(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kang MY et al. | Preventive effects of green tea (Camellia sinensis var. assamica) on diabetic nephropathy. | 2012 | Yonsei Med. J. | pmid:22187244 |
| Sagai M and Bocci V | Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? | 2011 | Med Gas Res | pmid:22185664 |
| Li G et al. | A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22178739 |
| Zhao L et al. | Pu-erh tea inhibits tumor cell growth by down-regulating mutant p53. | 2011 | Int J Mol Sci | pmid:22174618 |
| Zhang X et al. | Characterisation of anthocyanidin reductase from Shuchazao green tea. | 2012 | J. Sci. Food Agric. | pmid:22173936 |
| Kadoma Y and Fujisawa S | Radical-scavenging activity of dietary phytophenols in combination with co-antioxidants using the induction period method. | 2011 | Molecules | pmid:22173338 |
| Long LH and Halliwell B | The effects of oxaloacetate on hydrogen peroxide generation from ascorbate and epigallocatechin gallate in cell culture media: potential for altering cell metabolism. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22166196 |
| Roh C et al. | Label free inhibitor screening of hepatitis C virus (HCV) NS5B viral protein using RNA oligonucleotide. | 2011 | Sensors (Basel) | pmid:22163979 |
| Mahajan M et al. | Post-transcriptional silencing of flavonol synthase mRNA in tobacco leads to fruits with arrested seed set. | 2011 | PLoS ONE | pmid:22145036 |
| Sone T et al. | Randomized controlled trial for an effect of catechin-enriched green tea consumption on adiponectin and cardiovascular disease risk factors. | 2011 | Food Nutr Res | pmid:22144918 |
| Manalo DJ et al. | Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1α) and induces hepcidin (Hamp) in rat kidney. | 2011 | Biochem. Biophys. Res. Commun. | pmid:22138393 |
| Jacot JL and Sherris D | Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy. | 2011 | J Ophthalmol | pmid:22132311 |
| Park SJ et al. | Effects of Epigallocatechin-3-Gallate on the Expression of TGF-β1, PKC α/βII, and NF-κB in High-Glucose-Stimulated Glomerular Epithelial Cells. | 2011 | Chonnam Med J | pmid:22111071 |
| Calland N et al. | (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry. | 2012 | Hepatology | pmid:22105803 |
| Wang Y et al. | Simultaneous determination of seven bioactive components in Oolong tea Camellia sinensis: quality control by chemical composition and HPLC fingerprints. | 2012 | J. Agric. Food Chem. | pmid:22098505 |
| Chahar MK et al. | Flavonoids: A versatile source of anticancer drugs. | 2011 | Pharmacogn Rev | pmid:22096313 |
| Hanlin RL et al. | Detailed characterization of proanthocyanidins in skin, seeds, and wine of Shiraz and Cabernet Sauvignon wine grapes (Vitis vinifera). | 2011 | J. Agric. Food Chem. | pmid:22085086 |
| Lee UL and Choi SW | The chemopreventive properties and therapeutic modulation of green tea polyphenols in oral squamous cell carcinoma. | 2011 | ISRN Oncol | pmid:22084729 |
| Feucht W et al. | Nuclei of Tsuga canadensis: role of flavanols in chromatin organization. | 2011 | Int J Mol Sci | pmid:22072922 |
| Nabekura T | Overcoming multidrug resistance in human cancer cells by natural compounds. | 2010 | Toxins (Basel) | pmid:22069634 |