Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim AJ and Park S | Mulberry extract supplements ameliorate the inflammation-related hematological parameters in carrageenan-induced arthritic rats. | 2006 | J Med Food | pmid:17004912 |
| Solomon A et al. | Antioxidant activities and anthocyanin content of fresh fruits of common fig (Ficus carica L.). | 2006 | J. Agric. Food Chem. | pmid:17002444 |
| Fang Z et al. | Chemical composition of clarified bayberry (Myrica rubra Sieb. et Zucc.) juice sediment. | 2006 | J. Agric. Food Chem. | pmid:17002443 |
| Chen PN et al. | Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. | 2006 | Chem. Biol. Interact. | pmid:16970933 |
| Kondo T et al. | Novel and efficient synthesis of cyanidin 3-O-beta-D-glucoside from (+)-catechin via a flav-3-en-3-ol as a key intermediate. | 2006 | Org. Lett. | pmid:16869672 |
| Chirinos R et al. | High-performance liquid chromatography with photodiode array detection (HPLC-DAD)/HPLC-mass spectrometry (MS) profiling of anthocyanins from Andean Mashua Tubers (Tropaeolum tuberosum RuÃz and Pavón) and their contribution to the overall antioxidant activity. | 2006 | J. Agric. Food Chem. | pmid:16968067 |
| Ichiyanagi T et al. | Bioavailability and tissue distribution of anthocyanins in bilberry (Vaccinium myrtillus L.) extract in rats. | 2006 | J. Agric. Food Chem. | pmid:16939312 |
| Pinelo M et al. | Effect of clarification techniques and rat intestinal extract incubation on phenolic composition and antioxidant activity of black currant juice. | 2006 | J. Agric. Food Chem. | pmid:16939310 |
| Lazzè MC et al. | Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. | 2006 | Mol Nutr Food Res | pmid:16288501 |
| Bononi M et al. | 'Cyanidin volumetric index' and 'chromaticity coordinates ratio' to characterize red raspberry (Rubus idaeus). | 2006 Aug-Sep | Int J Food Sci Nutr | pmid:17135027 |
| Fedenko VS | [Cyanidin complexation with metal ions]. | 2006 Mar-Apr | Ukr Biokhim Zh (1999) | pmid:17100297 |
| Giordano L et al. | Development and validation of an LC-MS/MS analysis for simultaneous determination of delphinidin-3-glucoside, cyanidin-3-glucoside and cyanidin-3-(6-malonylglucoside) in human plasma and urine after blood orange juice administration. | 2007 | J Sep Sci | pmid:18027360 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Suzuki T et al. | Structural identification of anthocyanins and analysis of concentrations during growth and flowering in buckwheat (Fagopyrum esculentum Moench) petals. | 2007 | J. Agric. Food Chem. | pmid:17941697 |
| Li JB et al. | Anthocyanins from red flowers of Camellia reticulata LINDL. | 2007 | Biosci. Biotechnol. Biochem. | pmid:18037731 |
| Ozga JA et al. | Characterization of cyanidin- and quercetin-derived flavonoids and other phenolics in mature saskatoon fruits (Amelanchier alnifolia Nutt.). | 2007 | J. Agric. Food Chem. | pmid:17994693 |
| Pang Y et al. | Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula. | 2007 | Plant Physiol. | pmid:17885080 |
| Marinova K et al. | The Arabidopsis MATE transporter TT12 acts as a vacuolar flavonoid/H+ -antiporter active in proanthocyanidin-accumulating cells of the seed coat. | 2007 | Plant Cell | pmid:17601828 |
| Ayaz E and Alpsoy HC | [Garlic (Allium sativum) and traditional medicine]. | 2007 | Turkiye Parazitol Derg | pmid:17594659 |
| Galvano F et al. | Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. | 2007 | Ann. Ist. Super. Sanita | pmid:18209272 |
| Espley RV et al. | Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10. | 2007 | Plant J. | pmid:17181777 |
| Slimestad R et al. | Onions: a source of unique dietary flavonoids. | 2007 | J. Agric. Food Chem. | pmid:17997520 |
| Xu JW et al. | Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells. | 2007 | Atherosclerosis | pmid:17045269 |
| GarcÃa-MacÃas P et al. | Changes in the flavonoid and phenolic acid contents and antioxidant activity of red leaf lettuce (Lollo Rosso) due to cultivation under plastic films varying in ultraviolet transparency. | 2007 | J. Agric. Food Chem. | pmid:18001028 |
| Liu L et al. | Degradation of cyanidin 3-rutinoside in the presence of (-)-epicatechin and litchi pericarp polyphenol oxidase. | 2007 | J. Agric. Food Chem. | pmid:17914871 |
