(-)-Epigallocatechin is a lipid of Polyketides (PK) class. The involved functions are known as Protective Agents, inhibitors, Process, Drug Kinetics and Fermentation. (-)-epigallocatechin often locates in Hepatic, Blood, Membrane, Back and apical membrane. The associated genes with (-)-Epigallocatechin are ADRBK1 gene and FASTK Gene. The related lipids are 1,2-dilinolenoyl-3-(4-aminobutyryl)propane-1,2,3-triol. The related experimental models are Rodent Model and Transgenic Model.
To understand associated biological information of (-)-Epigallocatechin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with (-)-Epigallocatechin
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioblastoma | D005909 | 27 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015) and Rodent Model are used in the study 'Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals.' (Chow HH et al., 2005).
Transgenic Model are used in the study 'Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.' (Cox CJ et al., 2015).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Garbacki N et al. | Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats. | 2004 | BMC Pharmacol. | pmid:15498105 |
| Aneja R et al. | Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. | 2004 Jan-Jun | Mol. Med. | pmid:15502883 |
| Nimal Punyasiri PA et al. | Exobasidium vexans infection of Camellia sinensis increased 2,3-cis isomerisation and gallate esterification of proanthocyanidins. | 2004 | Phytochemistry | pmid:15504433 |
| Zhang L et al. | Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. | 2004 | Int J Pharm | pmid:15541906 |
| Koyama Y et al. | Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo. | 2004 | Planta Med. | pmid:15549673 |
| Furuyashiki T et al. | Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15564676 |
| Taguri T et al. | Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease. | 2004 | Biol. Pharm. Bull. | pmid:15577214 |
| Zhou B et al. | Evidence for alpha-tocopherol regeneration reaction of green tea polyphenols in SDS micelles. | 2005 | Free Radic. Biol. Med. | pmid:15589374 |
| Apak R et al. | Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. | 2004 | J. Agric. Food Chem. | pmid:15612784 |
| Wang R and Zhou W | Stability of tea catechins in the breadmaking process. | 2004 | J. Agric. Food Chem. | pmid:15612821 |
| Lee K | Transactivation of peroxisome proliferator-activated receptor alpha by green tea extracts. | 2004 | J. Vet. Sci. | pmid:15613816 |
| Proctor GB et al. | Salivary proteins interact with dietary constituents to modulate tooth staining. | 2005 | J. Dent. Res. | pmid:15615880 |
| Navarro RE et al. | Complexation of epigallocatechin gallate (a green tea extract, egcg) with Mn2+: nuclear spin relaxation by the paramagnetic ion. | 2005 | J. Inorg. Biochem. | pmid:15621293 |
| Kuo YC et al. | Isolation and immunomodulatory effect of flavonoids from Syzygium samarangense. | 2004 | Planta Med. | pmid:15643565 |
| Hung PF et al. | Antimitogenic effect of green tea (-)-epigallocatechin gallate on 3T3-L1 preadipocytes depends on the ERK and Cdk2 pathways. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15647388 |
| Babich H et al. | Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. | 2005 | Toxicol In Vitro | pmid:15649637 |
| Ikeda I et al. | Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats. | 2005 | J. Nutr. | pmid:15671206 |
| Lambert JD et al. | Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15686878 |
| Guendez R et al. | An analytical survey of the polyphenols of seeds of varieties of grape (Vitis vinifera) cultivated in Greece: implications for exploitation as a source of value-added phytochemicals. | Phytochem Anal | pmid:15688951 | |
| Lee YK et al. | VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance. | 2005 | Leukemia | pmid:15703780 |
| Kawai K | Comment on inhibitory effect of (-)-epigallocatechin 3-gallate, a polyphenol of green tea, on neutrophil chemotaxis in vitro and in vivo. | 2005 | J. Agric. Food Chem. | pmid:15713057 |
| Netsch MI et al. | Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality. | 2005 | Planta Med. | pmid:15729621 |
