Cyanidin is a lipid of Polyketides (PK) class. Cyanidin is associated with abnormalities such as Consumption-archaic term for TB, furuncle, Obesity, Cardiovascular Diseases and Endothelial dysfunction. The involved functions are known as anthocyanin biosynthetic process, Regulation, flavonoid biosynthetic process, Anabolism and anthocyanin metabolic process. Cyanidin often locates in Body tissue, integral to membrane, Autonomic nervous system, Blood and Tissue membrane. The associated genes with Cyanidin are anthocyanidin synthase, SLC2A8 gene, EPB41L2 gene, NKS1 gene and GLUCOSIDASE. The related lipids are Butanols. The related experimental models are Knock-out.
To understand associated biological information of Cyanidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cyanidin is suspected in Obesity, Chronic Disease, Diabetes Mellitus, Non-Insulin-Dependent, Cardiovascular Diseases, Heart Diseases, Inflammatory disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Cyanidin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Tooth Discoloration | D014075 | 7 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Wound Infection | D014946 | 12 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011) and Knock-out are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Disease model are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
Animal Disease Models are used in the study 'How can research on plants contribute to promoting human health?' (Martin C et al., 2011).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guo H et al. | Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells. | 2012 | Lipids Health Dis | pmid:22243683 |
| Milbury PE et al. | Bioavailablility of elderberry anthocyanins. | 2002 | Mech. Ageing Dev. | pmid:12044949 |
| Bijak M et al. | Thrombin inhibitory activity of some polyphenolic compounds. | 2014 | Med Chem Res | pmid:24610996 |
| Hirai S et al. | Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. | 2010 | Mediators Inflamm. | pmid:20508825 |
| Hämäläinen M et al. | Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. | 2007 | Mediators Inflamm. | pmid:18274639 |
| Burdulis D et al. | Study of diversity of anthocyanin composition in bilberry (Vaccinium myrtillus L.) fruits. | 2007 | Medicina (Kaunas) | pmid:18182842 |
| Burdulis D et al. | [Analysis of anthocyanin content in bilberry (Vaccinium myrtillus L.) fruit crude drugs by high-performance liquid chromatography method]. | 2007 | Medicina (Kaunas) | pmid:17768372 |
| Woodward GM et al. | Anthocyanin-derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation. | 2011 | Mol Nutr Food Res | pmid:21370450 |
| Marques C et al. | Pharmacokinetics of blackberry anthocyanins consumed with or without ethanol: A randomized and crossover trial. | 2016 | Mol Nutr Food Res | pmid:27306520 |
| Singh CK et al. | Combination chemoprevention with grape antioxidants. | 2016 | Mol Nutr Food Res | pmid:26829056 |
| Wang D et al. | Cyanidin-3-O-β-glucoside upregulates hepatic cholesterol 7α-hydroxylase expression and reduces hypercholesterolemia in mice. | 2012 | Mol Nutr Food Res | pmid:22495986 |
| Kay CD et al. | The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products. | 2009 | Mol Nutr Food Res | pmid:19415657 |
| Galvano F et al. | Protocatechuic acid: the missing human cyanidins' metabolite. | 2008 | Mol Nutr Food Res | pmid:18320575 |
| Garcia-Alonso M et al. | Electron spin resonance spectroscopy studies on the free radical scavenging activity of wine anthocyanins and pyranoanthocyanins. | 2005 | Mol Nutr Food Res | pmid:16254886 |
| Felgines C et al. | Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet. | 2009 | Mol Nutr Food Res | pmid:19653220 |
| Kassim A et al. | Environmental and seasonal influences on red raspberry anthocyanin antioxidant contents and identification of quantitative traits loci (QTL). | 2009 | Mol Nutr Food Res | pmid:19156716 |
| Felgines C et al. | Influence of glucose on cyanidin 3-glucoside absorption in rats. | 2008 | Mol Nutr Food Res | pmid:18646002 |