| Sasaki R et al. | Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. | 2007 | Biochem. Pharmacol. | pmid:17869225 |
| Felgines C et al. | Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. | 2007 | Br. J. Nutr. | pmid:17559698 |
| Stewart D et al. | Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. | 2007 | Mol Nutr Food Res | pmid:17492796 |
| Aaby K et al. | Characterization of phenolic compounds in strawberry (Fragaria x ananassa) fruits by different HPLC detectors and contribution of individual compounds to total antioxidant capacity. | 2007 | J. Agric. Food Chem. | pmid:17472391 |
| Milbury PE et al. | Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17460300 |
| Liu YC et al. | Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile. | 2007 | Life Sci. | pmid:17320913 |
| Hamauzu Y et al. | Reddish coloration of Chinese quince (Pseudocydonia sinensis) procyanidins during heat treatment and effect on antioxidant and antiinfluenza viral activities. | 2007 | J. Agric. Food Chem. | pmid:17300149 |
| Füzfai Z and Molnár-Perl I | Gas chromatographic-mass spectrometric fragmentation study of flavonoids as their trimethylsilyl derivatives: analysis of flavonoids, sugars, carboxylic and amino acids in model systems and in citrus fruits. | 2007 | J Chromatogr A | pmid:17289064 |
| Bakowska-Barczak AM et al. | Survey of bioactive components in Western Canadian berries. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066116 |
| Hosseinian FS and Beta T | Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries. | 2007 | J. Agric. Food Chem. | pmid:18052240 |
| Jordheim M et al. | Molar absorptivities and reducing capacity of pyranoanthocyanins and other anthocyanins. | 2007 | J. Agric. Food Chem. | pmid:18047275 |
| de Brito ES et al. | Anthocyanins present in selected tropical fruits: acerola, jambolão, jussara, and guajiru. | 2007 | J. Agric. Food Chem. | pmid:17929888 |
| Choi EH et al. | Cytoprotective effect of anthocyanins against doxorubicin-induced toxicity in H9c2 cardiomyocytes in relation to their antioxidant activities. | 2007 | Food Chem. Toxicol. | pmid:17524543 |
| Kim MJ et al. | Relationship between phenolic compounds, anthocyanins content and antioxidant activity in colored barley germplasm. | 2007 | J. Agric. Food Chem. | pmid:17516656 |
| Seitz C et al. | Redirection of anthocyanin synthesis in Osteospermum hybrida by a two-enzyme manipulation strategy. | 2007 | Phytochemistry | pmid:17286993 |
| Srivastava A et al. | Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. | 2007 | J. Agric. Food Chem. | pmid:17381106 |
| Burdulis D et al. | Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits. | 2007 | Medicina (Kaunas) | pmid:18182842 |
| Burdulis D et al. | [Analysis of anthocyanin content in bilberry (Vaccinium myrtillus L.) fruit crude drugs by high-performance liquid chromatography method]. | 2007 | Medicina (Kaunas) | pmid:17768372 |
| Castellarin SD and Di Gaspero G | Transcriptional control of anthocyanin biosynthetic genes in extreme phenotypes for berry pigmentation of naturally occurring grapevines. | 2007 | BMC Plant Biol. | pmid:17760970 |
| Lamy S et al. | Anthocyanidins inhibit migration of glioblastoma cells: structure-activity relationship and involvement of the plasminolytic system. | 2007 | J. Cell. Biochem. | pmid:16823770 |
| Bjorøy O et al. | Anthocyanin 3-galactosides from Cornus alba 'Sibirica' with glucosidation of the B-ring. | 2007 | Phytochemistry | pmid:17207823 |
| Terasawa N et al. | Identification and some properties of anthocyanin isolated from Zuiki, stalk of Colocasia esculenta. | 2007 | J. Agric. Food Chem. | pmid:17447784 |
| Bononi M and Tateo F | Stabilization of cranberry anthocyanins in nutraceutical capsules. | 2007 | Int J Food Sci Nutr | pmid:17469769 |
| Sorrenti V et al. | Heme oxygenase induction by cyanidin-3-O-beta-glucoside in cultured human endothelial cells. | 2007 | Mol Nutr Food Res | pmid:17440991 |
| Alcalde-Eon C et al. | Identification of dimeric anthocyanins and new oligomeric pigments in red wine by means of HPLC-DAD-ESI/MSn. | 2007 | J Mass Spectrom | pmid:17511019 |