Pelargonidin

Pelargonidin is a lipid of Polyketides (PK) class. The involved functions are known as Uptake, Intestinal Absorption, glucose uptake, Process and Metabolic Inhibition. Pelargonidin often locates in Serosal, Mucous Membrane, brush border membrane, Membrane and Cell surface. The associated genes with Pelargonidin are SLC5A1 gene, SLC2A2 gene, Homologous Gene, F3 gene and CRSP3 gene. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of Pelargonidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Pelargonidin?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Pelargonidin

MeSH term MeSH ID Detail
Cystitis D003556 23 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Total 2

PubChem Associated disorders and diseases

What pathways are associated with Pelargonidin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Pelargonidin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Pelargonidin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Pelargonidin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Pelargonidin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Pelargonidin?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Pelargonidin

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Authors Title Published Journal PubMed Link
pmid:
Sohanaki H et al. Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer's Disease Via Estrogen Receptor Independent Pathways. 2016 Acta Med Iran pmid:27309265
Kang H et al. Suppressive Effects of Pelargonidin on Endothelial Protein C Receptor Shedding via the Inhibition of TACE Activity and MAP Kinases. 2016 Am. J. Chin. Med. pmid:27222063
Forni C et al. Role of transglutaminase 2 in quercetin-induced differentiation of B16-F10 murine melanoma cells. 2009 Amino Acids pmid:18688565
De Rosso M et al. Study of anthocyanic profiles of twenty-one hybrid grape varieties by liquid chromatography and precursor-ion mass spectrometry. 2012 Anal. Chim. Acta pmid:22688043
Sugita O et al. A new method of measuring the antioxidant activity of polyphenols using cumene hydroperoxide. 2004 Ann. Clin. Biochem. pmid:14713390
Ross JA and Kasum CM Dietary flavonoids: bioavailability, metabolic effects, and safety. 2002 Annu. Rev. Nutr. pmid:12055336
Vauzour D et al. Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. 2008 Arch. Biochem. Biophys. pmid:18394421
Cvorovic J et al. Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells. 2010 Arch. Biochem. Biophys. pmid:20494645
Vafeiadou K et al. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. 2009 Arch. Biochem. Biophys. pmid:19467635
Xie DY et al. Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. 2004 Arch. Biochem. Biophys. pmid:14725861
Lee IC and Bae JS Suppressive effects of pelargonidin on PolyPhosphate-mediated vascular inflammatory responses. 2017 Arch. Pharm. Res. pmid:27826751
Min G et al. Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo. 2016 Arch. Pharm. Res. pmid:27778275
Ku SK et al. Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro. 2016 Arch. Pharm. Res. pmid:26762345
Abe Y et al. Detection of 1-O-malylglucose: pelargonidin 3-O-glucose-6''-O-malyltransferase activity in carnation (Dianthus caryophyllus). 2008 Biochem. Biophys. Res. Commun. pmid:18471436
Dreiseitel A et al. Inhibition of proteasome activity by anthocyanins and anthocyanidins. 2008 Biochem. Biophys. Res. Commun. pmid:18460339
Son JE et al. Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase. 2014 Biochem. Pharmacol. pmid:24582770
Hou DX et al. Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. 2005 Biochem. Pharmacol. pmid:15963474
Grigoriev SM et al. Regulation of mitochondrial KATP channel by redox agents. 1999 Biochim. Biophys. Acta pmid:10076019
Sahay A and Shakya M Structure prediction of dihydroflavonol 4- reductase and anthocyanidin synthase from spinach. 2010 Bioinformation pmid:21364828
Ganugapati J et al. Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus. 2012 Bioinformation pmid:22493522
Marinov BS and Ruzieva RKh [Opposite control of O2 affinity for hemoglobin by donors and acceptors]. 1990 Biokhimiia pmid:2078638
Gargouri M et al. The epimerase activity of anthocyanidin reductase from Vitis vinifera and its regiospecific hydride transfers. Biol. Chem. pmid:20030585
Sohanaki H et al. Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress. 2016 Biomed. Pharmacother. pmid:27470554
Takasawa R et al. Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. 2010 Bioorg. Med. Chem. pmid:20801663
Ku CS and Mun SP Optimization of the extraction of anthocyanin from Bokbunja (Rubus coreanus Miq.) marc produced during traditional wine processing and characterization of the extracts. 2008 Bioresour. Technol. pmid:18456493
Kaneko T et al. Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins. 2003 Biosci. Biotechnol. Biochem. pmid:12843669
Tanaka Y et al. Flower color modification by engineering of the flavonoid biosynthetic pathway: practical perspectives. 2010 Biosci. Biotechnol. Biochem. pmid:20834175
Yan Y et al. High-yield anthocyanin biosynthesis in engineered Escherichia coli. 2008 Biotechnol. Bioeng. pmid:18023053
Su V and Hsu BD Cloning and expression of a putative cytochrome P450 gene that influences the colour of Phalaenopsis flowers. 2003 Biotechnol. Lett. pmid:14719829
Aksamit-Stachurska A et al. Glycosyltransferase efficiently controls phenylpropanoid pathway. 2008 BMC Biotechnol. pmid:18321380
Kovinich N et al. Combined analysis of transcriptome and metabolite data reveals extensive differences between black and brown nearly-isogenic soybean (Glycine max) seed coats enabling the identification of pigment isogenes. 2011 BMC Genomics pmid:21801362
Grimplet J et al. Tissue-specific mRNA expression profiling in grape berry tissues. 2007 BMC Genomics pmid:17584945
Irani NG and Grotewold E Light-induced morphological alteration in anthocyanin-accumulating vacuoles of maize cells. 2005 BMC Plant Biol. pmid:15907203
Payyavula RS et al. Differential effects of environment on potato phenylpropanoid and carotenoid expression. 2012 BMC Plant Biol. pmid:22429339
Gillman JD et al. Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in brown hilum and brown seed coats. 2011 BMC Plant Biol. pmid:22070454
Boase MR et al. Isolation and antisense suppression of flavonoid 3', 5'-hydroxylase modifies flower pigments and colour in cyclamen. 2010 BMC Plant Biol. pmid:20540805
Chagné D et al. QTL and candidate gene mapping for polyphenolic composition in apple fruit. 2012 BMC Plant Biol. pmid:22269060
Telias A et al. Apple skin patterning is associated with differential expression of MYB10. 2011 BMC Plant Biol. pmid:21599973
Zamora-Ros R et al. Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. 2011 Br. J. Nutr. pmid:21481290
Azzini E et al. Bioavailability of strawberry antioxidants in human subjects. 2010 Br. J. Nutr. pmid:20487578
Felgines C et al. Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. 2007 Br. J. Nutr. pmid:17559698
Edirisinghe I et al. Strawberry anthocyanin and its association with postprandial inflammation and insulin. 2011 Br. J. Nutr. pmid:21736853
El Mohsen MA et al. Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats. 2006 Br. J. Nutr. pmid:16441916
Dreiseitel A et al. Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. 2009 Br. J. Pharmacol. pmid:19922539
Roghani M et al. Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism. 2010 Brain Res. Bull. pmid:20558255
Jeong S et al. Anti-inflammatory effects of pelargonidin on TGFBIp-induced responses. 2017 Can. J. Physiol. Pharmacol. pmid:28060523
Bakowska-Barczak AM et al. Survey of bioactive components in Western Canadian berries. 2007 Can. J. Physiol. Pharmacol. pmid:18066116
Lamy S et al. Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation. 2006 Carcinogenesis pmid:16308314
Xu Y et al. Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia. 2018 Chem. Commun. (Camb.) pmid:30394469