| Hollands W et al. | Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit. | 2008 | Mol Nutr Food Res | pmid:18645999 |
| Matsunaga N et al. | Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. | 2009 | Mol Nutr Food Res | pmid:19415665 |
| Knaup B et al. | Anthocyanins as lipoxygenase inhibitors. | 2009 | Mol Nutr Food Res | pmid:19072887 |
| Stewart D et al. | Metabolomic approach to identifying bioactive compounds in berries: advances toward fruit nutritional enhancement. | 2007 | Mol Nutr Food Res | pmid:17492796 |
| Kern M et al. | Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid. | 2007 | Mol Nutr Food Res | pmid:17729219 |
| Batista ÂG et al. | Jaboticaba berry peel intake prevents insulin-resistance-induced tau phosphorylation in mice. | 2017 | Mol Nutr Food Res | pmid:28544198 |
| Jakobs S et al. | Natural flavonoids are potent inhibitors of glycogen phosphorylase. | 2006 | Mol Nutr Food Res | pmid:16317787 |
| Lazzè MC et al. | Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. | 2006 | Mol Nutr Food Res | pmid:16288501 |
| Marko D et al. | The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. | 2004 | Mol Nutr Food Res | pmid:15497183 |
| Sorrenti V et al. | Heme oxygenase induction by cyanidin-3-O-beta-glucoside in cultured human endothelial cells. | 2007 | Mol Nutr Food Res | pmid:17440991 |
| Del Bo' C et al. | Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment. | 2016 | Mol Nutr Food Res | pmid:27324255 |
| Pourcel L et al. | The formation of Anthocyanic Vacuolar Inclusions in Arabidopsis thaliana and implications for the sequestration of anthocyanin pigments. | 2010 | Mol Plant | pmid:20085894 |
| Morant M et al. | Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2. | 2010 | Mol Plant | pmid:20008451 |
| Sun Y et al. | Arabidopsis TT19 functions as a carrier to transport anthocyanin from the cytosol to tonoplasts. | 2012 | Mol Plant | pmid:22201047 |
| Xu M et al. | Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2. | 2010 | Mol. Cancer | pmid:21034468 |
| Suttana W et al. | Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols. | 2010 | Mol. Cancer | pmid:20438634 |
| Luo X et al. | Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling. | 2012 | Mol. Cell. Biochem. | pmid:22120492 |
| Xu F et al. | Molecular cloning and function analysis of an anthocyanidin synthase gene from Ginkgo biloba, and its expression in abiotic stress responses. | 2008 | Mol. Cells | pmid:18779661 |
| Nishizaki Y et al. | Structure of the acyl-glucose-dependent anthocyanin 5-O-glucosyltransferase gene in carnations and its disruption by transposable elements in some varieties. | 2011 | Mol. Genet. Genomics | pmid:22048706 |
| Sasaki K et al. | Functional divergence within class B MADS-box genes TfGLO and TfDEF in Torenia fournieri Lind. | 2010 | Mol. Genet. Genomics | pmid:20872230 |
| Nakatsuka T et al. | Two different transposable elements inserted in flavonoid 3',5'-hydroxylase gene contribute to pink flower coloration in Gentiana scabra. | 2006 | Mol. Genet. Genomics | pmid:16362368 |
| Steigerwalt RD et al. | Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. | 2008 | Mol. Vis. | pmid:18618008 |
| Chen R et al. | Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells. | 2014 | Mol. Vis. | pmid:24623967 |
| Meng L et al. | Antioxidant activities of polyphenols extracted from Perilla frutescens varieties. | 2008 | Molecules | pmid:19127243 |
| Han FL et al. | Principal component regression analysis of the relation between CIELAB color and monomeric anthocyanins in young Cabernet Sauvignon wines. | 2008 | Molecules | pmid:19015625 |
| Sun LL et al. | Composition and antioxidant activity of the anthocyanins of the fruit of Berberis heteropoda Schrenk. | 2014 | Molecules | pmid:25415473 |
| Xia N et al. | Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. | 2014 | Molecules | pmid:24662080 |
| Zykin PA et al. | Anthocyanin Composition and Content in Rye Plants with Different Grain Color. | 2018 | Molecules | pmid:29671758 |
