Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Mutwil M et al. | PlaNet: combined sequence and expression comparisons across plant networks derived from seven species. | 2011 | Plant Cell | pmid:21441431 |
| Montefiori M et al. | Identification and characterisation of F3GT1 and F3GGT1, two glycosyltransferases responsible for anthocyanin biosynthesis in red-fleshed kiwifruit (Actinidia chinensis). | 2011 | Plant J. | pmid:21175894 |
| Khandelwal VK et al. | Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts. | 2011 | Evid Based Complement Alternat Med | pmid:20953394 |
| Paixão J et al. | Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. | 2011 | Apoptosis | pmid:21785847 |
| Woodward GM et al. | Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation. | 2011 | Mol Nutr Food Res | pmid:21370450 |
| Shrestha B et al. | In situ cell-by-cell imaging and analysis of small cell populations by mass spectrometry. | 2011 | Anal. Chem. | pmid:21388149 |
| Mallery SR et al. | Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins. | 2011 | Cancer Prev Res (Phila) | pmid:21558412 |
| Biegelmeyer R et al. | Comparative analysis of the chemical composition and antioxidant activity of red (Psidium cattleianum) and yellow (Psidium cattleianum var. lucidum) strawberry guava fruit. | 2011 | J. Food Sci. | pmid:22417549 |
| Nishizaki Y et al. | Structure of the acyl-glucose-dependent anthocyanin 5-O-glucosyltransferase gene in carnations and its disruption by transposable elements in some varieties. | 2011 | Mol. Genet. Genomics | pmid:22048706 |
| Song J et al. | Determination of cyanidin-3-glucoside (red kernel food colour) in beverages by high performance liquid chromatography and a study of its degradation by quadruple time-of-flight mass spectrometry. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:22014114 |
| Zhang Q et al. | A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3',5'-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans. | 2011 | Chem. Commun. (Camb.) | pmid:21892498 |
| Kanamoto Y et al. | A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. | 2011 | J. Agric. Food Chem. | pmid:21751816 |
| Woodward GM et al. | Anthocyanins remain stable during commercial blackcurrant juice processing. | 2011 | J. Food Sci. | pmid:21729077 |
| Min J et al. | Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. | 2011 | Neurosci. Lett. | pmid:21651957 |
| Ben-Simhon Z et al. | A pomegranate (Punica granatum L.) WD40-repeat gene is a functional homologue of Arabidopsis TTG1 and is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development. | 2011 | Planta | pmid:21643990 |
| Cuevas Montilla E et al. | Soluble and bound phenolic compounds in different Bolivian purple corn ( Zea mays L.) cultivars. | 2011 | J. Agric. Food Chem. | pmid:21639140 |
| Jordheim M et al. | Identification of cyanidin 3-O-β-(6″-(3-hydroxy-3-methylglutaroyl)glucoside) and other anthocyanins from wild and cultivated blackberries. | 2011 | J. Agric. Food Chem. | pmid:21635009 |
| Esselen M et al. | Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase I and II poisons in colon carcinoma cells. | 2011 | J. Agric. Food Chem. | pmid:21599019 |
| Ju JH et al. | Anti-obesity and antioxidative effects of purple sweet potato extract in 3T3-L1 adipocytes in vitro. | 2011 | J Med Food | pmid:21861722 |
| Wang D et al. | Cyanidin-3-O-β-glucoside with the aid of its metabolite protocatechuic acid, reduces monocyte infiltration in apolipoprotein E-deficient mice. | 2011 | Biochem. Pharmacol. | pmid:21569764 |
| Xue YL et al. | Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki. | 2011 | J. Agric. Food Chem. | pmid:21568325 |
| Jin Y et al. | A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects. | 2011 | Eur J Clin Nutr | pmid:21540876 |
| El Babili F et al. | Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. | 2011 | J. Food Sci. | pmid:21535822 |
