Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kwon SC and Kim YB | Antioxidative and aldose reductase-inhibitory effects of a fermentation filtrate of Rubus coreanus. | 2011 | Lab Anim Res | pmid:22232649 |
| Poulose SM et al. | Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells. | 2012 | J. Agric. Food Chem. | pmid:22224493 |
| Sun Y et al. | Arabidopsis TT19 functions as a carrier to transport anthocyanin from the cytosol to tonoplasts. | 2012 | Mol Plant | pmid:22201047 |
| Wu TY et al. | Effect of antioxidant activity and functional properties of Chingshey purple sweet potato fermented milk by Lactobacillus acidophilus, L. delbrueckii subsp. lactis, and L. gasseri strains. | 2012 | J. Food Sci. | pmid:22182227 |
| Sun CD et al. | Cyanidin-3-glucoside-rich extract from Chinese bayberry fruit protects pancreatic β cells and ameliorates hyperglycemia in streptozotocin-induced diabetic mice. | 2012 | J Med Food | pmid:22181073 |
| Panickar KS and Anderson RA | Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia. | 2011 | Int J Mol Sci | pmid:22174658 |
| Zhang X et al. | Characterisation of anthocyanidin reductase from Shuchazao green tea. | 2012 | J. Sci. Food Agric. | pmid:22173936 |
| Abe LT et al. | Potential dietary sources of ellagic acid and other antioxidants among fruits consumed in Brazil: jabuticaba (Myrciaria jaboticaba (Vell.) Berg). | 2012 | J. Sci. Food Agric. | pmid:22173652 |
| Fournier-Level A et al. | Genetic mechanisms underlying the methylation level of anthocyanins in grape (Vitis vinifera L.). | 2011 | BMC Plant Biol. | pmid:22171701 |
| Su M et al. | Physical changes and physiological characteristics of red and green peel during nectarine (cv. Hu018) maturation. | 2012 | J. Sci. Food Agric. | pmid:22144032 |
| Luo X et al. | Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling. | 2012 | Mol. Cell. Biochem. | pmid:22120492 |
| Yang Y et al. | SNARE-wedging polyphenols as small molecular botox. | 2012 | Planta Med. | pmid:22109835 |
| Kovinich N et al. | Identification of two anthocyanidin reductase genes and three red-brown soybean accessions with reduced anthocyanidin reductase 1 mRNA, activity, and seed coat proanthocyanidin amounts. | 2012 | J. Agric. Food Chem. | pmid:22107112 |
| Hall D et al. | Molecular cloning and biochemical characterization of the UDP-glucose: flavonoid 3-O-glucosyltransferase from Concord grape (Vitis labrusca). | 2012 | Phytochemistry | pmid:22098678 |
| Khater F et al. | Identification and functional characterization of cDNAs coding for hydroxybenzoate/hydroxycinnamate glucosyltransferases co-expressed with genes related to proanthocyanidin biosynthesis. | 2012 | J. Exp. Bot. | pmid:22090445 |
| Zhu W et al. | The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP-PKA-dependent signaling pathway. | 2012 | Free Radic. Biol. Med. | pmid:22085656 |
| Abidi W et al. | Evaluation of antioxidant compounds and total sugar content in a nectarine [Prunus persica (L.) Batsch] progeny. | 2011 | Int J Mol Sci | pmid:22072927 |
| Gillman JD et al. | Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in brown hilum and brown seed coats. | 2011 | BMC Plant Biol. | pmid:22070454 |
| Fusi E et al. | Alpha-tocopherol counteracts the cytotoxicity induced by ochratoxin a in primary porcine fibroblasts. | 2010 | Toxins (Basel) | pmid:22069637 |
| Nishizaki Y et al. | Structure of the acyl-glucose-dependent anthocyanin 5-O-glucosyltransferase gene in carnations and its disruption by transposable elements in some varieties. | 2011 | Mol. Genet. Genomics | pmid:22048706 |
| Fortes AM et al. | Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. | 2011 | BMC Plant Biol. | pmid:22047180 |
| Yamaura K et al. | Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis. | 2011 | Pharmacognosy Res | pmid:22022165 |
| Alvarez-Suarez JM et al. | Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. | 2011 | PLoS ONE | pmid:22016781 |
| Wu X et al. | Optimization of phenolic antioxidant extraction from Wuweizi (Schisandra chinensis) pulp using random-centroid optimazation methodology. | 2011 | Int J Mol Sci | pmid:22016656 |
| Song J et al. | Determination of cyanidin-3-glucoside (red kernel food colour) in beverages by high performance liquid chromatography and a study of its degradation by quadruple time-of-flight mass spectrometry. | 2011 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:22014114 |