| Lopes-Lutz D et al. | Characterization and quantification of polyphenols in Amazon grape (Pourouma cecropiifolia Martius). | 2010 | Molecules | pmid:21116224 |
| Cyboran-Mikołajczyk S et al. | The Impact of O-Glycosylation on Cyanidin Interaction with POPC Membranes: Structure-Activity Relationship. | 2018 | Molecules | pmid:30366469 |
| Akkarachiyasit S et al. | In vitro inhibitory effects of cyandin-3-rutinoside on pancreatic α-amylase and its combined effect with acarbose. | 2011 | Molecules | pmid:21368719 |
| Lazzé MC et al. | Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells. | 2003 | Mutat. Res. | pmid:12547288 |
| Cambie RC and Ferguson LR | Potential functional foods in the traditional Maori diet. | Mutat. Res. | pmid:12628508 | |
| Lee J et al. | Natural products and body weight control. | 2011 | N Am J Med Sci | pmid:22540057 |
| Meng S et al. | Natural dyes adsorbed on TiO2 nanowire for photovoltaic applications: enhanced light absorption and ultrafast electron injection. | 2008 | Nano Lett. | pmid:18788788 |
| Sparzak B et al. | HPLC analysis of polyphenols in the fruits of Rubus idaeus L. (Rosaceae). | 2010 | Nat. Prod. Res. | pmid:21104526 |
| Qin C et al. | Separation and elucidation of anthocyanins in the fruit of mockstrawberry (Duchesnea indica Focke). | 2009 | Nat. Prod. Res. | pmid:19851924 |
| Vodopivec BM et al. | Differences in the structure of anthocyanins from the two amphibious plants, Lobelia cardinalis and Nesaea crassicaulis. | 2013 | Nat. Prod. Res. | pmid:22694738 |
| Thummayot S et al. | Neuroprotective effects of cyanidin against Aβ-induced oxidative and ER stress in SK-N-SH cells. | 2016 | Neurochem. Int. | pmid:27697517 |
| Tarozzi A et al. | Cyanidin 3-O-glucopyranoside protects and rescues SH-SY5Y cells against amyloid-beta peptide-induced toxicity. | 2008 | Neuroreport | pmid:18797302 |
| Min J et al. | Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia. | 2011 | Neurosci. Lett. | pmid:21651957 |
| Tarozzi A et al. | Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells. | 2007 | Neurosci. Lett. | pmid:17709193 |
| Tarozzi A et al. | Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity. | 2010 | Neurosci. Lett. | pmid:20152881 |
| Chen G et al. | Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta. | 2009 | Neurotox Res | pmid:19384566 |
| Thummayot S et al. | Neuroprotective effect of purple rice extract and its constituent against amyloid beta-induced neuronal cell death in SK-N-SH cells. | 2014 | Neurotoxicology | pmid:25451968 |
| Yao Y and Vieira A | Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. | 2007 | Neurotoxicology | pmid:16956663 |
| Vignolini S et al. | The mirror crack'd: both pigment and structure contribute to the glossy blue appearance of the mirror orchid, Ophrys speculum. | 2012 | New Phytol. | pmid:23043621 |
| Wallerath T et al. | A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. | 2005 | Nitric Oxide | pmid:15740983 |
| Pergola C et al. | Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. | 2006 | Nitric Oxide | pmid:16517190 |
| Briviba K et al. | Neurotensin-and EGF-induced metabolic activation of colon carcinoma cells is diminished by dietary flavonoid cyanidin but not by its glycosides. | 2001 | Nutr Cancer | pmid:12094622 |
| Zikri NN et al. | Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. | 2009 | Nutr Cancer | pmid:20155622 |
| Aqil F et al. | Antioxidant and antiproliferative activities of anthocyanin/ellagitannin-enriched extracts from Syzygium cumini L. (Jamun, the Indian Blackberry). | 2012 | Nutr Cancer | pmid:22420901 |
| Chen PN et al. | Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. | 2005 | Nutr Cancer | pmid:16573384 |
| Seeram NP et al. | Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. | 2003 | Nutr Cancer | pmid:12925310 |
| Arendt BM et al. | Single and repeated moderate consumption of native or dealcoholized red wine show different effects on antioxidant parameters in blood and DNA strand breaks in peripheral leukocytes in healthy volunteers: a randomized controlled trial (ISRCTN68505294). | 2005 | Nutr J | pmid:16287499 |