| Santos J et al. | Inhibition of host- and bacteria-derived proteinases by natural anthocyanins. | 2011 | J. Periodont. Res. | pmid:21517858 |
| Lin LZ et al. | LC-PDA-ESI/MS(n) identification of new anthocyanins in purple Bordeaux radish ( Raphanus sativus L. variety). | 2011 | J. Agric. Food Chem. | pmid:21513350 |
| Lim TG et al. | Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity. | 2011 | Biochem. Pharmacol. | pmid:21501596 |
| Reichel M et al. | Changes in flavonoids and nonphenolic pigments during on-tree maturation and postharvest pericarp browning of litchi (Litchi chinensis Sonn.) as shown by HPLC-MSn. | 2011 | J. Agric. Food Chem. | pmid:21413696 |
| Reber JD et al. | Antioxidant capacity interactions and a chemical/structural model of phenolic compounds found in strawberries. | 2011 | Int J Food Sci Nutr | pmid:21385007 |
| Montilla EC et al. | Anthocyanin composition of black carrot (Daucus carota ssp. sativus var. atrorubens Alef.) cultivars Antonina, Beta Sweet, Deep Purple, and Purple Haze. | 2011 | J. Agric. Food Chem. | pmid:21381748 |
| Wei X et al. | Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity. | 2011 | J. Sci. Food Agric. | pmid:21360538 |
| Abdel-Moemin AR | Switching to black rice diets modulates low-density lipoprotein oxidation and lipid measurements in rabbits. | 2011 | Am. J. Med. Sci. | pmid:21289511 |
| Rababah TM et al. | Effect of jam processing and storage on total phenolics, antioxidant activity, and anthocyanins of different fruits. | 2011 | J. Sci. Food Agric. | pmid:21254073 |
| Tanaka J et al. | Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo. | 2011 | J. Agric. Food Chem. | pmid:21175193 |
| Agati G et al. | The biosynthesis of flavonoids is enhanced similarly by UV radiation and root zone salinity in L. vulgare leaves. | 2011 | J. Plant Physiol. | pmid:20850892 |
| Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
| Mewis I et al. | Specific poly-phenolic compounds in cell culture of Vitis vinifera L. cv. Gamay Fréaux. | 2011 | Appl. Biochem. Biotechnol. | pmid:21061087 |
| Liu Y et al. | Comparative study of phenolic compounds and antioxidant activity in different species of cherries. | 2011 | J. Food Sci. | pmid:22417346 |
| Saito N et al. | The blue anthocyanin pigments from the blue flowers of Heliophila coronopifolia L. (Brassicaceae). | 2011 | Phytochemistry | pmid:21903230 |
| Andrade JM et al. | Phenolic composition in different genotypes of Guabiju fruits (Myrcianthes pungens) and their potential as antioxidant and antichemotactic agents. | 2011 | J. Food Sci. | pmid:22417582 |
| Stalmach A et al. | Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. | 2011 | J. Agric. Food Chem. | pmid:21812481 |
| Moze S et al. | Phenolics in Slovenian bilberries ( Vaccinium myrtillus L.) and blueberries ( Vaccinium corymbosum L.). | 2011 | J. Agric. Food Chem. | pmid:21574578 |
| Vanzo A et al. | Exceptionally fast uptake and metabolism of cyanidin 3-glucoside by rat kidneys and liver. | 2011 | J. Nat. Prod. | pmid:21510696 |
| Lätti AK et al. | Phenolic compounds in berries and flowers of a natural hybrid between bilberry and lingonberry (Vaccinium × intermedium Ruthe). | 2011 | Phytochemistry | pmid:21382629 |
| Xu C et al. | Influence of growing season on phenolic compounds and antioxidant properties of grape berries from vines grown in subtropical climate. | 2011 | J. Agric. Food Chem. | pmid:21235208 |
| Pinho C et al. | Optimization of conditions for anthocyanin hydrolysis from red wine using response surface methodology (RSM). | 2011 | J. Agric. Food Chem. | pmid:21158431 |
| Kyselova Z | Toxicological aspects of the use of phenolic compounds in disease prevention. | 2011 | Interdiscip Toxicol | pmid:22319251 |
| You Q et al. | Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities. | 2011 | J. Agric. Food Chem. | pmid:21797278 |