| Lin LZ et al. | UHPLC-PDA-ESI/HRMS/MS(n) analysis of anthocyanins, flavonol glycosides, and hydroxycinnamic acid derivatives in red mustard greens (Brassica juncea Coss variety). | 2011 | J. Agric. Food Chem. | pmid:21970730 |
| Ishiguro K et al. | Functional analysis of Antirrhinum kelloggii flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase genes; critical role in flower color and evolution in the genus Antirrhinum. | 2012 | J. Plant Res. | pmid:21959781 |
| Saito N et al. | The blue anthocyanin pigments from the blue flowers of Heliophila coronopifolia L. (Brassicaceae). | 2011 | Phytochemistry | pmid:21903230 |
| Yonekura-Sakakibara K et al. | Two glycosyltransferases involved in anthocyanin modification delineated by transcriptome independent component analysis in Arabidopsis thaliana. | 2012 | Plant J. | pmid:21899608 |
| Zhang Q et al. | A gram scale synthesis of a multi-13C-labelled anthocyanin, [6,8,10,3',5'-13C5]cyanidin-3-glucoside, for use in oral tracer studies in humans. | 2011 | Chem. Commun. (Camb.) | pmid:21892498 |
| Ben Mansour H et al. | Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyllum. | 2011 | Ann. Clin. Microbiol. Antimicrob. | pmid:21880140 |
| Ju JH et al. | Anti-obesity and antioxidative effects of purple sweet potato extract in 3T3-L1 adipocytes in vitro. | 2011 | J Med Food | pmid:21861722 |
| Fujimura Y et al. | Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars. | 2011 | PLoS ONE | pmid:21853132 |
| Clark ST and Verwoerd WS | A systems approach to identifying correlated gene targets for the loss of colour pigmentation in plants. | 2011 | BMC Bioinformatics | pmid:21849042 |
| Horbowicz M et al. | Effects of methyl jasmonate on accumulation of flavonoids in seedlings of common buckwheat (Fagopyrum esculentum Moench). | 2011 | Acta. Biol. Hung. | pmid:21840829 |
| He Q et al. | Natural variation in petal color in Lycoris longituba revealed by anthocyanin components. | 2011 | PLoS ONE | pmid:21829604 |
| Stalmach A et al. | Identification of (poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. | 2011 | J. Agric. Food Chem. | pmid:21812481 |
| Maldonado-Rojas W and Olivero-Verbel J | Potential interaction of natural dietary bioactive compounds with COX-2. | 2011 | J. Mol. Graph. Model. | pmid:21803623 |
| Kovinich N et al. | Combined analysis of transcriptome and metabolite data reveals extensive differences between black and brown nearly-isogenic soybean (Glycine max) seed coats enabling the identification of pigment isogenes. | 2011 | BMC Genomics | pmid:21801362 |
| You Q et al. | Inhibitory effects of muscadine anthocyanins on α-glucosidase and pancreatic lipase activities. | 2011 | J. Agric. Food Chem. | pmid:21797278 |
| Scazzocchio B et al. | Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes. | 2011 | Diabetes | pmid:21788573 |
| Paixão J et al. | Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. | 2011 | Apoptosis | pmid:21785847 |
| Rawat S et al. | Assessment of Antioxidant Properties in Fruits of Myrica esculenta: A Popular Wild Edible Species in Indian Himalayan Region. | 2011 | Evid Based Complement Alternat Med | pmid:21785629 |
| Marin-Kuan M et al. | Evidence for a role of oxidative stress in the carcinogenicity of ochratoxin a. | 2011 | J Toxicol | pmid:21776264 |
| Virmaux N et al. | Modulation of rod cyclic GMP-phosphodiesterase activity by anthocyanidin derivatives. | 1990 | Biochem. Soc. Trans. | pmid:2177424 |
| Adisakwattana S et al. | Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase. | 2011 | J Clin Biochem Nutr | pmid:21765605 |
| Ohno S et al. | A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). | 2011 | J. Exp. Bot. | pmid:21765172 |
| Duchnowicz P et al. | Hypolipidemic and antioxidant effects of hydroxycinnamic acids, quercetin, and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study). | 2012 | Eur J Nutr | pmid:21755326 |
| Kanamoto Y et al. | A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice. | 2011 | J. Agric. Food Chem. | pmid:21751816 |
| Ernst IM et al. | Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes. | 2012 | Br. J. Nutr. | pmid:21745425 |