in grape berry tissues. | 2007 | BMC Genomics | pmid:17584945 |
| Bjorøy O et al. | Anthocyanin 3-galactosides from Cornus alba 'Sibirica' with glucosidation of the B-ring. | 2007 | Phytochemistry | pmid:17207823 |
| Terasawa N et al. | Identification and some properties of anthocyanin isolated from Zuiki, stalk of Colocasia esculenta. | 2007 | J. Agric. Food Chem. | pmid:17447784 |
| Bononi M and Tateo F | Stabilization of cranberry anthocyanins in nutraceutical capsules. | 2007 | Int J Food Sci Nutr | pmid:17469769 |
| Sorrenti V et al. | Heme oxygenase induction by cyanidin-3-O-beta-glucoside in cultured human endothelial cells. | 2007 | Mol Nutr Food Res | pmid:17440991 |