| Kumar D et al. | A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae). | 2011 | Pharmacogn Rev | pmid:22279376 |
| Fournier-Level A et al. | Genetic mechanisms underlying the methylation level of anthocyanins in grape (Vitis vinifera L.). | 2011 | BMC Plant Biol. | pmid:22171701 |
| Gillman JD et al. | Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in brown hilum and brown seed coats. | 2011 | BMC Plant Biol. | pmid:22070454 |
| Yamaura K et al. | Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis. | 2011 | Pharmacognosy Res | pmid:22022165 |
| Fujimura Y et al. | Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars. | 2011 | PLoS ONE | pmid:21853132 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Kovinich N et al. | Combined analysis of transcriptome and metabolite data reveals extensive differences between black and brown nearly-isogenic soybean (Glycine max) seed coats enabling the identification of pigment isogenes. | 2011 | BMC Genomics | pmid:21801362 |
| Rawat S et al. | Assessment of Antioxidant Properties in Fruits of Myrica esculenta: A Popular Wild Edible Species in Indian Himalayan Region. | 2011 | Evid Based Complement Alternat Med | pmid:21785629 |
| Adisakwattana S et al. | Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase. | 2011 | J Clin Biochem Nutr | pmid:21765605 |
| Shimazaki M et al. | Pink-colored grape berry is the result of short insertion in intron of color regulatory gene. | 2011 | PLoS ONE | pmid:21695059 |
| Martin C et al. | How can research on plants contribute to promoting human health? | 2011 | Plant Cell | pmid:21586682 |
| Liang Z et al. | CIELAB coordinates in response to berry skin anthocyanins and their composition in Vitis. | 2011 | J. Food Sci. | pmid:21535819 |
| Suzuki R et al. | Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. | 2011 | Nutr Metab (Lond) | pmid:21385419 |
| Venkatesha SH et al. | Immunomodulation of Autoimmune Arthritis by Herbal CAM. | 2011 | Evid Based Complement Alternat Med | pmid:21234398 |
| Kortstee AJ et al. | Anthocyanin production as a potential visual selection marker during plant transformation. | 2011 | Transgenic Res. | pmid:21340526 |
| Jakesevic M et al. | Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion. | 2011 | BMC Complement Altern Med | pmid:21272305 |
| Ali MB et al. | Berry skin development in Norton grape: distinct patterns of transcriptional regulation and flavonoid biosynthesis. | 2011 | BMC Plant Biol. | pmid:21219654 |
| Sharma M et al. | Identification of the pr1 gene product completes the anthocyanin biosynthesis pathway of maize. | 2011 | Genetics | pmid:21385724 |
| Maldonado-Rojas W and Olivero-Verbel J | Potential interaction of natural dietary bioactive compounds with COX-2. | 2011 | J. Mol. Graph. Model. | pmid:21803623 |
| Wang SC et al. | Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model. | 2011 | Evid Based Complement Alternat Med | pmid:19965962 |
| Fortes AM et al. | Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. | 2011 | BMC Plant Biol. | pmid:22047180 |
| Horbowicz M et al. | Effects of methyl jasmonate on accumulation of flavonoids in seedlings of common buckwheat (Fagopyrum esculentum Moench). | 2011 | Acta. Biol. Hung. | pmid:21840829 |
| Choi JG et al. | In Vitro and In Vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract against Salmonella. | 2011 | Evid Based Complement Alternat Med | pmid:19687188 |
| Kayodé AP et al. | Uncommonly high levels of 3-deoxyanthocyanidins and antioxidant capacity in the leaf sheaths of dye sorghum. | 2011 | J. Agric. Food Chem. | pmid:21322653 |
| Massaad CA | Neuronal and vascular oxidative stress in Alzheimer's disease. | 2011 | Curr Neuropharmacol | pmid:22654724 |
| Bhuiyan MI et al. | The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygen-glucose Deprivation. | 2011 | Korean J. Physiol. Pharmacol. | pmid:22359473 |
