(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chow HH et al. | Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. | 2001 | Cancer Epidemiol. Biomarkers Prev. | pmid:11205489 |
| Beppu M et al. | Water-soluble antioxidants inhibit macrophage recognition of oxidized erythrocytes. | 2001 | Biol. Pharm. Bull. | pmid:11379784 |
| Meng X et al. | Formation and identification of 4'-O-methyl-(-)-epigallocatechin in humans. | 2001 | Drug Metab. Dispos. | pmid:11353745 |
| Jin CF et al. | Different effects of five catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2001 | J. Agric. Food Chem. | pmid:11743804 |
| Tanaka T et al. | Two types of oxidative dimerization of the black tea polyphenol theaflavin. | 2001 | J. Agric. Food Chem. | pmid:11743764 |
| Satoh K et al. | Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats. | 2002 | Food Chem. Toxicol. | pmid:12065214 |
| Sachinidis A et al. | Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins. | 2002 | FASEB J. | pmid:12039871 |
| Nakagawa T and Yokozawa T | Direct scavenging of nitric oxide and superoxide by green tea. | 2002 | Food Chem. Toxicol. | pmid:12419687 |
| Dhawan A et al. | Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. | 2002 | Mutat. Res. | pmid:11909753 |
| Annabi B et al. | Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. | 2002 | Biochim. Biophys. Acta | pmid:11853893 |
| Inoue MB et al. | Potentiometric and (1)H NMR studies of complexation of Al(3+) with (-)-epigallocatechin gallate, a major active constituent of green tea. | 2002 | J. Inorg. Biochem. | pmid:11750019 |
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| Cai Y et al. | Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats. | 2002 | Drug Metab. Dispos. | pmid:12386131 |
| Kinjo J et al. | Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells. | 2002 | Biol. Pharm. Bull. | pmid:12230128 |
| Kida K et al. | Deodorizing effects of tea catechins on amines and ammonia. | 2002 | Biosci. Biotechnol. Biochem. | pmid:11999411 |
| Sun CL et al. | Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. | 2002 | Carcinogenesis | pmid:12189193 |
| Furuno K et al. | The contribution of the pyrogallol moiety to the superoxide radical scavenging activity of flavonoids. | 2002 | Biol. Pharm. Bull. | pmid:11824550 |
| Tillekeratne LM et al. | Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. | 2002 | Bioorg. Med. Chem. Lett. | pmid:11844664 |
| Kang HW et al. | Isolation and characterization of alkyl peroxy radical scavenging compound from leaves of Laurus nobilis. | 2002 | Biol. Pharm. Bull. | pmid:11824536 |
| Mochizuki M et al. | Kinetic analysis and mechanistic aspects of autoxidation of catechins. | 2002 | Biochim. Biophys. Acta | pmid:11853955 |
| Kennedy DO et al. | Cellular thiol status-dependent inhibition of tumor cell growth via modulation of retinoblastoma protein phosphorylation by (-)-epigallocatechin. | 2002 | Cancer Lett. | pmid:11880178 |
| Tanaka T et al. | Synthesis of theaflavin from epicatechin and epigallocatechin by plant homogenates and role of epicatechin quinone in the synthesis and degradation of theaflavin. | 2002 | J. Agric. Food Chem. | pmid:11902970 |
| Salucci M et al. | Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2). | 2002 | Br. J. Cancer | pmid:12085217 |
| Nagaoka H et al. | Spectrofluorometric determination of catechins with 1,2-diphenylethylenediamine. | 2002 | Anal Sci | pmid:12200848 |
| Ito H et al. | Antitumor activity of compounds isolated from leaves of Eriobotrya japonica. | 2002 | J. Agric. Food Chem. | pmid:11929303 |
| Cai YJ et al. | Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. | 2002 | Chem. Phys. Lipids | pmid:12426080 |
| Plumb GW et al. | Antioxidant properties of gallocatechin and prodelphinidins from pomegranate peel. | 2002 | Redox Rep. | pmid:11981454 |
| Sartippour MR et al. | Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. | 2002 | J. Nutr. | pmid:12163680 |
| Hynes MJ and Coinceanainn MO | Investigation of the release of iron from ferritin by naturally occurring antioxidants. | 2002 | J. Inorg. Biochem. | pmid:12009251 |
| Yokozawa T et al. | Study on the components of luobuma with peroxynitrite-scavenging activity. | 2002 | Biol. Pharm. Bull. | pmid:12081141 |
| Young JF et al. | Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. | 2002 | Br. J. Nutr. | pmid:12064344 |
| Zuo Y et al. | Simultaneous determination of catechins, caffeine and gallic acids in green, Oolong, black and pu-erh teas using HPLC with a photodiode array detector. | 2002 | Talanta | pmid:18968631 |
| Morris K | Tea chemicals confirmed as cancer-busting compounds. | 2002 | Lancet Oncol. | pmid:12067792 |
| Saito M et al. | Green tea polyphenols inhibit metalloproteinase activities in the skin, muscle, and blood of rainbow trout. | 2002 | J. Agric. Food Chem. | pmid:12428978 |
| Murakami C et al. | Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12224642 |
| Sanae F et al. | Effects of catechins on vascular tone in rat thoracic aorta with endothelium. | 2002 | Life Sci. | pmid:12270760 |
| Vergote D et al. | (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. | 2002 | Breast Cancer Res. Treat. | pmid:12462380 |
| Lee MJ et al. | Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12376503 |
| Levites Y et al. | Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action. | 2002 | J. Biol. Chem. | pmid:12058035 |
| Choi JY et al. | Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. | 2002 | Neurotoxicology | pmid:12387363 |
| González de MejÃa E et al. | Topoisomerase I and II enzyme inhibitory aqueous extract of Ardisia compressa and ardisin protect against benomyl oxidation of hepatocytes. | 2002 | J. Agric. Food Chem. | pmid:12475294 |
| Turner ND et al. | Opportunities for nutritional amelioration of radiation-induced cellular damage. | 2002 | Nutrition | pmid:12361786 |
| Carini M et al. | Antioxidant and photoprotective activity of a lipophilic extract containing neolignans from Krameria triandra roots. | 2002 | Planta Med. | pmid:11914952 |
| Fernández PL et al. | Study of catechin and xanthine tea profiles as geographical tracers. | 2002 | J. Agric. Food Chem. | pmid:11902920 |
| Luo XD et al. | Polyphenolic antioxidants from the fruits of Chrysophyllum cainito L. (Star Apple). | 2002 | J. Agric. Food Chem. | pmid:11879006 |
| Kandil FE et al. | Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. | 2002 | J. Agric. Food Chem. | pmid:11853481 |
| Locher R et al. | Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. | 2002 | Eur. J. Pharmacol. | pmid:11755158 |
| Nie G et al. | Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. | 2002 | Arch. Biochem. Biophys. | pmid:11747313 |
| Cantos E et al. | Varietal differences among the polyphenol profiles of seven table grape cultivars studied by LC-DAD-MS-MS. | 2002 | J. Agric. Food Chem. | pmid:12236700 |
| Lin SC et al. | Regulation of IGFBP-5 expression during tumourigenesis and differentiation of oral keratinocytes. | 2002 | J. Pathol. | pmid:12375264 |