(-)-Epicatechin

(-)-Epicatechin is a lipid of Polyketides (PK) class.

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Meng X et al. Identification and characterization of methylated and ring-fission metabolites of tea catechins formed in humans, mice, and rats. 2002 Chem. Res. Toxicol. pmid:12184788
Kobayashi W et al. Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill. 2002 Biol. Pharm. Bull. pmid:12186408
Hossain SJ et al. Polyphenol-induced inhibition of the response of na(+)/glucose cotransporter expressed in Xenopus oocytes. 2002 J. Agric. Food Chem. pmid:12188632
Nie G et al. Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells. 2002 Redox Rep. pmid:12189048
Sun CL et al. Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. 2002 Carcinogenesis pmid:12189193
Delaunay JC et al. Preparative isolation of polyphenolic compounds from Vitis vinifera by centrifugal partition chromatography. 2002 J Chromatogr A pmid:12198840
Nagaoka H et al. Spectrofluorometric determination of catechins with 1,2-diphenylethylenediamine. 2002 Anal Sci pmid:12200848
Roig R et al. Procyanidins protect Fao cells against hydrogen peroxide-induced oxidative stress. 2002 Biochim. Biophys. Acta pmid:12204329
Filipe P et al. Mechanisms of flavonoid repair reactions with amino acid radicals in models of biological systems: a pulse radiolysis study in micelles and human serum albumin. 2002 Biochim. Biophys. Acta pmid:12204344
de Mejía EG and Ramírez-Mares MV Leaf extract from Ardisia compressa protects against 1-nitropyrene-induced cytotoxicity and its antioxidant defense disruption in cultured rat hepatocytes. 2002 Toxicology pmid:12204551
Lu YP et al. Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12205293
Saeki K et al. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. 2002 Biochem. J. pmid:12206715
Seeram NP and Nair MG Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechins. 2002 J. Agric. Food Chem. pmid:12207466
Kagaya N et al. Suppression of cytotoxin-induced cell death in isolated hepatocytes by tea catechins. 2002 Eur. J. Pharmacol. pmid:12208314
Singh R et al. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. 2002 Arthritis Rheum. pmid:12209512
Chen L et al. Tea catechins protect against lead-induced cytotoxicity, lipid peroxidation, and membrane fluidity in HepG2 cells. 2002 Toxicol. Sci. pmid:12215669
Gupta S et al. Comparative antimutagenic and anticlastogenic effects of green tea and black tea: a review. 2002 Mutat. Res. pmid:12220589
Imanishi N et al. Additional inhibitory effect of tea extract on the growth of influenza A and B viruses in MDCK cells. 2002 Microbiol. Immunol. pmid:12222936
Chen A et al. The antioxidant (-)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression. 2002 Biochem. J. pmid:12223099
Zhong Z et al. Prevention of hepatic ischemia-reperfusion injury by green tea extract. 2002 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12223356
Murakami C et al. Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells. 2002 Biosci. Biotechnol. Biochem. pmid:12224642
Kagaya N et al. Enhancing effect of zinc on hepatoprotectivity of epigallocatechin gallate in isolated rat hepatocytes. 2002 Biol. Pharm. Bull. pmid:12230108
Kinjo J et al. Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells. 2002 Biol. Pharm. Bull. pmid:12230128
Rhee SJ et al. Green tea catechin improves microsomal phospholipase A2 activity and the arachidonic acid cascade system in the kidney of diabetic rats. 2002 Asia Pac J Clin Nutr pmid:12230237
Rhee SJ et al. Effects of green tea catechin on prostaglandin synthesis of renal glomerular and renal dysfunction in streptozotocin-induced diabetic rats. 2002 Asia Pac J Clin Nutr pmid:12230238
McKim SE et al. Cocoa extract protects against early alcohol-induced liver injury in the rat. 2002 Arch. Biochem. Biophys. pmid:12234488
Svedström U et al. High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn. 2002 J Chromatogr A pmid:12236514
Hosny M and Rosazza JP Novel oxidations of (+)-catechin by horseradish peroxidase and laccase. 2002 J. Agric. Food Chem. pmid:12236676
Es-Safi NE et al. Role of aldehydic derivatives in the condensation of phenolic compounds with emphasis on the sensorial properties of fruit-derived foods. 2002 J. Agric. Food Chem. pmid:12236681
Cantos E et al. Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. 2002 J. Agric. Food Chem. pmid:12236700
Fujimura Y et al. Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells. 2002 J. Agric. Food Chem. pmid:12236706
Wang EJ et al. Elevation of P-glycoprotein function by a catechin in green tea. 2002 Biochem. Biophys. Res. Commun. pmid:12237135
Kazi A et al. Inhibition of bcl-x(l) phosphorylation by tea polyphenols or epigallocatechin-3-gallate is associated with prostate cancer cell apoptosis. 2002 Mol. Pharmacol. pmid:12237322