| Rizvi SI et al. | Protective role of tea catechins against oxidation-induced damage of type 2 diabetic erythrocytes. | Clin. Exp. Pharmacol. Physiol. | pmid:15730438 | |
| Gyémánt N et al. | In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. | 2005 Mar-Apr | In Vivo | pmid:15796199 |
| Ozcan A et al. | Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats. | 2005 | Arch. Toxicol. | pmid:15800758 |
| Mukai K et al. | Structure-activity relationship of the tocopherol-regeneration reaction by catechins. | 2005 | Free Radic. Biol. Med. | pmid:15808422 |
| Feucht W et al. | Flavanols in somatic cell division and male meiosis of tea (Camellia sinensis) anthers. | 2005 | Plant Biol (Stuttg) | pmid:15822012 |
| Chen D et al. | Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. | 2005 | Biochem. Pharmacol. | pmid:15857617 |
| Kim M et al. | (-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells. | 2005 | Carcinogenesis | pmid:15860507 |
| Doss MX et al. | Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases. | 2005 | J. Nutr. Biochem. | pmid:15866224 |
| Anger DL et al. | Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols. | 2005 | Br. J. Pharmacol. | pmid:15895106 |
| Nakai M et al. | Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. | 2005 | J. Agric. Food Chem. | pmid:15913331 |
| Luo H et al. | Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. | 2006 | Carcinogenesis | pmid:15930028 |
| Mizushina Y et al. | Structural analysis of catechin derivatives as mammalian DNA polymerase inhibitors. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15950188 |
| Chow HH et al. | Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. | 2005 | Clin. Cancer Res. | pmid:15958649 |
| Lyu SY and Park WB | Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids. | 2005 | Arch. Pharm. Res. | pmid:15974445 |
| Lin SC et al. | The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells. | 2006 | Cancer Lett. | pmid:15975707 |
| Di Paola R et al. | Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. | 2005 | Respir. Res. | pmid:15987519 |
| Mazauric JP and Salmon JM | Interactions between yeast lees and wine polyphenols during simulation of wine aging: I. Analysis of remnant polyphenolic compounds in the resulting wines. | 2005 | J. Agric. Food Chem. | pmid:15998128 |
| Cortell JM et al. | Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) and wine proanthocyanidins. | 2005 | J. Agric. Food Chem. | pmid:15998151 |
| Vovk I et al. | Separation of eight selected flavan-3-ols on cellulose thin-layer chromatographic plates. | 2005 | J Chromatogr A | pmid:16001555 |
| Suzuki Y et al. | Dose-dependent suppression of tea catechins with a galloyl moiety on postprandial hypertriglyceridemia in rats. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16041132 |
| Hayashi N et al. | Reduction of catechin astringency by the complexation of gallate-type catechins with pectin. | 2005 | Biosci. Biotechnol. Biochem. | pmid:16041135 |
| Huang HY and Lien WC | Analyses of phenolic compounds by microemulsion electrokinetic chromatography. | 2005 | Electrophoresis | pmid:16041702 |
| Yao L et al. | Seasonal variations of phenolic compounds in Australia-grown tea (Camellia sinensis). | 2005 | J. Agric. Food Chem. | pmid:16076137 |
| Kumar NS and Rajapaksha M | Separation of catechin constituents from five tea cultivars using high-speed counter-current chromatography. | 2005 | J Chromatogr A | pmid:16078712 |
| Yang C et al. | Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. | 2005 | Toxicology | pmid:16085347 |
| Naka T et al. | Modulation of branching morphogenesis of fetal mouse submandibular gland by sodium ascorbate and epigallocatechin gallate. | 2005 Sep-Oct | In Vivo | pmid:16097443 |
| Mukai K et al. | Kinetic study of the quenching reaction of singlet oxygen by tea catechins in ethanol solution. | 2005 | Free Radic. Biol. Med. | pmid:16109305 |
| Herrero M et al. | Pressurized liquid extraction-capillary electrophoresis-mass spectrometry for the analysis of polar antioxidants in rosemary extracts. | 2005 | J Chromatogr A | pmid:16114236 |