| Devi PS et al. | Evaluation of antiproliferative activity of red sorghum bran anthocyanin on a human breast cancer cell line (mcf-7). | 2011 | Int J Breast Cancer | pmid:22312562 |
| Kwon SC and Kim YB | Antioxidative and aldose reductase-inhibitory effects of a fermentation filtrate of Rubus coreanus. | 2011 | Lab Anim Res | pmid:22232649 |
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| Abidi W et al. | Evaluation of antioxidant compounds and total sugar content in a nectarine [Prunus persica (L.) Batsch] progeny. | 2011 | Int J Mol Sci | pmid:22072927 |
| Alvarez-Suarez JM et al. | Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. | 2011 | PLoS ONE | pmid:22016781 |
| Wu X et al. | Optimization of phenolic antioxidant extraction from Wuweizi (Schisandra chinensis) pulp using random-centroid optimazation methodology. | 2011 | Int J Mol Sci | pmid:22016656 |
| Lin LZ et al. | UHPLC-PDA-ESI/HRMS/MS(n) analysis of anthocyanins, flavonol glycosides, and hydroxycinnamic acid derivatives in red mustard greens (Brassica juncea Coss variety). | 2011 | J. Agric. Food Chem. | pmid:21970730 |
| Ben Mansour H et al. | Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyllum. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21880140 |
| Clark ST and Verwoerd WS | A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. | 2011 | BMC Bioinformatics | pmid:21849042 |
| He Q et al. | Natural variation in petal color in Lycoris longituba revealed by anthocyanin components. | 2011 | PLoS ONE | pmid:21829604 |
| Marin-Kuan M et al. | Evidence for a role of oxidative stress in the carcinogenicity of ochratoxin a. | 2011 | J Toxicol | pmid:21776264 |
| Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
| Zou TB et al. | Optimization of ultrasound-assisted extraction of anthocyanins from mulberry, using response surface methodology. | 2011 | Int J Mol Sci | pmid:21686165 |
| Ke Z et al. | Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain. | 2011 | J. Neurosci. Res. | pmid:21671257 |
| Rajbhandari R et al. | Determination of cranberry phenolic metabolites in rats by liquid chromatography-tandem mass spectrometry. | 2011 | J. Agric. Food Chem. | pmid:21634376 |
| Kim KT et al. | Neuroprotective effect of anthocyanin on experimental traumatic spinal cord injury. | 2011 | J Korean Neurosurg Soc | pmid:21607177 |
| Telias A et al. | Apple skin patterning is associated with differential expression of MYB10. | 2011 | BMC Plant Biol. | pmid:21599973 |
| Huang SS et al. | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. | 2011 | Evid Based Complement Alternat Med | pmid:21584194 |
| Udani JK et al. | Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. | 2011 | Nutr J | pmid:21569436 |
| Wei YZ et al. | Differential expression of anthocyanin biosynthetic genes in relation to anthocyanin accumulation in the pericarp of Litchi chinensis Sonn. | 2011 | PLoS ONE | pmid:21559331 |
| Yang H et al. | Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice. | 2011 | J. Agric. Food Chem. | pmid:21302942 |
| Wei SD et al. | Antioxidant activities of fractions of polymeric procyanidins from stem bark of Acacia confusa. | 2011 | Int J Mol Sci | pmid:21541049 |
| Gou JY et al. | Negative regulation of anthocyanin biosynthesis in Arabidopsis by a miR156-targeted SPL transcription factor. | 2011 | Plant Cell | pmid:21487097 |
| Feng Y et al. | A three-component gene expression system and its application for inducible flavonoid overproduction in transgenic Arabidopsis thaliana. | 2011 | PLoS ONE | pmid:21408135 |
| Akkarachiyasit S et al. | In vitro inhibitory effects of cyandin-3-rutinoside on pancreatic α-amylase and its combined effect with acarbose. | 2011 | Molecules | pmid:21368719 |
| Kim CK et al. | Identification and characterization of seed-specific transcription factors regulating anthocyanin biosynthesis in black rice. | 2011 | J. Appl. Genet. | pmid:21286901 |