Backhouse N et al. Bioactive phenolic derivatives from Acaena splendens methanol extract. 2002 Phytother Res pmid:12237815
Chen PC et al. A green tea-derived polyphenol, epigallocatechin-3-gallate, inhibits IkappaB kinase activation and IL-8 gene expression in respiratory epithelium. 2002 Inflammation pmid:12238566
Gunnarsson GT and Desai UR Interaction of designed sulfated flavanoids with antithrombin: lessons on the design of organic activators. 2002 J. Med. Chem. pmid:12238925
Gertsch J et al. Relative quantification of mRNA levels in Jurkat T cells with RT-real time-PCR (RT-rt-PCR): new possibilities for the screening of anti-inflammatory and cytotoxic compounds. 2002 Pharm. Res. pmid:12240952
Bagchi M et al. Role of reactive oxygen species in the development of cytotoxicity with various forms of chewing tobacco and pan masala. 2002 Toxicology pmid:12270596
Sanae F et al. Effects of catechins on vascular tone in rat thoracic aorta with endothelium. 2002 Life Sci. pmid:12270760
Pearson DA et al. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. 2002 Thromb. Res. pmid:12297125
Holt RR et al. Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. 2002 Am. J. Clin. Nutr. pmid:12324293
Ebeler SE et al. Dietary catechin delays tumor onset in a transgenic mouse model. 2002 Am. J. Clin. Nutr. pmid:12324302
Cao Y et al. Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection. 2002 Anal Bioanal Chem pmid:12324852
Orner GA et al. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). 2002 Mutat. Res. pmid:12351151
Saito A et al. Synthetic studies of proanthocyanidins. Highly stereoselective synthesis of the catechin dimer, procyanidin-B3. 2002 Biosci. Biotechnol. Biochem. pmid:12353644
Simonetti P et al. Procyanidins from Vitis vinifera seeds: in vivo effects on oxidative stress. 2002 J. Agric. Food Chem. pmid:12358505
Ottaviani JI et al. Influence of flavan-3-ols and procyanidins on UVC-mediated formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in isolated DNA. 2002 Arch. Biochem. Biophys. pmid:12361708
Ahmed S et al. Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. 2002 Free Radic. Biol. Med. pmid:12374621
Lin SC et al. Regulation of IGFBP-5 expression during tumourigenesis and differentiation of oral keratinocytes. 2002 J. Pathol. pmid:12375264
Lee MJ et al. Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. 2002 Cancer Epidemiol. Biomarkers Prev. pmid:12376503
Abrahams S et al. Identification and biochemical characterization of mutants in the proanthocyanidin pathway in Arabidopsis. 2002 Plant Physiol. pmid:12376625
Goodin MG et al. Estrogen receptor-mediated actions of polyphenolic catechins in vivo and in vitro. 2002 Toxicol. Sci. pmid:12377984
DiCesare D et al. A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico. 2002 Am. J. Gastroenterol. pmid:12385443
Cai Y et al. Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats. 2002 Drug Metab. Dispos. pmid:12386131
Ahmed I et al. Differential modulation of growth and glutathione metabolism in cultured rat astrocytes by 4-hydroxynonenal and green tea polyphenol, epigallocatechin-3-gallate. 2002 Neurotoxicology pmid:12387357
Choi JY et al. Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. 2002 Neurotoxicology pmid:12387363
Bastianetto S and Quirion R Natural extracts as possible protective agents of brain aging. 2002 Sep-Oct Neurobiol. Aging pmid:12392793
Wang YC and Bachrach U The specific anti-cancer activity of green tea (-)-epigallocatechin-3-gallate (EGCG). 2002 Amino Acids pmid:12395181
Rosenkranz S et al. Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the "French paradox". 2002 FASEB J. pmid:12397093
Rios LY et al. Cocoa procyanidins are stable during gastric transit in humans. 2002 Am. J. Clin. Nutr. pmid:12399286
Fujiki H et al. Green tea: cancer preventive beverage and/or drug. 2002 Cancer Lett. pmid:12406542
Hirose M et al. Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses. 2002 Cancer Lett. pmid:12406561
Gupta S et al. Antimutagenic effects of black tea (World Blend) and its two active polyphenols theaflavins and thearubigins in Salmonella assays. 2002 Phytother Res pmid:12410547
Liang YC et al. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory skin edema and ornithine decarboxylase activity by theaflavin-3,3'-digallate in mouse. 2002 Nutr Cancer pmid:12416263
Nakagawa T and Yokozawa T Direct scavenging of nitric oxide and superoxide by green tea. 2002 Food Chem. Toxicol. pmid:12419687
Lee S and Jung S 13C NMR spectroscopic analysis on the chiral discrimination of N-acetylphenylalanine, catechin and propranolol induced by cyclic-(1-->2)-beta-D-glucans (cyclosophoraoses). 2002 Carbohydr. Res. pmid:12423959
Cai YJ et al. Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. 2002 Chem. Phys. Lipids pmid:12426080
Kalender S et al. Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats. 2002 Braz. J. Med. Biol. Res. pmid:12426639
