MeSH term | MeSH ID | Detail |
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Cystitis | D003556 | 23 associated lipids |
Parkinsonian Disorders | D020734 | 20 associated lipids |
Pelargonidin is a lipid of Polyketides (PK) class. The involved functions are known as Uptake, Intestinal Absorption, glucose uptake, Process and Metabolic Inhibition. Pelargonidin often locates in Serosal, Mucous Membrane, brush border membrane, Membrane and Cell surface. The associated genes with Pelargonidin are SLC5A1 gene, SLC2A2 gene, Homologous Gene, F3 gene and CRSP3 gene. The related experimental models are Knock-out.
To understand associated biological information of Pelargonidin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Pelargonidin
MeSH term | MeSH ID | Detail |
---|---|---|
Cystitis | D003556 | 23 associated lipids |
Parkinsonian Disorders | D020734 | 20 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Sohanaki H et al. | Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer's Disease Via Estrogen Receptor Independent Pathways. | 2016 | Acta Med Iran | pmid:27309265 |
Kang H et al. | Suppressive Effects of Pelargonidin on Endothelial Protein C Receptor Shedding via the Inhibition of TACE Activity and MAP Kinases. | 2016 | Am. J. Chin. Med. | pmid:27222063 |
Forni C et al. | Role of transglutaminase 2 in quercetin-induced differentiation of B16-F10 murine melanoma cells. | 2009 | Amino Acids | pmid:18688565 |
De Rosso M et al. | Study of anthocyanic profiles of twenty-one hybrid grape varieties by liquid chromatography and precursor-ion mass spectrometry. | 2012 | Anal. Chim. Acta | pmid:22688043 |
Sugita O et al. | A new method of measuring the antioxidant activity of polyphenols using cumene hydroperoxide. | 2004 | Ann. Clin. Biochem. | pmid:14713390 |
Ross JA and Kasum CM | Dietary flavonoids: bioavailability, metabolic effects, and safety. | 2002 | Annu. Rev. Nutr. | pmid:12055336 |
Vauzour D et al. | Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. | 2008 | Arch. Biochem. Biophys. | pmid:18394421 |
Cvorovic J et al. | Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells. | 2010 | Arch. Biochem. Biophys. | pmid:20494645 |
Vafeiadou K et al. | The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. | 2009 | Arch. Biochem. Biophys. | pmid:19467635 |
Xie DY et al. | Anthocyanidin reductases from Medicago truncatula and Arabidopsis thaliana. | 2004 | Arch. Biochem. Biophys. | pmid:14725861 |
Lee IC and Bae JS | Suppressive effects of pelargonidin on PolyPhosphate-mediated vascular inflammatory responses. | 2017 | Arch. Pharm. Res. | pmid:27826751 |
Min G et al. | Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo. | 2016 | Arch. Pharm. Res. | pmid:27778275 |
Ku SK et al. | Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro. | 2016 | Arch. Pharm. Res. | pmid:26762345 |
Abe Y et al. | Detection of 1-O-malylglucose: pelargonidin 3-O-glucose-6''-O-malyltransferase activity in carnation (Dianthus caryophyllus). | 2008 | Biochem. Biophys. Res. Commun. | pmid:18471436 |
Dreiseitel A et al. | Inhibition of proteasome activity by anthocyanins and anthocyanidins. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18460339 |
Son JE et al. | Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase. | 2014 | Biochem. Pharmacol. | pmid:24582770 |
Hou DX et al. | Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. | 2005 | Biochem. Pharmacol. | pmid:15963474 |
Grigoriev SM et al. | Regulation of mitochondrial KATP channel by redox agents. | 1999 | Biochim. Biophys. Acta | pmid:10076019 |
Sahay A and Shakya M | Structure prediction of dihydroflavonol 4- reductase and anthocyanidin synthase from spinach. | 2010 | Bioinformation | pmid:21364828 |
Ganugapati J et al. | Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus. | 2012 | Bioinformation | pmid:22493522 |
Marinov BS and Ruzieva RKh | [Opposite control of O2 affinity for hemoglobin by donors and acceptors]. | 1990 | Biokhimiia | pmid:2078638 |
Gargouri M et al. | The epimerase activity of anthocyanidin reductase from Vitis vinifera and its regiospecific hydride transfers. | Biol. Chem. | pmid:20030585 | |