| Udani JK et al. | Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study. | 2011 | Nutr J | pmid:21569436 |
| Deguchi Y and Miyazaki K | Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract. | 2010 | Nutr Metab (Lond) | pmid:20181067 |
| Nunn AV et al. | Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? | 2009 | Nutr Metab (Lond) | pmid:19371409 |
| Jang HH et al. | Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation. | 2012 | Nutr Metab (Lond) | pmid:22458550 |
| Suzuki R et al. | Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway. | 2011 | Nutr Metab (Lond) | pmid:21385419 |
| Sarr M et al. | In vitro vasorelaxation mechanisms of bioactive compounds extracted from Hibiscus sabdariffa on rat thoracic aorta. | 2009 | Nutr Metab (Lond) | pmid:19883513 |
| Hassimotto NM et al. | Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. | 2008 | Nutr Res | pmid:19083408 |
| Lee SJ et al. | Grape skin improves antioxidant capacity in rats fed a high fat diet. | 2009 | Nutr Res Pract | pmid:20098580 |
| Kim MK et al. | Identification and quantification of anthocyanin pigments in colored rice. | 2008 | Nutr Res Pract | pmid:20126365 |
| Park MY et al. | Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin. | 2008 | Nutr Res Pract | pmid:20126360 |
| Bae JY et al. | Protective actions of Rubus coreanus ethanol extract on collagenous extracellular matrix in ultraviolet-B irradiation-induced human dermal fibroblasts. | 2007 | Nutr Res Pract | pmid:20368951 |
| Tsao R | Chemistry and biochemistry of dietary polyphenols. | 2010 | Nutrients | pmid:22254006 |
| Suantawee T et al. | Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent Ca Channels. | 2017 | Nutrients | pmid:28788070 |
| Fortalezas S et al. | Antioxidant properties and neuroprotective capacity of strawberry tree fruit (Arbutus unedo). | 2010 | Nutrients | pmid:22254017 |
| Fang J | Classification of fruits based on anthocyanin types and relevance to their health effects. | Nutrition | pmid:26250485 | |
| Hoorens B et al. | Neighbour identity hardly affects litter-mixture effects on decomposition rates of New Zealand forest species. | 2010 | Oecologia | pmid:19756760 |
| Katsuzaki H et al. | Cyanidin 3-O-beta-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells. | Oncol. Rep. | pmid:12579261 | |
| Kondo T et al. | Novel and efficient synthesis of cyanidin 3-O-beta-D-glucoside from (+)-catechin via a flav-3-en-3-ol as a key intermediate. | 2006 | Org. Lett. | pmid:16869672 |
| Pandey KB and Rizvi SI | Plant polyphenols as dietary antioxidants in human health and disease. | 2009 Nov-Dec | Oxid Med Cell Longev | pmid:20716914 |
| Akhlaghi M and Bandy B | Preconditioning and acute effects of flavonoids in protecting cardiomyocytes from oxidative cell death. | 2012 | Oxid Med Cell Longev | pmid:22829963 |
| Vauzour D | Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | 2012 | Oxid Med Cell Longev | pmid:22701758 |
| Mulabagal V et al. | Quantitative analysis of anthocyanins in Euterpe oleracea (açaÃ) dietary supplement raw materials and capsules by Q-TOF liquid chromatography/mass spectrometry. | 2012 | Pharm Biol | pmid:22900515 |
| Ugalde CM et al. | Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers. | 2009 | Pharm. Res. | pmid:19137418 |
| Ozgen M et al. | Total phenolic, anthocyanin contents and antioxidant capacity of selected elderberry (Sambucus canadensis L.) accessions. | 2010 | Pharmacogn Mag | pmid:20931079 |
| Ozen T and Türkekul I | Antioxidant activities of Sarcodon imbricatum wildly grown in the Black Sea Region of Turkey. | 2010 | Pharmacogn Mag | pmid:20668572 |
| Kumar D et al. | A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae). | 2011 | Pharmacogn Rev | pmid:22279376 |
| Mohanty S and Cock IE | The chemotherapeutic potential of Terminalia ferdinandiana: Phytochemistry and bioactivity. | 2012 | Pharmacogn Rev | pmid:22654402 |
| Korać RR and Khambholja KM | Potential of herbs in skin protection from ultraviolet radiation. | 2011 | Pharmacogn Rev | pmid:22279374 |