Lung HL et al. Anti-proliferative and differentiation-inducing activities of the green tea catechin epigallocatechin-3-gallate (EGCG) on the human eosinophilic leukemia EoL-1 cell line. 2002 Life Sci. pmid:12427485
Sharpless KE et al. Value assignment of nutrient concentrations in standard reference material 2384 baking chocolate. 2002 J. Agric. Food Chem. pmid:12428961
Pedrielli P and Skibsted LH Antioxidant synergy and regeneration effect of quercetin, (-)-epicatechin, and (+)-catechin on alpha-tocopherol in homogeneous solutions of peroxidating methyl linoleate. 2002 J. Agric. Food Chem. pmid:12428973
Saito M et al. Green tea polyphenols inhibit metalloproteinase activities in the skin, muscle, and blood of rainbow trout. 2002 J. Agric. Food Chem. pmid:12428978
Anderson RA and Polansky MM Tea enhances insulin activity. 2002 J. Agric. Food Chem. pmid:12428980
Li ZG et al. Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats. 2002 Int. J. Oncol. pmid:12429978
Deguchi H et al. Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D. 2002 Int. J. Oncol. pmid:12429981
Tobi SE et al. The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation. 2002 Int. J. Cancer pmid:12432544
Lozano C et al. Cation-exchange micropreparative separation of galloylated and non-galloylated sulphur conjugated catechins. 2002 J Chromatogr A pmid:12437183
Masuda M et al. Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction. 2002 Nov-Dec J. Exp. Ther. Oncol. pmid:12440226
Cren-Olivé C et al. Free radical chemistry of flavan-3-ols: determination of thermodynamic parameters and of kinetic reactivity from short (ns) to long (ms) time scale. 2002 J. Am. Chem. Soc. pmid:12440901
Tanaka T et al. Accumulation of epigallocatechin quinone dimers during tea fermentation and formation of theasinensins. 2002 J. Nat. Prod. pmid:12444680
Nagai K et al. (-)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant. 2002 Brain Res. pmid:12445701
Towatari K et al. Polyphenols from the heartwood of Cercidiphyllum japonicum and their effects on proliferation of mouse hair epithelial cells. 2002 Planta Med. pmid:12451489
Van Der Sluis AA et al. Activity and concentration of polyphenolic antioxidants in apple juice. 1. Effect of existing production methods. 2002 J. Agric. Food Chem. pmid:12452634
Lapidot T et al. Antioxidant and prooxidant effects of phenolics on pancreatic beta-cells in vitro. 2002 J. Agric. Food Chem. pmid:12452635
Hu ZQ et al. Additive, indifferent and antagonistic effects in combinations of epigallocatechin gallate with 12 non-beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. 2002 J. Antimicrob. Chemother. pmid:12461032
Vergote D et al. (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. 2002 Breast Cancer Res. Treat. pmid:12462380
Rossetto M et al. Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. 2002 Arch. Biochem. Biophys. pmid:12464277
Edelmann A and Lendl B Toward the optical tongue: flow-through sensing of tannin-protein interactions based on FTIR spectroscopy. 2002 J. Am. Chem. Soc. pmid:12465987
Chen ZY et al. (-)epicatechin induces and modulates endothelium-dependent relaxation in isolated rat mesenteric artery rings. 2002 Acta Pharmacol. Sin. pmid:12466059
Hirasawa M et al. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. 2002 J. Periodont. Res. pmid:12472837
Kamimura A and Takahashi T Procyanidin B-3, isolated from barley and identified as a hair-growth stimulant, has the potential to counteract inhibitory regulation by TGF-beta1. 2002 Exp. Dermatol. pmid:12473061
Oki T et al. Polymeric procyanidins as radical-scavenging components in red-hulled rice. 2002 J. Agric. Food Chem. pmid:12475265
Torres JL et al. Valorization of grape (Vitis vinifera) byproducts. Antioxidant and biological properties of polyphenolic fractions differing in procyanidin composition and flavonol content. 2002 J. Agric. Food Chem. pmid:12475269
Seimiya H et al. Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. 2002 Mol. Cancer Ther. pmid:12479362
Fujisaw S et al. Kinetic evaluation of the reactivity of flavonoids as radical scavengers. 2002 SAR QSAR Environ Res pmid:12479376
Dell'Aica I et al. (-)Epigallocatechin-3-gallate directly inhibits MT1-MMP activity, leading to accumulation of nonactivated MMP-2 at the cell surface. 2002 Lab. Invest. pmid:12480918
Maeda K et al. Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. 2003 Atherosclerosis pmid:12482547
Tedeschi E et al. Antiinflammatory action of EGCG, the main component of green tea, through STAT-1 inhibition. 2002 Ann. N. Y. Acad. Sci. pmid:12485906
Blache D et al. (+)-Catechin inhibits platelet hyperactivity induced by an acute iron load in vivo. 2002 Free Radic. Biol. Med. pmid:12488135
Abd El Mohsen MM et al. Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. 2002 Free Radic. Biol. Med. pmid:12488137