(-)-Epicatechin

(-)-Epicatechin is a lipid of Polyketides (PK) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 55698 references associated with (-)-Epicatechin in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Authors Title Published Journal PubMed Link
Beltz LA et al. Mechanisms of cancer prevention by green and black tea polyphenols. 2006 Anticancer Agents Med Chem pmid:17017850
Yiannakopoulou ECh Green tea catechins: Proposed mechanisms of action in breast cancer focusing on the interplay between survival and apoptosis. 2014 Anticancer Agents Med Chem pmid:24069935
Zhang L et al. Novel mechanisms of anticancer activities of green tea component epigallocatechin- 3-gallate. 2014 Anticancer Agents Med Chem pmid:24851882
Valcic S et al. Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines. 1996 Anticancer Drugs pmid:8826614
Stammler G and Volm M Green tea catechins (EGCG and EGC) have modulating effects on the activity of doxorubicin in drug-resistant cell lines. 1997 Anticancer Drugs pmid:9095331
Sen T et al. Epigallocatechin-3-gallate (EGCG) downregulates gelatinase-B (MMP-9) by involvement of FAK/ERK/NFkappaB and AP-1 in the human breast cancer cell line MDA-MB-231. 2010 Anticancer Drugs pmid:20527725
Shin SC and Choi JS Effects of epigallocatechin gallate on the oral bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats. 2009 Anticancer Drugs pmid:19491656
Chisholm K et al. Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells. 2004 Anticancer Drugs pmid:15457130
Takahashi H et al. The preventive effect of green tea on the gap junction intercellular communication in renal epithelial cells treated with a renal carcinogen. 2004 Nov-Dec Anticancer Res. pmid:15736408
Sukhthankar M et al. (-)-Epigallocatechin-3-gallate (EGCG) post-transcriptionally and post-translationally suppresses the cell proliferative protein TROP2 in human colorectal cancer cells. 2010 Anticancer Res. pmid:20682974
Rao SD and Pagidas K Epigallocatechin-3-gallate, a natural polyphenol, inhibits cell proliferation and induces apoptosis in human ovarian cancer cells. 2010 Anticancer Res. pmid:20682977
Hashimoto K and Sakagami H Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line. 2008 May-Jun Anticancer Res. pmid:18630530
Hsu S et al. Role of p21WAF1 in green tea polyphenol-induced growth arrest and apoptosis of oral carcinoma cells. 2005 Jan-Feb Anticancer Res. pmid:15816520
Waleh NS et al. Novel D-ring analog of epigallocatechin-3-gallate inhibits tumor growth and VEGF expression in breast carcinoma cells. 2005 Jan-Feb Anticancer Res. pmid:15816564
Satonaka H et al. (-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways. 2017 Anticancer Res. pmid:29061787
Seiler N et al. Synergism between apple procyanidins and lysosomotropic drugs: potential in chemoprevention. Anticancer Res. pmid:17094456
Takeuchi R et al. Effect of anticancer agents on codeinone-induced apoptosis in human cancer cell lines. 2005 Nov-Dec Anticancer Res. pmid:16309196
Papiez MA et al. (-)-Epicatechin enhances etoposide-induced antileukaemic effect in rats with acute myeloid leukaemia. 2012 Anticancer Res. pmid:22753754
Gao Y et al. Inhibitory Effects of the Four Main Theaflavin Derivatives Found in Black Tea on Ovarian Cancer Cells. 2016 Anticancer Res. pmid:26851019
Yunos NM et al. Synergism from sequenced combinations of curcumin and epigallocatechin-3-gallate with cisplatin in the killing of human ovarian cancer cells. 2011 Anticancer Res. pmid:21508356
Chung SS and Vadgama JV Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFκB signaling. 2015 Anticancer Res. pmid:25550533
Kim HS et al. EGCG blocks tumor promoter-induced MMP-9 expression via suppression of MAPK and AP-1 activation in human gastric AGS cells. 2004 Mar-Apr Anticancer Res. pmid:15161022
Kazi A et al. Structure-activity relationships of synthetic analogs of (-)-epigallocatechin-3-gallate as proteasome inhibitors. 2004 Mar-Apr Anticancer Res. pmid:15161048