Sohanaki H et al. | Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress. | 2016 | Biomed. Pharmacother. | pmid:27470554 |
Takasawa R et al. | Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. | 2010 | Bioorg. Med. Chem. | pmid:20801663 |
Ku CS and Mun SP | Optimization of the extraction of anthocyanin from Bokbunja (Rubus coreanus Miq.) marc produced during traditional wine processing and characterization of the extracts. | 2008 | Bioresour. Technol. | pmid:18456493 |
Kaneko T et al. | Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843669 |
Tanaka Y et al. | Flower color modification by engineering of the flavonoid biosynthetic pathway: practical perspectives. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20834175 |
Yan Y et al. | High-yield anthocyanin biosynthesis in engineered Escherichia coli. | 2008 | Biotechnol. Bioeng. | pmid:18023053 |
Su V and Hsu BD | Cloning and expression of a putative cytochrome P450 gene that influences the colour of Phalaenopsis flowers. | 2003 | Biotechnol. Lett. | pmid:14719829 |
Aksamit-Stachurska A et al. | Glycosyltransferase efficiently controls phenylpropanoid pathway. | 2008 | BMC Biotechnol. | pmid:18321380 |
Kovinich N et al. | Combined analysis of transcriptome and metabolite data reveals extensive differences between black and brown nearly-isogenic soybean (Glycine max) seed coats enabling the identification of pigment isogenes. | 2011 | BMC Genomics | pmid:21801362 |
Grimplet J et al. | Tissue-specific mRNA expression profiling in grape berry tissues. | 2007 | BMC Genomics | pmid:17584945 |
Irani NG and Grotewold E | Light-induced morphological alteration in anthocyanin-accumulating vacuoles of maize cells. | 2005 | BMC Plant Biol. | pmid:15907203 |
Payyavula RS et al. | Differential effects of environment on potato phenylpropanoid and carotenoid expression. | 2012 | BMC Plant Biol. | pmid:22429339 |
Gillman JD et al. | Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in brown hilum and brown seed coats. | 2011 | BMC Plant Biol. | pmid:22070454 |
Boase MR et al. | Isolation and antisense suppression of flavonoid 3', 5'-hydroxylase modifies flower pigments and colour in cyclamen. | 2010 | BMC Plant Biol. | pmid:20540805 |
Chagné D et al. | QTL and candidate gene mapping for polyphenolic composition in apple fruit. | 2012 | BMC Plant Biol. | pmid:22269060 |
Telias A et al. | Apple skin patterning is associated with differential expression of MYB10. | 2011 | BMC Plant Biol. | pmid:21599973 |
Zamora-Ros R et al. | Estimation of the intake of anthocyanidins and their food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. | 2011 | Br. J. Nutr. | pmid:21481290 |
Azzini E et al. | Bioavailability of strawberry antioxidants in human subjects. | 2010 | Br. J. Nutr. | pmid:20487578 |
Felgines C et al. | Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. | 2007 | Br. J. Nutr. | pmid:17559698 |
Edirisinghe I et al. | Strawberry anthocyanin and its association with postprandial inflammation and insulin. | 2011 | Br. J. Nutr. | pmid:21736853 |
El Mohsen MA et al. | Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats. | 2006 | Br. J. Nutr. | pmid:16441916 |
Dreiseitel A et al. | Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. | 2009 | Br. J. Pharmacol. | pmid:19922539 |
Roghani M et al. | Oral pelargonidin exerts dose-dependent neuroprotection in 6-hydroxydopamine rat model of hemi-parkinsonism. | 2010 | Brain Res. Bull. | pmid:20558255 |
Jeong S et al. | Anti-inflammatory effects of pelargonidin on TGFBIp-induced responses. | 2017 | Can. J. Physiol. Pharmacol. | pmid:28060523 |
Bakowska-Barczak AM et al. | Survey of bioactive components in Western Canadian berries. | 2007 | Can. J. Physiol. Pharmacol. | pmid:18066116 |
Lamy S et al. | Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation. | 2006 | Carcinogenesis | pmid:16308314 |
Xu Y et al. | Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia. | 2018 | Chem. Commun. (Camb.) | pmid:30394469 |