(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Beppu M et al. | Water-soluble antioxidants inhibit macrophage recognition of oxidized erythrocytes. | 2001 | Biol. Pharm. Bull. | pmid:11379784 |
| Warden BA et al. | Catechins are bioavailable in men and women drinking black tea throughout the day. | 2001 | J. Nutr. | pmid:11385060 |
| Li C et al. | Analysis of urinary metabolites of tea catechins by liquid chromatography/electrospray ionization mass spectrometry. | 2001 | Chem. Res. Toxicol. | pmid:11409941 |
| Muto S et al. | Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450. | 2001 | Mutat. Res. | pmid:11470492 |
| Anderson RF et al. | Green tea catechins partially protect DNA from (.)OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals. | 2001 | Carcinogenesis | pmid:11470748 |
| Yoshioka H et al. | Spin-trapping study on the hydroxyl radical formed from a tea catechin-Cu(II) system. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11577706 |
| Hong J et al. | Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. | 2001 | Biochem. Pharmacol. | pmid:11705450 |
| Kennedy JA et al. | Composition of grape skin proanthocyanidins at different stages of berry development. | 2001 | J. Agric. Food Chem. | pmid:11714327 |
| Pan CY et al. | Enhancement of inward Ca(2+) currents in bovine chromaffin cells by green tea polyphenol extracts. | 2002 | Neurochem. Int. | pmid:11738479 |
| Tanaka T et al. | Two types of oxidative dimerization of the black tea polyphenol theaflavin. | 2001 | J. Agric. Food Chem. | pmid:11743764 |
| Jin CF et al. | Different effects of five catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2001 | J. Agric. Food Chem. | pmid:11743804 |
| Nie G et al. | Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2002 | Arch. Biochem. Biophys. | pmid:11747313 |
| Inoue MB et al. | Potentiometric and (1)H NMR studies of complexation of Al(3+) with (-)-epigallocatechin gallate, a major active constituent of green tea. | 2002 | J. Inorg. Biochem. | pmid:11750019 |
| Locher R et al. | Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. | 2002 | Eur. J. Pharmacol. | pmid:11755158 |
| Bhatia N et al. | Differential responses of skin cancer-chemopreventive agents silibinin, quercetin, and epigallocatechin 3-gallate on mitogenic signaling and cell cycle regulators in human epidermoid carcinoma A431 cells. | 2001 | Nutr Cancer | pmid:11759294 |
| Wang LQ et al. | The heterocyclic ring fission and dehydroxylation of catechins and related compounds by Eubacterium sp. strain SDG-2, a human intestinal bacterium. | 2001 | Chem. Pharm. Bull. | pmid:11767089 |
| Zhu BT et al. | Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase. | 2001 | Xenobiotica | pmid:11780762 |
| Van Amelsvoort JM et al. | Plasma concentrations of individual tea catechins after a single oral dose in humans. | 2001 | Xenobiotica | pmid:11780763 |
| Kang HW et al. | Isolation and characterization of alkyl peroxy radical scavenging compound from leaves of Laurus nobilis. | 2002 | Biol. Pharm. Bull. | pmid:11824536 |
| Furuno K et al. | The contribution of the pyrogallol moiety to the superoxide radical scavenging activity of flavonoids. | 2002 | Biol. Pharm. Bull. | pmid:11824550 |
| Tillekeratne LM et al. | Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11844664 |
| Kandil FE et al. | Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. | 2002 | J. Agric. Food Chem. | pmid:11853481 |
| Annabi B et al. | Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. | 2002 | Biochim. Biophys. Acta | pmid:11853893 |
| Mochizuki M et al. | Kinetic analysis and mechanistic aspects of autoxidation of catechins. | 2002 | Biochim. Biophys. Acta | pmid:11853955 |
| Luo XD et al. | Polyphenolic antioxidants from the fruits of Chrysophyllum cainito L. (Star Apple). | 2002 | J. Agric. Food Chem. | pmid:11879006 |
| Kennedy DO et al. | Cellular thiol status-dependent inhibition of tumor cell growth via modulation of retinoblastoma protein phosphorylation by (-)-epigallocatechin. | 2002 | Cancer Lett. | pmid:11880178 |
| Fernández PL et al. | Study of catechin and xanthine tea profiles as geographical tracers. | 2002 | J. Agric. Food Chem. | pmid:11902920 |
| Tanaka T et al. | Synthesis of theaflavin from epicatechin and epigallocatechin by plant homogenates and role of epicatechin quinone in the synthesis and degradation of theaflavin. | 2002 | J. Agric. Food Chem. | pmid:11902970 |
| Dhawan A et al. | Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. | 2002 | Mutat. Res. | pmid:11909753 |
| Carini M et al. | Antioxidant and photoprotective activity of a lipophilic extract containing neolignans from Krameria triandra roots. | 2002 | Planta Med. | pmid:11914952 |
| Ito H et al. | Antitumor activity of compounds isolated from leaves of Eriobotrya japonica. | 2002 | J. Agric. Food Chem. | pmid:11929303 |
| Sartippour MR et al. | Green tea and its catechins inhibit breast cancer xenografts. | 2001 | Nutr Cancer | pmid:11962250 |
| Plumb GW et al. | Antioxidant properties of gallocatechin and prodelphinidins from pomegranate peel. | 2002 | Redox Rep. | pmid:11981454 |
| Kida K et al. | Deodorizing effects of tea catechins on amines and ammonia. | 2002 | Biosci. Biotechnol. Biochem. | pmid:11999411 |
| Hynes MJ and Coinceanainn MO | Investigation of the release of iron from ferritin by naturally occurring antioxidants. | 2002 | J. Inorg. Biochem. | pmid:12009251 |
| Sachinidis A et al. | Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins. | 2002 | FASEB J. | pmid:12039871 |
| Levites Y et al. | Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action. | 2002 | J. Biol. Chem. | pmid:12058035 |
| Young JF et al. | Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. | 2002 | Br. J. Nutr. | pmid:12064344 |
| Satoh K et al. | Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. | 2002 | Food Chem. Toxicol. | pmid:12065214 |
| Morris K | Tea chemicals confirmed as cancer-busting compounds. | 2002 | Lancet Oncol. | pmid:12067792 |
| Yokozawa T et al. | Study on the components of luobuma with peroxynitrite-scavenging activity. | 2002 | Biol. Pharm. Bull. | pmid:12081141 |
| Salucci M et al. | Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2). | 2002 | Br. J. Cancer | pmid:12085217 |
| Tang FY and Meydani M | Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production. | 2001 | Nutr Cancer | pmid:12094614 |
| Sarni-Manchado P and Cheynier V | Study of non-covalent complexation between catechin derivatives and peptides by electrospray ionization mass spectrometry. | 2002 | J Mass Spectrom | pmid:12112743 |
| Tan X et al. | Changes in ceramide levels upon catechins-induced apoptosis in LoVo cells. | 2002 | Life Sci. | pmid:12148694 |
| Sartippour MR et al. | Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. | 2002 | J. Nutr. | pmid:12163680 |
| Sun CL et al. | Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. | 2002 | Carcinogenesis | pmid:12189193 |
| Nagaoka H et al. | Spectrofluorometric determination of catechins with 1,2-diphenylethylenediamine. | 2002 | Anal Sci | pmid:12200848 |
| de MejÃa EG and RamÃrez-Mares MV | Leaf extract from Ardisia compressa protects against 1-nitropyrene-induced cytotoxicity and its antioxidant defense disruption in cultured rat hepatocytes. | 2002 | Toxicology | pmid:12204551 |
| Murakami C et al. | Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224642 |