Gao Z et al. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. 2009 Anticancer Res. pmid:19528461
Uchiyama H et al. Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®). 2016 Anticancer Res. pmid:27354644
Yamamoto T et al. Protective effects of EGCG on salivary gland cells treated with gamma-radiation or cis-platinum(II)diammine dichloride. 2004 Sep-Oct Anticancer Res. pmid:15517917
Kim MH and Chung J Synergistic cell death by EGCG and ibuprofen in DU-145 prostate cancer cell line. 2007 Nov-Dec Anticancer Res. pmid:18225555
Wu PP et al. (-)-Epigallocatechin gallate induced apoptosis in human adrenal cancer NCI-H295 cells through caspase-dependent and caspase-independent pathway. 2009 Anticancer Res. pmid:19414399
Martins A et al. Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells. 2010 Anticancer Res. pmid:20393003
Mazumder ME et al. Epigallocatechin gallate acts synergistically in combination with cisplatin and designed trans-palladiums in ovarian cancer cells. 2012 Anticancer Res. pmid:23155251
Enkhbat T et al. Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy. 2018 Anticancer Res. pmid:30396944
Moseley VR et al. Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells. 2013 Anticancer Res. pmid:24324066
Puig T et al. Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals. 2008 Nov-Dec Anticancer Res. pmid:19189648
Hsieh TC and Wu JM Targeting CWR22Rv1 prostate cancer cell proliferation and gene expression by combinations of the phytochemicals EGCG, genistein and quercetin. 2009 Anticancer Res. pmid:19846946
Kim D et al. Induction of apoptosis of SW480 human colon cancer cells by (-)-epicatechin isolated from Bulnesia sarmienti. 2012 Anticancer Res. pmid:23225437
Ohishi T et al. Anti-inflammatory Action of Green Tea. 2016 Antiinflamm Antiallergy Agents Med Chem pmid:27634207
Dormeyer M et al. Rational design of anticytoadherence inhibitors for Plasmodium falciparum based on the crystal structure of human intercellular adhesion molecule 1. 2006 Antimicrob. Agents Chemother. pmid:16436732
Stapleton PD et al. Potentiation of catechin gallate-mediated sensitization of Staphylococcus aureus to oxacillin by nongalloylated catechins. 2006 Antimicrob. Agents Chemother. pmid:16436737
Hu ZQ et al. Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus. 2002 Antimicrob. Agents Chemother. pmid:11796378
Zhao WH et al. Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus. 2001 Antimicrob. Agents Chemother. pmid:11353619
Isaacs CE et al. Digallate dimers of (-)-epigallocatechin gallate inactivate herpes simplex virus. 2011 Antimicrob. Agents Chemother. pmid:21947401
Zhao WH et al. Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus. 2002 Antimicrob. Agents Chemother. pmid:12069986
Paveto C et al. Anti-Trypanosoma cruzi activity of green tea (Camellia sinensis) catechins. 2004 Antimicrob. Agents Chemother. pmid:14693520
Isaacs CE and Xu W Theaflavin-3,3'-digallate and lactic acid combinations reduce herpes simplex virus infectivity. 2013 Antimicrob. Agents Chemother. pmid:23716050
Isaacs CE et al. Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus. 2008 Antimicrob. Agents Chemother. pmid:18195068
Sudano Roccaro A et al. Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells. 2004 Antimicrob. Agents Chemother. pmid:15155186
da Silva CR et al. Synergistic effect of the flavonoid catechin, quercetin, or epigallocatechin gallate with fluconazole induces apoptosis in Candida tropicalis resistant to fluconazole. 2014 Antimicrob. Agents Chemother. pmid:24366745
Yamazaki T et al. Biosynthesized tea polyphenols inactivate Chlamydia trachomatis in vitro. 2005 Antimicrob. Agents Chemother. pmid:15917555
Navarro-Martínez MD et al. Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophilia. 2005 Antimicrob. Agents Chemother. pmid:15980368
Mabe K et al. In vitro and in vivo activities of tea catechins against Helicobacter pylori. 1999 Antimicrob. Agents Chemother. pmid:10390246